Abstract:
PURPOSE:Study aimed to examine buttons removed from patients originally grafted for KC (group 1) for signs of recurrence at a cellular level and compare them with buttons removed from patients originally grafted for other conditions (group 2). The study further aimed to compare buttons from group 1 exhibiting high astigmatism (group 3) with the other buttons in the study (group 4). METHODS:Together with clinical data, corneal buttons were collected at repeat penetrating keratoplasty and labeled immunohistochemically with a panel of antibodies to structural proteins to assist microanatomical interpretation. Image analysis of montaged images of many individual sections was performed using custom software. The resulting data were analyzed statistically for significant differences between groups 1/2 and 3/4. RESULTS:Little evidence of KC recurrence could be found despite statistically significant differences between groups 1/2 in corneal thinning at both graft-host junction (GHJ) (P = 0.035) and within the graft (P = 0.001), epithelial thickening at the GHJ only (P < 0.001), high astigmatism (P = 0.028), and history of high intraocular pressure (P = 0.032) or rejection (P = 0.002) and between groups 3/4 in corneal thinning at both GHJ (P = 0.002) and within the graft (P = 0.003), epithelial thickening at the GHJ only (P = 0.003), and high astigmatism (P < 0.001). CONCLUSION:This study has highlighted the rarity of recurrence of KC in transplanted donor corneas and the corresponding difficulty in detecting early signs of the disease.
journal_name
Corneajournal_title
Corneaauthors
Brookes NH,Niederer RL,Hickey D,McGhee CN,Sherwin Tdoi
10.1097/ICO.0b013e3181967024subject
Has Abstractpub_date
2009-07-01 00:00:00pages
688-93issue
6eissn
0277-3740issn
1536-4798journal_volume
28pub_type
杂志文章相关文献
CORNEA文献大全abstract:PURPOSE:To evaluate the effectiveness of intraoperative mitomycin C in preventing the recurrence of primary pterygium. METHODS:In this prospective, randomized study, 38 eyes of 35 patients with primary pterygium were evaluated. In 19 eyes, the "bare sclera technique" combined with intraoperative application of 0.2 mg/...
journal_title:Cornea
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00003226-200007000-00013
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:To measure corneal epithelial thickness (CET) in patients with glaucoma using anterior-segment optical coherence tomography and to evaluate CET changes in relation to corneal epithelial microvilli analyzed by scanning electron microscopy (SEM). METHODS:Twenty-two eyes (16 patients) being treated with preservat...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001752
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To determine whether glucocorticoids suppress corneal lymphatic vessel growth (lymphangiogenesis) or induce lymphatic vessel regression. METHODS:We measured human lymphatic endothelial cell proliferation and collagen-induced tubulogenesis in culture conditions with and without dexamethasone, a potent glucocort...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318213f39f
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To report a recent significant increase of the number of patients diagnosed with Acanthamoeba keratitis (AK) at Wills Eye Hospital between 2004 and 2005. To determine the risk factors, clinical characteristics, treatments, and outcomes of patients with AK. METHODS:Retrospective consecutive case series of 20 ey...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31805b7e63
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:To determine whether a combination of early amniotic membrane transplantation (AMT) and early topical corticosteroid treatment could be a safe adjuvant therapy during antibacterial treatment in severe bacterial keratitis (BK) for relieving pain, avoiding iatrogenic epithelial toxicity, and allowing earlier use ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31802b28df
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To determine the factors associated with clinically significant dry eye after keratorefractive surgery. METHODS:This is a large database retrospective study that included consecutive cases of myopic laser in situ keratomileusis (LASIK) or photorefractive keratectomy performed between 2008 and 2016 at Care-Visi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002152
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:To study dry eye and analyze pathogenic factors in patients after cataract surgery. METHODS:A total of 37 patients (50 eyes) were studied by using a 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ25) and Ocular Surface Disease Index (OSDI) 3 days before and 1 week, 1 month, and 3 months a...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31812f67ca
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of supratarsal triamcinolone injection in the treatment of superior limbic keratoconjunctivitis (SLK). METHODS:Forty eyes of 20 patients were diagnosed with SLK. All eyes with long-standing severe ocular irritation unresponsive to topical steroid and artificial tears were treated with ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318030d230
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To report a case of successful medical treatment with oral posaconazole in refractory fungal keratitis caused by Paecilomyces lilacinus. METHODS:Case report. RESULTS:A 57-year-old male, soft contact lens wearer presented with irritation, pain, photophobia, and reduced vision. Slit-lamp examination showed a la...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000143
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:To demonstrate the role of intrinsic hyaluronic acid (HA) in the entrapment of inflammatory cells by amniotic membrane (AM) in vitro. METHODS:HA concentration in AM was analyzed by the sandwich protein binding assay, and the approximate molecular weight was measured by gel filtration chromatography. To localiz...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000133999.45262.83
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:To present a case of acute idiopathic endotheliitis occurred early after corneal collagen cross-linking (CXL) for progressive keratoconus, and to discuss possible risk factors, causes, and other similar complications in the literature. METHODS:A 24-year-old woman with bilateral keratoconus underwent a corneal ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000110
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Xeroderma pigmentosum (XP) is an extreme hypersensitivity to sunlight causing skin freckling and pigmentary changes because of defective DNA repair mechanisms. The purpose of this article is to evaluate the spectrum of ocular and systemic features in XP at a tertiary eye care center in India over 32 years. MET...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002499
更新日期:2020-11-30 00:00:00
