Effectiveness of topical infliximab in a mouse model of experimental dry eye.

abstract：PURPOSE:To evaluate changes in the donor corneal endothelium in the intact globe and in the in vivo rabbit cornea to characterize more fully the formation of "dark events" without relief images in the endothelial mosaic. METHODS:Six ex vivo human donor corneas in the intact globe and an in vivo rabbit model were used ...

journal_title：Cornea

authors： Nartey IN,Cavanagh HD,Jester JV,Andrews P,Petroll WM

更新日期：1998-09-01 00:00:00

abstract：:This paper reviews the data of Frank et al. in the light of increasing concern over the safety of contact lenses used for extended wear. Relative risks were calculated for four types of contact lenses (CLs): extended wear soft, daily wear soft, rigid gas-permeable (RGP), and polymethylmethacrylate (PMMA) lenses--worn ...

journal_title：Cornea

authors： Bailey CS

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To report the use of excimer laser phototherapeutic keratectomy (PTK) in the treatment of corneal subepithelial nodular scarring in a child with Rothmund-Thomson syndrome (RTS), a form of ectodermal dysplasia. METHODS:A case report and review of the literature. RESULTS:Excimer laser PTK successfully treated t...

journal_title：Cornea

authors： Stahl J,Fulcher S,Berkeley R

更新日期：2000-01-01 00:00:00

abstract：:Fourteen patients presenting with neuropsychiatric manifestations of Wilson's disease were treated with oral tetrathiomolybdate (TM) for 8 weeks followed by oral zinc (Zn) maintenance therapy. The patients were evaluated prospectively at baseline and at yearly intervals for up to 5 years by slit-lamp biomicroscopy and...

journal_title：Cornea

authors： Esmaeli B,Burnstine MA,Martonyi CL,Sugar A,Johnson V,Brewer GJ

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:To report intraoperative and 1-year postoperative results of the pachy-bubble technique for deep anterior lamellar keratoplasty (DALK). METHODS:This prospective interventional case series included 110 eyes of 107 patients with anterior corneal pathology who underwent DALK, including 78 with keratoconus. Outcom...

journal_title：Cornea

authors： Ghanem RC,Bogoni A,Ghanem VC

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To report eyes with keratoconus that progressed during pregnancy. METHODS:Seven eyes of 4 patients with progression of keratoconus during pregnancy were included in this study. The mean age of patients and the mean follow-up duration were 29.3 years and 39 months, respectively. Progressive keratoconus was docu...

journal_title：Cornea

authors： Bilgihan K,Hondur A,Sul S,Ozturk S

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To measure subbasal nerve density and orientation in normal human corneas across a broad age range. METHODS:Sixty-five normal corneas of 65 subjects were examined by using tandem scanning confocal microscopy. Ages of subjects ranged from 15 to 79 years (mean 46 +/- 19 years), with 5 subjects from each hemideca...

journal_title：Cornea

authors： Erie JC,McLaren JW,Hodge DO,Bourne WM

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:To review the outcome of 3 techniques for managing type 2 bubbles (between Descemet's membrane [DM] and stroma) formed during big bubble (BB) deep anterior lamellar keratoplasty (DALK) in different corneal pathologies. METHODS:This is an interventional case series study of patients with type 2 bubbles formed d...

journal_title：Cornea

authors： Goweida MB,Ragab AM,Liu C

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:To analyze factors implicating the association of ReNu with MoistureLoc (ReNu ML) multipurpose contact lens solution (MPS) with the increased incidence of Fusarium keratitis. METHODS:Used contact lens cases with and without contact lenses and MPS containers were collected from patients with confirmed or possib...

journal_title：Cornea

authors： Zhang S,Ahearn DG,Noble-Wang JA,Stulting RD,Schwam BL,Simmons RB,Pierce GE,Crow SA Jr

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined m...

journal_title：Cornea

authors： Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:To investigate the long-term effect and safety of collagen cross-linking (CXL) on patients with bullous keratopathy (BK) in a randomized control manner. It is, to our knowledge, the first randomized control study on the effect of CXL on BK. METHODS:Subjects were randomized to receive CXL as in the standard pro...

