Successful treatment of microsporidial keratoconjunctivitis with topical fumagillin in a patient with AIDS.

Abstract:

:There recently have been several reports of microsporidial keratoconjunctivitis caused by the organism Encephalitozoon hellem. However, treatment of this infection has been largely ineffective. We report a case of a 35-year-old Hispanic woman with AIDS and E. hellem keratoconjunctivitis confirmed with light, electron, and immunofluorescence microscopy that resolved promptly with topical fumagillin, a crystalline antibiotic with proven efficacy against Encephalitozoon species. No corneal or systemic toxicities were noted using the dosage and preparation employed (10 mg/ml suspension in balanced salt solution). An easily prepared, topical fumagillin suspension appears to be a safe, effective treatment for E. hellem keratoconjunctivitis.

journal_name

Cornea

journal_title

Cornea

authors

Rosberger DF,Serdarevic ON,Erlandson RA,Bryan RT,Schwartz DA,Visvesvara GS,Keenan PC

doi

10.1097/00003226-199305000-00013

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

261-5

issue

3

eissn

0277-3740

issn

1536-4798

journal_volume

12

pub_type

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