Abstract:
PURPOSE:We present the clinicopathologic correlations of two case and two other clinical cases of topical anesthetic abuse keratopathy that were originally diagnosed as Acanthamoeba keratitis because of ring keratitis presentation and characteristic history. METHODS:Four patients who were referred to us with suspected Acanthamoeba keratitis are included. Each was initially treated for amoebic keratitis, by using established protocols, and only later was the true origin (topical anesthetic abuse) uncovered. The clinical and surgical histories, pathologic analysis of the corneal specimens, and follow-up of < or = 4 years are included. RESULTS:Our four cases show another cause for ring infiltration of the cornea. Two cases resulted in corneal transplantation and multiple other medical or surgical treatments in an attempt to restore vision but had poor outcomes of finger-counting vision. Two other cases responded to intensive medical treatments with return of useful vision. Evaluation of the surgical specimens revealed a previously unpublished finding of near total cell death within the corneal stroma. CONCLUSION:Topical anesthetic abuse resulting in sight-threatening keratitis may be seen as a masquerade syndrome in many cases. Because of the often poor outcome, we must be aware of this entity, prevent abuse, and be vigilant in our prohibition of topical anesthetic for any therapeutic use.
journal_name
Corneajournal_title
Corneaauthors
Varga JH,Rubinfeld RS,Wolf TC,Stutzman RD,Peele KA,Clifford WS,Madigan Wsubject
Has Abstractpub_date
1997-07-01 00:00:00pages
424-9issue
4eissn
0277-3740issn
1536-4798journal_volume
16pub_type
杂志文章相关文献
CORNEA文献大全abstract:OBJECTIVE:Corneal lesions such as ulcers and erosions are major complications observed in patients with severe ocular allergic diseases. We aimed to look into the relationship between specific clinical conjunctival findings and the severity of corneal complications. METHODS:Thirty eyes of 6 patients with vernal kerato...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000114836.13127.45
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:To describe the histopathology of the cornea in microphthalmia with linear streaks (MLS) syndrome. METHODS:Two patients with MLS syndrome underwent penetrating keratoplasty. This study describes the histopathology and investigates immunophenotype of the corneal extracellular matrix by using keratan sulfate and...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000611352.03660.a7
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:The depth of corneal crosslinking (CXL) does not seem homogeneous within the treatment area but shows a reduction toward the periphery of the cornea. This study was undertaken to investigate this reduction effect and to look for possible solutions. METHODS:Ten corneas were investigated by means of an optical c...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318269059b
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To present four cases of localized corneal amyloidosis secondary to trichiasis and to discuss its pathogenesis. METHODS:Medical and pathologic records of four patients with corneal amyloidosis secondary to trichiasis were reviewed retrospectively. Two patients underwent trichiasis surgery and then lamellar ker...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/00003226-200307000-00020
更新日期:2003-07-01 00:00:00
abstract::Immunologic rejection is the main cause of corneal graft failure, especially in vascularized corneal beds. The purpose of this study was to investigate the effect of systemic Cyclosporine-A (CsA) on the survival of corneal allografts in heavily vascularized rabbit corneal beds, following alkali burn. Heavy corneal vas...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199409000-00013
更新日期:1994-09-01 00:00:00
abstract:PURPOSE:The goal of this study was to prospectively assess the deep lamellar endothelial keratoplasty (DLEK) wound anatomy and its evolution during the 12 months after surgery, using optical coherence tomography (OCT). METHODS:The eyes of 8 patients (1 eye per patient) who consecutively underwent DLEK for Fuchs dystro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181c58f32
更新日期:2010-07-01 00:00:00
abstract::Corneal complications of herpes zoster ophthalmicus include pseudodendritic keratitis, late mucous adherent keratopathy, varied forms of stromal keratitis, and exposure/neurotrophic keratopathy. Prophylactic therapy of acute herpes zoster ophthalmicus with oral acyclovir is of proven benefit in reducing the incidence ...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:Hyperglycemia in diabetes mellitus (DM) might induce changes in corneal biomechanics. Therefore, biomechanical properties of the cornea were measured using the ocular response analyzer and the Corvis ST. METHODS:In the study, 35 eyes of 35 diabetic patients were included. After an ophthalmological examination,...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001879
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To assess the influence of donor characteristics on the outcome of anterior lamellar keratoplasty (ALK) and to evaluate whether corneal donor tissue considered unsuitable for penetrating or posterior lamellar keratoplasty due to poor endothelial condition may be safely used for ALK. METHODS:Institutional setti...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318285c8b4
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To evaluate tear meniscus changes in patients with Sjögren syndrome (SS) receiving oral pilocarpine with Visante optical coherence tomography (OCT). METHODS:Eight patients with primary SS were recruited in this prospective interventional case series study. Patients received pilocarpine tablets twice a day for ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318261eb4a
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To investigate the distribution and relative level of expression of the receptor tyrosine kinases, epidermal growth factor receptor (EGFR), ErbB2 and ErbB3, in human ocular surface epithelia. METHODS:Immunofluorescent staining was performed to identify expression of the EGFR, ErbB2 and ErbB3 in the corneal, li...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200101000-00016
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To analyze whether plasma rich in growth factors (PRGF) eye drops preserve their biological characteristics and activity after storage for 3 and 6 months at -20°C, at 4°C, and at room temperature for 72 hours, compared with fresh samples (t0). METHODS:Blood from 6 healthy donors was harvested and centrifuged t...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000489
更新日期:2015-09-01 00:00:00
abstract::The authors sought to determine whether adenovirus could infect human corneal epithelium in vivo. They reviewed the medical records of six patients with adenovirus-positive viral corneal cultures who were examined at the Bascom Palmer Eye Institute between March 21, 1986, and December 31, 1992. The six patients with a...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::In herpetic stromal keratitis (HSK), herpes simplex virus type-1 DNA fragments and herpes simplex virus-immunoglobulin G immune complexes are present in corneas long after the infective virus has disappeared. These viral components are highly immunogenic and potentiate the production of proinflammatory cytokines and c...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182a2dfc5
