Abstract:
PURPOSE:In our report, we present a suspected case of donor-derived Acanthamoeba keratitis after deep anterior lamellar keratoplasty. To the authors' knowledge, there have been no confirmed cases of Acanthamoeba keratitis transmission through corneal transplantation. METHODS:Deep anterior lamellar keratoplasty was performed on the right eye of a 33-year-old man with severe bilateral keratoconus and an intolerance to all forms of contact lenses. The postoperative visual acuity deteriorated, while inflammation, rising ocular pressure, increasing corneal thickness, and severe eye pain began to present. Confocal imaging revealed hyperreflective cysts and trophozoite figures representative of amoebic keratitis. Despite an additional penetrating keratoplasty, antiamoeba therapy, and corneal crosslinking, the patient's condition worsened, resulting in stromal melt and corneal perforation. Emergent combined surgery of temporary keratoprosthesis, vitrectomy, lensectomy, and iridectomy was performed, along with Ahmed valve shunt placement and another penetrating keratoplasty. RESULTS:The infection was resistant to aggressive antiamoeba therapy, but after the emergent combined surgery, the graft re-epithelialized quickly and has since remained clear, with no presence of keratitis. CONCLUSIONS:Several signs led us to believe that this case was donor-derived. There was little opportunity for graft exposure to the amoeba, and deep amoebic cysts and trophozoites were present on postoperative week 1-a highly unusual time course and depth of invasion for primary amoebic infection. In addition, pathological analysis revealed cysts only within the confines of the donor tissue and none in the recipient; Acanthamoeba cysts would have been present in the recipient rim tissue if the infection originated from the patient himself.
journal_name
Corneajournal_title
Corneaauthors
Ward MS,Bontu S,Martheswaran T,Mamalis N,Moshirfar Mdoi
10.1097/ICO.0000000000002517subject
Has Abstractpub_date
2020-09-16 00:00:00eissn
0277-3740issn
1536-4798pub_type
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