journal_title：Cornea

authors： Choy BNK,Ng ALK,Zhu MM,Liu CC,Xu S,Lai JSM

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:To report the histopathologic findings in the host tissue of 2 human keratoconic corneas undergoing maximum-depth anterior lamellar keratoplasty (MDALK) using the manual dissection technique described by Melles. METHODS:Corneal buttons were examined from 2 patients with keratoconus who underwent MDALK using th...

journal_title：Cornea

authors： Saw VP,Ng T,Crouch R,Maloof AJ

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:To develop a rat model of chronic Acanthamoeba polyphaga keratitis suitable for pharmacologic assessment of therapeutic agents. METHODS:An A. polyphaga isolate (ATCC #50495) was grown in peptone-yeast extract-glucose medium. Five-weeks-old, Sprague-Dawley male rats were injected with 10(3) or 10(4) trophozoite...

journal_title：Cornea

authors： Vasseneix C,Gargala G,François A,Hellot MF,Duclos C,Muraine M,Benichou J,Ballet JJ,Brasseur G,Favennec L

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To evaluate the effectiveness of intraoperative mitomycin C in preventing the recurrence of primary pterygium. METHODS:In this prospective, randomized study, 38 eyes of 35 patients with primary pterygium were evaluated. In 19 eyes, the "bare sclera technique" combined with intraoperative application of 0.2 mg/...

journal_title：Cornea

authors： Yanyali AC,Talu H,Alp BN,Karabas L,Ay GM,Caglar Y

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To report risk factors, clinical course, and outcome in patients with infectious keratitis following implantation of intracorneal ring segments (ICRS). METHODS:The records of 8 patients with culture-proven infectious keratitis after ICRS (Ferrara or Intacs) implantation were retrospectively reviewed. Age, gend...

journal_title：Cornea

authors： Hofling-Lima AL,Branco BC,Romano AC,Campos MQ,Moreira H,Miranda D,Kwitko S,de Freitas D,Casanova FH,Sartori M,Schor P,Souza LB

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To report a newly developed noninvasive method to measure the radius of tear meniscus curvature (reflective meniscometry) and its application to normal eyes, dry eyes, and other ocular surface conditions. METHODS:Two types of meniscometer--photographic and video--were devised. Both use tear meniscus as a conca...

journal_title：Cornea

authors： Yokoi N,Bron AJ,Tiffany JM,Kinoshita S

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To describe the technique and outcomes of limbal stem cell-sparing lamellar keratoplasty (LSCS-LKP) for the management of advanced keratoglobus (KGB). METHODS:In a sequential interventional case series from March 2010 to December 2012, 8 eyes of 6 patients with advanced KGB underwent an LSCS-LKP. Three patient...

journal_title：Cornea

authors： Karimian F,Baradaran-Rafii A,Faramarzi A,Akbari M

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To compare the rate of epithelial healing of corneal erosion in an animal model with 2 commercial formulations of fourth-generation fluoroquinolones: 0.3% gatifloxacin and 0.5% moxifloxacin. METHODS:Corneal erosions, 6 mm in diameter, were created in 28 rabbit eyes. The rabbits were randomized to receive topic...

journal_title：Cornea

authors： Barequet IS,Habot-Wilner Z,Lavinsky F,Ziv H,Belkin M,Rosner M

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Diabetes is accompanied by an increased autofluorescence of the cornea, probably because of accumulation of advanced glycation end products (AGEs). The pathogenic mechanism is still unknown. This study aimed to quantify differences in corneal cell densities between diabetic patients and healthy controls. METHO...

journal_title：Cornea

authors： Quadrado MJ,Popper M,Morgado AM,Murta JN,Van Best JA

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To evaluate human corneal endothelial mucin layer thickness and ultrastructure after phacoemulsification and irrigation-aspiration with either next generation ophthalmic irrigating solution (NGOIS) or BSS PLUS. METHODS:Paired human corneas were mounted in an artificial anterior chamber, exposed to 3 minutes of...