abstract:PURPOSE:To evaluate the thickness and depth of lamina cribrosa (LC) in the optic nerve head region of the eyes in patients with nonglaucomatous keratoconus and to compare the thickness and depth with those of age-matched controls. METHODS:This was a cross-sectional, observational study comprising 45 patients with kera...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001379
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To assess the characteristics of BioMask as a potential masking agent for use with the excimer laser. METHOD:We addressed ablation rate, smoothness, ease of use, dioptric shift, treatment of standardized irregular topography, and ability of BioMask to induce dioptric change in vivo. RESULTS:BioMask ablates at...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199903000-00003
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:To report two patients with glaucoma who exhibited severe damage to the corneal endothelium after a trabeculectomy with mitomycin C (MMC). METHODS:This study includes clinical histories and specular microscopic pictures of the cases. RESULTS:Both patients were middle-aged women, underwent trabeculectomy with ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200204000-00012
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:To study two cases of corneal scarring due to trauma (one case) and infection (one case) unrelated to a previous photorefractive keratectomy (PRK) for the correction of myopia. METHODS:The patients are part of an Institutional Review Board-approved study of the safety and efficacy of PRK. Both patients underwe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199811000-00007
更新日期:1998-11-01 00:00:00
abstract::The present study describes biochemical and morphological differences of pseudophakic bullous keratopathy (PBK) corneas as compared with normal corneas. At the ultrastructural level, all PBK corneas studied had abnormal fibrillar material posterior to the Descemet's membrane. In addition, two of the six PBK buttons ha...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:PURPOSE:To evaluate clinical and ultrasonographic findings associated with advanced microbial keratitis with concurrent endophthalmitis. METHODS:We performed a retrospective analytical study of patients with severe microbial keratitis who underwent ocular ultrasonography for possible endophthalmitis at our institution...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002349
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To review our previous studies regarding the morphology of the cornea in pseudoexfoliation syndrome (PEX) and anatomical discrepancies between PEX and contralateral eyes in unilateral PEX. METHODS:We used in vivo confocal microscopy to observe the corneas of PEX, contralateral, and normal control eyes. Morphol...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182a3657d
更新日期:2013-11-01 00:00:00
abstract::The iridocorneal-endothelial (ICE) syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The pu...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the psychometric properties of the Keratoconus Outcomes Research Questionnaire (KORQ) in patients enrolled in the Save Sight Keratoconus Registry. METHODS:A cross-sectional study was conducted utilizing prospectively collected web-based registry data. The psychometric prop...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002169
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of amniotic membrane in corneal ulcers refractive to conventional treatment and amniotic membrane with fibrin glue in corneal perforations. METHODS:Amniotic membrane transplantation (AMT) was performed in 33 eyes from 32 patients for corneal ulcers refractive to conventional treatment....
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000151547.08113.d1
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To characterize the clinical presentation of limbal stem cell deficiency (LSCD) associated with glaucoma surgeries. METHODS:This is a retrospective cross-sectional study of patients with LSCD and glaucoma who presented to the Stein Eye Institute at the University of California, Los Angeles, between 2009 and 20...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002249
更新日期:2020-05-01 00:00:00
abstract::Two containers ("Iowa" and "Virginia") commonly used for transporting donor corneas, and various packing methods were evaluated for constancy of temperature maintenance. The larger Iowa container was found to be superior for extended storage. Packing methods that allowed the vials (containing McCarey-Kaufman medium) t...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:To compare the outcome of bifold forceps and cartridge injector suture pull-through insertion techniques for Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS:A retrospective review was conducted of the medical records of all patients treated with DSAEK at the University of Iowa Hospitals ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181eadb84
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To assess the use of serial computed tomography (CT) in the detection of osteo-odonto-lamina resorption in osteo-odonto-keratoprosthesis (OOKP) and to investigate the use of new volumetric software, Advanced Lung Analysis software (3D-ALA; GE Healthcare), for detecting changes in OOKP laminar volume. METHODS:A...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31825425d0
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:We aimed to investigate the possible association of proteoglycans with D-periodic collagen fibrils in the human cornea and sclera, using energy-filtering transmission electron microscopy (EF-TEM) and atomic force microscopy (AFM). METHODS:Human cornea and sclera were digested with keratanase to eliminate kerat...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200108000-00019
更新日期:2001-08-01 00:00:00
abstract:PURPOSE:To report our experience in the treatment of intraepithelial neoplasia of the conjunctiva using topical bevacizumab. METHODS:Ten eyes of 10 patients with conjunctival neoplasia received 25 mg/mL bevacizumab topically. Changes in the lesions were documented weekly using digital photography. After topical treatm...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000194
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To review the development of artificial corneas (prostheses and tissue equivalents) for transplantation, and to provide recent updates on our tissue-engineered replacement corneas. METHODS:Modified natural polymers and synthetic polymers were screened for their potential to replace damaged portions of the huma...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/01.ico.0000263120.68768.f8
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:The etiology of keratoconus has been the subject of numerous studies. Here, we review the body of literature that attempts to determine what causes keratoconus. METHODS:A review of the published literature was performed to evaluate the possible causes of keratoconus and how the different etiologies may play a ...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e31823f8c72
更新日期:2012-06-01 00:00:00