Abstract:
:The histological and ultrastructural pathology of two corneas that were removed from an infant with congenital glaucoma prior to keratoplasty is described. Clinically, the glaucoma was suspected to be due to an inapparent congenital viral infection, although there was no serological proof. Macroscopic and light microscopic examination of the posterior corneal surface revealed an irregular network of heavily pigmented cells that were overlying an incomplete endothelium and a grossly thickened Descemet's membrane. By scanning and transmission electron microscopy, these melanin-laden cells exhibited the features of iris stromal melanocytes. No evidence of viral infection could be found. The possible mechanisms leading to this unusual morphology are considered and will be discussed in relation to current theories on the etiology of congenital glaucoma.
journal_name
Corneajournal_title
Corneaauthors
Löffler KUsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
70-4issue
1eissn
0277-3740issn
1536-4798journal_volume
10pub_type
杂志文章相关文献
CORNEA文献大全abstract::Corneal neovascularization complicates many anterior segment diseases. Corneal laser photocoagulation using yellow light (577 nm) has been shown to reduce corneal neovascularization. No histopathologic studies of the effects of this treatment on the eye have been reported, however. Target (cornea) and nontarget (iris,...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199305000-00001
更新日期:1993-05-01 00:00:00
abstract:PURPOSE:To evaluate matrix metalloproteinases (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 expression in a case of conjunctival intraepithelial squamous cell carcinoma (SCC) treated with topical 5-fluorouracil (5-FU) chemotherapy. METHODS:Clinicopathologic case report. RESULTS:A 71-year-old male...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318190937d
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:Hyperglycemia in diabetes mellitus (DM) might induce changes in corneal biomechanics. Therefore, biomechanical properties of the cornea were measured using the ocular response analyzer and the Corvis ST. METHODS:In the study, 35 eyes of 35 diabetic patients were included. After an ophthalmological examination,...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001879
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To investigate the long-term effect and safety of collagen cross-linking (CXL) on patients with bullous keratopathy (BK) in a randomized control manner. It is, to our knowledge, the first randomized control study on the effect of CXL on BK. METHODS:Subjects were randomized to receive CXL as in the standard pro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002395
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To review the indications and patient characteristics for penetrating keratoplasty (PKP). METHODS:Retrospective review of records at the Pathology Service, Department of Ophthalmology, University of Toronto from 1964 to 1997. RESULTS:The 6,222 records were reviewed. The leading indications for PKP were regraf...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200001000-00002
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of various ceramides on the apoptosis of corneal fibroblasts and to determine the pathway on which they act. METHOD:Corneal fibroblasts isolated and cultured from New Zealand white rabbits were exposed to various concentrations of ceramide types II and VI and phytoceramide types II and V...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000134000.52886.c3
更新日期:2005-01-01 00:00:00
abstract::We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days we observed an 86% reduction in cell counts. Confluent HCE was...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199209000-00010
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:We report 2 cases in which cataract extraction with a foldable acrylic toric intraocular lens (IOL) implantation was used to correct (irregular) corneal astigmatism in patients with keratoconus and cataract. METHODS:Case 1 was a 78-year-old man with cataract and keratoconus in the left eye. He underwent phacoe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31820009d4
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To report a case of endophthalmitis caused by Clostridium sordellii. METHODS:A 33-year-old man sustained a penetrating injury of the right eye that resulted in several ocular surgical procedures including pars plana vitrectomy, scleral buckling, scleral-sutured posterior chamber intraocular lens, and penetrati...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000116528.57227.2f
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:To assess changes in color discernment after Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS:In this prospective, single-center study, the study group was composed of 26 patients with FECD, aged 46 to 85 years, who underwent DMEK as a singl...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000871
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To report the first use of Descemet stripping automated endothelial keratoplasty (DSAEK) for spontaneous Descemet membrane detachment in a patient with osteogenesis imperfecta (OI), keratoconus, and acute bullous keratopathy. METHODS:A case report of a 25-year-old man with OI and symptomatic unilateral bullous...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318225418b
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To present a novel noncontact meibography system with anterior segment optical coherence tomography (OCT), which is widely used in clinics for the anterior segment (cornea, anterior chamber angle, etc.), and compare the results with preexisting infrared meibography. METHODS:This research was carried out at the...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318247b2fd
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To report a cluster of postoperative Acanthamoeba endophthalmitis after routine cataract surgeries. METHODS:A brief summary of sentinel events leading to the referral of 4 patients of postoperative endophthalmitis to our hospital is followed by clinical descriptions and the various diagnostic approaches and in...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002603
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:To investigate corneal stiffness and analyze its possible influence on other corneal biomechanical and nonbiomechanical parameters in myopic eyes of Chinese patients. METHODS:A total of 387 healthy (right) myopic eyes were included in this study. Corneal visualization Scheimpflug technology was used to measure...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001605
