Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.

Abstract:

:We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days we observed an 86% reduction in cell counts. Confluent HCE was not sensitive to 454A12-rRA at equivalent concentrations of immunotoxin. These data confirm previous observations regarding selective sensitivity of proliferating ocular tissue to immunotoxin, but suggest that HCE is less sensitive to 454A12-rRA than other ocular cell types.

journal_name

Cornea

journal_title

Cornea

authors

Fulcher SF,Foulks GN,Wilkerson M,Cobo LM,Jaffe GJ,Hatchell DL

doi

10.1097/00003226-199209000-00010

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

413-7

issue

5

eissn

0277-3740

issn

1536-4798

journal_volume

11

pub_type

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