Alkali Burn Over a LASIK Flap.

Abstract:

PURPOSE:To describe the management and outcome of an ocular surface alkali burn in the setting of previous laser in situ keratomileusis (LASIK). METHODS:This is a case report and review of relevant literature. RESULTS:A 25-year-old man with a history of LASIK presented 4 weeks after a sodium hydroxide splash to his left eye with visual acuity of 20/60 and a nonhealing epithelial defect adjacent to sectoral inferior limbal ischemia in the setting of trichiasis from upper eyelid cicatricial entropion. After topical corticosteroids were discontinued following the repair of the entropion, the patient returned 3 days later with worsening vision and severe diffuse lamellar keratitis with the melting of the LASIK flap. After promptly lifting the flap and debriding the interface, inflammation was managed with oral, instead of topical, corticosteroids. Over several weeks, the epithelium healed, and inflammation and interface edema resolved. At 10 years of follow-up, the patient had developed a localized pseudopterygium with mild corneal neovascularization but maintained 20/20 uncorrected visual acuity. CONCLUSIONS:A chemical burn over a LASIK flap poses a challenge for managing corticosteroids, which are required to prevent diffuse lamellar keratitis but can also contribute to keratolysis beyond the first week after an alkali injury. Oral corticosteroid therapy may be beneficial in this situation, with a low threshold to lift the LASIK flap and debride the interface if inflammation occurs.

journal_name

Cornea

journal_title

Cornea

authors

Witsberger EM,Patel SV

doi

10.1097/ICO.0000000000002604

subject

Has Abstract

pub_date

2020-12-03 00:00:00

eissn

0277-3740

issn

1536-4798

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Conjunctival involvement in chronic recurrent multifocal osteomyelitis.

    abstract:PURPOSE:To report a case of chronic recurrent multifocal osteomyelitis (CRMO) with conjunctival involvement. METHODS:Retrospective chart review. RESULTS:A 10-year-old girl who complained of fatigue and debilitating pain in both hips and legs for >1 year had recurrent episodes of redness and discharge in both eyes wit...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181589309

    authors: Ozbek Z,Makay B,Unsal E,Durak I,Gunes D,Anal O,Ozer E

    更新日期:2008-01-01 00:00:00

  • Preliminary in vitro evaluation of 2-octyl cyanoacrylate (Dermabond) to seal corneal incisions.

    abstract:OBJECTIVE:To compare the efficacy of Dermabond with conventional nylon sutures for sealing linear corneal incisions. METHODS:A keratome knife was used to create a 4-mm full-thickness linear corneal incision anterior to the limbal arcade in 20 fresh pig eyes. The incision was sealed with Dermabond tissue adhesive or cl...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000159734.75672.c4

    authors: Leung GY,Peponis V,Varnell ED,Lam DS,Kaufman HE

    更新日期:2005-11-01 00:00:00

  • Gross factors in treatment of nonhealing corneal ulcers and recurrent erosions.

    abstract::Epidermal growth factor (EGF) is known to promote corneal epithelial wound healing in experimental scrape and keratectomy models. We studied its efficacy in treating alkali-burned epithelial ulceration. EGF induced hyperplasia and cell proliferation to resurface the denuded and denatured corneal stroma, but it did not...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Singh G,Foster CS

    更新日期:1989-01-01 00:00:00

  • Sclerocorneal Intrastromal Lamellar Keratoplasty for Pellucid Marginal Degeneration.

    abstract:PURPOSE:Surgical management of advanced pellucid marginal degeneration is challenging. To correct both corneal thinning and induced corneal astigmatism, we propose a modified intrastromal lamellar sclero-keratoplasty. METHODS:Corneal thinning was mapped using perioperative optical coherence tomography (OCT). Then thro...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000813

    authors: Guindolet D,Petrovic A,Doan S,Cochereau I,Gabison EE

    更新日期:2016-06-01 00:00:00

  • Dry Eye Assessment in Patients With Vitiligo.

    abstract:PURPOSE:To evaluate tear osmolarity and tear film parameters in patients with vitiligo. METHODS:A total of 25 eyes of 25 patients with vitiligo with periocular involvement (group 1), 30 eyes of 30 patients with vitiligo without periocular involvement (group 2), and 20 eyes of 20 controls (group 3) were evaluated using...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001469

    authors: Erdur SK,Aydin R,Balevi A,Ozsutcu M,Kocabora MS

    更新日期:2018-04-01 00:00:00

  • Epithelium-off corneal collagen cross-linking versus transepithelial cross-linking for pediatric keratoconus.

