Randomized clinical study for comparative evaluation of fourth-generation fluoroquinolones with the combination of fortified antibiotics in the treatment of bacterial corneal ulcers.

Abstract:

PURPOSE:Comparative evaluation of efficacy of monotherapy with moxifloxacin (0.5%) or gatifloxacin (0.3%) with combination therapy of cefazolin (5%) and tobramycin (1.3%) in treatment of bacterial corneal ulcers. METHODS:Patients diagnosed with bacterial keratitis (ulcer diameter 2-8 mm) were randomized to 1 of the 3 treatment groups (tobramycin 1.3% and cefazolin 5%, gatifloxacin 0.3%, or moxifloxacin 0.5%). After obtaining corneal scrapings, assigned study medication was instilled hourly for 48 hours and tapered as per clinical response. Healing of ulcer, duration to cure, adverse reactions, antibiogram profile, treatment failures, final visual acuity, and corneal opacity size were evaluated. RESULTS:A total of 61 patients were enrolled [cefazolin and tobramycin (n = 20), gatifloxacin (n = 21), and moxifloxacin (n = 20)]. Overall, 57 patients (93%) healed on treatment. On comparison of the mean time taken to heal, no statistically significant difference was found among all the 3 treatment groups (P = 0.98). Positive bacterial culture was obtained in only 38 patients (62%). There was no significant difference in the bacterial isolates in each treatment group. There were 4 (7%) treatment failures (perforation or nonhealing ulcer): 1 (5%) each in moxifloxacin and gatifloxacin group and 2 (10%) in fortified antibiotics group. All regimens were well tolerated. CONCLUSION:The study failed to find a difference in the efficacy of monotherapy with fourth-generation fluoroquinolones in the treatment of bacterial corneal ulcers of 2-8 mm size when compared with combination therapy of fortified antibiotics.

journal_name

Cornea

journal_title

Cornea

authors

Shah VM,Tandon R,Satpathy G,Nayak N,Chawla B,Agarwal T,Sharma N,Titiyal JS,Vajpayee RB

doi

10.1097/ICO.0b013e3181ca2ba3

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

751-7

issue

7

eissn

0277-3740

issn

1536-4798

journal_volume

29

pub_type

杂志文章,随机对照试验

相关文献

CORNEA文献大全
  • Effect of cross-linking on corneal thickness in patients with corneal edema.

    abstract:PURPOSE:To investigate the pachymetric changes of collagen cross-linking in corneas with edema because of endothelial dysfunction. METHODS:Interventional case series included 25 eyes of 25 consecutive patients with corneal edema for at least 4 months related to Fuchs endothelial dystrophy, corneal graft failure, and p...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181c296c2

    authors: Cordeiro Barbosa MM,Barbosa JB Jr,Hirai FE,Hofling-Lima AL

    更新日期:2010-06-01 00:00:00

  • Dissection plane in deep anterior lamellar keratoplasty using the big-bubble technique.

    abstract:PURPOSE:To find the level of dissection in keratoconic corneas undergoing deep anterior lamellar keratoplasty (DALK) using the big-bubble technique. METHODS:In 3 keratoconic eyes that underwent DALK, the operation was converted into penetrating keratoplasty after complete big-bubble formation because of extensive tear...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ba7016

    authors: Jafarinasab MR,Rahmati-Kamel M,Kanavi MR,Feizi S

    更新日期:2010-04-01 00:00:00

  • Posterior scleritis secondary to Pseudomonas aeruginosa keratitis.

    abstract:PURPOSE:To report a case of Pseudomonas aeruginosa keratitis that progressed to posterior scleritis. METHODS:Observational case report. RESULTS:A 64-year-old woman was treated for P. aeruginosa keratitis. Twelve days later, she was diagnosed with posterior scleritis and treated with oral ciprofloxacin. Her condition ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000154403.78838.90

    authors: Fahim K,Houghton O,Dastjerdi M,Mian SI

    更新日期:2005-10-01 00:00:00

  • Eccentrically Punched Descemet Membrane Endothelial Keratoplasty Grafts Expand the Descemet Membrane Endothelial Keratoplasty Donor Pool: One Eye Bank's Reappraisal of the Central Clear Zone Convention.

