Abstract:
:The mechanism of ocular surface allergy in the forms of atopic conjunctivitis and vernal keratoconjunctivitis has been highlighted by specific functions of chemokines. In the context of late-phase allergic responses, these molecules have key roles in recruitment and activation of leukocytes. Their interaction with ligands is redundantly regulated; however, results from strategies to block subsets of chemokines have revealed unexpected or highly organized roles of these mediators. Exemplified by analyses of CCL11 function, current concepts of ocular allergy support CCL11 as central mediator. We emphasize the functions as modulator of mast cell activation/differentiation. With the prospect of understanding these functions, new modalities of drugs specifically developed to target CCL11/CCR3 interaction have been discussed.
journal_name
Corneajournal_title
Corneaauthors
Miyazaki D,Nakamura T,Komatsu N,Nawata N,Ikeda Y,Inoue Y,Higashi H,Ono SJdoi
10.1097/01.ico.0000136671.50777.fesubject
Has Abstractpub_date
2004-11-01 00:00:00pages
S48-54issue
8 Suppleissn
0277-3740issn
1536-4798pii
00003226-200411001-00009journal_volume
23pub_type
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