    abstract:PURPOSE:To compare efficiency and safety of epithelium-off corneal cross-linking (CXL) and transepithelial cross-linking (TE-CXL) in pediatric patients with progressive keratoconus. METHODS:Uncorrected and corrected visual acuity, corneal topography and pachymetry (Pentacam; Oculus Pentacam), and in vivo confocal micr...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31826cf32d

    authors: Magli A,Forte R,Tortori A,Capasso L,Marsico G,Piozzi E

    更新日期:2013-05-01 00:00:00

  • Primary graft failure: a case control investigation of a purported cluster.

    abstract::Primary graft failure is a rare but major complication of penetrating keratoplasty. An apparent clustering of four cases during a 1-month period led to a review of all 778 keratoplasties performed by nine surgeons at Massachusetts Eye and Ear Infirmary from July 1, 1986 to June 30, 1988. The objectives of this study w...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199407000-00005

    authors: Mead MD,Hyman L,Grimson R,Schein OD

    更新日期:1994-07-01 00:00:00

  • Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia.

    abstract:PURPOSE:To investigate the distribution and relative level of expression of the receptor tyrosine kinases, epidermal growth factor receptor (EGFR), ErbB2 and ErbB3, in human ocular surface epithelia. METHODS:Immunofluorescent staining was performed to identify expression of the EGFR, ErbB2 and ErbB3 in the corneal, li...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200101000-00016

    authors: Liu Z,Carvajal M,Carraway CA,Carraway K,Pflugfelder SC

    更新日期:2001-01-01 00:00:00

  • Ocular mucin visualization by confocal laser scanning microscopy.

    abstract:PURPOSE:To describe a new method of visualizing human conjunctiva goblet cell mucin secretion by using a combination of impression cytology and laser scanning microscopy. METHODS:By assembling a Z-stack of confocal microscopy images taken from human impression cytology samples, we obtained 3-dimensional information ab...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31816092dd

    authors: Peral A,Pintor J

    更新日期:2008-05-01 00:00:00

  • Characterization of Corneal Donor Tissue Lesions by Anterior Segment Optical Coherence Tomography Compared With Eye Bank Technician Slit-Lamp Examination.

    abstract:PURPOSE:To compare anterior segment spectral-domain optical coherence tomography (OCT) with eye bank technician slit-lamp examination (SLE) in characterizing lesions in donor corneas. METHODS:Twenty-nine donor corneas identified by eye bank technicians to have opacities or lesions potentially representing pathologic f...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001700

    authors: Hsu ST,Perry I,Botsay S,Ko N,Stinnett SS,Kuo AN,Shieh C

    更新日期:2018-10-01 00:00:00

  • Corneal Endothelium and Phacoemulsification.

    abstract::Phacoemulsification has become the most commonly used procedure in cataract surgery owing to the development of new devices and surgical techniques; however, corneal endothelial damage still represents a serious complication. Although several factors are known to cause corneal endothelial damage, effects of irrigating...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000990

    authors: Takahashi H

    更新日期:2016-11-01 00:00:00

  • Expression of Peroxiredoxin 2 and Vascular Endothelial Growth Factor Receptor 2 in Pterygium.

    abstract:PURPOSE:The expression of peroxiredoxin 2 and vascular endothelial growth factor receptor 2 (VEGFR2) was detected in pterygium to investigate whether they are involved in the pathogenesis or recurrence of pterygium and to evaluate the association between peroxiredoxin 2 and VEGFR2 in pterygium. METHODS:Ten normal bulb...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001213

    authors: Wang Y,Lin J,Chen L,Wang L,Hao P,Han R,Ying M,Li X

    更新日期:2017-07-01 00:00:00

  • Colocalization of hyaluronan and water in rabbit corneas after photorefractive keratectomy by specific staining for hyaluronan and by quantitative microradiography.

    abstract:PURPOSE:Endogenous hyaluronan (HA) has previously been shown to be a part of corneal wound healing after photorefractive keratectomy (PRK). HA is known to bind considerable amounts of water. This study aimed to show whether HA colocalized with water in the wound area after PRK. METHODS:Five New Zealand White rabbits w...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Weber BA,Fagerholm P,Johansson B

    更新日期:1997-09-01 00:00:00

  • Toxicity of Intracameral Injection of Fourth-Generation Fluoroquinolones on the Corneal Endothelium.