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To describe a simple finding, consisting of a double-line reflection from the graft inside the anterior chamber, that can be used to determine the correct donor tissue orientation in Descemet membrane endothelial keratoplasty: which we would like to call Berrospi's sign. METHODS:Evaluation of the presence of l...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001889
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To report a case of Alternaria alternata keratitis analyzed with in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (OCT). METHODS:A 68-year-old man with unilateral keratitis was evaluated using IVCM (Heidelberg Retina Tomograph II; Heidelberg, Germany) and anterior segment OC...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181dae1f3
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To evaluate the long-term changes in anterior and posterior corneal irregular astigmatism and curvatures after small incision lenticule extraction (SMILE). METHODS:Fifty eyes of 28 patients underwent SMILE for myopic astigmatism. All procedures were performed using the VisuMax® femtosecond laser. A Scheimpflug...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001532
更新日期:2018-07-01 00:00:00
abstract::The purpose of this study was to evaluate clinical ocular adenoviral isolates for differences among and within serotypes with respect to in vitro infectivity titers and clinical course. The study design included a retrospective chart review and the determination of in vitro infectivity titers (TCID90s) of 90 clinical ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199507000-00007
更新日期:1995-07-01 00:00:00
abstract:PURPOSE:To report a photorefractive keratectomy (PRK)-treated patient who first developed stromal opacities with a typical granular pattern 9 years after surgery, which was confirmed as heterozygous Avellino dystrophy by DNA analysis. METHODS:A 37-year-old woman, who had undergone PRK 17 years ago, has been followed f...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31818a7df7
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare the effect of chloramphenicol eye drops or ointment, high-concentration hyaluronic acid, or no treatment on reepithelialization of corneal erosions in an experimental model. METHODS:Uniform 6-mm corneal erosions were created in 23 rabbit eyes. The rabbits were randomized to...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000215
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To evaluate if donor corneas obtained from deaths occurring because of septicemia can be used for corneal transplantation. STUDY DESIGN:Prospective study. METHODS:Eleven septicemic donor corneas were used in the study and 10 donor corneas from deaths because of causes other than septicemia were used as contro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000858
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To investigate the absorption of moxifloxacin into human aqueous humor after administration of moxifloxacin hydrochloride ophthalmic solution, 0.5% as base. METHODS:Cataract patients were randomly allocated to receive 1 drop every 15 minutes for 4 doses before surgery (group 1) or 1 drop 4 times per day on the...
journal_title:Cornea
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/01.ico.0000157423.78275.a2
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To assess the efficacy and safety of intraductal meibomian gland probing in patients with obstructive meibomian gland dysfunction who experienced little improvement with eyelid warming, massage, or artificial tears. METHODS:Forty-nine patients with obstructive meibomian gland dysfunction were randomly divided ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000777
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To evaluate the thickness and depth of lamina cribrosa (LC) in the optic nerve head region of the eyes in patients with nonglaucomatous keratoconus and to compare the thickness and depth with those of age-matched controls. METHODS:This was a cross-sectional, observational study comprising 45 patients with kera...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001379
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To evaluate tear osmolarity and tear film parameters in patients with vitiligo. METHODS:A total of 25 eyes of 25 patients with vitiligo with periocular involvement (group 1), 30 eyes of 30 patients with vitiligo without periocular involvement (group 2), and 20 eyes of 20 controls (group 3) were evaluated using...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001469
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:To describe the clinical characteristics, diagnosis, treatment, and visual outcome of 61 cases of Fusarium keratitis in Mexico. METHODS:Retrospective, comparative study of 61 patients with clinically and culture-confirmed Fusarium keratitis, who were attended at an eye hospital in Mexico City from 1981 to 2001...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31819bc2ea
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To compare the results of repeat Descemet stripping automated endothelial keratoplasty (DSAEK) with those of primary DSAEK. MATERIALS AND METHODS:This retrospective study consisted of all consecutive eyes that underwent one or more repeat DSAEK surgeries after primary DSAEK performed at Villa Serena-Villa Igea...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000810
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To assess the efficacy of using a bandage contact lens (BCL) for 3 months for recurrent corneal erosions (RCE) to facilitate epithelial adhesion. METHODS:Retrospective study of patients presented to the Casey Eye Institute (Portland, OR) with RCE after failing at least 6 weeks of medical lubrication therapy. S...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181e84689
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine whether long-term wear of a fluid-filled scleral lens alters basal tear production, corneal sensation, corneal nerve density, and corneal nerve morphology in 2 disease categories. METHODS:Patients recruited from the Prosthetic Replacement of the Ocular Surface Ecosystem (...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000381
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To retrospectively evaluate the results of myopic photorefractive keratectomy (PRK) for different levels of intended correction, including analysis of loss of best spectacle-corrected visual acuity. METHODS:Four hundred seventy-five consecutive eyes with 1 year of follow-up that had PRK for the correction of 1...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200003000-00011
更新日期:2000-03-01 00:00:00