Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.

Abstract:

PURPOSE:To compare the effects of levobunolol hydrochloride and timolol maleate on tear volume, precorneal tear film stability, and corneal epithelial barrier function in normal human eyes. SUBJECTS AND METHODS:The study population consisted of 14 healthy volunteers. To obtain pretreatment baseline values, we determined the radius of the tear meniscus (RTM) by meniscometry; the noninvasive breakup time (NIBUT) of the precorneal tear film with a tear specular microscope; and corneal fluorescein uptake with a fluorophotometer. Levobunolol hydrochloride (0.5%) or timolol maleate solution (0.5%) was instilled twice daily for 4 weeks into 1 eye; the contralateral eye was treated with the other topical drug twice daily for the same period. At the end of the study period, the same tests were performed, and the pre- and posttreatment results were compared. RESULTS:Timolol solution did, and levobunolol did not, significantly reduce NIBUT from the baseline values. RTM was significantly decreased by treatment with either timolol or levobunolol solution. Corneal fluorescein uptake was not significantly changed, although it was higher after treatment with both topical drugs. CONCLUSIONS:Four-week treatment with timolol solution resulted in significant instability of the precorneal tear film. Both timolol and levobunolol solution significantly decreased tear volume on the ocular surface. These results indicate that levobunolol solution applied twice daily has equal effects on the tear volume and corneal epithelial barrier function as does timolol solution applied twice daily and that it affects precorneal tear film stability less than timolol solution.

journal_name

Cornea

journal_title

Cornea

authors

Ishibashi T,Yokoi N,Kinoshita S

doi

10.1097/00003226-200311000-00001

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

709-15

issue

8

eissn

0277-3740

issn

1536-4798

journal_volume

22

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Effect of intravitreal ranibizumab on corneal endothelium in age-related macular degeneration.

    abstract:PURPOSE:To determine the effect of intravitreal injection of ranibizumab on the corneal endothelium in patients with choroidal neovascularization in age-related macular degeneration. METHODS:Observational prospective case series study. Fifty-two eyes of 52 consecutive patients (29 men, 23 women; age range, 61-80 years...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ca33d2

    authors: Pérez-Rico C,Benítez-Herreros J,Castro-Rebollo M,Gómez-Sangil Y,Germain F,Montes-Mollón MA,Teus MA

    更新日期:2010-08-01 00:00:00

  • Successful Müller muscle-conjunctiva resection in patients with Boston keratoprosthesis type I.

    abstract:PURPOSE:To present a case series of patients with Boston keratoprosthesis type I (KPro) who have had successful ptosis repair with Müller muscle-conjunctiva resection (MMCR). METHODS:Patients with KPros managed with MMCR for ptosis were identified. Records were examined to obtain preoperative and postoperative visual ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000043

    authors: Lim JM,Bang GM,Cortina MS,de la Cruz J,Setabutr P

    更新日期:2014-03-01 00:00:00

  • Moderately Long-Term Safety and Efficacy of Repeat Penetrating Keratoplasty.

    abstract:PURPOSE:To investigate the moderately long-term safety and efficacy of repeat penetrating keratoplasty (PK) for treatment of a failed PK graft. METHODS:Retrospective consecutive clinical case series. Of 992 consecutive cases that underwent PK at Baptist Eye Institute, Kyoto, Japan, between April 1998 and September 201...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001694

    authors: Kitazawa K,Wakimasu K,Kayukawa K,Yokota I,Inatomi T,Hieda O,Sotozono C,Kinoshita S

    更新日期:2018-10-01 00:00:00

  • Nevirapine-induced Stevens-Johnson syndrome in an HIV patient.

    abstract:PURPOSE:To report a case of nevirapine-induced Stevens-Johnson syndrome (SJS) misdiagnosed as viral keratitis. METHODS:A 35-year-old AIDS patient, on antiretroviral therapy (ART) with stavudine, nevirapine, and lamivudine, developed bilateral ocular congestion and irritation. He was being treated elsewhere for bilater...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31815b941b

    authors: Jain V,Shome D,Natarajan S

    更新日期:2008-04-01 00:00:00

  • Descemet-stripping automated endothelial keratoplasty by using suture for donor insertion.

    abstract:PURPOSE:To describe a new technique for donor insertion in cases of Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:This is a retrospective case series study of a novel method to introduce the donor tissue in DSAEK. This is a report of 16 cases that underwent the DSAEK procedure. The surgical te...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31816f62bd

    authors: Sarnicola V,Toro P

    更新日期:2008-08-01 00:00:00

  • The corneal-thickness profile in Hong Kong Chinese.

