Corneal transplant rejection rate and severity after endothelial keratoplasty.

Abstract:

PURPOSE:To examine the corneal transplant rejection rate and the rate of graft failure subsequent to rejection in the first 2 years after endothelial keratoplasty (EK) and to compare this to background data for similar cases of penetrating keratoplasty (PK). METHODS:Anonymized data from consecutive cases of EK [deep lamellar (DLEK) or Descemet stripping (DSEK)] for Fuchs corneal endothelial dystrophy or pseudophakic bullous keratopathy operated on before August 2004 were collected in 4 participating centers. The number and timing of rejection episodes and cases of subsequent graft failure were recorded, together with the time to cessation of topical steroid medication. Two-year postoperative findings were compared with background data for similar patients undergoing PK recorded in the Swedish Corneal Transplant Registry. RESULTS:Rejection episodes were less frequent after EK than PK (P = 0.035). Fifteen (7.5%) of 199 EK cases had a rejection episode in the first 2 years after surgery versus 92 (13%) of 708 PK cases. Graft failure after rejection in EK may have been less frequent than in PK (P = 0.063), with only 1 (6.7%) case of rejection after EK versus 26 (28.3%) cases of rejection after PK proceeding to graft failure. A strong trend toward continued use of low-dose topical steroid medication was observed in the EK group. Eighty percent of EK patients were still taking topical steroid medication 2 years after surgery, whereas topical steroid medication had been ceased within a year of surgery in almost all PK patients in the comparator group. CONCLUSIONS:Corneal transplant rejection is less frequent and may be less severe after EK than after PK. It is not yet clear whether these apparent differences are simply a product of relatively prolonged postoperative topical steroid cover in EK patients.

journal_name

Cornea

journal_title

Cornea

authors

Allan BD,Terry MA,Price FW Jr,Price MO,Griffin NB,Claesson M

doi

10.1097/ICO.0b013e31812f66e5

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1039-42

issue

9

eissn

0277-3740

issn

1536-4798

pii

00003226-200710000-00004

journal_volume

26

pub_type

杂志文章,多中心研究

相关文献

CORNEA文献大全
  • The relation of conjunctival and corneal findings in severe ocular allergies.

    abstract:OBJECTIVE:Corneal lesions such as ulcers and erosions are major complications observed in patients with severe ocular allergic diseases. We aimed to look into the relationship between specific clinical conjunctival findings and the severity of corneal complications. METHODS:Thirty eyes of 6 patients with vernal kerato...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000114836.13127.45

    authors: Tanaka M,Dogru M,Takano Y,Miyake-Kashima M,Asano-Kato N,Fukagawa K,Tsubota K,Fujishima H

    更新日期:2004-07-01 00:00:00

  • In vivo confocal microscopy of corneal insect foreign body.

    abstract:PURPOSE:To report a case of insect corneal foreign body with in vivo confocal microscopy performed. METHODS:Clinical presentation, clinical pictures, and treatment are discussed. Confocal microscopy of the injured cornea was performed in areas showing foreign bodies with and without infiltrations seen under the slit-l...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200301000-00013

    authors: Wong BW,Lai JS,Law RW,Lam DS

    更新日期:2003-01-01 00:00:00

  • A review of relative risks associated with four types of contact lenses.

    abstract::This paper reviews the data of Frank et al. in the light of increasing concern over the safety of contact lenses used for extended wear. Relative risks were calculated for four types of contact lenses (CLs): extended wear soft, daily wear soft, rigid gas-permeable (RGP), and polymethylmethacrylate (PMMA) lenses--worn ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199010001-00024

    authors: Bailey CS

    更新日期:1990-01-01 00:00:00

  • Six different mutations of TGFBI (betaig-h3, keratoepithelin) gene found in Japanese corneal dystrophies.

    abstract:PURPOSE:To investigate mutations of the human transforming growth factor beta-induced gene (TGFBI), transforming growth factor-beta-induced gene product (betaig-h3, keratoepithelin), in Japanese patients with Avellino corneal dystrophy (ACD), lattice corneal dystrophy (LCD), granular corneal dystrophy (GCD), and Reis-B...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00003226-200011000-00015

    authors: Fujiki K,Hotta Y,Nakayasu K,Yamaguchi T,Kato T,Uesugi Y,Ha NT,Endo S,Ishida N,Lu WN,Kanai A

    更新日期:2000-11-01 00:00:00

  • Epi-Bowman Blunt Keratectomy Versus Diluted EtOH Epithelial Removal in Myopic Photorefractive Keratectomy: A Prospective Contralateral Eye Study.

