Corneal nerve structure and function after long-term wear of fluid-filled scleral lens.

Abstract:

PURPOSE:The aim of this study was to determine whether long-term wear of a fluid-filled scleral lens alters basal tear production, corneal sensation, corneal nerve density, and corneal nerve morphology in 2 disease categories. METHODS:Patients recruited from the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment program at the Weill Cornell Medical College were categorized into 2 groups: distorted corneas (DC) or ocular surface disease (OSD). We measured tear production, central corneal sensation, subbasal nerve density and tortuosity, and stromal nerve thickness before and after long-term wear of the prosthetic device used in PROSE treatment, defined as at least 60 days of wear for a minimum of 8 hours a day. RESULTS:Twenty patients were included in the study. After long-term wear of the prosthetic device, tear production decreased in patients with DC (21.2 ± 8.5 to 10.4 ± 4.6 mm; P < 0.0001) but did not change in patients with OSD (7.5 ± 5.2 to 8.7 ± 7.2 mm; P = 0.71). Corneal sensation increased in the DC group (45.6 ± 9.2 to 55.0 ± 5.6 mm; P < 0.05). There was no significant change in sensation in patients with OSD (45.0 ± 8.7 to 49.1 ± 14.8 mm; P = 0.37). Subbasal nerve density, subbasal nerve tortuosity, and stromal nerve thickness remained unchanged in both DC and OSD groups after long-term wear (P > 0.05). CONCLUSIONS:Patients with DC had significantly reduced basal tear production and increased corneal sensation after long-term wear of the scleral lens, but patients with OSD did not show any changes in tear production or corneal sensation.

journal_name

Cornea

journal_title

Cornea

authors

Wang Y,Kornberg DL,St Clair RM,Lee M,Muhic I,Ciralsky JB,Alzaga Fernandez A,Sood P,Sippel KC,Rosenblatt MI

doi

10.1097/ICO.0000000000000381

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

427-32

issue

4

eissn

0277-3740

issn

1536-4798

journal_volume

34

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Development and characterization of acellular porcine corneal matrix using sodium dodecylsulfate.

    abstract:PURPOSE:The objective of this study was to produce a porcine corneal acellular matrix (ACM) and assess its possibility for biomedical applications. METHODS:Porcine corneas were treated with various concentrations of sodium dodecylsulfate for different lengths of time. Optimal conditions for processing the ACM were not...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181dc8184

    authors: Zhou Y,Wu Z,Ge J,Wan P,Li N,Xiang P,Gao Q,Wang Z

    更新日期:2011-01-01 00:00:00

  • Anterior segment optical coherence tomography for transepithelial phototherapeutic keratectomy in central corneal stromal scarring.

    abstract:PURPOSE:To demonstrate the use of anterior segment optical coherence tomography (ASOCT) in planning phototherapeutic keratectomy (PTK) removal of central corneal stromal scarring. METHODS:A 62-year-old male presented with central corneal scars associated with significant ocular surface disease. Videokeratographies obt...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181930b9f

    authors: Ma JJ,Tseng SS,Yarascavitch BA

    更新日期:2009-09-01 00:00:00

  • Risk Factors for Dry Eye After Refractive Surgery.

    abstract:PURPOSE:To determine the factors associated with clinically significant dry eye after keratorefractive surgery. METHODS:This is a large database retrospective study that included consecutive cases of myopic laser in situ keratomileusis (LASIK) or photorefractive keratectomy performed between 2008 and 2016 at Care-Visi...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002152

    authors: Shehadeh-Mashor R,Mimouni M,Shapira Y,Sela T,Munzer G,Kaiserman I

    更新日期:2019-12-01 00:00:00

  • Case Report: Suspected Donor Transmission of Acanthamoeba Keratitis After Deep Anterior Lamellar Keratoplasty.

    abstract:PURPOSE:In our report, we present a suspected case of donor-derived Acanthamoeba keratitis after deep anterior lamellar keratoplasty. To the authors' knowledge, there have been no confirmed cases of Acanthamoeba keratitis transmission through corneal transplantation. METHODS:Deep anterior lamellar keratoplasty was per...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002517

    authors: Ward MS,Bontu S,Martheswaran T,Mamalis N,Moshirfar M

    更新日期:2020-09-16 00:00:00

  • New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry.

