Surface ultrastructure of collagen fibrils and their association with proteoglycans in human cornea and sclera by atomic force microscopy and energy-filtering transmission electron microscopy.

abstract：PURPOSE:To evaluate the corneal topographic characteristics of first-degree relatives of patients with keratoconus with corneal topography to determine the incidence of clinical keratoconus and topographic abnormalities. METHODS:Between February and August 2006, Orbscan II analysis was done in 144 eyes of 72 cases who...

journal_title：Cornea

authors： Kaya V,Utine CA,Altunsoy M,Oral D,Yilmaz OF

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Descemetocele is a severe complication of corneal ulceration associated with a high risk of perforation. We describe a modified air-assisted deep anterior lamellar keratoplasty (DALK) technique for the surgical management of small and large epithelialized descemetoceles. METHODS:Two representative cases are pr...

journal_title：Cornea

authors： Gabison EE,Doan S,Catanese M,Chastang P,Ben M'hamed M,Cochereau I

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:To investigate mutations of the human transforming growth factor beta-induced gene (TGFBI), transforming growth factor-beta-induced gene product (betaig-h3, keratoepithelin), in Japanese patients with Avellino corneal dystrophy (ACD), lattice corneal dystrophy (LCD), granular corneal dystrophy (GCD), and Reis-B...

journal_title：Cornea

authors： Fujiki K,Hotta Y,Nakayasu K,Yamaguchi T,Kato T,Uesugi Y,Ha NT,Endo S,Ishida N,Lu WN,Kanai A

更新日期：2000-11-01 00:00:00

abstract：:An understanding of corneal optics is important to optimize the visual outcome after eye surgery. Recent advances in the surgical techniques of lamellar keratoplasty have changed the strategies used for corneal transplantation. Lamellar keratoplasty has the advantage of having a lower rate of graft rejection, superior...

journal_title：Cornea

authors： Yamaguchi T,Satake Y,Dogru M,Ohnuma K,Negishi K,Shimazaki J

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To determine the effect of routine use of prophylactic oral acyclovir after penetrating keratoplasty (PK) for herpes simplex virus (HSV) keratitis on recurrence, rejection, and graft failure rates. METHODS:Records from 70 consecutive patients who underwent PK for HSV keratitis at the W.K. Kellogg Eye Center be...

journal_title：Cornea

authors： Garcia DD,Farjo Q,Musch DC,Sugar A

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To assess the morphologic differences of three types of lattice corneal dystrophies (LCDs) from histologic, immunohistochemical, and ultrastructural studies. METHODS:Corneas from three patients, one LCD1, one His626Arg-LCD, and one LCD3A were processed for Congo red, betaig-h3(541-564) antibodies immunostainin...

journal_title：Cornea

authors： Schmitt-Bernard CF,Schneider C,Argilés A

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To evaluate the current standard of care of ophthalmologists who are likely to encounter ocular surface squamous neoplasia (OSSN) in their practices and to compare this with data gathered in 2003. METHODS:Invitations to a web-based survey were sent to members of the Ocular Microbiology and Immunology Group. In...

journal_title：Cornea

authors： Adler E,Turner JR,Stone DU

更新日期：2013-12-01 00:00:00

abstract：:The cell culture method was used to quantitatively evaluate the cytotoxicity to porcine corneal endothelial cells by drugs in the usual concentrations of intracameral injections (ICI). Time-dependent cytotoxicity of drugs was evaluated quantitatively; dye exclusion assay by trypan blue was used as a viability assay; a...

journal_title：Cornea

authors： Chang CH,Lin CP,Wang HZ

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To compare acid-base and oxidation-reduction indicators and to investigate the effect of buffer and temperature on the colorimetric detection of microbial growth in corneal preservation media. METHODS:Corneal preservation media containing gentamicin, without or with HEPES buffer, were prepared with either phen...

journal_title：Cornea

authors： Chu YI,Penland RL,Wilhelmus KR

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To analyze tear meniscus dimensions with Fourier domain-optical coherence tomography (FD-OCT) in patients with type 2 diabetes mellitus. METHODS:Patients with type 2 diabetes without diabetic retinopathy (DR) (n = 54), with nonproliferative DR (n = 45), with proliferative DR (PDR) (n = 25), and controls (n = 4...