    abstract:PURPOSE:To compare the outcomes and complications of Epi-Bowman blunt keratectomy (EBK) using a blunt epikeratome (Epi-Clear, Orca Surgical, Israel), with alcohol delamination of the corneal epithelium during photorefractive keratectomy (PRK) in contralateral eyes. METHODS:This prospective, randomized contralateral ey...

    journal_title:Cornea

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ICO.0000000000001863

    authors: Vingopoulos F,Kanellopoulos AJ

    更新日期:2019-05-01 00:00:00

  • Effectiveness of topical infliximab in a mouse model of experimental dry eye.

    abstract:PURPOSE:To investigate the efficacy of a topical anti-tumor necrosis factor-α agent, infliximab, in a mouse model of experimental dry eye (EDE). METHODS:EDE was induced in C57BL/6 mice, with or without topical treatment consisting of balanced salt solution or 0.001%, 0.01%, or 0.1% infliximab solutions. Tear volume an...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31826a80ea

    authors: Li Z,Choi W,Oh HJ,Yoon KC

    更新日期:2012-11-01 00:00:00

  • Keratoconus and normal-tension glaucoma: a study of the possible association with abnormal biomechanical properties as measured by corneal hysteresis.

    abstract:PURPOSE:To test the hypothesis that patients with keratoconus and pellucid who have glaucoma or are glaucoma suspects have lower corneal hysteresis (CH) and/or corneal resistance factor (CRF) measurements compared with controls. METHODS:A prospective study at a tertiary eye center of patients with keratoconus and pell...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ca363c

    authors: Cohen EJ,Myers JS

    更新日期:2010-09-01 00:00:00

  • Advanced fusarium keratitis progressing to endophthalmitis.

    abstract:PURPOSE:To review the clinical course, treatment, and visual outcomes of keratitis with endophthalmitis caused by the filamentary fungus Fusarium. METHOD:One hundred fifty-nine cases of Fusarium keratitis at Bascom Palmer Eye Institute between January 1, 1987 and August 21, 2000 were reviewed. Ten patients with cultur...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200305000-00004

    authors: Dursun D,Fernandez V,Miller D,Alfonso EC

    更新日期:2003-05-01 00:00:00

  • Descemet stripping automated endothelial keratoplasty for spontaneous descemet membrane detachment in a patient with osteogenesis imperfecta.

    abstract:PURPOSE:To report the first use of Descemet stripping automated endothelial keratoplasty (DSAEK) for spontaneous Descemet membrane detachment in a patient with osteogenesis imperfecta (OI), keratoconus, and acute bullous keratopathy. METHODS:A case report of a 25-year-old man with OI and symptomatic unilateral bullous...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318225418b

    authors: Gorovoy MS,Gorovoy IR,Ullman S,Gorovoy JB

    更新日期:2012-07-01 00:00:00

  • Quantitation of ultraviolet light-absorbing fractions of the cornea.

    abstract::This study attempts to measure the quantitative contribution of major chemical fractions of the whole bovine cornea to ultraviolet (UV) absorption between 240 and 300 nm, with special attention to the biologically significant range of 290-300 nm. The cornea was divided into water-insoluble, nonprotein small water-solu...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199505000-00007

    authors: Mitchell J,Cenedella RJ

    更新日期:1995-05-01 00:00:00

  • Intracameral amphotericin B injection in the management of deep keratomycosis.

    abstract:PURPOSE:To report the use of intracameral amphotericin B in the management of deep keratomycosis. METHODS:Four patients with deep keratomycosis unresponsive to conventional medical treatment underwent repeated intracameral injections of 5 microg amphotericin B in 0.1 mL 5% dextrose through a paracentesis. Three to 13 ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200210000-00004

    authors: Kuriakose T,Kothari M,Paul P,Jacob P,Thomas R

    更新日期:2002-10-01 00:00:00

  • Temperature variations in eyebank containers: comparative study of corneal transport containers and packing methods.

    abstract::Two containers ("Iowa" and "Virginia") commonly used for transporting donor corneas, and various packing methods were evaluated for constancy of temperature maintenance. The larger Iowa container was found to be superior for extended storage. Packing methods that allowed the vials (containing McCarey-Kaufman medium) t...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: York KK,Ward DE,Smith RE

    更新日期:1985-01-01 00:00:00

  • A novel approach to processing descemet stripping automated endothelial keratoplasty specimens for histopathologic analysis.

