Absorption of topical moxifloxacin ophthalmic solution into human aqueous humor.

Abstract:

PURPOSE:To investigate the absorption of moxifloxacin into human aqueous humor after administration of moxifloxacin hydrochloride ophthalmic solution, 0.5% as base. METHODS:Cataract patients were randomly allocated to receive 1 drop every 15 minutes for 4 doses before surgery (group 1) or 1 drop 4 times per day on the day before surgery plus the same preoperative regimen as group 1 (group 2). The last dose was administered 0.25, 0.50, 1, 2, or 3 hours before aqueous humor sampling. Samples from 30 patients per group were analyzed by a validated HPLC/MS/MS method. RESULTS:For group 1, the mean +/- SD C(max) was 1.50 +/- 0.75 microg/mL and occurred at 0.5 hour after dosing. The mean C(max) for group 2 was 1.74 +/- 0.66 microg/mL and was reached at 1 to 2 hours. Mean AUC(0-3h) for groups 1 and 2 were 3.16 +/- 0.29 and 4.41 +/- 0.48 microg.h/mL, respectively. The difference in AUC(0-3h) was statistically significant (P = 0.04), but the difference in Cmax was not. CONCLUSIONS:Topical moxifloxacin was well absorbed. Maximum moxifloxacin concentrations were approximately 30 times higher than the median MICs for common pathogens in bacterial endophthalmitis, indicating that either regimen may provide sufficient concentrations to prevent postoperative endophthalmitis.

journal_name

Cornea

journal_title

Cornea

authors

Katz HR,Masket S,Lane SS,Sall K,Orr SC,Faulkner RD,McCue BA,Dahlin DC

doi

10.1097/01.ico.0000157423.78275.a2

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

955-8

issue

8

eissn

0277-3740

issn

1536-4798

pii

00003226-200511000-00012

journal_volume

24

pub_type

杂志文章,多中心研究,随机对照试验

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