Corneal pathology in microphthalmia with linear skin defects syndrome.

Abstract:

PURPOSE:To describe the histopathology of the cornea in microphthalmia with linear streaks (MLS) syndrome. METHODS:Two patients with MLS syndrome underwent penetrating keratoplasty. This study describes the histopathology and investigates immunophenotype of the corneal extracellular matrix by using keratan sulfate and collagen type III antibodies. RESULTS:Clinical examination revealed bilateral sclerocornea and characteristic skin changes. By light microscopy, central corneal stroma in both patients showed vascularization and irregular thick collagen lamellae typical of sclerocornea. In addition, corneal thinning, anterior synechiae, and the absence of the Descemet membrane were noted, which was suggestive of Peters anomaly. Diffuse and intense anti-keratan sulfate staining and minimal anti-collagen type III stromal staining were seen in both corneal buttons. CONCLUSIONS:The cornea in MLS may clinically resemble sclerocornea. Histologic features resemble those previously described in sclerocornea and also seen in anterior segment dysgeneses. Keratan sulfate and collagen type III labeling suggests that the corneal extracellular matrix resembled cornea and not sclera.

journal_name

Cornea

journal_title

Cornea

authors

Kapur R,Tu EY,Toyran S,Shah P,Vangveeravong S,Lloyd WC 3rd,Edward DP

doi

10.1097/01.ico.0000611352.03660.a7

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

734-8

issue

6

eissn

0277-3740

issn

1536-4798

pii

00003226-200807000-00022

journal_volume

27

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Topical interferon alpha-2a treatment of herpes simplex keratitis resistant to multiple antiviral medications in an immunosuppressed patient.

    abstract::The treatment of herpes simplex keratitis has ranged from simple debridement to the use of prototypic antiviral agents specific to the herpes family, such as acyclovir. The various treatment modalities for dendritic keratitis, for the most part, have been effective. However, in recent years numerous reports of antivir...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199505000-00017

    authors: Minkovitz JB,Pepose JS

    更新日期:1995-05-01 00:00:00

  • Morphology and barrier function of the corneal epithelium after penetrating keratoplasty: association with original diseases, tear function, and suture removal.

    abstract:PURPOSE:To study changes in structure and barrier function of the corneal epithelium after penetrating keratoplasty. METHODS:Sixty-nine eyes of 56 patients undergoing penetrating keratoplasty were studied. Fifty-six age-matched normal eyes served as controls. Corneal epithelial structure was studied by using specular ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Shimazaki J,Shimmura S,Mochizuki K,Tsubota K

    更新日期:1999-09-01 00:00:00

  • Conjunctival impression cytology in patients wearing contact lenses.

    abstract:PURPOSE:Evaluation of contact lens-induced cytologic changes on the conjunctival surface. METHODS:Fifty eyes of 25 patients wearing soft or rigid gas-permeable contact lenses, and 50 healthy eyes of 25 control subjects were examined with conjunctival impression cytology. Of the patients wearing contact lenses, 40% did...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Adar S,Kanpolat A,Sürücü S,Ucakhan OO

    更新日期:1997-05-01 00:00:00

  • Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas.

    abstract::After n-heptanol removal of the total corneal epithelium and a limbal lamellar keratectomy, 23 rabbit eyes developed features of limbal stem cell deficiency including conjunctival epithelial ingrowth, vascularization and chronic inflammation. One month later, 10 control eyes received a total keratectomy, and 13 experi...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Kim JC,Tseng SC

    更新日期:1995-09-01 00:00:00

  • Descemet Membrane Endothelial Keratoplasty: Development of Contrast Sensitivity and Color Vision in Patients With Fuchs Endothelial Corneal Dystrophy.

    abstract:PURPOSE:To assess the developments in contrast sensitivity, color vision, and subjective perception after Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS:Included in this study were pseudophakic, unilateral DMEK patients with bilateral FECD having ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002320

    authors: Bayyoud T,Wilhelm H,Gelisken F,Martus P,Bartz-Schmidt KU,Thaler S

    更新日期:2020-07-01 00:00:00

  • Inhibitory effects of tranilast on the proliferation and functions of human pterygium-derived fibroblasts.

