Tolerance of Micronized Mineral Pigments for Intrastromal Keratopigmentation: A Histopathology and Immunopathology Experimental Study.

Abstract:

PURPOSE:To study the tolerance and biocompatibility of mineral pigments for corneal pigmentation histopathologically and immunologically in an experimental animal model. METHODS:Manual intralamellar keratopigmentation was performed in 28 New Zealand white rabbits using micronized mineral pigments. Histopathological examination was performed 3 months after the surgery to determine the level of pigment diffusion, the level of inflammation, and the presence/absence of neovascularization. An immunological analysis was also performed. RESULTS:No pigment diffusion or changes in color, inflammation, or neovascularization were detected in the treated eyes. Histopathological examination corroborated clinical results regarding inflammation. Pigmented corneas showed a good cosmetic appearance without signs of ocular toxicity. From the immunological perspective, the pigments do not generate an inflammatory response in the rabbit cornea or in vitro. CONCLUSIONS:Micronized mineral pigments could be a valid alternative treatment for corneal pigmentation. Manual intralamellar keratopigmentation technique presented good cosmetic appearance without adverse effects in the treated eyes.

journal_name

Cornea

journal_title

Cornea

authors

Amesty MA,Rodriguez AE,Hernández E,De Miguel MP,Alio JL

doi

10.1097/ICO.0000000000000900

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1199-205

issue

9

eissn

0277-3740

issn

1536-4798

journal_volume

35

pub_type

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