    abstract:PURPOSE:To review our previous studies regarding the morphology of the cornea in pseudoexfoliation syndrome (PEX) and anatomical discrepancies between PEX and contralateral eyes in unilateral PEX. METHODS:We used in vivo confocal microscopy to observe the corneas of PEX, contralateral, and normal control eyes. Morphol...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182a3657d

    authors: Zheng X

    更新日期:2013-11-01 00:00:00

  • The relative value of confocal microscopy and superficial corneal scrapings in the diagnosis of Acanthamoeba keratitis.

    abstract:PURPOSE:To compare the relative diagnostic value of confocal microscopy and superficial corneal cultures in the diagnosis of Acanthamoeba keratitis by using clinical and microbiologic definitions of disease. METHODS:Results of confocal microscopy, superficial corneal smear, and superficial corneal culture were analyze...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31816f27bf

    authors: Tu EY,Joslin CE,Sugar J,Booton GC,Shoff ME,Fuerst PA

    更新日期:2008-08-01 00:00:00

  • Donor-related risk factors and preoperative recipient-related risk factors for graft failure.

    abstract:PURPOSE:The aim of this study was to evaluate the outcome of penetrating keratoplasties, at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany, using organ-cultured donor corneas and to identify preoperative risk factors, which may influence the event of graft failure. METHODS:In this study, 3...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000225

    authors: Yu AL,Kaiser M,Schaumberger M,Messmer E,Kook D,Welge-Lussen U

    更新日期:2014-11-01 00:00:00

  • Regression of Kayser-Fleischer rings during oral zinc therapy: correlation with systemic manifestations of Wilson's disease.

    abstract::Fourteen patients presenting with neuropsychiatric manifestations of Wilson's disease were treated with oral tetrathiomolybdate (TM) for 8 weeks followed by oral zinc (Zn) maintenance therapy. The patients were evaluated prospectively at baseline and at yearly intervals for up to 5 years by slit-lamp biomicroscopy and...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Esmaeli B,Burnstine MA,Martonyi CL,Sugar A,Johnson V,Brewer GJ

    更新日期:1996-11-01 00:00:00

  • Use of Corneas From Septic Donors for Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To evaluate the suitability of corneas from septic donors for transplantation by analyzing the discard rate in the eye bank and the clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) using organ-cultured corneal grafts from septic versus nonseptic donors. METHODS:This retrospective study inc...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002443

    authors: Vasiliauskaitė I,de Jong M,Quilendrino R,van der Wees J,Oellerich S,Melles GRJ

    更新日期:2021-01-01 00:00:00

  • Thickness and Curvature Changes of Human Corneal Grafts in Dextran-Containing Organ Culture Medium Before Keratoplasty.

    abstract:PURPOSE:To determine the changes of corneal thickness and curvature of human corneal grafts in organ culture medium II, containing dextran T500 6%, before keratoplasty. METHODS:We examined the tomography of 24 corneas from our eye bank transferred from medium I into medium II. Images were repeated hourly during 24 hou...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002543

    authors: Hamon L,Daas L,Mäurer S,Weinstein I,Quintin A,Schulz K,Langenbucher A,Seitz B

    更新日期:2020-12-04 00:00:00

  • Amniotic membrane transplantation after the primary surgical management of band keratopathy.

    abstract:PURPOSE:To determine the safety and efficacy of amniotic membrane transplantation to restore and maintain a stable corneal epithelium and reduce ocular surface pain after surgical removal of band keratopathy arising from ocular causes. METHODS:Fifteen patients (16 eyes) from two centers with band keratopathy secondary...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00003226-200105000-00004

    authors: Anderson DF,Prabhasawat P,Alfonso E,Tseng SC

    更新日期:2001-05-01 00:00:00

  • In vivo confocal microscopic findings of two siblings with Maroteaux-Lamy syndrome.

    abstract:PURPOSE:To describe the clinical and in vivo confocal microscopic findings of the cornea in 2 male siblings with Maroteaux-Lamy syndrome. METHODS:Two male siblings 27 and 22 years of age who had been diagnosed with Maroteaux-Lamy syndrome underwent ophthalmologic assessment. In vivo confocal microscopy of their cornea...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31802be383

    authors: Mocan MC,Eldem B,Irkec M

    更新日期:2007-01-01 00:00:00

  • Femtosecond laser-assisted inverted mushroom keratoplasty.

    abstract:PURPOSE:To evaluate best-corrected visual acuity (BCVA), refractive outcome, corneal topography, optical coherence tomography, and endothelial cell density 12 months after femtosecond laser-assisted inverted mushroom keratoplasty. METHODS:We performed a prospective study of a surgical case series of 5 patients undergo...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/QAI.0b013e31815bad0c

    authors: Cheng YY,Tahzib NG,van Rij G,van Cleynenbreugel H,Pels E,Hendrikse F,Nuijts R