journal_title：Cornea

authors： Ghate DA,Holley G,Dollinger H,Bullock JP,Markwardt K,Edelhauser HF

更新日期：2008-10-01 00:00:00

abstract：:Persistent donor corneal epithelial defects following penetrating keratoplasty may lead to graft failure. We herein describe a method for providing corneal protection using a temporary suture tarsorrhaphy. This technique is simple and completely reversible, and it allows continued observation and instillation of topic...

journal_title：Cornea

authors： Koenig SB,Harris GJ

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To report a case of nevirapine-induced Stevens-Johnson syndrome (SJS) misdiagnosed as viral keratitis. METHODS:A 35-year-old AIDS patient, on antiretroviral therapy (ART) with stavudine, nevirapine, and lamivudine, developed bilateral ocular congestion and irritation. He was being treated elsewhere for bilater...

journal_title：Cornea

authors： Jain V,Shome D,Natarajan S

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To compare paired human corneas after storage at 4 degrees C in Chen medium (CM) and Optisol-GS medium (OM) for 7, 10, 14, and 21 days. METHODS:One cornea of each pair from nine human donors was randomly stored in either CM or OM, with its mate cornea stored in the other medium. Three pairs of corneas were sto...

journal_title：Cornea

authors： Nelson LR,Hodge DO,Bourne WM

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:The purpose of this report was to describe an uncommon wavelike epitheliopathy after phacoemulsification in a 59-year-old man with well-controlled diabetes mellitus. METHODS:Retrospective case report. RESULTS:A 59-year-old man with a history of well-controlled diabetes mellitus presented to us with irritation...

journal_title：Cornea

authors： Babu K,Narasimha Murthy K,Ramachandra Murthy K

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:To identify changing trends in indications for penetrating keratoplasty and associated surgical procedures. METHODS:Review of charts from all patients who underwent penetrating keratoplasty at Wills Eye Hospital from January 1, 1989 through December 31, 1995. RESULTS:A total of 2,442 corneal transplants were ...

journal_title：Cornea

authors： Lois N,Kowal VO,Cohen EJ,Rapuano CJ,Gault JA,Raber IM,Laibson PR

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:To study the factors affecting the time to onset of ocular graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS:A retrospective chart review of 200 patients with ocular GVHD was performed to evaluate the association between various do...

journal_title：Cornea

authors： Shikari H,Amparo F,Saboo U,Dana R

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Corneal epithelial stem cells are deficient in cases of limbal disorders, leading to conjunctival epithelial ingrowth, vascularization, and eventually visual disturbance. We introduced the eye development-associated transcription factor pax6 to embryonic stem (ES) cells and tested whether pax6-transfected cells...

journal_title：Cornea

authors： Ueno H,Kurokawa MS,Kayama M,Homma R,Kumagai Y,Masuda C,Takada E,Tsubota K,Ueno S,Suzuki N

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To evaluate endothelial cell damage after eye bank preparation and passage through 1 of 2 different injectors for Descemet membrane endothelial keratoplasty grafts. METHODS:Eighteen Descemet membrane endothelial keratoplasty grafts were prepared by Lions VisionGift with the standard partial prepeel technique a...

journal_title：Cornea

authors： Schallhorn JM,Holiman JD,Stoeger CG,Chamberlain W

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To review ocular injuries secondary to airbag deployment that were seen in our institution and were reported in the literature. METHODS:Patients examined at our institution between 1997 and 2000 were evaluated for ocular injuries caused by airbags. A review of the medical literature using Medline was performed...

journal_title：Cornea

authors： Ball DC,Bouchard CS

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To describe a new technique for handling Descemet stripping automated endothelial keratoplasty (DSAEK) specimens intraoperatively and during processing. METHODS:The processing method begins by adding a drop of eosin to the specimen intraoperatively, followed by submersion in 10% formalin solution. The specimen...

journal_title：Cornea

authors： Steven Houston SK,Morgan O,Olsakovsky LA,Phillips PM,Ghazi NG

更新日期：2010-12-01 00:00:00