    abstract:PURPOSE:To ascertain whether offsetting the Descemet membrane endothelial keratoplasty (DMEK) punch can expand the donor pool in conjunction with prepunched and preloaded services by recapturing the corneas otherwise excluded by the conventional central clear zone criteria. METHODS:In this retrospective review of corn...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002348

    authors: Kornberg DL,Prabhu S,Sales CS,Williams RS,Clover J,Tran KD

    更新日期:2020-10-01 00:00:00

  • Incidence of HIV antibody-positive eye/cornea donors in hospital versus medical examiner cases.

    abstract::We retrospectively examined Michigan Eye-Bank and Transplantation Center data on all eye/cornea donors in Michigan and Illinois for whom human immunodeficiency virus (HIV) antibody screening results were available. This was done to compare the HIV-antibody positive serology rate in hospital versus medical examiner don...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Danneffel MB,Sugar A

    更新日期:1990-07-01 00:00:00

  • Surgical monovision and monovision reversal in LASIK.

    abstract:PURPOSE:This study was designed to assess the success of surgical monovision in presbyopic patients. METHODS:A university refractive surgery center retrospective chart review of 82 patients who elected to undergo surgical monovision with laser in situ keratomileusis (LASIK) between January 2000 and January 2003 was co...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000178722.19317.7b

    authors: Reilly CD,Lee WB,Alvarenga L,Caspar J,Garcia-Ferrer F,Mannis MJ

    更新日期:2006-02-01 00:00:00

  • Supratarsal triamcinolone injection in the treatment of superior limbic keratoconjunctivitis.

    abstract:PURPOSE:To evaluate the efficacy of supratarsal triamcinolone injection in the treatment of superior limbic keratoconjunctivitis (SLK). METHODS:Forty eyes of 20 patients were diagnosed with SLK. All eyes with long-standing severe ocular irritation unresponsive to topical steroid and artificial tears were treated with ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318030d230

    authors: Shen YC,Wang CY,Tsai HY,Lee YF

    更新日期:2007-05-01 00:00:00

  • Laser in situ keratomileusis flap stability during simulated aircraft ejection in a rabbit model.

    abstract:PURPOSE:To determine the stability of the laser in situ keratomileusis (LASIK) flap in a rabbit model when subjected to vertical acceleration at nine times the force of gravity (+9 Gz) in an aircraft cockpit ejection simulator. METHODS:Thirty-six eyes from 25 New Zealand white rabbits underwent LASIK flap creation wit...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200303000-00013

    authors: Goodman RL,Johnson DA,Dillon H,Edelhauser HF,Waller SG

    更新日期:2003-03-01 00:00:00

  • Comparison of 5% Sulfur Hexafluoride Versus 100% Air Tamponade in Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To compare the rebubbling rate and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) with 5% sulfur hexafluoride (SF6) gas versus 100% air as a tamponade for graft attachment. METHODS:Retrospective, comparative, interventional case series including 368 consecutive pseudophakic eyes with Fu...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001299

    authors: Ampazas P,Droutsas K,Giallouros E,Schroeder FM,Sekundo W

    更新日期:2017-10-01 00:00:00

  • Extracellular matrix components in a case of retrocorneal membrane associated with syphilitic interstitial keratitis.

    abstract:PURPOSE:A web-like retrocorneal membrane (RCM) is an uncommon complication of chronic syphilitic interstitial keratitis. Extracellular matrix components have not yet been defined in this structure, although previous histologic examinations have suggested the presence of collagen. We examined the presence and distributi...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200101000-00019

    authors: Kawaguchi R,Saika S,Wakayama M,Ooshima A,Ohnishi Y,Yabe H

    更新日期:2001-01-01 00:00:00

  • Nontraumatic corneal perforation.