    abstract:PURPOSE:To describe a new technique for handling Descemet stripping automated endothelial keratoplasty (DSAEK) specimens intraoperatively and during processing. METHODS:The processing method begins by adding a drop of eosin to the specimen intraoperatively, followed by submersion in 10% formalin solution. The specimen...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181da57f3

    authors: Steven Houston SK,Morgan O,Olsakovsky LA,Phillips PM,Ghazi NG

    更新日期:2010-12-01 00:00:00

  • Tear film osmolarity in patients treated for glaucoma or ocular hypertension.

    abstract:PURPOSE:To evaluate tear film osmolarity in patients treated with intraocular pressure-lowering medications. METHODS:Forty patients treated for glaucoma or ocular hypertension (OHT) were consecutively recruited for the study. Each patient was asked to complete an evaluation of ocular surface disease symptoms, the Ocul...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31823f8cb6

    authors: Labbé A,Terry O,Brasnu E,Van Went C,Baudouin C

    更新日期:2012-09-01 00:00:00

  • Intracorneal hemorrhage secondary to aphakic contact lens wear.

    abstract::Two cases of intracorneal hemorrhage developing as a complication of aphakic contact lens use are reported. Patient 1 had a penetrating keratoplasty to restore vision and therefore the histologic examination could be performed on the corneal button. In patient 2 the contact lens use was discontinued with partial resol...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199201000-00011

    authors: al-Hussaini AK,Friedlander MH,Karcioglu ZA

    更新日期:1992-01-01 00:00:00

  • Corneal Neurotization With a Great Auricular Nerve Graft: Effective Reinnervation Demonstrated by In Vivo Confocal Microscopy.

    abstract:PURPOSE:We describe the first case of minimally invasive corneal neurotization with the great auricular nerve (GAN) to treat unilateral neurotrophic keratopathy. We assessed corneal sensation and reinnervation by esthesiometry and confocal microscopy over 12 months of follow-up, and we provide a detailed description of...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001549

    authors: Benkhatar H,Levy O,Goemaere I,Borderie V,Laroche L,Bouheraoua N

    更新日期:2018-05-01 00:00:00

  • The brilliant beauty of the eye: light reflex from the cornea and tear film.

    abstract:PURPOSE:Light reflex from the cornea and tear film as contributors to beautiful eyes ("eye sparkling") are reviewed. METHODS:A systematic literature review was conducted using "Purkinje-Sanson image," "corneal light reflex," "corneal topography," "corneal wavefront aberration," and "tear interference image" as search ...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/01.ico.0000247219.18295.5e

    authors: Goto E

    更新日期:2006-12-01 00:00:00

  • Method for expressing clinical and statistical significance of ocular and corneal wave front error aberrations.

    abstract:PURPOSE:The significance of ocular or corneal aberrations may be subject to misinterpretation whenever eyes with different pupil sizes or the application of different Zernike expansion orders are compared. A method is shown that uses simple mathematical interpolation techniques based on normal data to rapidly determine...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318221ce7d

    authors: Smolek MK

    更新日期:2012-03-01 00:00:00

  • Expression of p63 in pterygium and normal conjunctiva.

    abstract:PURPOSE:The p63 gene has been identified as a marker of epithelial stem cells. Because pterygium may arise through an expansion of the proliferative capacity of the conjunctiva, we sought to document the expression of p63 in normal conjunctiva and pterygium specimens. METHODS:Immunostaining for p63 expression was perf...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200401000-00011

    authors: Sakoonwatanyoo P,Tan DT,Smith DR

    更新日期:2004-01-01 00:00:00

  • Vortex keratopathy of the corneal graft.

    abstract::We examined the surface epithelium of 30 eyes with color specular microscopy at 3-month intervals 1-18 months following penetrating keratoplasty. At least three examinations were performed on most eyes. We found a vortex keratopathy to be present in 70% of these eyes. In nine eyes, this vortex pattern was present at e...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199103000-00001

    authors: Mathers WD,Lemp MA

    更新日期:1991-03-01 00:00:00

  • Conjunctival impression cytology in patients wearing contact lenses.

    abstract:PURPOSE:Evaluation of contact lens-induced cytologic changes on the conjunctival surface. METHODS:Fifty eyes of 25 patients wearing soft or rigid gas-permeable contact lenses, and 50 healthy eyes of 25 control subjects were examined with conjunctival impression cytology. Of the patients wearing contact lenses, 40% did...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Adar S,Kanpolat A,Sürücü S,Ucakhan OO

    更新日期:1997-05-01 00:00:00

  • Excision of granulation tissue and free conjunctival autograft in the management of necrotizing scleritis.