    abstract:PURPOSE:This study investigated the topographic corneal thickness in four groups of Hong Kong Chinese. METHODS:The corneal thickness was determined with an ultrasound pachometer mounted on a X-Y plate. A head rest was used to reduce further any movement from the subject during the measurement. After the central cornea...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199807000-00008

    authors: Lam AK,Douthwaite WA

    更新日期:1998-07-01 00:00:00

  • Randomized Control Trial on the Effectiveness of Collagen Cross-linking on Bullous Keratopathy.

    abstract:PURPOSE:To investigate the long-term effect and safety of collagen cross-linking (CXL) on patients with bullous keratopathy (BK) in a randomized control manner. It is, to our knowledge, the first randomized control study on the effect of CXL on BK. METHODS:Subjects were randomized to receive CXL as in the standard pro...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002395

    authors: Choy BNK,Ng ALK,Zhu MM,Liu CC,Xu S,Lai JSM

    更新日期:2020-11-01 00:00:00

  • Measurement of Quality of Life in Keratoconus.

    abstract:PURPOSE:To identify and assess the quality of questionnaires used to measure quality of life in keratoconus and guide selection of the most appropriate questionnaire for evaluating the impact of keratoconus. METHODS:A literature search was carried out in Scopus, Web of Science, PubMed, MEDLINE, Cochrane, and PsycINFO ...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000002170

    authors: Kandel H,Pesudovs K,Watson SL

    更新日期:2020-03-01 00:00:00

  • Outcomes of Flap Lift Laser In Situ Keratomileusis Enhancements in a Large Patient Population: Does Application of a Bandage Contact Lens Affect Incidence of Epithelial Ingrowth?

    abstract:PURPOSE:To compare the incidence of corneal epithelial ingrowth (EIG) and the visual outcomes of enhancement with laser in situ keratomileusis (LASIK) by flap lift when a bandage soft contact lens (CL) was fitted after the procedure and when it was not. METHODS:This is a multicenter, retrospective, interventional case...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0000000000002132

    authors: Ortega-Usobiaga J,Baviera-Sabater J,Llovet-Osuna F,González-López F,Bilbao-Calabuig R,Llovet-Rausell A,Beltrán-Sanz J

    更新日期:2019-12-01 00:00:00

  • Conjunctival malignant melanoma-associated pseudomelanoma of the apposing tarsal conjunctiva.

    abstract:PURPOSE:To describe a case of conjunctival malignant melanoma associated with pseudomelanomatous alteration of the apposing tarsal conjunctiva. METHODS:A 93-year-old woman presented with an elevated, pigmented mass on her superior bulbar conjunctiva. The tumor was associated with increased pigmentation of the apposing...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000226358.26678.98

    authors: Reddy S,Finger PT,Kurli M,Bui A,Iacob CE

    更新日期:2006-10-01 00:00:00

  • Identifying the origin of single corneal cells by DNA fingerprinting: part II-- application to limbal allografting.

    abstract:PURPOSE:Successful limbal allotransplantation allows regression of limbal stem cell deficiency features. Transplant survival is presumed if clinical improvement occurs. However, positive proof of surviving transplanted stem cells remains difficult. This follow-up study attempted to prove donor cell survival 5 years aft...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200105000-00014

    authors: Henderson TR,Findlay I,Matthews PL,Noble BA

    更新日期:2001-05-01 00:00:00

  • Outcomes of repeat endothelial keratoplasty in patients with failed deep lamellar endothelial keratoplasty.

    abstract:PURPOSE:To report the outcomes of repeat endothelial keratoplasty (EK) in patients with previous failed deep lamellar endothelial keratoplasty (DLEK). METHODS:This retrospective interventional case series involved the review of clinical records of patients with failed DLEK surgery who underwent repeat EK surgery. RES...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31821522b4

    authors: Kim P,Brodbaker E,Lichtinger A,Yeung SN,Bahar I,Iovieno A,Amiran MD,Rootman DS

    更新日期:2011-11-01 00:00:00

  • Successful treatment of Paecilomyces lilacinus keratitis with oral posaconazole.

    abstract:PURPOSE:To report a case of successful medical treatment with oral posaconazole in refractory fungal keratitis caused by Paecilomyces lilacinus. METHODS:Case report. RESULTS:A 57-year-old male, soft contact lens wearer presented with irritation, pain, photophobia, and reduced vision. Slit-lamp examination showed a la...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000143

    authors: Arnoldner MA,Kheirkhah A,Jakobiec FA,Durand ML,Hamrah P

    更新日期:2014-07-01 00:00:00

  • Visante optical coherence tomography and tear function test evaluation of cholinergic treatment response in patients with sjögren syndrome.

