What causes keratoconus?

abstract：:We describe the findings in nine Asian-Indian patients with gelatinous droplike corneal dystrophy (GDCD). Most patients showed initial signs of bilateral decreased vision and photophobia at an early age. The siblings were affected in four cases, and parental consanguinity was recorded in seven cases. We classified the...

journal_title：Cornea

authors： Li S,Edward DP,Ratnakar KS,Reddy M,Tso MO

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...

journal_title：Cornea

authors： Jain S,De la Cruz J,Kang E,Kojima T,Chang JH,Kim JY

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:Lamellar techniques for selective replacement of diseased corneal structures have recently been improved. Descemet membrane endothelial keratoplasty (DMEK) allows the sole replacement of the endothelium--Descemet membrane layer (EDM). However, wide-spread use of DMEK is currently limited because of problems wit...

journal_title：Cornea

authors： Kruse FE,Laaser K,Cursiefen C,Heindl LM,Schlötzer-Schrehardt U,Riss S,Bachmann BO

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To evaluate the prevalence of positive microbiology results (culture and/or Gram stain) in donor cornea tissue with newer transplant methods and to assess if the results subsequently correlate with higher incidence of clinical infection. METHODS:A retrospective review of the microbiology records of 569 consecu...

journal_title：Cornea

authors： Garg S,Said B,Farid M,Steinert RF

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the association between a Mediterranean dietary pattern (MeDi) and Vitamin D levels on dry eye syndrome (DES). METHODS:This was a cross-sectional study. Male patients seen in the Miami Veterans Affairs eye clinic with normal eyelid, corneal, and conjunctival anatomy were r...

journal_title：Cornea

authors： Galor A,Gardener H,Pouyeh B,Feuer W,Florez H

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:This study was designed to study an alternative technique of lamellar separation of corneal layers for therapeutic keratoplasty in place of an en bloc removal of host corneal button in eyes with perforated corneal ulcers with pseudocornea. METHODS:Twelve eyes with perforated corneal ulcers with pseudocornea in...

journal_title：Cornea

authors： Vajpayee RB,Singhvi A,Sharma N,Sinha R

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The aim was to assess the clinical outcomes of corneal graft infections caused by multi-drug resistant Pseudomonas aeruginosa (MDR-PA). METHODS:This is a retrospective case series of 38 patients with corneal graft infections caused by MDR-PA managed from June to December 2011. Clinical and demographic details,...

journal_title：Cornea

authors： Jain R,Murthy SI,Motukupally SR

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To report a case of interface infection by Candida albicans after deep anterior lamellar keratoplasty (DALK). METHODS:A 30-year-old man with keratoconus underwent DALK. Four weeks after surgery, the patient developed multiple infiltrates in the graft-host interface with absence of intraocular infection. Donor ...

journal_title：Cornea

authors： Fontana L,Parente G,Di Pede B,Tassinari G

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To review the clinical course, treatment, and visual outcomes of keratitis with endophthalmitis caused by the filamentary fungus Fusarium. METHOD:One hundred fifty-nine cases of Fusarium keratitis at Bascom Palmer Eye Institute between January 1, 1987 and August 21, 2000 were reviewed. Ten patients with cultur...

journal_title：Cornea

authors： Dursun D,Fernandez V,Miller D,Alfonso EC

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To review the development of artificial corneas (prostheses and tissue equivalents) for transplantation, and to provide recent updates on our tissue-engineered replacement corneas. METHODS:Modified natural polymers and synthetic polymers were screened for their potential to replace damaged portions of the huma...

journal_title：Cornea

authors： Griffith M,Hakim M,Shimmura S,Watsky MA,Li F,Carlsson D,Doillon CJ,Nakamura M,Suuronen E,Shinozaki N,Nakata K,Sheardown H

更新日期：2002-10-01 00:00:00

abstract：:There have been reports of the clearing of sclera that has been grafted into the cornea. This clearing was studied in the rabbit by transplanting full-thickness scleral buttons or by implanting slivers of sclera, both autografts and allografts, into the cornea. Some clearing around the edges of the implanted scleral t...