    abstract:PURPOSE:To study the predisposing conditions, treatments, and visual outcomes of nontraumatic corneal perforations. METHODS:A retrospective chart review was conducted of all nontraumatic corneal perforations seen between January 1992 and December 1998, with > or = 3 months of follow-up, at the Cornea Service Wills Eye...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200005000-00011

    authors: Lekskul M,Fracht HU,Cohen EJ,Rapuano CJ,Laibson PR

    更新日期:2000-05-01 00:00:00

  • Moderately Long-Term Safety and Efficacy of Repeat Penetrating Keratoplasty.

    abstract:PURPOSE:To investigate the moderately long-term safety and efficacy of repeat penetrating keratoplasty (PK) for treatment of a failed PK graft. METHODS:Retrospective consecutive clinical case series. Of 992 consecutive cases that underwent PK at Baptist Eye Institute, Kyoto, Japan, between April 1998 and September 201...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001694

    authors: Kitazawa K,Wakimasu K,Kayukawa K,Yokota I,Inatomi T,Hieda O,Sotozono C,Kinoshita S

    更新日期:2018-10-01 00:00:00

  • Experimental transplantation of corneal epithelium-like cells induced by Pax6 gene transfection of mouse embryonic stem cells.

    abstract:PURPOSE:Corneal epithelial stem cells are deficient in cases of limbal disorders, leading to conjunctival epithelial ingrowth, vascularization, and eventually visual disturbance. We introduced the eye development-associated transcription factor pax6 to embryonic stem (ES) cells and tested whether pax6-transfected cells...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31814fa814

    authors: Ueno H,Kurokawa MS,Kayama M,Homma R,Kumagai Y,Masuda C,Takada E,Tsubota K,Ueno S,Suzuki N

    更新日期:2007-12-01 00:00:00

  • Safety profile of bevacizumab on cultured human corneal cells.

    abstract:PURPOSE:To study the corneal biocompatibility of bevacizumab on various cultured human corneal cells. METHODS:Cell cultures of corneal keratinocytes (CKs), corneal fibroblasts (CFs), and corneal endothelial cells (CECs) were harvested from human donor eyes and exposed to various concentrations of bevacizumab (0.25-5.0...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3180de1d0a

    authors: Yoeruek E,Spitzer MS,Tatar O,Aisenbrey S,Bartz-Schmidt KU,Szurman P

    更新日期:2007-09-01 00:00:00

  • Peripheral nonulcerative keratitis as a presenting sign of microscopic polyangiitis.

    abstract:PURPOSE:To report a 16-year-old woman who had peripheral keratitis as a presenting sign of microscopic polyangiitis (MPA), which rapidly progressed to acute renal failure. METHOD:Case report. RESULTS:The patient's vasculitis was diagnosed by renal biopsy, which was evaluated with histologic, immunofluorescence, and e...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200107000-00016

    authors: Darlington JK,Mannis MJ,Segal WA,Feiz V,Klug DE

    更新日期:2001-07-01 00:00:00

  • Gentamicin-resistant pseudomonal infection. Rationale for a redefinition of ophthalmic antimicrobial sensitivities.

    abstract::Eight pseudomonal species were involved in 106 invasive infections of the eye; all were community acquired. Eighteen percent of the total and 9% of the Pseudomonas aeruginosa strains were gentamicin resistant, as defined using conventional criteria. All 10 cases of "resistant" pseudomonal (nine P. aeruginosa) keratiti...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Ormerod LD,Heseltine PN,Alfonso E,Becker MI,Kenyon KR,Baerveldt G,Smith RE

    更新日期:1989-09-01 00:00:00

  • Fulminant Acanthamoeba Endophthalmitis After Cataract Surgery-A Case Report.