    abstract:PURPOSE:To describe a novel use of conjunctival autograft in the management of surgically induced scleral necrosis that occurred after squint surgery. METHODS:Interventional case report. RESULTS:A 22-year-old man underwent bilateral adjustable squint surgery. Two weeks postoperatively, he developed conjunctival retra...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181b532e5

    authors: Gregory ME,Weir CR,Ramaesh K

    更新日期:2010-05-01 00:00:00

  • Keratitis resulting from Thielavia subthermophila Mouchacca.

    abstract:PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined m...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31819717f4

    authors: Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE

    更新日期:2009-10-01 00:00:00

  • Exceptional case of bone resorption in an osteo-odonto-keratoprosthesis. A scanning electron microscopy and X-ray microanalysis study.

    abstract::This article reports the findings of investigations on an osteo-odonto-keratoprosthesis in an eye that was enucleated owing to severe complications 12 years after implantation. Scanning electron microscopy and electron probe X-ray microanalysis showed extensive resorption of the bone that was used as a supporting elem...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Caiazza S,Falcinelli G,Pintucci S

    更新日期:1990-01-01 00:00:00

  • Measures for preventing recurrence after pterygium surgery.

    abstract:PURPOSE:To introduce an improved technique of pterygium surgery and to compare postoperative results between this technique and previous techniques. METHODS:In a retrospective survey, the records of 216 consecutive eyes with primary pterygium that underwent surgery by three different techniques were reviewed. The new ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200110000-00006

    authors: Akura J,Kaneda S,Matsuura K,Setogawa A,Takeda K,Honda S

    更新日期:2001-10-01 00:00:00

  • Terrien's marginal degeneration with corneal cyst.

    abstract::Spontaneous ruptures in Descemet's membrane in Terrien's degeneration can result in a corneal intralamellar pocket of fluid. We present a case and discuss its management. ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Romanchuk KG,Hamilton WK,Braig RF

    更新日期:1990-01-01 00:00:00

  • Diagnosis of subclinical keratoconus using posterior elevation measured with 2 different methods.

    abstract:PURPOSE:To compare the efficacy of posterior corneal elevation, measured by 2 methods, in discriminating subclinical keratoconus from normal corneas. METHODS:In 30 consecutive patients with subclinical keratoconus, and 37 candidates for refractive surgery, posterior corneal elevation was measured using Pentacam's rota...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182854774

    authors: de Sanctis U,Aragno V,Dalmasso P,Brusasco L,Grignolo F

    更新日期:2013-07-01 00:00:00

  • Efficacy of 2-Month Treatment With Cord Blood Serum Eye Drops in Ocular Surface Disease: An In Vivo Confocal Microscopy Study.

    abstract:PURPOSE:To investigate the morphological changes of corneal epithelium and subbasal nerves by in vivo confocal microscopy in patients with ocular surface disease (OSD) treated with cord blood serum (CBS) eye drops. METHODS:Twenty patients with OSD (mean age 61.1 ± 12.6 years) were included in this prospective 1-arm st...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001257

    authors: Giannaccare G,Buzzi M,Fresina M,Velati C,Versura P

    更新日期:2017-08-01 00:00:00

  • Trends in the etiology of infectious corneal ulcers at the F. I. Proctor Foundation.

    abstract:OBJECTIVE:We analyzed laboratory results from corneal ulcers seen from 1976 to 1999 at the Francis I. Proctor Foundation, a referral center in San Francisco, to determine the relative frequencies of pathogens and to analyze for trends in frequencies of the most common pathogens. The results were compared with a previou...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200405000-00009

    authors: Varaprasathan G,Miller K,Lietman T,Whitcher JP,Cevallos V,Okumoto M,Margolis TP,Yinghui M,Cunningham ET Jr

    更新日期:2004-05-01 00:00:00

  • Use of a Purpose-Built Impression Cytology Device for Gene Expression Quantification at the Ocular Surface Using Quantitative PCR and Droplet Digital PCR.

    abstract:PURPOSE:To describe an impression cytology (IC) technique using a purpose-built, sterile, EYEPRIM IC device that can be coupled with a TRIzol reagent-based RNA extraction protocol to yield sufficient RNA for gene expression analysis. METHODS:IC samples using the EYEPRIM device were collected from the bulbar conjunctiv...

    journal_title:Cornea

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ICO.0000000000001792

    authors: Ganesalingam K,Ismail S,Craig JP,Sherwin T

    更新日期:2019-01-01 00:00:00