The effect of subconjunctival suramin on corneal neovascularization in rabbits.

Abstract:

PURPOSE:To evaluate the effect of subconjunctival injection of suramin on corneal neovascularization in rabbits. METHODS:Corneal neovascularization was induced by silk suturing of the corneal stroma in 40 eyes of 40 male New Zealand white rabbits. Five days after suture placement, all rabbits were randomly divided into 4 groups of 10 rabbits and were treated subconjunctivally with balanced salt solution 0.1 mL (group 1), suramin 0.1 mL (10 mg/mL and 100 mg/mL, groups 2 and 3, respectively), and bevacizumab 2.5 mg/0.1 mL (group 4). Digital photographs of eyes were obtained and analyzed on days 7, 14, and 28 after subconjunctival injections. In addition, vascular endothelial growth factor (VEGF) enzyme-linked immunosorbent assay (ELISA) and immunohistochemical analyses were used to estimate the level of VEGF and the expression of VEGF and basic FGF in neovascularized cornea, respectively. RESULTS:The neovascularized area in control was increased significantly for 14 days after subconjunctival injection, but slightly decreased on day 28. On days 7 and 14, group 4 exhibited greater antiangiogenic effect than group 3, but group 3 exhibited greater antiangiogenic effect than group 4 on day 28. VEGF ELISA analysis showed the mean concentration of VEGF in group 4 was significantly lower than with other treatments for the first 14 days, but the mean concentration of VEGF in group 4 was similar to that with group 3 on day 28. Immunohistochemical analysis showed that the expressions of both VEGF and basic fibroblast growth factor (FGF) were reduced in group 3 and that bevacizumab reduced VEGF expression relative to basic FGF on day 28. CONCLUSION:Subconjunctival suramin 100 mg/mL exhibited less antiangiogenic effect than bevacizumab 2.5 mg during the early period of treatment, but it had a longer effect than that of bevacizumab later. Therefore, the combination of subconjunctival bevacizumab and suramin may provide a more potent effect in early treatment as well as a longer antiangiogenic effect in neovascularized cornea.

journal_name

Cornea

journal_title

Cornea

authors

Lee HS,Chung SK

doi

10.1097/ICO.0b013e3181ae91e3

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

86-92

issue

1

eissn

0277-3740

issn

1536-4798

journal_volume

29

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Primary Localized Conjunctival Amyloidosis Presenting Corneal Whorl-like Opacity Patterns.

    abstract:PURPOSE:To report an unusual case of corneal whorl-like opacity patterns in a patient of primary localized conjunctival amyloidosis. METHODS:Case report and review of literature. RESULTS:A 35-year old man with a case of primary localized conjunctival amyloidosis presented with corneal whorl-like opacity patterns and ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002343

    authors: Sharma VK,Agarwal M,Tyagi A,Sati A

    更新日期:2020-07-01 00:00:00

  • Use of topical bevacizumab for conjunctival intraepithelial neoplasia.

    abstract:PURPOSE:To report our experience in the treatment of intraepithelial neoplasia of the conjunctiva using topical bevacizumab. METHODS:Ten eyes of 10 patients with conjunctival neoplasia received 25 mg/mL bevacizumab topically. Changes in the lesions were documented weekly using digital photography. After topical treatm...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000194

    authors: Özcan AA,Çiloğlu E,Esen E,Şimdivar GH

    更新日期:2014-11-01 00:00:00

  • Therapeutic effect of topical 5-fluorouracil in conjunctival squamous carcinoma is associated with changes in matrix metalloproteinases and tissue inhibitor of metalloproteinases expression.

    abstract:PURPOSE:To evaluate matrix metalloproteinases (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 expression in a case of conjunctival intraepithelial squamous cell carcinoma (SCC) treated with topical 5-fluorouracil (5-FU) chemotherapy. METHODS:Clinicopathologic case report. RESULTS:A 71-year-old male...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318190937d

    authors: Iovieno A,Lambiase A,Moretti C,Perrella E,Bonini S

    更新日期:2009-08-01 00:00:00

  • Epidemiology of Ocular Surface Squamous Neoplasia in a Veterans Affairs Population.

    abstract:PURPOSE:To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. METHODS:Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs H...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31829e3c80

    authors: McClellan AJ,McClellan AL,Pezon CF,Karp CL,Feuer W,Galor A

    更新日期:2013-10-01 00:00:00

  • Secondary localized amyloidosis of the cornea associated with tertiary syphilis.

    abstract::Secondary corneal amyloidosis is a rare finding and only 17 cases have been reported in the literature. A case of unilateral secondary localized corneal amyloidosis is presented in a patient with bilateral interstitial keratitis and other stigmata of tertiary syphilis. ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Hill JC,Maske R,Bowen RM