journal_title：Cornea

authors： Maurice DM,Singh T

更新日期：1996-03-01 00:00:00

abstract：:Salzmann's nodular degeneration is a rare, noninflammatory, slowly progressive, degenerative condition. Bluish-white nodules raised above the surface of the cornea characterize it. It has usually developed in corneas with a history of phlyctenulosis, trachoma, vernal keratoconjunctivitis, measles, scarlet fever, and v...

journal_title：Cornea

authors： Das S,Link B,Seitz B

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To determine the effects of single radial or horizontal suture placement in 2-step clear corneal incision (CCI) wound apposition and permeability to particles of India ink. METHODS:Five fresh human globes were included. Two 25-gauge needles connected to a saline solution bag and to a digital manometer were ins...

journal_title：Cornea

authors： May WN,Castro-Combs J,Kashiwabuchi RT,Tattiyakul W,Qureshi-Said S,Hirai F,Behrens A

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:This study was designed to identify factors that predict longitudinal increases in corneal curvature as measured by the First Definite Apical Clearance Lens (FDACL) and flatter keratometric reading (Flat K) in keratoconus. METHODS:The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study is a long-...

journal_title：Cornea

authors： McMahon TT,Edrington TB,Szczotka-Flynn L,Olafsson HE,Davis LJ,Schechtman KB,CLEK Study Group.

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:To analyze the variations in tear quantity and quality after corneal collagen cross-linking (CXL) in patients with keratoconus. METHODS:This is a prospective observational study of 24 eyes with keratoconus that underwent epithelium-off CXL. The variables studied were tear film osmolarity, subjective symptoms (...

journal_title：Cornea

authors： Recalde JI,Acera A,Rodríguez-Agirretxe I,Sánchez-Tena MA,San-Cristóbal J,Durán JA

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To report a case of infectious crystalline keratopathy caused by Gemella haemolysans. METHODS:Observational case report. A 65-year-old woman underwent penetrating keratoplasty for contact lens-related Acanthamoeba keratitis and developed a nonhealing epithelial defect. Despite continued prophylaxis with topica...

journal_title：Cornea

authors： Elmallah MK,Munir WM,Janda WM,Tu EY

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To compare endothelial cell analysis by the center and flex-center methods in corneas with guttae of differing severity and to determine the minimum countable cell number for using only the flex-center method. METHODS:Forty-seven eyes with corneal guttae and 50 age-matched normal controls were enrolled in the ...

journal_title：Cornea

authors： Huang J,Liu X,Tepelus TC,Nazikyan T,Chopra V,Sadda SR,Lee OL

更新日期：2017-12-01 00:00:00

abstract：:Persistent donor corneal epithelial defects following penetrating keratoplasty may lead to graft failure. We herein describe a method for providing corneal protection using a temporary suture tarsorrhaphy. This technique is simple and completely reversible, and it allows continued observation and instillation of topic...

journal_title：Cornea

authors： Koenig SB,Harris GJ

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To compare corneal endothelial cell loss after cataract surgery by phacoemulsification and by Aqualase. METHODS:This was a prospective, randomized study of 75 eyes of 75 patients undergoing cataract surgery. Patients were randomly assigned to receive either phacoemulsification or Aqualase for cataract removal....

journal_title：Cornea

authors： Hu V,Hughes EH,Patel N,Whitefield LA

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To describe a new minimally invasive surgical technique for the symptomatic management of bullous keratopathy in blind eyes. METHODS:Four patients with severe corneal edema due to endothelial decompensation and no visual function in the affected eye presented for the relief of their ocular symptoms (pain and t...

journal_title：Cornea

authors： Kymionis GD,Diakonis VF,Kankariya VP,Plaka AD,Panagopoulou SI,Kontadakis GA,Grentzelos MA,Tsilimbaris MK,Pallikaris IG