journal_title：Cornea

authors： Baek J,Doh SH,Chung SK

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To present the clinical outcome of 2 cases of severe dry eye associated with Nivolumab, with 1 case progressing to corneal perforation. DESIGN:Case report. CASE 1:: A 58-year-old man with metastatic melanoma was referred for the management of severe bilateral dry eyes after undergoing his sixth cycle of Nivol...

journal_title：Cornea

authors： Nguyen AT,Elia M,Materin MA,Sznol M,Chow J

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare topographic and biomechanical properties of corneas in patients with acromegaly with those of healthy individuals. METHODS:Thirty-five patients with acromegaly (study group) and 35 healthy individuals (control group) were enrolled in this prospective study. Topographic meas...

journal_title：Cornea

authors： Altinkaynak H,Duru N,Ersoy R,Kalkan Akcay E,Ugurlu N,Cagil N,Cakir B

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To assess the reproducibility of relatives' replies to questions asked at the time of corneal donation and again 2 months later concerning infectious disease risk factors and to identify characteristics associated with inconsistent responses. METHODS:A reinterview study involving individuals who answered quest...

journal_title：Cornea

authors： Scardino MK,Hwang SJ,Hanna CL,Danneffel-Mandelkorn MB,Wilhelmus KR

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To evaluate the histologic changes in corneal structure after femtosecond laser preparation of posterior lamellar discs, more specifically, the smoothness of the stromal bed and the accuracy of the predicted depth of the horizontal lamellar cut. MATERIALS AND METHODS:Nineteen human donor eyes unsuitable for tr...

journal_title：Cornea

authors： Cheng YY,Kang SJ,Grossniklaus HE,Pels E,Duimel HJ,Frederik PM,Hendrikse F,Nuijts RM

更新日期：2009-01-01 00:00:00

abstract：:In recent years, deep lamellar keratoplasty (DLKP) has become an alternative surgical approach successfully applied to the treatment of opaque cornea with normal endothelial function. However, techniques for performing DLKP are not standardized and have not been perfected compared with penetrating keratoplasty. We dev...

journal_title：Cornea

authors： Yao YF

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To compare anterior segment spectral-domain optical coherence tomography (OCT) with eye bank technician slit-lamp examination (SLE) in characterizing lesions in donor corneas. METHODS:Twenty-nine donor corneas identified by eye bank technicians to have opacities or lesions potentially representing pathologic f...

journal_title：Cornea

authors： Hsu ST,Perry I,Botsay S,Ko N,Stinnett SS,Kuo AN,Shieh C

更新日期：2018-10-01 00:00:00

abstract：:The histological and ultrastructural pathology of two corneas that were removed from an infant with congenital glaucoma prior to keratoplasty is described. Clinically, the glaucoma was suspected to be due to an inapparent congenital viral infection, although there was no serological proof. Macroscopic and light micros...

journal_title：Cornea

authors： Löffler KU

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To describe a new minimally invasive surgical technique for the symptomatic management of bullous keratopathy in blind eyes. METHODS:Four patients with severe corneal edema due to endothelial decompensation and no visual function in the affected eye presented for the relief of their ocular symptoms (pain and t...

journal_title：Cornea

authors： Kymionis GD,Diakonis VF,Kankariya VP,Plaka AD,Panagopoulou SI,Kontadakis GA,Grentzelos MA,Tsilimbaris MK,Pallikaris IG

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:Decorin is a small chondroitin sulfate proteoglycan that inhibits vascular endothelial cell migration and tube formation. Membrane type 1-matrix metalloproteinase (MT1-MMP) has been shown to be an important angiogenic enzyme in the cornea. We evaluated the specific role of MT1-MMP in decorin cleavage in the cor...

journal_title：Cornea

authors： Mimura T,Chang JH,Kim TI,Onguchi T,Kojima T,Sakimoto T,Azar DT

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:To evaluate the stromal interface quality after femtosecond laser full lamellar cuts in gamma-irradiated corneas (VisionGraft sterile cornea) and to determine the limits of the cut depth using the VisionGraft as donor corneas for laser-assisted lamellar anterior keratoplasty. METHODS:Fourteen VisionGraft corne...