    abstract:PURPOSE:To evaluate tear meniscus changes in patients with Sjögren syndrome (SS) receiving oral pilocarpine with Visante optical coherence tomography (OCT). METHODS:Eight patients with primary SS were recruited in this prospective interventional case series study. Patients received pilocarpine tablets twice a day for ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318261eb4a

    authors: Ibrahim OM,Dogru M,Kawashima S,Wakamatsu TH,Tsubota K,Fujishima H

    更新日期:2013-05-01 00:00:00

  • Management of Type 2 Bubble Formed During Big Bubble Deep Anterior Lamellar Keratoplasty.

    abstract:PURPOSE:To review the outcome of 3 techniques for managing type 2 bubbles (between Descemet's membrane [DM] and stroma) formed during big bubble (BB) deep anterior lamellar keratoplasty (DALK) in different corneal pathologies. METHODS:This is an interventional case series study of patients with type 2 bubbles formed d...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001815

    authors: Goweida MB,Ragab AM,Liu C

    更新日期:2019-02-01 00:00:00

  • Corneal Transplantation in New Zealand 2000 to 2009.

    abstract:PURPOSE:To quantify all minor/major adverse events in a large cohort of consecutive corneal transplants, particularly in respect to penetrating keratoplasty (PKP). METHODS:All corneal transplants in the Auckland region over a 10-year period (2000-2009) were identified through the New Zealand National Eye Bank. Relevan...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001481

    authors: Crawford AZ,Krishnan T,Ormonde SE,Patel DV,McGhee CN

    更新日期:2018-03-01 00:00:00

  • Multimodal Assessment of Corneal Thinning Using Optical Coherence Tomography, Scheimpflug Imaging, Pachymetry, and Slit-Lamp Examination.

    abstract:PURPOSE:To assess the relationship between corneal thinning measured by clinician-graded slit-lamp examination compared with ultrasound pachymetry (USP), anterior segment optical coherence tomography (AS-OCT), and the Pentacam. METHODS:Patients with corneal thinning underwent USP, AS-OCT, Pentacam measurements and sta...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001151

    authors: Oatts JT,Keenan JD,Mannis T,Lietman TM,Rose-Nussbaumer J

    更新日期:2017-04-01 00:00:00

  • Corneal perforation associated with silicone oil in the anterior chamber.

    abstract:PURPOSE:To describe the management of three cases of corneal perforation associated with silicone oil in the anterior chamber. METHODS:Review of 3 case records. RESULTS:Three cases of perforation associated with silicone oil in the anterior chamber are reviewed. One patient required gluing and a bandage contact lens,...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31807a28f0

    authors: Ghosheh FR,Rapuano CJ

    更新日期:2007-10-01 00:00:00

  • Eccentrically Punched Descemet Membrane Endothelial Keratoplasty Grafts Expand the Descemet Membrane Endothelial Keratoplasty Donor Pool: One Eye Bank's Reappraisal of the Central Clear Zone Convention.

    abstract:PURPOSE:To ascertain whether offsetting the Descemet membrane endothelial keratoplasty (DMEK) punch can expand the donor pool in conjunction with prepunched and preloaded services by recapturing the corneas otherwise excluded by the conventional central clear zone criteria. METHODS:In this retrospective review of corn...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002348

    authors: Kornberg DL,Prabhu S,Sales CS,Williams RS,Clover J,Tran KD

    更新日期:2020-10-01 00:00:00

  • Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease.

    abstract:PURPOSE:To bioengineer a corneal surface replacement using ex vivo expanded, cultured corneal epithelial stem cells seeded on a matrix derived from amniotic membrane and use this bioengineered graft to manage difficult ocular surface disease. METHODS:Fourteen patients with ocular surface disease unresponsive to standa...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200007000-00003

    authors: Schwab IR,Reyes M,Isseroff RR

    更新日期:2000-07-01 00:00:00

  • Keratitis resulting from Thielavia subthermophila Mouchacca.

    abstract:PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined m...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31819717f4

    authors: Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE

    更新日期:2009-10-01 00:00:00

  • Ocular microfluctuations and videokeratoscopy.