    更新日期:1990-04-01 00:00:00

  • Mutation analysis of CHST6 gene in Chinese patients with macular corneal dystrophy.

    abstract:PURPOSE:To examine the carbohydrate sulfotransferase 6 (CHST6) gene in Chinese patients with macular corneal dystrophy (MCD). METHODS:Nineteen unrelated Chinese families with MCD, including 24 patients and 3 unaffected relatives, were examined. Genomic DNA was extracted from peripheral blood leukocytes. The coding reg...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ca2e74

    authors: Liu Z,Tian X,Iida N,Fujiki K,Xie P,Wang W,Ma Z,Kanai A,Murakami A

    更新日期:2010-08-01 00:00:00

  • Descemet membrane detachment after heavy silicone oil removal from the anterior chamber.

    abstract:PURPOSE:The aim of this study was to report a case of a central Descemet membrane detachment after heavy silicone oil removal from the anterior chamber. METHODS:This is a case report of a patient operated with scleral buckling and heavy silicone oil implantation for recurrent retinal detachment. In the patient's follo...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000056

    authors: Kymionis GD,Tsoulnaras KI,Xanthopoulou NA,Klados NE,Tsilimbaris MK

    更新日期:2014-03-01 00:00:00

  • A new nonhuman primate model of severe dry eye.

    abstract:PURPOSE:The aim of this study was to establish a new rhesus monkey model of severe dry eye. METHODS:A total of 8 rhesus monkeys were used for the study. Four monkeys had their main lacrimal gland and nictitating membrane surgically removed (group 1). Another 4 monkeys had a similar surgery with further application of ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000085

    authors: Qin Y,Tan X,Zhang Y,Jie Y,Labbe A,Pan Z

    更新日期:2014-05-01 00:00:00

  • Comparison of bifold forceps and cartridge injector suture pull-through insertion techniques for Descemet stripping automated endothelial keratoplasty.

    abstract:PURPOSE:To compare the outcome of bifold forceps and cartridge injector suture pull-through insertion techniques for Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS:A retrospective review was conducted of the medical records of all patients treated with DSAEK at the University of Iowa Hospitals ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181eadb84

    authors: Wendel LJ,Goins KM,Sutphin JE,Wagoner MD

    更新日期:2011-03-01 00:00:00

  • The effect of aqualase and phacoemulsification on the corneal endothelium.

    abstract:PURPOSE:To compare corneal endothelial cell loss after cataract surgery by phacoemulsification and by Aqualase. METHODS:This was a prospective, randomized study of 75 eyes of 75 patients undergoing cataract surgery. Patients were randomly assigned to receive either phacoemulsification or Aqualase for cataract removal....

    journal_title:Cornea

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ICO.0b013e3181af7c43

    authors: Hu V,Hughes EH,Patel N,Whitefield LA

    更新日期:2010-03-01 00:00:00

  • Management of Type 2 Bubble Formed During Big Bubble Deep Anterior Lamellar Keratoplasty.

    abstract:PURPOSE:To review the outcome of 3 techniques for managing type 2 bubbles (between Descemet's membrane [DM] and stroma) formed during big bubble (BB) deep anterior lamellar keratoplasty (DALK) in different corneal pathologies. METHODS:This is an interventional case series study of patients with type 2 bubbles formed d...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001815

    authors: Goweida MB,Ragab AM,Liu C

    更新日期:2019-02-01 00:00:00

  • Solitary epibulbar neurofibroma in older adult patients.

    abstract:PURPOSE:To report a solitary epibulbar neurofibroma in 2 elderly patients without systemic neurofibromatosis. METHODS:Case reports and literature review. RESULTS:A 67-year-old man presented with a 2-month history of left epibulbar mass. On slit-lamp examination, an 8- × 8-mm amelanotic, translucent, gelatinous, circu...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000370

    authors: Tanaka TS,Elner VM,Demirci H

    更新日期:2015-04-01 00:00:00

  • Amniotic membrane transplantation with anterior stromal micropuncture for treatment of painful bullous keratopathy in eyes with poor visual potential.

    abstract:PURPOSE:To report the use of anterior stromal micropuncture and amniotic membrane transplantation in the management of painful bullous keratopathy in patients with poor visual potential. METHODS:Interventional case series. A retrospective review was performed to identify all patients who were treated by one of us (A.J...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000244876.92879.c1

    authors: Sonmez B,Kim BT,Aldave AJ

    更新日期:2007-02-01 00:00:00

  • Nanoscale topography of the corneal epithelial basement membrane and Descemet's membrane of the human.