    abstract:PURPOSE:To report a case of Acanthamoeba endophthalmitis after an uneventful cataract surgery. METHODS:Description, management, and outcomes of a biopsy-proven case of Acanthamoeba endophthalmitis. RESULTS:Two days after a routine cataract surgery elsewhere, the patient presented with acute endophthalmitis diagnosed ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002289

    authors: Raghavan A,Veerappan S,Rangarajan V,Rajaraman R,Salian R,Mk J,L D,Ganesh Vr R,Venkatapathy N,Rammohan R

    更新日期:2020-08-01 00:00:00

  • Laboratory Evaluation of Femtosecond Laser Lamellar Cuts in Gamma-Irradiated Corneas.

    abstract:PURPOSE:To evaluate the stromal interface quality after femtosecond laser full lamellar cuts in gamma-irradiated corneas (VisionGraft sterile cornea) and to determine the limits of the cut depth using the VisionGraft as donor corneas for laser-assisted lamellar anterior keratoplasty. METHODS:Fourteen VisionGraft corne...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000614

    authors: Zhang C,Liu L,Tang M,Li Y,Chamberlain W,Huang D

    更新日期:2015-11-01 00:00:00

  • Development and characterization of acellular porcine corneal matrix using sodium dodecylsulfate.

    abstract:PURPOSE:The objective of this study was to produce a porcine corneal acellular matrix (ACM) and assess its possibility for biomedical applications. METHODS:Porcine corneas were treated with various concentrations of sodium dodecylsulfate for different lengths of time. Optimal conditions for processing the ACM were not...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181dc8184

    authors: Zhou Y,Wu Z,Ge J,Wan P,Li N,Xiang P,Gao Q,Wang Z

    更新日期:2011-01-01 00:00:00

  • Impression cytology study of conjunctival epithelial phenotypes on the healing ocular surface after pterygium excision.

    abstract:PURPOSE:To compare the process of conjunctival epithelial regeneration after three types of pterygium excision procedures. METHODS:Thirty-eight patients (45 eyes) with primary pterygium were randomly assigned to a bare-sclera procedure (group 1, 15 eyes of 12 patients), bare-sclera with intraoperative mitomycin C (MMC...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003226-200104000-00002

    authors: Tseng SH,Chen YT,Cheng HC,Huang FC,Lee SC,Chen FK

    更新日期:2001-04-01 00:00:00

  • The effect of the fourth-generation fluoroquinolones on corneal reepithelialization after penetrating keratoplasty.

    abstract:PURPOSE:To compare the effects of topical moxifloxacin and gatifloxacin on corneal reepithelialization after penetrating keratoplasty. METHODS:In this single-center, open-label, prospective study, 46 consecutive patients requiring penetrating keratoplasty were alternately assigned to receive either postoperative moxif...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.ico.0000157420.11448.d4

    authors: Moshirfar M,Marx DP,Kumar R

    更新日期:2005-10-01 00:00:00

  • Corneal endothelial cell damage after lens extraction using the fluid-based system compared to ultrasound phacoemulsification in human cadaver eyes.

    abstract:PURPOSE:To compare the endothelial cell damage after lens removal using a fluid-based system to conventional ultrasound. METHODS:Twenty human cadaver eyes were randomized to undergo phacoemulsification using either a fluid-based system or conventional ultrasound. After surgery, each corneoscleral button was removed, s...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000130184.56514.51

    authors: Sandoval HP,Al Sarraf O,Vroman DT,Solomon KD

    更新日期:2004-10-01 00:00:00

  • Descemet Membrane Endothelial Keratoplasty After Failed Penetrating Keratoplasty.

    abstract:PURPOSE:To demonstrate the feasibility of Descemet membrane endothelial keratoplasty (DMEK) performed after previous penetrating keratoplasty (PK) failure and to describe primary outcomes. METHODS:Twenty-eight eyes of 28 patients who underwent DMEK after primary PK failure between January 2013 and November 2017 were i...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001834

    authors: Pierné K,Panthier C,Courtin R,Mazharian A,Souedan V,Gatinel D,Saad A

    更新日期:2019-03-01 00:00:00

  • Detection of herpes simplex virus type 1 in failed descemet stripping automated endothelial keratoplasty grafts.

