Suppression of corneal allograft rejection by systemic cyclosporine-A in heavily vascularized rabbit corneas following alkali burns.


:Immunologic rejection is the main cause of corneal graft failure, especially in vascularized corneal beds. The purpose of this study was to investigate the effect of systemic Cyclosporine-A (CsA) on the survival of corneal allografts in heavily vascularized rabbit corneal beds, following alkali burn. Heavy corneal vascularization was induced in one eye of 20 rabbits by alkali burn. Forty-five days later, penetrating keratoplasty was performed in all the heavily vascularized corneas. Twenty-five mg/kg/day of CsA was intramuscularly administered to 10 rabbits for 30 days. The other 10 rabbits were treated with the solvent without CsA and were used as a matched control group. The results show a significant difference in corneal allograft survival between the two groups. All corneal grafts in the untreated group were intensely rejected and vascularized within 3 weeks. Nine of the 10 corneal transplants, in the CsA-treated group, remained transparent without signs of immunologic rejection for > 180 days. In one corneal transplant, minor signs of rejection occurred. We suggest that CsA, when given systemically, is a potent drug in the prevention of immunologic rejection in high-risk corneal transplantations, such as allografts, in heavily vascularized corneas following alkali burn.






Rehany U,Waisman M




Has Abstract


1994-09-01 00:00:00














  • Hemangiogenesis and lymphangiogenesis in corneal pathology.

    abstract:PURPOSE:We characterized the presence of hemangiogenesis (HA) and lymphangiogenesis (LA) in human corneal specimens exhibiting 13 underlying pathologies. METHODS:Human corneal specimens were obtained from consenting subjects (n = 2 or n = 3 for each pathology; total sample size, n = 35). The pathological specimens wer...


    pub_type: 杂志文章


    authors: Tshionyi M,Shay E,Lunde E,Lin A,Han KY,Jain S,Chang JH,Azar DT

    更新日期:2012-01-01 00:00:00

  • Multimodal Assessment of Corneal Thinning Using Optical Coherence Tomography, Scheimpflug Imaging, Pachymetry, and Slit-Lamp Examination.

    abstract:PURPOSE:To assess the relationship between corneal thinning measured by clinician-graded slit-lamp examination compared with ultrasound pachymetry (USP), anterior segment optical coherence tomography (AS-OCT), and the Pentacam. METHODS:Patients with corneal thinning underwent USP, AS-OCT, Pentacam measurements and sta...


    pub_type: 杂志文章


    authors: Oatts JT,Keenan JD,Mannis T,Lietman TM,Rose-Nussbaumer J

    更新日期:2017-04-01 00:00:00

  • Fungal keratitis caused by Scedosporium apiospermum: report of two cases and review of treatment.

    abstract:PURPOSE:We report our experience in treating two cases of Scedosporium apiospermum keratitis and provide a review of basic scientific and clinical data regarding the treatment of this visually devastating disease. METHOD:We present a case report and literature review. RESULTS:A 35-year-old woman and a 73-year-old man...


    pub_type: 杂志文章,评审


    authors: Wu Z,Ying H,Yiu S,Irvine J,Smith R

    更新日期:2002-07-01 00:00:00

  • KeraRing intrastromal corneal ring segments for correction of keratoconus.

    abstract:PURPOSE:Intrastromal corneal ring segments (ICRSs) are small arc-like implants that are being used increasingly as a minimally invasive treatment for patients with keratoconus. This study assessed the effectiveness of KeraRing implants, a type of ICRS, to treat keratoconus. METHODS:Retrospective case series descriptiv...


    pub_type: 杂志文章


    authors: Gharaibeh AM,Muhsen SM,AbuKhader IB,Ababneh OH,Abu-Ameerh MA,Albdour MD

    更新日期:2012-02-01 00:00:00

  • New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry.

    abstract:PURPOSE:To review our previous studies regarding the morphology of the cornea in pseudoexfoliation syndrome (PEX) and anatomical discrepancies between PEX and contralateral eyes in unilateral PEX. METHODS:We used in vivo confocal microscopy to observe the corneas of PEX, contralateral, and normal control eyes. Morphol...


    pub_type: 杂志文章


    authors: Zheng X

    更新日期:2013-11-01 00:00:00

  • Sclerocorneal Intrastromal Lamellar Keratoplasty for Pellucid Marginal Degeneration.

    abstract:PURPOSE:Surgical management of advanced pellucid marginal degeneration is challenging. To correct both corneal thinning and induced corneal astigmatism, we propose a modified intrastromal lamellar sclero-keratoplasty. METHODS:Corneal thinning was mapped using perioperative optical coherence tomography (OCT). Then thro...