    abstract:PURPOSE:The aim of this study was to compare the cellular susceptibility patterns and morphologic changes in the corneal endothelium associated with the use of fourth-generation fluoroquinolones. METHOD:Endothelial susceptibility was assessed through intracameral injection of besifloxacin, gatifloxacin, and moxifloxac...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000967

    authors: E Silva FB,Carrijo-Carvalho LC,Teixeira A,de Freitas D,Carvalho FR

    更新日期:2016-12-01 00:00:00

  • Visual Function and Higher-Order Aberrations in Eyes After Corneal Transplantation: How to Improve Postoperative Quality of Vision.

    abstract::An understanding of corneal optics is important to optimize the visual outcome after eye surgery. Recent advances in the surgical techniques of lamellar keratoplasty have changed the strategies used for corneal transplantation. Lamellar keratoplasty has the advantage of having a lower rate of graft rejection, superior...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000000589

    authors: Yamaguchi T,Satake Y,Dogru M,Ohnuma K,Negishi K,Shimazaki J

    更新日期:2015-11-01 00:00:00

  • Excision of granulation tissue and free conjunctival autograft in the management of necrotizing scleritis.

    abstract:PURPOSE:To describe a novel use of conjunctival autograft in the management of surgically induced scleral necrosis that occurred after squint surgery. METHODS:Interventional case report. RESULTS:A 22-year-old man underwent bilateral adjustable squint surgery. Two weeks postoperatively, he developed conjunctival retra...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181b532e5

    authors: Gregory ME,Weir CR,Ramaesh K

    更新日期:2010-05-01 00:00:00

  • Endophthalmitis in Advanced Microbial Keratitis: Risk Factors and Examination Findings.

    abstract:PURPOSE:To evaluate clinical and ultrasonographic findings associated with advanced microbial keratitis with concurrent endophthalmitis. METHODS:We performed a retrospective analytical study of patients with severe microbial keratitis who underwent ocular ultrasonography for possible endophthalmitis at our institution...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002349

    authors: Christopher KL,Hood CT,Mian SI,Ayres B

    更新日期:2020-09-01 00:00:00

  • Quantitation of ultraviolet light-absorbing fractions of the cornea.

    abstract::This study attempts to measure the quantitative contribution of major chemical fractions of the whole bovine cornea to ultraviolet (UV) absorption between 240 and 300 nm, with special attention to the biologically significant range of 290-300 nm. The cornea was divided into water-insoluble, nonprotein small water-solu...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199505000-00007

    authors: Mitchell J,Cenedella RJ

    更新日期:1995-05-01 00:00:00

  • Trends in the etiology of infectious corneal ulcers at the F. I. Proctor Foundation.

    abstract:OBJECTIVE:We analyzed laboratory results from corneal ulcers seen from 1976 to 1999 at the Francis I. Proctor Foundation, a referral center in San Francisco, to determine the relative frequencies of pathogens and to analyze for trends in frequencies of the most common pathogens. The results were compared with a previou...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200405000-00009

    authors: Varaprasathan G,Miller K,Lietman T,Whitcher JP,Cevallos V,Okumoto M,Margolis TP,Yinghui M,Cunningham ET Jr

    更新日期:2004-05-01 00:00:00

  • Corneal chromoblastomycosis.

    abstract:PURPOSE:We sought to illustrate the difficulty in managing uncommon, pigmented mold-related corneal ulceration and to highlight the role of itraconazole in treating these patients. METHOD:We describe the management and clinical course of a patient with a recurring corneal infection caused by Fonsecaea pedrosoi and dis...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:

    authors: Barton K,Miller D,Pflugfelder SC

    更新日期:1997-03-01 00:00:00

  • Comparison of pterygium recurrence rates after limbal conjunctival autograft transplantation and other techniques: meta-analysis.

    abstract:PURPOSE:Meta-analysis to compare pterygium surgery outcomes using limbal conjunctival autograft (LCAG) and other techniques. METHODS:A comprehensive literature search was conducted through June 2011 using PubMed, Embase, and the Cochrane Registry to identify all randomized control trials reported so far, comparing the...

    journal_title:Cornea

    pub_type: 杂志文章,meta分析

    doi:10.1097/ICO.0b013e31823cbecb

    authors: Zheng K,Cai J,Jhanji V,Chen H

    更新日期:2012-12-01 00:00:00

  • Roles of chemokines in ocular allergy and possible therapeutic strategies.