    abstract:PURPOSE:Quantitatively define and compare the nanoscale topography of the corneal epithelial basement membrane (anterior basement membrane) and Descemet's membrane (posterior basement membrane) of the human. METHODS:Human corneas not suitable for transplantation were obtained from the Wisconsin Eye Bank. The corneas w...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200001000-00012

    authors: Abrams GA,Schaus SS,Goodman SL,Nealey PF,Murphy CJ

    更新日期:2000-01-01 00:00:00

  • Rabbit Model of Corneal Endothelial Injury Established Using the Nd: YAG Laser.

    abstract:PURPOSE:To develop a new rabbit model of corneal endothelial injury using a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser. METHODS:The corneal endothelia of 2 groups of New Zealand white rabbits were treated with an Nd:YAG laser in a uniformly scattered fashion. Rabbits in group A underwent laser burns on the...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001324

    authors: Zhang W,Hu Y,Lu L,Liu Y,Yang X,Sun H,Ruan J,Chen J,Yao Q,Yan C,Gu P,Fu Y,Shao C,Fan X

    更新日期:2017-10-01 00:00:00

  • Corneal Cross-Linking With Verteporfin and Nonthermal Laser Therapy.

    abstract:PURPOSE:To test whether verteporfin with a nonthermal laser increases corneal mechanical stiffness and resistance to enzymatic degradation ex vivo. METHODS:Thirty human corneas (n = 5 per group) were treated with verteporfin alone (V), irradiated with nonthermal laser therapy (689 nm) alone (NTL), or received combined...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001473

    authors: Alageel SA,Arafat SN,Salvador-Culla B,Kolovou PE,Jahanseir K,Kozak A,Braithwaite GJC,Ciolino JB

    更新日期:2018-03-01 00:00:00

  • Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease.

    abstract:PURPOSE:To evaluate the efficacy of superficial keratectomy and conjunctival advancement hood flap (SKCAHF) for the treatment of bullous keratopathy in canine patients. METHODS:Nine dogs (12 eyes) diagnosed with progressive corneal edema underwent superficial keratectomy followed by placement of conjunctival advanceme...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000966

    authors: Horikawa T,Thomasy SM,Stanley AA,Calderon AS,Li J,Linton LL,Murphy CJ

    更新日期:2016-10-01 00:00:00

  • Clinical backgrounds of postoperative keratoplasty patients with spontaneous wound dehiscence or gaps after suture removal.

    abstract:PURPOSE:To report that spontaneous postkeratoplasty wound dehiscence or gaps caused by suture removal may occur years after penetrating and deep lamellar keratoplasty. METHODS:We retrospectively reviewed the medical records of 667 keratoplasty patients (890 eyes). This study included 8 eyes of 8 patients (3 men and 5 ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000284

    authors: Fujii S,Matsumoto Y,Fukui M,Fujitake J,Kawakita T,Shimmura S,Tsubota K

    更新日期:2014-12-01 00:00:00

  • Corneal transplant rejection rate and severity after endothelial keratoplasty.

    abstract:PURPOSE:To examine the corneal transplant rejection rate and the rate of graft failure subsequent to rejection in the first 2 years after endothelial keratoplasty (EK) and to compare this to background data for similar cases of penetrating keratoplasty (PK). METHODS:Anonymized data from consecutive cases of EK [deep l...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0b013e31812f66e5

    authors: Allan BD,Terry MA,Price FW Jr,Price MO,Griffin NB,Claesson M

    更新日期:2007-10-01 00:00:00

  • Axenfeld's anomaly associated with Down's syndrome.

    abstract::We report a case of a patient with Down's syndrome and keratoconus with acute hydrops who was incidentally noted to have Axenfeld's anomaly. We also review the systemic abnormalities associated with Axenfeld's anomaly and the implications of the diagnosis. To our knowledge, Axenfeld's anomaly has not previously been r...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199203000-00012

    authors: Stokes DW,Parrish CM

    更新日期:1992-03-01 00:00:00

  • Impression cytologic analysis after corneal collagen cross-linking using riboflavin and ultraviolet-A light in the treatment of keratoconus.

    abstract:PURPOSE:To report impression cytologic (IC) results after corneal cross-linking (CXL) using riboflavin and ultraviolet-A light in the treatment of keratoconus and compare the data with those from a group of subjects with the same disease. METHODS:Forty eyes were distributed into 2 groups: patients in group 1 underwent...

    journal_title:Cornea

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ICO.0b013e3181d4f91a

    authors: Renesto Ada C,Barros Jde N,Campos M

    更新日期:2010-10-01 00:00:00

  • Surgical Management of Limbal Dermoids Using Anterior Corneal Buttons From Descemet Stripping Automated Endothelial Keratoplasty Donor Tissue as Patch Grafts.