    abstract:PURPOSE:To determine the prevalence of herpes simplex virus type 1 (HSV-1) DNA in failed Descemet membrane stripping automated endothelial keratoplasty (DSAEK) grafts. METHODS:A retrospective interventional case series of patients with DSAEK graft failure treated at the New York Eye and Ear Infirmary between January 2...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31829b6d0c

    authors: Yin D,Huang A,Warrow D,Ritterband DC,Seedor JA,McCormick SA,Milman T

    更新日期:2013-09-01 00:00:00

  • Intrastromal antifungal injection with secondary lamellar interface infusion for late-onset infectious keratitis after DSAEK.

    abstract:PURPOSE:The aim of this study was to report the successful medical management of 2 cases of late-onset endothelial keratoplasty-related stromal interface infections. METHODS:All cases of endothelial keratoplasty-related infections treated with intrastromal antifungal injections were compiled. The following information...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000192

    authors: Tu EY,Hou J

    更新日期:2014-09-01 00:00:00

  • Recurrence of corneal neovascularization associated with lipid deposition after subconjunctival injection of bevacizumab.

    abstract:PURPOSE:To report 7 cases of recurrent corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab for the treatment of corneal NV-induced lipid keratopathy. METHODS:We conducted a prospective interventional case series that included 20 eyes of chronic lipid keratopathy that rec...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31825ec407

    authors: Chu HS,Chen TC,Hu FR,Chen WL

    更新日期:2013-11-01 00:00:00

  • Alkali Burn Over a LASIK Flap.

    abstract:PURPOSE:To describe the management and outcome of an ocular surface alkali burn in the setting of previous laser in situ keratomileusis (LASIK). METHODS:This is a case report and review of relevant literature. RESULTS:A 25-year-old man with a history of LASIK presented 4 weeks after a sodium hydroxide splash to his l...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002604

    authors: Witsberger EM,Patel SV

    更新日期:2020-12-03 00:00:00

  • Frequency of positive donor rim cultures after penetrating keratoplasty using hypothermic and organ-cultured donor corneas.

    abstract:PURPOSE:To compare the frequency of positive rim cultures after penetrating keratoplasty using corneas preserved by hypothermic and organ culture storage. To evaluate the influence of standard procurement techniques on the frequency of microbial donor rim contamination. METHODS:Six hundred four donor corneas stored at...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3180415d7e

    authors: Fontana L,Errani PG,Zerbinati A,Musacchi Y,Di Pede B,Tassinari G

    更新日期:2007-06-01 00:00:00

  • Comparison of Tono-Pen AVIA intraocular pressure measurements performed at limbus with central corneal Tono-Pen AVIA intraocular pressure.

    abstract:PURPOSE:To compare Tono-Pen AVIA (TPA) intraocular pressure (IOP) measurements performed at the limbus with central corneal Tono-Pen AVIA (TPA) intraocular pressure. METHODS:Fifty-one patients attending our outpatient department with a best corrected visual acuity of ≥ 20/40, no corneal disease, and no astigmatism gre...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31827c9d25

    authors: Sharma R,Majumdar S,Sobti A,Arora T,Agarwal T,Dada T

    更新日期:2013-07-01 00:00:00

  • Riboflavin/ultraviolet a crosslinking of the paracentral cornea.

    abstract:PURPOSE:The depth of corneal crosslinking (CXL) does not seem homogeneous within the treatment area but shows a reduction toward the periphery of the cornea. This study was undertaken to investigate this reduction effect and to look for possible solutions. METHODS:Ten corneas were investigated by means of an optical c...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318269059b

    authors: Koller T,Schumacher S,Fankhauser F 2nd,Seiler T

    更新日期:2013-02-01 00:00:00