Abstract:
:There recently have been several reports of microsporidial keratoconjunctivitis caused by the organism Encephalitozoon hellem. However, treatment of this infection has been largely ineffective. We report a case of a 35-year-old Hispanic woman with AIDS and E. hellem keratoconjunctivitis confirmed with light, electron, and immunofluorescence microscopy that resolved promptly with topical fumagillin, a crystalline antibiotic with proven efficacy against Encephalitozoon species. No corneal or systemic toxicities were noted using the dosage and preparation employed (10 mg/ml suspension in balanced salt solution). An easily prepared, topical fumagillin suspension appears to be a safe, effective treatment for E. hellem keratoconjunctivitis.
journal_name
Corneajournal_title
Corneaauthors
Rosberger DF,Serdarevic ON,Erlandson RA,Bryan RT,Schwartz DA,Visvesvara GS,Keenan PCdoi
10.1097/00003226-199305000-00013subject
Has Abstractpub_date
1993-05-01 00:00:00pages
261-5issue
3eissn
0277-3740issn
1536-4798journal_volume
12pub_type
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