Recurrence of keratoconic pathology in penetrating keratoplasty buttons originally transplanted for keratoconus.

Abstract:

PURPOSE:Study aimed to examine buttons removed from patients originally grafted for KC (group 1) for signs of recurrence at a cellular level and compare them with buttons removed from patients originally grafted for other conditions (group 2). The study further aimed to compare buttons from group 1 exhibiting high astigmatism (group 3) with the other buttons in the study (group 4). METHODS:Together with clinical data, corneal buttons were collected at repeat penetrating keratoplasty and labeled immunohistochemically with a panel of antibodies to structural proteins to assist microanatomical interpretation. Image analysis of montaged images of many individual sections was performed using custom software. The resulting data were analyzed statistically for significant differences between groups 1/2 and 3/4. RESULTS:Little evidence of KC recurrence could be found despite statistically significant differences between groups 1/2 in corneal thinning at both graft-host junction (GHJ) (P = 0.035) and within the graft (P = 0.001), epithelial thickening at the GHJ only (P < 0.001), high astigmatism (P = 0.028), and history of high intraocular pressure (P = 0.032) or rejection (P = 0.002) and between groups 3/4 in corneal thinning at both GHJ (P = 0.002) and within the graft (P = 0.003), epithelial thickening at the GHJ only (P = 0.003), and high astigmatism (P < 0.001). CONCLUSION:This study has highlighted the rarity of recurrence of KC in transplanted donor corneas and the corresponding difficulty in detecting early signs of the disease.

journal_name

Cornea

journal_title

Cornea

authors

Brookes NH,Niederer RL,Hickey D,McGhee CN,Sherwin T

doi

10.1097/ICO.0b013e3181967024

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

688-93

issue

6

eissn

0277-3740

issn

1536-4798

journal_volume

28

pub_type

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