    abstract:PURPOSE:We studied the possibility that tranilast, an antiallergic and antiproliferative drug, may be beneficial for the treatment of pterygium. METHODS:Pterygium-derived cells were identified by immunohistochemical methods. Growth rate of pterygium-derived cells was determined by using a hemocytometer. Chemotaxis was...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200005000-00021

    authors: Isaji M,Kikuchi S,Miyata H,Ajisawa Y,Araki-Inazawa K,Tsukamoto Y,Amano Y

    更新日期:2000-05-01 00:00:00

  • Temporary suture tarsorrhaphy after penetrating keratoplasty.

    abstract::Persistent donor corneal epithelial defects following penetrating keratoplasty may lead to graft failure. We herein describe a method for providing corneal protection using a temporary suture tarsorrhaphy. This technique is simple and completely reversible, and it allows continued observation and instillation of topic...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199103000-00005

    authors: Koenig SB,Harris GJ

    更新日期:1991-03-01 00:00:00

  • Safety profile of bevacizumab on cultured human corneal cells.

    abstract:PURPOSE:To study the corneal biocompatibility of bevacizumab on various cultured human corneal cells. METHODS:Cell cultures of corneal keratinocytes (CKs), corneal fibroblasts (CFs), and corneal endothelial cells (CECs) were harvested from human donor eyes and exposed to various concentrations of bevacizumab (0.25-5.0...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3180de1d0a

    authors: Yoeruek E,Spitzer MS,Tatar O,Aisenbrey S,Bartz-Schmidt KU,Szurman P

    更新日期:2007-09-01 00:00:00

  • Posterior polymorphous dystrophy associated with nonkeratoconic steep corneal curvatures.

    abstract:PURPOSE:To report a case series of eyes with posterior polymorphous corneal dystrophy and steep nonkeratoconic corneas. METHODS:Retrospective, descriptive, nonrandomized case series. RESULTS:Thirty-five eyes of 18 patients (14 cases from 6 families and 4 isolated cases) with diffuse posterior polymorphous corneal dys...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182114452

    authors: Raber IM,Fintelmann R,Chhabra S,Ribeiro MP,Eagle RC Jr,Orlin SE

    更新日期:2011-10-01 00:00:00

  • Slit-lamp, confocal, and light microscopic findings of corneal siderosis.

    abstract:PURPOSE:To report the clinical, histopathologic, and confocal findings of corneal siderosis. METHODS:A 35-year-old man presented after a car battery explosion with diffuse left corneal anterior stromal pigment deposition and an intraocular metallic foreign body of the left iris. The corneal pigment was analyzed by con...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318145330b

    authors: Witherspoon SR,Hogan RN,Petroll WM,Mootha VV

    更新日期:2007-12-01 00:00:00

  • Keratinizing corneal intraepithelial neoplasia.

    abstract::Corneal intraepithelial neoplasia (CIN) is the term applied by some authors to the spectrum of disease ranging from mild dysplasia to carcinoma in situ. Such lesions usually are associated with dysplastic or neoplastic processes at the limbus or adjacent conjunctiva; isolated corneal dysplasia is rare. Clinically, CIN...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Brown HH,Glasgow BJ,Holland GN,Foos RY

    更新日期:1989-09-01 00:00:00

  • The fate of scleral grafts in the cornea.

    abstract::There have been reports of the clearing of sclera that has been grafted into the cornea. This clearing was studied in the rabbit by transplanting full-thickness scleral buttons or by implanting slivers of sclera, both autografts and allografts, into the cornea. Some clearing around the edges of the implanted scleral t...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199603000-00015

    authors: Maurice DM,Singh T

    更新日期:1996-03-01 00:00:00

  • In vivo corneal and conjunctival epithelial nuclear stain.

    abstract::Epithelium plays a very important structural and functional role in the cornea and conjunctiva. Evaluation of the epithelium is the first step in diagnosing many pathologic states. We have developed a new technique for the in vivo staining of nuclei of corneal and conjunctival epithelium in rabbits and guinea pigs. Se...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Wander AH,Neumeister RD,Tschismadia I,Choromokos EA,Masukawa T

    更新日期:1985-01-01 00:00:00

  • New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry.