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To evaluate the long-term changes in anterior and posterior corneal irregular astigmatism and curvatures after small incision lenticule extraction (SMILE). METHODS:Fifty eyes of 28 patients underwent SMILE for myopic astigmatism. All procedures were performed using the VisuMax® femtosecond laser. A Scheimpflug...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001532
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To evaluate and compare 1-year postoperative visual acuity, refractive results, endothelial cell density (ECD), and complications in a consecutive group of patients who underwent deep lamellar endothelial keratoplasty (DLEK) with those who underwent penetrating keratoplasty (PK) performed by 1 surgeon. METHODS...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31815b8304
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:To determine the epidemiology, risk factors, clinical features, and prognosis of fungal keratitis caused by Exserohilum. METHODS:All culture-proven cases of keratomycosis caused by Exserohilum presented from January 2012 to December 2014 were retrospectively analyzed using a computerized database. RESULTS:Amo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000774
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To report an unusual case of corneal whorl-like opacity patterns in a patient of primary localized conjunctival amyloidosis. METHODS:Case report and review of literature. RESULTS:A 35-year old man with a case of primary localized conjunctival amyloidosis presented with corneal whorl-like opacity patterns and ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002343
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To describe the histopathologic characteristics of a 51-year-old Castroviejo square graft that remained functional for more than 50 years and to describe the wound-healing characteristics over this period of time. METHODS:An 80-year-old woman with a history of keratoconus underwent penetrating keratoplasty wit...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181861cb2
更新日期:2009-04-01 00:00:00
abstract::The present study describes biochemical and morphological differences of pseudophakic bullous keratopathy (PBK) corneas as compared with normal corneas. At the ultrastructural level, all PBK corneas studied had abnormal fibrillar material posterior to the Descemet's membrane. In addition, two of the six PBK buttons ha...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Confocal microscopy provides a new, noninvasive way of imaging the human cornea in vivo. One of its most important clinical uses is the diagnosis and management of infectious keratitis. The authors used tandem scanning confocal microscopy to image the corneas in two culture-proven cases of Aspergillus keratitis. Funga...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Dry eye syndrome (DES) is a common eye disease caused by tear deficiency or excessive tear evaporation. Because the tear film layers play a major role in the pathogenesis of the evaporative dry eye, some previous articles have suggested the possible mechanism of dyslipidemia and DES. However, the previous resul...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002133
更新日期:2020-02-01 00:00:00
abstract::Severe microbial keratitis developed in a 74-year-old women receiving long-term corticosteroids. Corneal smears revealed slender, fusiform gram-negative bacilli, but the lesion continued to worsen despite intensive antibiotic treatment. After several days, Capnocytophaga sputigena was identified on culture. Specific a...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To examine the validity of the observations made by specialist corneal surgeons that there seems to be an absence or loss of older patients with keratoconus (KC). METHODS:Using a PubMed search and key words such as KC, epidemiology, mortality, mitral valve prolapse, atopy, and asthma, the literature related to...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e31825aba0e
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To demonstrate the use of anterior segment optical coherence tomography (ASOCT) in planning phototherapeutic keratectomy (PTK) removal of central corneal stromal scarring. METHODS:A 62-year-old male presented with central corneal scars associated with significant ocular surface disease. Videokeratographies obt...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181930b9f
更新日期:2009-09-01 00:00:00
abstract::Penetrating keratoplasty (PKP) in conjunction with postoperative corticosteroids may reactivate latent herpes simplex virus type 1 (HSV-1) to cause persistent postoperative epithelial defects. The clinical diagnosis of HSV keratitis after penetrating keratoplasty is difficult because the postoperative appearance may b...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to describe the clinicopathologic correlation of textural interface opacities (TIOs) in a Descemet stripping automated endothelial keratoplasty (DSAEK) donor button after its removal. METHODS:A 75-year-old woman underwent combined phacoemulsification with intraocular lens placement an...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000057
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To determine if Cornisol is as effective as Optisol-GS as an intermediate-term corneal storage medium. METHODS:A prospective, in vitro, randomized, partially masked study using paired donor corneas. Optical grade tissues not suitable for surgery were used. After performing baseline slit lamp evaluation, one ti...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/ICO.0000000000000912
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To report the first case of fungal keratitis caused by presumed Carpoligna species. METHODS:A 37-year-old gardener sustained a full-thickness, stellate corneal laceration while cutting wood outdoors with a circular saw. Two months after surgical repair, he developed a severe infectious keratitis with descemeto...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181af3954
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To assess ultrastructural modifications in keratocytes and inflammatory cell response in rabbit corneas after riboflavin and ultraviolet A exposure using immunofluorescence microscopy. METHODS:Twenty adult New Zealand albino rabbits weighing 2.0–3.0 kg were used in this study. Two rabbits served as controls.Th...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181bdf1cc
更新日期:2010-04-01 00:00:00