Roles of chemokines in ocular allergy and possible therapeutic strategies.

Abstract:

:The mechanism of ocular surface allergy in the forms of atopic conjunctivitis and vernal keratoconjunctivitis has been highlighted by specific functions of chemokines. In the context of late-phase allergic responses, these molecules have key roles in recruitment and activation of leukocytes. Their interaction with ligands is redundantly regulated; however, results from strategies to block subsets of chemokines have revealed unexpected or highly organized roles of these mediators. Exemplified by analyses of CCL11 function, current concepts of ocular allergy support CCL11 as central mediator. We emphasize the functions as modulator of mast cell activation/differentiation. With the prospect of understanding these functions, new modalities of drugs specifically developed to target CCL11/CCR3 interaction have been discussed.

journal_name

Cornea

journal_title

Cornea

authors

Miyazaki D,Nakamura T,Komatsu N,Nawata N,Ikeda Y,Inoue Y,Higashi H,Ono SJ

doi

10.1097/01.ico.0000136671.50777.fe

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

S48-54

issue

8 Suppl

eissn

0277-3740

issn

1536-4798

pii

00003226-200411001-00009

journal_volume

23

pub_type

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