Abstract:
PURPOSE:To analyze tear meniscus dimensions with Fourier domain-optical coherence tomography (FD-OCT) in patients with type 2 diabetes mellitus. METHODS:Patients with type 2 diabetes without diabetic retinopathy (DR) (n = 54), with nonproliferative DR (n = 45), with proliferative DR (PDR) (n = 25), and controls (n = 45) were enrolled. Hemoglobin A1c and Early Treatment Diabetic Retinopathy Study (ETDRS) stages of DR were evaluated. Schirmer test (ST), tear breakup time test, and fluorescein corneal staining were carried out. Tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) were obtained by FD-OCT. RESULTS:TMH, TMD, and TMA in the diabetes and control groups were 233 ± 79 μm, 148 ± 53 μm, and 0.026 ± 0.015 mm, and 261 ± 67 μm, 167 ± 49 μm, and 0.032 ± 0.017 mm, respectively. All parameters were lower in diabetes (all P < 0.01). And the values in PDR were 185 ± 90 μm, 117 ± 50 μm, and 0.017 ± 0.010 mm which were lower than those in control and nonproliferative DR (227 ± 71 μm, 144 ± 50 μm, and 0.023 ± 0.010 mm) (all P < 0.01). TMH, TMD, and TMA correlated with ST (P < 0.01, P = 0.02, and P < 0.01, respectively) and the corneal staining score (all P < 0.01). Patients with longer diabetes duration and a history of panretinal photocoagulation showed significantly decreased TMH, TMD, and TMA (P < 0.01). CONCLUSIONS:OCT, along with tear breakup time and ST, is an effective way to assess tear function in type 2 diabetes. Patients with PDR and a history of panretinal photocoagulation showed lower tear meniscus parameters. The decrease in tear meniscus parameters was correlated with diabetes duration.
journal_name
Corneajournal_title
Corneaauthors
Baek J,Doh SH,Chung SKdoi
10.1097/ICO.0000000000000651subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1534-40issue
12eissn
0277-3740issn
1536-4798journal_volume
34pub_type
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