    abstract:PURPOSE:To review our previous studies regarding the morphology of the cornea in pseudoexfoliation syndrome (PEX) and anatomical discrepancies between PEX and contralateral eyes in unilateral PEX. METHODS:We used in vivo confocal microscopy to observe the corneas of PEX, contralateral, and normal control eyes. Morphol...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182a3657d

    authors: Zheng X

    更新日期:2013-11-01 00:00:00

  • The change in ocular higher-order aberrations after pterygium excision with conjunctival autograft: a 1-year prospective clinical trial.

    abstract:PURPOSE:To investigate the effects of pterygium excision with conjunctival autograft plus corneal polishing on ocular higher-order aberrations (HOAs) and to monitor the changes throughout the first postoperative year. METHODS:A total of 18 eyes of 16 patients with primary pterygium who had an indication for surgical e...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182431465

    authors: Gumus K,Topaktas D,Göktaş A,Karakucuk S,Oner A,Mirza GE

    更新日期:2012-12-01 00:00:00

  • Keratoconus, myopia, and personality.

    abstract:PURPOSE:To determine whether there is an association between keratoconus and personality attributes including obsessionality traits. METHODS:We reviewed all charts in the regional contact lens clinic, identifying patients who had attended from January 1997 to January 2000 and had a diagnosis of either keratoconus or m...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200304000-00011

    authors: Cooke CA,Cooper C,Dowds E,Frazer DG,Jackson AJ

    更新日期:2003-04-01 00:00:00

  • Rabbit Model of Corneal Endothelial Injury Established Using the Nd: YAG Laser.

    abstract:PURPOSE:To develop a new rabbit model of corneal endothelial injury using a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser. METHODS:The corneal endothelia of 2 groups of New Zealand white rabbits were treated with an Nd:YAG laser in a uniformly scattered fashion. Rabbits in group A underwent laser burns on the...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001324

    authors: Zhang W,Hu Y,Lu L,Liu Y,Yang X,Sun H,Ruan J,Chen J,Yao Q,Yan C,Gu P,Fu Y,Shao C,Fan X

    更新日期:2017-10-01 00:00:00

  • Expression of phosphorylated heat shock protein 27 during corneal epithelial wound healing.

    abstract:PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31823f7685

    authors: Jain S,De la Cruz J,Kang E,Kojima T,Chang JH,Kim JY

    更新日期:2012-07-01 00:00:00

  • Optical coherence tomography anatomy of the corneal endothelial transplantation wound.

    abstract:PURPOSE:The goal of this study was to prospectively assess the deep lamellar endothelial keratoplasty (DLEK) wound anatomy and its evolution during the 12 months after surgery, using optical coherence tomography (OCT). METHODS:The eyes of 8 patients (1 eye per patient) who consecutively underwent DLEK for Fuchs dystro...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181c58f32

    authors: Ferré LA,Nada O,Sherknies D,Boisjoly H,Brunette I

    更新日期:2010-07-01 00:00:00

  • Incidence and Outcomes of Positive Donor Rim Cultures and Infections in the Cornea Preservation Time Study.

    abstract:PURPOSE:To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS). METHODS:Donor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Incidence...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0000000000001654

    authors: Mian SI,Aldave AJ,Tu EY,Ayres BD,Jeng BH,Macsai MS,Nordlund ML,Penta JG,Pramanik S,Szczotka-Flynn LB,Ayala AR,Liang W,Maguire MG,Lass JH

    更新日期:2018-09-01 00:00:00

  • Morphological and fluorophotometric analysis of the corneal endothelium after radial keratotomy.

    abstract:PURPOSE:To evaluate the morphometric and fluorophotometric characteristics of corneal endothelium after an eight-incision radial keratotomy (RK). METHODS:A total of 43 eyes of 26 patients underwent RK and 44 eyes of 23 patients were used as age-matched controls. All patients underwent specular microscopic and fluoroph...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199809000-00003

    authors: Tseng SH,Chen FK

    更新日期:1998-09-01 00:00:00

  • The prevalence of positive hepatitis B, hepatitis C, and HIV serology in cornea donors prescreened by medical and social history in Ontario, Canada.

    abstract:PURPOSE:To determine the prevalence of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) in the serum of cornea donors who had been previously screened by social and medical history by the Eye Bank of Canada, Ontario Division. METHOD:A retrospective examination of the donor records of the Ey...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Armstrong SA,Gangam N,Chipman ML,Rootman DS

    更新日期:1997-09-01 00:00:00

  • KeraRing intrastromal corneal ring segments for correction of keratoconus.