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:To demonstrate the feasibility of Descemet membrane endothelial keratoplasty (DMEK) performed after previous penetrating keratoplasty (PK) failure and to describe primary outcomes. METHODS:Twenty-eight eyes of 28 patients who underwent DMEK after primary PK failure between January 2013 and November 2017 were i...

journal_title：Cornea

authors： Pierné K,Panthier C,Courtin R,Mazharian A,Souedan V,Gatinel D,Saad A

更新日期：2019-03-01 00:00:00

abstract：:Two cases of intracorneal hemorrhage developing as a complication of aphakic contact lens use are reported. Patient 1 had a penetrating keratoplasty to restore vision and therefore the histologic examination could be performed on the corneal button. In patient 2 the contact lens use was discontinued with partial resol...

journal_title：Cornea

authors： al-Hussaini AK,Friedlander MH,Karcioglu ZA

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The purpose of this research is 2-fold. First of all, the level of keratopathy development in patients with congenital aniridia is studied. In addition, a correlation between the effects of ocular surgery on the severity of keratopathy is made. METHODS:A thorough search for the total number of patients with an...

journal_title：Cornea

authors： Edén U,Riise R,Tornqvist K

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:To evaluate the reliability between pneumatonometry intraocular pressure (IOP) measurement in different scleral locations and corneal IOP in a penetrating keratoplasty (PK) setting. Our aim is to validate a method that can potentially be used for patients with keratoprostheses. METHODS:This is a prospective ob...

journal_title：Cornea

authors： Magalhaes OA,Aldave AJ

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To determine the safety and efficacy of amniotic membrane transplantation to restore and maintain a stable corneal epithelium and reduce ocular surface pain after surgical removal of band keratopathy arising from ocular causes. METHODS:Fifteen patients (16 eyes) from two centers with band keratopathy secondary...

journal_title：Cornea

authors： Anderson DF,Prabhasawat P,Alfonso E,Tseng SC

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:To report the outcomes of corneal fine needle diathermy (FND) with adjuvant intrastromal and subconjunctival bevacizumab injection for corneal neovascularization (CN) in children. METHODS:Medical records of all children who had undergone FND with adjuvant bevacizumab injection were reviewed retrospectively. Tr...

journal_title：Cornea

authors： Elbaz U,Mireskandari K,Shen C,Ali A

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To evaluate and compare the in vitro antimicrobial activity of levofloxacin versus ciprofloxacin and ofloxacin against ocular isolates from patients with bacterial conjunctivitis. METHODS:The in vitro antimicrobial susceptibilities of ocular isolates to levofloxacin, ofloxacin, and ciprofloxacin were determine...

journal_title：Cornea

authors： Graves A,Henry M,O'Brien TP,Hwang DG,Van Buskirk A,Trousdale MD

更新日期：2001-04-01 00:00:00

abstract：:This trial was a randomized, double-masked, crossover study during which patients with keratoconjunctivitis sicca underwent 6 weeks of treatment with either cyclosporine 1% ophthalmic ointment or placebo followed by 6 weeks of the alternative treatment. Washout periods using only unpreserved artificial tears preceded ...

journal_title：Cornea

authors： Laibovitz RA,Solch S,Andriano K,O'Connell M,Silverman MH

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:To evaluate the quality of stromal bed and the safety on endothelium in preparation of donor tissue for Descemet stripping automated endothelial keratoplasty in a masked fashion using 2 mechanical microkeratomes and a femtosecond laser. METHODS:Deep anterior lamellar dissection was performed on 15 donor cornea...

journal_title：Cornea

authors： Mootha VV,Heck E,Verity SM,Petroll WM,Lakshman N,Muftuoglu O,Bowman RW,McCulley JP,Cavanagh HD

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:To quantify all minor/major adverse events in a large cohort of consecutive corneal transplants, particularly in respect to penetrating keratoplasty (PKP). METHODS:All corneal transplants in the Auckland region over a 10-year period (2000-2009) were identified through the New Zealand National Eye Bank. Relevan...

journal_title：Cornea

authors： Crawford AZ,Krishnan T,Ormonde SE,Patel DV,McGhee CN

更新日期：2018-03-01 00:00:00