    pub_type: 杂志文章


    authors: Guindolet D,Petrovic A,Doan S,Cochereau I,Gabison EE

    更新日期:2016-06-01 00:00:00

  • Sequential Intracorneal Ring Segment Implantation and Corneal Transepithelial Collagen Cross-Linking in Keratoconus.

    abstract:PURPOSE:To assess the clinical outcomes after sequential surgical implantation of intracorneal ring segments and transepithelial corneal collagen cross-linking (TE-CXL) in keratoconic eyes. METHODS:In this consecutive randomized study, 40 eyes of 29 patients with progressive mild to moderate keratoconus were included ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Elsaftawy HS,Ahmed MH,Saif MY,Mousa R

    更新日期:2015-11-01 00:00:00

  • Efficacy of 2-Month Treatment With Cord Blood Serum Eye Drops in Ocular Surface Disease: An In Vivo Confocal Microscopy Study.

    abstract:PURPOSE:To investigate the morphological changes of corneal epithelium and subbasal nerves by in vivo confocal microscopy in patients with ocular surface disease (OSD) treated with cord blood serum (CBS) eye drops. METHODS:Twenty patients with OSD (mean age 61.1 ± 12.6 years) were included in this prospective 1-arm st...


    pub_type: 杂志文章


    authors: Giannaccare G,Buzzi M,Fresina M,Velati C,Versura P

    更新日期:2017-08-01 00:00:00

  • Nevirapine-induced Stevens-Johnson syndrome in an HIV patient.

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    pub_type: 杂志文章


    authors: Jain V,Shome D,Natarajan S

    更新日期:2008-04-01 00:00:00

  • Corneal nerve structure and function after long-term wear of fluid-filled scleral lens.

    abstract:PURPOSE:The aim of this study was to determine whether long-term wear of a fluid-filled scleral lens alters basal tear production, corneal sensation, corneal nerve density, and corneal nerve morphology in 2 disease categories. METHODS:Patients recruited from the Prosthetic Replacement of the Ocular Surface Ecosystem (...


    pub_type: 杂志文章


    authors: Wang Y,Kornberg DL,St Clair RM,Lee M,Muhic I,Ciralsky JB,Alzaga Fernandez A,Sood P,Sippel KC,Rosenblatt MI

    更新日期:2015-04-01 00:00:00

  • Colonization of hydrogel lenses with Streptococcus pneumoniae: risk of development of corneal infiltrates.

    abstract:PURPOSE:To report the association between colonization of contact lenses with Streptococcus pneumoniae and the observation of corneal infiltrative events in a group of patients wearing disposable hydrogel lenses on an extended-wear schedule. METHODS:In a prospective clinical trial, 330 patients wore disposable hydroge...


    pub_type: 临床试验,杂志文章


    authors: Sankaridurg PR,Sharma S,Willcox M,Sweeney DF,Naduvilath TJ,Holden BA,Rao GN

    更新日期:1999-05-01 00:00:00

  • Exceptional case of bone resorption in an osteo-odonto-keratoprosthesis. A scanning electron microscopy and X-ray microanalysis study.

    abstract::This article reports the findings of investigations on an osteo-odonto-keratoprosthesis in an eye that was enucleated owing to severe complications 12 years after implantation. Scanning electron microscopy and electron probe X-ray microanalysis showed extensive resorption of the bone that was used as a supporting elem...


    pub_type: 杂志文章


    authors: Caiazza S,Falcinelli G,Pintucci S

    更新日期:1990-01-01 00:00:00

  • Donor-related risk factors and preoperative recipient-related risk factors for graft failure.

    abstract:PURPOSE:The aim of this study was to evaluate the outcome of penetrating keratoplasties, at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany, using organ-cultured donor corneas and to identify preoperative risk factors, which may influence the event of graft failure. METHODS:In this study, 3...


    pub_type: 杂志文章


    authors: Yu AL,Kaiser M,Schaumberger M,Messmer E,Kook D,Welge-Lussen U

    更新日期:2014-11-01 00:00:00

  • The association of keratoconus with immune disorders.

    abstract:PURPOSE:To evaluate the association between keratoconus (KC) and immune disorders (IDs). METHODS:A retrospective observational case-control study of all the members in the Central District of Clalit Health Services in Israel who were diagnosed to have KC (years 2000-2007; n = 426) and 1704 age- and gender-matched cont...