journal_title：Cornea

authors： Zhang C,Liu L,Tang M,Li Y,Chamberlain W,Huang D

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To report on a patient in whom hyperopic Implantable Collamer Lenses (ICL, STAAR Surgical, Nidau, Switzerland) and limbal relaxing incisions have been beneficial for the correction of hyperopic astigmatism after laser in situ keratomileusis (LASIK). METHODS:The 48-year-old man had undergone LASIK to correct hi...

journal_title：Cornea

authors： Kamiya K,Shimizu K,Komatsu M

更新日期：2010-01-01 00:00:00

abstract：:Fresh and organ-culture preserved human corneas were examined for HLA-A,B,C (class I) and HLA-DR (class II) histocompatibility antigens using mouse monoclonal antibodies and an indirect immunofluorescence technique. HLA-A,B,C antigens were detected on epithelial cells and on keratocytes, but not on endothelial cells i...

journal_title：Cornea

authors： Pels E,van der Gaag R

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To determine if concurrent use of 5% natamycin and 2% econazole offers greater benefits than monotherapy with 5% natamycin for the management of fungal keratitis. METHODS:Subjects presenting to the cornea service were treated with 5% natamycin and 2% econazole used concurrently. We compared the results with a ...

journal_title：Cornea

authors： Prajna NV,Nirmalan PK,Mahalakshmi R,Lalitha P,Srinivasan M

更新日期：2004-11-01 00:00:00

abstract：:The many published studies on sterile procedures used by eye banks have included none until now on ways to optimize sterile handling of corneas procured in the morgues of forensic pathologists. The present study sought to discover if fewer positive cultures would be reported at the time of surgery from corneas which h...

journal_title：Cornea

authors： Farge EJ,Fort RA

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:To evaluate corneal graft survival over a 5-year period and to investigate whether factors related to the donor, eye bank practices, the recipient, surgery, and postoperative course influenced the outcome. METHODS:Nine hundred ninety-eight patients were randomly selected and monitored in the subsequent 3 years...

journal_title：Cornea

authors： Fasolo A,Capuzzo C,Fornea M,Franch A,Birattari F,Carito G,Cucco F,Prosdocimo G,Sala M,Delle Noci N,Primavera V,Frigo AC,Grigoletto F,Ponzin D,CORTES Study Group.

更新日期：2011-12-01 00:00:00

abstract：:The records of 39 patients undergoing 40 consecutive penetrating keratoplasties were reviewed to identify donor factors that might correlate with the presence of an epithelial defect on the first postoperative day. Of the 40 transplanted corneas, 13 (32.5%) had no epithelial defect, 18 (45%) had some epithelial defect...

journal_title：Cornea

authors： Kim T,Palay DA,Lynn M

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:We characterized the presence of hemangiogenesis (HA) and lymphangiogenesis (LA) in human corneal specimens exhibiting 13 underlying pathologies. METHODS:Human corneal specimens were obtained from consenting subjects (n = 2 or n = 3 for each pathology; total sample size, n = 35). The pathological specimens wer...

journal_title：Cornea

authors： Tshionyi M,Shay E,Lunde E,Lin A,Han KY,Jain S,Chang JH,Azar DT

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To report a case of interface infection by Candida albicans after deep anterior lamellar keratoplasty (DALK). METHODS:A 30-year-old man with keratoconus underwent DALK. Four weeks after surgery, the patient developed multiple infiltrates in the graft-host interface with absence of intraocular infection. Donor ...

journal_title：Cornea

authors： Fontana L,Parente G,Di Pede B,Tassinari G

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To compare Tono-Pen AVIA (TPA) intraocular pressure (IOP) measurements performed at the limbus with central corneal Tono-Pen AVIA (TPA) intraocular pressure. METHODS:Fifty-one patients attending our outpatient department with a best corrected visual acuity of ≥ 20/40, no corneal disease, and no astigmatism gre...

journal_title：Cornea

authors： Sharma R,Majumdar S,Sobti A,Arora T,Agarwal T,Dada T

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:Clinical research addressing the issue of donor globe decontamination is yet to establish convincing data for the optimal choice of an antimicrobial agent. METHODS:In a donor-globe decontamination study, the antimicrobial effectiveness of a fluoroquinolone antibiotic (ciprofloxacin, 0.3%) was evaluated for the...

journal_title：Cornea

authors： Gopinathan U,Reddy MK,Nadkarni MS,Dasari S,Rao GN

更新日期：1998-01-01 00:00:00