    更新日期:2008-07-01 00:00:00

  • Expression of p63 in pterygium and normal conjunctiva.

    abstract:PURPOSE:The p63 gene has been identified as a marker of epithelial stem cells. Because pterygium may arise through an expansion of the proliferative capacity of the conjunctiva, we sought to document the expression of p63 in normal conjunctiva and pterygium specimens. METHODS:Immunostaining for p63 expression was perf...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200401000-00011

    authors: Sakoonwatanyoo P,Tan DT,Smith DR

    更新日期:2004-01-01 00:00:00

  • Impression cytology study of conjunctival epithelial phenotypes on the healing ocular surface after pterygium excision.

    abstract:PURPOSE:To compare the process of conjunctival epithelial regeneration after three types of pterygium excision procedures. METHODS:Thirty-eight patients (45 eyes) with primary pterygium were randomly assigned to a bare-sclera procedure (group 1, 15 eyes of 12 patients), bare-sclera with intraoperative mitomycin C (MMC...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003226-200104000-00002

    authors: Tseng SH,Chen YT,Cheng HC,Huang FC,Lee SC,Chen FK

    更新日期:2001-04-01 00:00:00

  • Corneal thickness is reduced in dry eye.

    abstract:PURPOSE:To evaluate and compare corneal thickness in normal and dry eyes. METHODS:The Orbscan corneal topography system was used to measure the corneal thickness at nine locations in the central and peripheral (superior, superonasal, nasal, inferonasal, inferior, inferotemporal, temporal, superotemporal) cornea in 38 ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199907000-00002

    authors: Liu Z,Pflugfelder SC

    更新日期:1999-07-01 00:00:00

  • Characterization of Corneal Donor Tissue Lesions by Anterior Segment Optical Coherence Tomography Compared With Eye Bank Technician Slit-Lamp Examination.

    abstract:PURPOSE:To compare anterior segment spectral-domain optical coherence tomography (OCT) with eye bank technician slit-lamp examination (SLE) in characterizing lesions in donor corneas. METHODS:Twenty-nine donor corneas identified by eye bank technicians to have opacities or lesions potentially representing pathologic f...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001700

    authors: Hsu ST,Perry I,Botsay S,Ko N,Stinnett SS,Kuo AN,Shieh C

    更新日期:2018-10-01 00:00:00

  • The effect of subconjunctival suramin on corneal neovascularization in rabbits.

    abstract:PURPOSE:To evaluate the effect of subconjunctival injection of suramin on corneal neovascularization in rabbits. METHODS:Corneal neovascularization was induced by silk suturing of the corneal stroma in 40 eyes of 40 male New Zealand white rabbits. Five days after suture placement, all rabbits were randomly divided int...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ae91e3

    authors: Lee HS,Chung SK

    更新日期:2010-01-01 00:00:00

  • New graft inserter for descemet stripping automated endothelial keratoplasty.

    abstract:PURPOSE:The aim of this study was to introduce a newly developed graft inserter for Descemet stripping automated endothelial keratoplasty, which can be readily used with 1 hand, and to examine endothelial cell loss (ECL) after graft insertion using this new inserter in an ex vivo rabbit model. METHODS:Rabbit corneal g...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000073

    authors: Toyama T,Honda N,Usui T,Amano S

    更新日期:2014-04-01 00:00:00

  • Successful treatment of microsporidial keratoconjunctivitis with topical fumagillin in a patient with AIDS.

    abstract::There recently have been several reports of microsporidial keratoconjunctivitis caused by the organism Encephalitozoon hellem. However, treatment of this infection has been largely ineffective. We report a case of a 35-year-old Hispanic woman with AIDS and E. hellem keratoconjunctivitis confirmed with light, electron,...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199305000-00013

    authors: Rosberger DF,Serdarevic ON,Erlandson RA,Bryan RT,Schwartz DA,Visvesvara GS,Keenan PC

    更新日期:1993-05-01 00:00:00

  • A safe Nd:YAG retroprosthetic membrane removal technique for keratoprosthesis.

    abstract:PURPOSE:To describe a technique for Nd:YAG laser photodiscission of retroprosthetic membrane (RPM) in keratoprosthesis patients that minimizes damage to the optic. METHODS:Prospective review of Boston type I keratoprosthesis patients at 1 site who received Nd:YAG treatment for RPM from 2005 to 2009. Outcomes were base...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181cda001

    authors: Chak G,Aquavella JV

    更新日期:2010-10-01 00:00:00

  • Onset of ocular graft-versus-host disease symptoms after allogeneic hematopoietic stem cell transplantation.