    pub_type: 杂志文章


    authors: Nemet AY,Vinker S,Bahar I,Kaiserman I

    更新日期:2010-11-01 00:00:00

  • Herpes simplex virus keratitis: histopathologic neovascularization and corneal allograft failure.

    abstract:PURPOSE:To identify whether histopathologic presence of neovascularization is predictive for allograft failure following penetrating keratoplasty for herpes simplex virus (HSV) keratitis. METHODS:Retrospective, interventional case series of 62 consecutive patients with HSV keratitis who underwent penetrating keratopla...


    pub_type: 杂志文章


    authors: Garcia DD,Shtein RM,Musch DC,Elner VM

    更新日期:2009-10-01 00:00:00

  • In vivo and in vitro demonstration of epithelial cell-induced myofibroblast differentiation of keratocytes and an inhibitory effect by amniotic membrane.

    abstract:PURPOSE:To examine the role of epithelial cells in inducing the differentiation of keratocytes into myofibroblasts and to determine whether this effect may be inhibited by amniotic membrane matrix. METHODS:In vivo, a 9-mm diameter, partial-thickness corneal flap was created in 12 rabbit eyes (6 rabbits), which were eq...


    pub_type: 杂志文章


    authors: Choi TH,Tseng SC

    更新日期:2001-03-01 00:00:00

  • Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas.

    abstract:PURPOSE:Pseudophakic/aphakic bullous keratopathy (PBK/ABK) human corneas accumulate an extracellular matrix glycoprotein tenascin-C (TN-C), an important modulator of cell adhesion and migration. Here, the purpose was to identify specific TN-C mRNA splice variants in normal and PBK/ABK human corneas. METHODS:Convention...


    pub_type: 杂志文章


    authors: Saghizadeh M,Khin HL,Bourdon MA,Kenney MC,Ljubimov AV

    更新日期:1998-05-01 00:00:00

  • The effect of aqualase and phacoemulsification on the corneal endothelium.

    abstract:PURPOSE:To compare corneal endothelial cell loss after cataract surgery by phacoemulsification and by Aqualase. METHODS:This was a prospective, randomized study of 75 eyes of 75 patients undergoing cataract surgery. Patients were randomly assigned to receive either phacoemulsification or Aqualase for cataract removal....


    pub_type: 杂志文章,随机对照试验


    authors: Hu V,Hughes EH,Patel N,Whitefield LA

    更新日期:2010-03-01 00:00:00

  • Preservation of Biological Activity of Plasma and Platelet-Derived Eye Drops After Their Different Time and Temperature Conditions of Storage.

    abstract:PURPOSE:To analyze whether plasma rich in growth factors (PRGF) eye drops preserve their biological characteristics and activity after storage for 3 and 6 months at -20°C, at 4°C, and at room temperature for 72 hours, compared with fresh samples (t0). METHODS:Blood from 6 healthy donors was harvested and centrifuged t...


    pub_type: 杂志文章


    authors: Anitua E,de la Fuente M,Riestra A,Merayo-Lloves J,Muruzábal F,Orive G

    更新日期:2015-09-01 00:00:00

  • Medical management of Beauveria bassiana keratitis.

    abstract:PURPOSE:To describe a case of Beauveria bassiana keratitis and to discuss the management of this rare condition. METHODS:An 82-year-old woman underwent surgical repair of a graft wound dehiscence. Seven months later, shortly after the removal of sutures, the patient developed a fungal keratitis. B. bassiana was identi...


    pub_type: 杂志文章


    authors: Kisla TA,Cu-Unjieng A,Sigler L,Sugar J

    更新日期:2000-05-01 00:00:00

  • Ocular microfluctuations and videokeratoscopy.

    abstract:PURPOSE:We aimed to minimize the effect of ocular microfluctuations during videokeratoscopy to improve the qualitative and quantitative analysis of corneal topography. METHODS:A technique was developed to measure the tilt, displacement, and cyclotorsion in multiple videokeratographs from the same cornea. This informat...


    pub_type: 杂志文章


    authors: Buehren T,Lee BJ,Collins MJ,Iskander DR

    更新日期:2002-05-01 00:00:00

  • Serial 3-dimensional computed tomography and a novel method of volumetric analysis for the evaluation of the osteo-odonto-keratoprosthesis.

    abstract:PURPOSE:To assess the use of serial computed tomography (CT) in the detection of osteo-odonto-lamina resorption in osteo-odonto-keratoprosthesis (OOKP) and to investigate the use of new volumetric software, Advanced Lung Analysis software (3D-ALA; GE Healthcare), for detecting changes in OOKP laminar volume. METHODS:A...


