Ciprofloxacin ointment versus ciprofloxacin drops for therapy of experimental Pseudomonas keratitis.

Abstract:

:To compare the efficacy of ciprofloxacin hydrochloride ointment with that of ciprofloxacin drops for treatment of experimental Pseudomonas keratitis, rabbit eyes were infected by intrastromal injection of 10(3) colony-forming units (CFU) log-phase P. aeruginosa. Infected and uninfected eyes were treated with either 0.3% ciprofloxacin ointment applied hourly for 6 h or 0.3% ciprofloxacin drops applied every 15 min for 6 h. Infected eyes treated with the ointment or drop vehicle alone served as placebo controls. Ciprofloxacin ointment significantly reduced the number of viable bacteria (CFU) per cornea more than four logs compared to the placebo control (p < 0.0001). Ciprofloxacin drops significantly reduced the number of bacteria (CFU) per cornea > 7 logs as compared with placebo-treated controls (p < 0.0001). Ciprofloxacin ointment may be a useful adjunct to conventional topical drops for therapy of bacterial keratitis.

journal_name

Cornea

journal_title

Cornea

authors

Hobden JA,O'Callaghan RJ,Insler MS,Hill JM

doi

10.1097/00003226-199303000-00008

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

138-41

issue

2

eissn

0277-3740

issn

1536-4798

journal_volume

12

pub_type

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