    abstract::The mechanism of ocular surface allergy in the forms of atopic conjunctivitis and vernal keratoconjunctivitis has been highlighted by specific functions of chemokines. In the context of late-phase allergic responses, these molecules have key roles in recruitment and activation of leukocytes. Their interaction with lig...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/01.ico.0000136671.50777.fe

    authors: Miyazaki D,Nakamura T,Komatsu N,Nawata N,Ikeda Y,Inoue Y,Higashi H,Ono SJ

    更新日期:2004-11-01 00:00:00

  • Automated analysis of wide-field specular photomicrographs.

    abstract::This report describes computerized image enhancement and analysis from the digitized image of a wide-field specular micrograph to produce an output of frequency distribution of cell areas. The steps involved including image smoothing and averaging, followed by automated scanning to detect individual cell boundaries, a...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Hirst LW,Sterner RE,Grant DG

    更新日期:1984-01-01 00:00:00

  • Modified deep anterior lamellar keratoplasty in the management of small and large epithelialized descemetoceles.

    abstract:PURPOSE:Descemetocele is a severe complication of corneal ulceration associated with a high risk of perforation. We describe a modified air-assisted deep anterior lamellar keratoplasty (DALK) technique for the surgical management of small and large epithelialized descemetoceles. METHODS:Two representative cases are pr...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182031c81

    authors: Gabison EE,Doan S,Catanese M,Chastang P,Ben M'hamed M,Cochereau I

    更新日期:2011-10-01 00:00:00

  • Effect of prophylactic oral acyclovir after penetrating keratoplasty for herpes simplex keratitis.

    abstract:PURPOSE:To determine the effect of routine use of prophylactic oral acyclovir after penetrating keratoplasty (PK) for herpes simplex virus (HSV) keratitis on recurrence, rejection, and graft failure rates. METHODS:Records from 70 consecutive patients who underwent PK for HSV keratitis at the W.K. Kellogg Eye Center be...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3180e79b77

    authors: Garcia DD,Farjo Q,Musch DC,Sugar A

    更新日期:2007-09-01 00:00:00

  • Microsporidial stromal keratitis masquerading as acute graft rejection.

    abstract:PURPOSE:To describe the clinical features, disease course, management, and visual outcome of stromal microsporidial keratitis involving the corneal graft in an immunocompetent patient. METHODS:Case report. RESULTS:We report the case of a 21-year-old immunocompetent woman, who underwent penetrating keratoplasty for ad...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000337

    authors: Pradhan S,Mascarenhas J,Srinivasan M

    更新日期:2015-03-01 00:00:00

  • Fibrin glue-assisted augmented amniotic membrane transplantation for the treatment of large noninfectious corneal perforations.

    abstract:PURPOSE:To evaluate and report the efficacy of fibrin glue (FG)-assisted augmented amniotic membrane transplantation (AMT) in patients with large corneal perforations. METHODS:In a retrospective case series, 10 patients with corneal perforations more than 2 mm in diameter were treated with "FG-assisted augmented AMT."...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181861c54

    authors: Kim HK,Park HS

    更新日期:2009-02-01 00:00:00

  • Selective Endothelial Removal for Peters Anomaly.

    abstract:PURPOSE:Peters anomaly is the most common cause of congenital corneal opacities. Although conservative management is often ineffective except in mild cases, surgical intervention in the form of penetrating keratoplasty is fraught with unpredictability and often has unacceptable postoperative outcomes. As such, there is...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000001472

    authors: Soh YQ,Mehta JS

    更新日期:2018-03-01 00:00:00

  • Fulminant Acanthamoeba Endophthalmitis After Cataract Surgery-A Case Report.

    abstract:PURPOSE:To report a case of Acanthamoeba endophthalmitis after an uneventful cataract surgery. METHODS:Description, management, and outcomes of a biopsy-proven case of Acanthamoeba endophthalmitis. RESULTS:Two days after a routine cataract surgery elsewhere, the patient presented with acute endophthalmitis diagnosed ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002289

    authors: Raghavan A,Veerappan S,Rangarajan V,Rajaraman R,Salian R,Mk J,L D,Ganesh Vr R,Venkatapathy N,Rammohan R

    更新日期:2020-08-01 00:00:00

  • Corneal perforation associated with silicone oil in the anterior chamber.

    abstract:PURPOSE:To describe the management of three cases of corneal perforation associated with silicone oil in the anterior chamber. METHODS:Review of 3 case records. RESULTS:Three cases of perforation associated with silicone oil in the anterior chamber are reviewed. One patient required gluing and a bandage contact lens,...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31807a28f0

    authors: Ghosheh FR,Rapuano CJ

    更新日期:2007-10-01 00:00:00