    pub_type: 杂志文章


    authors: Sipkova Z,Lam FC,Francis I,Herold J,Liu C

    更新日期:2013-04-01 00:00:00

  • Anatomical Changes in the Anterior Chamber Volume After Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To evaluate changes in the anterior chamber of eyes that have undergone Descemet membrane endothelial keratoplasty (DMEK) and to identify factors that affect these changes. METHODS:This retrospective study included 25 pseudophakic eyes of 25 patients who underwent DMEK. We determined the preoperative and posto...


    pub_type: 杂志文章


    authors: Onouchi H,Hayashi T,Shimizu T,Matsuzawa A,Suzuki Y,Kato N

    更新日期:2020-09-29 00:00:00

  • Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease.

    abstract:PURPOSE:To bioengineer a corneal surface replacement using ex vivo expanded, cultured corneal epithelial stem cells seeded on a matrix derived from amniotic membrane and use this bioengineered graft to manage difficult ocular surface disease. METHODS:Fourteen patients with ocular surface disease unresponsive to standa...


    pub_type: 杂志文章


    authors: Schwab IR,Reyes M,Isseroff RR

    更新日期:2000-07-01 00:00:00

  • The stability of corneal topography in the post-blink interval.

    abstract:PURPOSE:Videokeratoscopes provide a wealth of information about the topography of the ocular surface. Although there have been numerous studies of the accuracy and precision of videokeratoscopes with inanimate test objects, little information exists on their precision (repeatability) for real eyes. METHODS:To investig...


    pub_type: 杂志文章


    authors: Buehren T,Collins MJ,Iskander DR,Davis B,Lingelbach B

    更新日期:2001-11-01 00:00:00

  • Functional Morphology of the Lipid Layer of the Tear Film.

    abstract::Meibomian glands secrete the oily layer of the tear film, which prevents excessive evaporation of tear fluid. Dysfunction of meibomian glands is not only one of the causes of evaporative dry eye but also one of the main causes of entire dry eye. To understand the pathophysiology of meibomian gland dysfunction, it is i...


    pub_type: 杂志文章,评审


    authors: Arita R,Fukuoka S,Morishige N

    更新日期:2017-11-01 00:00:00

  • Expression of Peroxiredoxin 2 and Vascular Endothelial Growth Factor Receptor 2 in Pterygium.

    abstract:PURPOSE:The expression of peroxiredoxin 2 and vascular endothelial growth factor receptor 2 (VEGFR2) was detected in pterygium to investigate whether they are involved in the pathogenesis or recurrence of pterygium and to evaluate the association between peroxiredoxin 2 and VEGFR2 in pterygium. METHODS:Ten normal bulb...


    pub_type: 杂志文章


    authors: Wang Y,Lin J,Chen L,Wang L,Hao P,Han R,Ying M,Li X

    更新日期:2017-07-01 00:00:00

  • Effect of Descemet Membrane Endothelial Keratoplasty on Color Vision in Patients With Fuchs Dystrophy.

    abstract:PURPOSE:To assess changes in color discernment after Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS:In this prospective, single-center study, the study group was composed of 26 patients with FECD, aged 46 to 85 years, who underwent DMEK as a singl...


    pub_type: 杂志文章


    authors: Price DA,Price MO,Lopez A,Price FW Jr

    更新日期:2016-08-01 00:00:00

  • Conjunctival impression cytology by using a thermosensitive adhesive: polymerized N-isopropyl acrylamide.

    abstract:PURPOSE:We aimed to evaluate a new technique using a thermosensitive glue coating for impression cytology of the ocular surface. METHODS:We prepared plasma polymerized N-isopropyl acrylamide (pNIPAM)-coated parylene C (poly(monochloro-p-xylylene)) films to obtain cytological samples from the conjunctival surface. We c...


    pub_type: 杂志文章


    authors: Tunc M,Yildirim U,Yuksel H,Cheng X,Humayun M,Ratner B

    更新日期:2009-08-01 00:00:00

  • Surgical monovision and monovision reversal in LASIK.

    abstract:PURPOSE:This study was designed to assess the success of surgical monovision in presbyopic patients. METHODS:A university refractive surgery center retrospective chart review of 82 patients who elected to undergo surgical monovision with laser in situ keratomileusis (LASIK) between January 2000 and January 2003 was co...


    pub_type: 杂志文章


    authors: Reilly CD,Lee WB,Alvarenga L,Caspar J,Garcia-Ferrer F,Mannis MJ

    更新日期:2006-02-01 00:00:00