    abstract:PURPOSE:Intrastromal corneal ring segments (ICRSs) are small arc-like implants that are being used increasingly as a minimally invasive treatment for patients with keratoconus. This study assessed the effectiveness of KeraRing implants, a type of ICRS, to treat keratoconus. METHODS:Retrospective case series descriptiv...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182215a15

    authors: Gharaibeh AM,Muhsen SM,AbuKhader IB,Ababneh OH,Abu-Ameerh MA,Albdour MD

    更新日期:2012-02-01 00:00:00

  • Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery.

    abstract:PURPOSE:To study dry eye and analyze pathogenic factors in patients after cataract surgery. METHODS:A total of 37 patients (50 eyes) were studied by using a 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ25) and Ocular Surface Disease Index (OSDI) 3 days before and 1 week, 1 month, and 3 months a...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31812f67ca

    authors: Li XM,Hu L,Hu J,Wang W

    更新日期:2007-10-01 00:00:00

  • In Vivo Confocal Microscopy Findings in Bowman Layer Transplantation.

    abstract:PURPOSE:To report the in vivo confocal microscopy (IVCM) findings of a case who underwent femtosecond laser-assisted Bowman layer transplantation (BLT). METHODS:This is a case report. RESULTS:In a 25-year-old man with previous diagnosis of keratoconus in whom a BLT was performed using the femtosecond laser-assisted t...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002561

    authors: García de Oteyza G,Vazquez-Romo KA,Hernández-Quintela E,de Wit Carter G,García-Albisua AM

    更新日期:2020-10-19 00:00:00

  • Refractive Surgery: Malpractice Litigation Outcomes.

    abstract:PURPOSE:To review data on malpractice claims related to refractive surgery to identify common allegations and injuries and financial outcomes. METHODS:The WestlawNext database was reviewed for all malpractice lawsuits/settlements related to refractive eye surgery. Data evaluated included patient demographics, type of ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001289

    authors: Custer BL,Ballard SR,Carroll RB,Barnes SD,Justin GA

    更新日期:2017-10-01 00:00:00

  • Lectin binding patterns of the human cornea. Comparison of frozen and paraffin sections.

    abstract::Twelve FITC-conjugated lectins were used to establish a reaction pattern with cellular and noncellular components in fresh-frozen and formalin-fixed paraffin sections of 11 normal human corneas. In frozen sections the epithelium demonstrated the most active lectin staining; keratocytes and endothelium stained to a les...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Brandon DM,Nayak SK,Binder PS

    更新日期:1988-01-01 00:00:00

  • The coincidence of HSV-1 ocular cultures with HSV-1 corneal epithelial defects in rabbits after experimental penetrating keratoplasty.

    abstract::Penetrating keratoplasty (PKP) in conjunction with postoperative corticosteroids may reactivate latent herpes simplex virus type 1 (HSV-1) to cause persistent postoperative epithelial defects. The clinical diagnosis of HSV keratitis after penetrating keratoplasty is difficult because the postoperative appearance may b...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Portnoy SL,Beyer CF,Hill JM,Kaufman HE

    更新日期:1991-01-01 00:00:00

  • Corneal subepithelial nodular scarring treated with phototherapeutic keratectomy in a child with Rothmund-Thomson syndrome.

    abstract:PURPOSE:To report the use of excimer laser phototherapeutic keratectomy (PTK) in the treatment of corneal subepithelial nodular scarring in a child with Rothmund-Thomson syndrome (RTS), a form of ectodermal dysplasia. METHODS:A case report and review of the literature. RESULTS:Excimer laser PTK successfully treated t...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200001000-00022

    authors: Stahl J,Fulcher S,Berkeley R

    更新日期:2000-01-01 00:00:00

  • Influence of Pilocarpine and Timolol on Human Meibomian Gland Epithelial Cells.

    abstract:PURPOSE:Investigators have discovered that topical antiglaucoma drugs may induce meibomian gland dysfunction. This response may contribute to the dry eye disease commonly found in patients with glaucoma taking such medications. We hypothesize that drug action involves a direct effect on human meibomian gland epithelial...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001181

    authors: Zhang Y,Kam WR,Liu Y,Chen X,Sullivan DA

    更新日期:2017-06-01 00:00:00