    abstract:PURPOSE:We aimed to minimize the effect of ocular microfluctuations during videokeratoscopy to improve the qualitative and quantitative analysis of corneal topography. METHODS:A technique was developed to measure the tilt, displacement, and cyclotorsion in multiple videokeratographs from the same cornea. This informat...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200205000-00003

    authors: Buehren T,Lee BJ,Collins MJ,Iskander DR

    更新日期:2002-05-01 00:00:00

  • MoisturePlus contact lens solution as a source of acanthamoeba keratitis.

    abstract::Recently, it was suggested that the use of the Advanced Medical Optics Complete MoisturePlus multipurpose cleaning solution might be a risk factor for contracting Acanthamoeba keratitis, and the manufacturer voluntarily recalled it in May 2007. Polymerase chain reaction amplification and sequencing of a variable part ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318183a34b

    authors: Hasler S,Dedes W,Mathis A,Grimm F,Thiel MA

    更新日期:2009-02-01 00:00:00

  • Treatment of Refractory Keratitis After a Boston Type I Keratoprosthesis With Corneal Collagen Cross-Linking.

    abstract:PURPOSE:To report a patient with refractory keratitis after a Boston type I keratoprosthesis treated with corneal collagen cross-linking (CXL). METHODS:Case report. RESULTS:A 29-year-old man with a history of chemical burn in the left eye underwent keratoprosthesis implantation. He developed infectious keratitis 4 mo...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000509

    authors: Zarei-Ghanavati S,Irandoost F

    更新日期:2015-09-01 00:00:00

  • Refractive Surgery: Malpractice Litigation Outcomes.

    abstract:PURPOSE:To review data on malpractice claims related to refractive surgery to identify common allegations and injuries and financial outcomes. METHODS:The WestlawNext database was reviewed for all malpractice lawsuits/settlements related to refractive eye surgery. Data evaluated included patient demographics, type of ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001289

    authors: Custer BL,Ballard SR,Carroll RB,Barnes SD,Justin GA

    更新日期:2017-10-01 00:00:00

  • Five-Year Outcomes of Ultrathin Descemet Stripping Automated Endothelial Keratoplasty.

    abstract:PURPOSE:To report 5-year outcomes of ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) with a central graft thickness intended to be <100 μm. METHODS:This retrospective, consecutive, interventional case series included 354 eyes with endothelial decompensation due to various causes (Fuchs endot...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001999

    authors: Madi S,Leon P,Nahum Y,DʼAngelo S,Giannaccare G,Beltz J,Busin M

    更新日期:2019-09-01 00:00:00

  • Eyelid Tattooing Induces Meibomian Gland Loss and Tear Film Instability.

    abstract:PURPOSE:To investigate the changes of meibomian gland (MG) and tear film stability in subjects with eyelid tattoos. METHODS:Forty female subjects were recruited. Ten subjects had eyelid tattoos and 30 subjects did not (control group). Tear film break-up time (TBUT) measurement and fluorescein staining were performed t...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000452

    authors: Lee YB,Kim JJ,Hyon JY,Wee WR,Shin YJ

    更新日期:2015-07-01 00:00:00

  • Corneal complications of herpes zoster ophthalmicus. Prevention and treatment.

    abstract::Corneal complications of herpes zoster ophthalmicus include pseudodendritic keratitis, late mucous adherent keratopathy, varied forms of stromal keratitis, and exposure/neurotrophic keratopathy. Prophylactic therapy of acute herpes zoster ophthalmicus with oral acyclovir is of proven benefit in reducing the incidence ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Cobo LM

    更新日期:1988-01-01 00:00:00

  • Evaluation of corneal topography with Orbscan II in first-degree relatives of patients with keratoconus.

    abstract:PURPOSE:To evaluate the corneal topographic characteristics of first-degree relatives of patients with keratoconus with corneal topography to determine the incidence of clinical keratoconus and topographic abnormalities. METHODS:Between February and August 2006, Orbscan II analysis was done in 144 eyes of 72 cases who...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318165d110

    authors: Kaya V,Utine CA,Altunsoy M,Oral D,Yilmaz OF

    更新日期:2008-06-01 00:00:00

  • Prolonged impairment of corneal innervation after exposure to sulfur mustard and its relation to the development of delayed limbal stem cell deficiency.

    abstract:PURPOSE:Ocular injuries after exposure to the vesicant sulfur mustard (SM) are characterized by acute corneal erosions and inflammation of the anterior segment that may be followed by delayed limbal stem cell deficiency (LSCD), expressed clinically by corneal neovascularization and epithelial defects. The present study...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318262e885

    authors: Kadar T,Dachir S,Cohen M,Gutman H,Cohen L,Brandeis R,Horwitz V,Amir A

    更新日期:2013-04-01 00:00:00