    abstract:PURPOSE:To assess the surgical and clinical outcomes of anterior lamellar keratoplasty using anterior corneal buttons from Descemet stripping automated endothelial keratoplasty (DSAEK) donor tissue. METHODS:Retrospective data from 8 patients with unilateral limbal dermoids, treated between February 2011 and January 20...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001021

    authors: Wu KI,Chu HS,Pai AS,Hou YC,Lin SY,Chen WL,Hu FR

    更新日期:2017-01-01 00:00:00

  • In vivo confocal microscopy and anterior segment optical coherence tomography in a case of alternaria keratitis.

    abstract:PURPOSE:To report a case of Alternaria alternata keratitis analyzed with in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (OCT). METHODS:A 68-year-old man with unilateral keratitis was evaluated using IVCM (Heidelberg Retina Tomograph II; Heidelberg, Germany) and anterior segment OC...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181dae1f3

    authors: Martone G,Pichierri P,Franceschini R,Moramarco A,Ciompi L,Tosi GM,Balestrazzi A

    更新日期:2011-04-01 00:00:00

  • Comparison of Tono-Pen AVIA intraocular pressure measurements performed at limbus with central corneal Tono-Pen AVIA intraocular pressure.

    abstract:PURPOSE:To compare Tono-Pen AVIA (TPA) intraocular pressure (IOP) measurements performed at the limbus with central corneal Tono-Pen AVIA (TPA) intraocular pressure. METHODS:Fifty-one patients attending our outpatient department with a best corrected visual acuity of ≥ 20/40, no corneal disease, and no astigmatism gre...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31827c9d25

    authors: Sharma R,Majumdar S,Sobti A,Arora T,Agarwal T,Dada T

    更新日期:2013-07-01 00:00:00

  • Donor eyes. A comparison of characteristics and outcomes for Eye Bank and local tissue.

    abstract::The Corneal Recipient Registry was begun in 1985 to collect information on all recipients of corneal grafts in the province of Ontario, Canada, and on the donors providing tissue. While most of the tissue is handled by the Eye Bank of Canada (Ontario Division), ophthalmologists in centers away from the Eye Bank often ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Chipman ML,Willett P,Basu PK,Wolf A

    更新日期:1989-01-01 00:00:00

  • A case of infectious crystalline keratopathy occurring long after penetrating keratoplasty.

    abstract:PURPOSE:To report a 64-year-old woman's case of infectious crystalline keratopathy (ICK) that occurred 9 years after the penetrating keratoplasty (PKP). METHODS:This study includes clinical history and histopathologic findings of the case. RESULTS:As historic background, the patient underwent PKP for lattice dystroph...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199801000-00018

    authors: Matsumoto A,Sano Y,Nishida K,Yokoi N,Hara J,Kinoshita S

    更新日期:1998-01-01 00:00:00

  • Intraoperative mitomycin C in the treatment of pterygium.

    abstract:PURPOSE:To evaluate the effectiveness of intraoperative mitomycin C in preventing the recurrence of primary pterygium. METHODS:In this prospective, randomized study, 38 eyes of 35 patients with primary pterygium were evaluated. In 19 eyes, the "bare sclera technique" combined with intraoperative application of 0.2 mg/...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003226-200007000-00013

    authors: Yanyali AC,Talu H,Alp BN,Karabas L,Ay GM,Caglar Y

    更新日期:2000-07-01 00:00:00

  • Xylene keratopathy: a case report and review of the literature.

    abstract:PURPOSE:To report a case of direct contact xylene-related vacuolar keratopathy. METHODS:Interventional case report and review of the literature. RESULTS:Xylene keratopathy is a distinct clinical entity characterized by significantly decreased visual acuity, increased corneal thickness, and the presence of corneal epi...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/00003226-200301000-00023

    authors: Trujillo F,Dang D,Starck T

    更新日期:2003-01-01 00:00:00

  • UV-A Collagen Cross-Linking Treatment of Bullous Keratopathy Combined With Corneal Ulcer.

    abstract:PURPOSE:To evaluate the therapeutic effect of corneal cross-linking (CXL) in 2 cases of bullous keratopathy combined with corneal ulcer. METHODS:Two patients (2 eyes) were recruited for the sake of the study. Both suffered from bullous keratopathy and presented a gradually deteriorating, vision-threatening, central co...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181a81802

    authors: Kozobolis V,Labiris G,Gkika M,Sideroudi H,Kaloghianni E,Papadopoulou D,Toufexis G

    更新日期:2010-02-01 00:00:00

  • Tear film volume and protein analysis in full-term newborn infants.

    abstract:PURPOSE:To investigate infant tear film secretion and protein profile, and to compare major tear proteins, such as immunoglobulin A, lactoferrin, and lysozyme, with those of adult controls. METHODS:Tears were collected, with a cellulose rod, from 40 healthy infants (19 female infants and 21 male infants, gestational d...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181f22cd9

    authors: Esmaeelpour M,Watts PO,Boulton ME,Cai J,Murphy PJ

    更新日期:2011-04-01 00:00:00