    abstract:OBJECTIVE:To study the factors affecting the time to onset of ocular graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS:A retrospective chart review of 200 patients with ocular GVHD was performed to evaluate the association between various do...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000340

    authors: Shikari H,Amparo F,Saboo U,Dana R

    更新日期:2015-03-01 00:00:00

  • Suppression of corneal allograft rejection by systemic cyclosporine-A in heavily vascularized rabbit corneas following alkali burns.

    abstract::Immunologic rejection is the main cause of corneal graft failure, especially in vascularized corneal beds. The purpose of this study was to investigate the effect of systemic Cyclosporine-A (CsA) on the survival of corneal allografts in heavily vascularized rabbit corneal beds, following alkali burn. Heavy corneal vas...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199409000-00013

    authors: Rehany U,Waisman M

    更新日期:1994-09-01 00:00:00

  • Heterozygous Avellino corneal dystrophy 9 years after photorefractive keratectomy: natural or laser-induced accelerated course?

    abstract:PURPOSE:To report a photorefractive keratectomy (PRK)-treated patient who first developed stromal opacities with a typical granular pattern 9 years after surgery, which was confirmed as heterozygous Avellino dystrophy by DNA analysis. METHODS:A 37-year-old woman, who had undergone PRK 17 years ago, has been followed f...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31818a7df7

    authors: Park SH,Mok J,Joo CK,Kim MS

    更新日期:2009-05-01 00:00:00

  • Corneal laceration by sharp objects in children seven years of age and younger.

    abstract:PURPOSE:Young children are prone to develop amblyopia after penetrating injury. We sought to evaluate the management of penetrating corneal injury without intraocular foreign body (IOFB) in children

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3180301534

    authors: Segev F,Assia EI,Harizman N,Barequet I,Almer Z,Raz J,Moisseiev J

    更新日期:2007-04-01 00:00:00

  • Effectiveness of topical infliximab in a mouse model of experimental dry eye.

    abstract:PURPOSE:To investigate the efficacy of a topical anti-tumor necrosis factor-α agent, infliximab, in a mouse model of experimental dry eye (EDE). METHODS:EDE was induced in C57BL/6 mice, with or without topical treatment consisting of balanced salt solution or 0.001%, 0.01%, or 0.1% infliximab solutions. Tear volume an...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31826a80ea

    authors: Li Z,Choi W,Oh HJ,Yoon KC

    更新日期:2012-11-01 00:00:00

  • Estimation of Prevalence of Meibomian Gland Dysfunction in Japan.

    abstract:PURPOSE:To estimate the prevalence of meibomian gland dysfunction (MGD) in the Japanese population using new diagnostic criteria, including lid margin abnormalities and signs of occlusion of the meibomian gland orifices as essential signs. METHODS:The participants were consecutive patients scheduled for cataract surge...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001208

    authors: Amano S,Inoue K

    更新日期:2017-06-01 00:00:00

  • Intracameral amphotericin B injection in the management of deep keratomycosis.

    abstract:PURPOSE:To report the use of intracameral amphotericin B in the management of deep keratomycosis. METHODS:Four patients with deep keratomycosis unresponsive to conventional medical treatment underwent repeated intracameral injections of 5 microg amphotericin B in 0.1 mL 5% dextrose through a paracentesis. Three to 13 ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200210000-00004

    authors: Kuriakose T,Kothari M,Paul P,Jacob P,Thomas R

    更新日期:2002-10-01 00:00:00

  • Adhesion of Acanthamoeba on Silicone Hydrogel Contact Lenses.

    abstract:PURPOSE:To evaluate adhesion of Acanthamoeba trophozoites to different silicone hydrogel contact lens (SHCL) generations with and without multipurpose contact lens care solution (MPS) treatment. METHODS:Acanthamoeba lugdunensis L3a trophozoites were inoculated onto discs trimmed from SHCLs: first generation, Air Optix...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000788

    authors: Lee GH,Lee JE,Park MK,Yu HS

    更新日期:2016-05-01 00:00:00

  • Expression of phosphorylated heat shock protein 27 during corneal epithelial wound healing.

    abstract:PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31823f7685

    authors: Jain S,De la Cruz J,Kang E,Kojima T,Chang JH,Kim JY

    更新日期:2012-07-01 00:00:00