Abstract:
:We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days we observed an 86% reduction in cell counts. Confluent HCE was not sensitive to 454A12-rRA at equivalent concentrations of immunotoxin. These data confirm previous observations regarding selective sensitivity of proliferating ocular tissue to immunotoxin, but suggest that HCE is less sensitive to 454A12-rRA than other ocular cell types.
journal_name
Corneajournal_title
Corneaauthors
Fulcher SF,Foulks GN,Wilkerson M,Cobo LM,Jaffe GJ,Hatchell DLdoi
10.1097/00003226-199209000-00010subject
Has Abstractpub_date
1992-09-01 00:00:00pages
413-7issue
5eissn
0277-3740issn
1536-4798journal_volume
11pub_type
杂志文章相关文献
CORNEA文献大全abstract::We report a case of corneal allograft rejection that occurred in a gravid woman 1 year following transplantation. This is the first report, to our knowledge, of corneal allograft rejection occurring in a pregnant woman. ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-198706040-00009
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to report a case of a central Descemet membrane detachment after heavy silicone oil removal from the anterior chamber. METHODS:This is a case report of a patient operated with scleral buckling and heavy silicone oil implantation for recurrent retinal detachment. In the patient's follo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000056
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To compare the endothelial cell damage after lens removal using a fluid-based system to conventional ultrasound. METHODS:Twenty human cadaver eyes were randomized to undergo phacoemulsification using either a fluid-based system or conventional ultrasound. After surgery, each corneoscleral button was removed, s...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000130184.56514.51
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:To describe an invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. METHODS:A 51-year-old man developed a conjunctival mass that was excised and proved to be a spindle cell carcinoma. A tumor recurrence 20 months later was evaluated by ultrasound biomicroscopy (UBM) ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3180cfe80e
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To determine the factors associated with sporadic diffuse lamellar keratitis (DLK) after microkeratome laser-assisted in situ keratomileusis (LASIK). METHODS:This large database retrospective study included consecutive cases of LASIK performed between 2007 and 2016 at Care-Vision Laser Centers, Tel-Aviv, Israe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001674
更新日期:2018-09-01 00:00:00
abstract::Primary graft failure is a rare but major complication of penetrating keratoplasty. An apparent clustering of four cases during a 1-month period led to a review of all 778 keratoplasties performed by nine surgeons at Massachusetts Eye and Ear Infirmary from July 1, 1986 to June 30, 1988. The objectives of this study w...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199407000-00005
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:To determine if Cornisol is as effective as Optisol-GS as an intermediate-term corneal storage medium. METHODS:A prospective, in vitro, randomized, partially masked study using paired donor corneas. Optical grade tissues not suitable for surgery were used. After performing baseline slit lamp evaluation, one ti...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/ICO.0000000000000912
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To investigate the changes of meibomian gland (MG) and tear film stability in subjects with eyelid tattoos. METHODS:Forty female subjects were recruited. Ten subjects had eyelid tattoos and 30 subjects did not (control group). Tear film break-up time (TBUT) measurement and fluorescein staining were performed t...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000452
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:The compositional, structural, and functional relationships of meibum may provide insights into the loss of tear film stability. Although the conformation of meibum lipids has been studied rigorously, that of tear lipids has not. METHODS:Tear lipids (TLHSCT) and meibum (MHSCT) from patients who had hematopoiet...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002095
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To provide insight into the mechanism by which epidermal growth factor (EGF) stimulates corneal epithelial migration, we investigated the possible interaction between EGF and cyclic AMP (cAMP) signaling pathways during epithelial migration with an organ culture system for the rabbit cornea. METHODS:Rabbit corn...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200305000-00014
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:One of the most disturbing trends in recent years is the growth of resistant strains of bacteria with the simultaneous dearth of new antimicrobial agents. Thus, new antimicrobial agents for the use on the ocular surface are needed. METHODS:We synthesized a variety of ionic liquid compounds, which possess 2 pos...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31823f0a86
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To compare acid-base and oxidation-reduction indicators and to investigate the effect of buffer and temperature on the colorimetric detection of microbial growth in corneal preservation media. METHODS:Corneal preservation media containing gentamicin, without or with HEPES buffer, were prepared with either phen...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200007000-00023
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:To report the indications, long-term structural and functional outcomes, and prognostic factors for the success of penetrating and lamellar corneal patch grafts. METHODS:This is a retrospective analysis of 49 patients who underwent the corneal patch graft procedure over 8 years. The baseline, preoperative, and...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002529
更新日期:2020-09-29 00:00:00
abstract:PURPOSE:To evaluate best-corrected visual acuity (BCVA), refractive outcome, corneal topography, optical coherence tomography, and endothelial cell density 12 months after femtosecond laser-assisted inverted mushroom keratoplasty. METHODS:We performed a prospective study of a surgical case series of 5 patients undergo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/QAI.0b013e31815bad0c
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:To determine whether preserved amniotic membrane can be used to reconstruct the ocular surface after excision of the invading granulation material typical of LOGIC syndrome (laryngeal and ocular granulation tissue in children from the Indian subcontinent). METHODS:Granulation tissue was dissected and excised f...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200110000-00016
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To report the first case of fungal keratitis caused by presumed Carpoligna species. METHODS:A 37-year-old gardener sustained a full-thickness, stellate corneal laceration while cutting wood outdoors with a circular saw. Two months after surgical repair, he developed a severe infectious keratitis with descemeto...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181af3954
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To determine keratometric astigmatism (KA), posterior corneal astigmatism (PCA), and total corneal astigmatism (TCA) in 951 normal eyes, to establish a model for estimating TCA from anterior corneal data, and to test this method in a new group of eyes with toric intraocular lenses (TIOLs). METHODS:We used a Pe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001224
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:To investigate the absorption of moxifloxacin into human aqueous humor after administration of moxifloxacin hydrochloride ophthalmic solution, 0.5% as base. METHODS:Cataract patients were randomly allocated to receive 1 drop every 15 minutes for 4 doses before surgery (group 1) or 1 drop 4 times per day on the...
journal_title:Cornea
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/01.ico.0000157423.78275.a2
更新日期:2005-11-01 00:00:00
abstract::The introduction of the excimer laser for keratorefractive surgery in the 1990 s permanently reshaped the treatment landscape for correcting refractive errors, such as myopia, hyperopia, and astigmatism. Until that point, these treatments had relied on less predictable techniques, such as radial keratotomy and automat...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e31826ab0a7
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To describe the association of water exposure with contact lens (CL)-related disease and explore the guidelines regarding water exposure to CL wearers, provided by CL manufacturing industry, global public health, and CL-related professional associations. METHODS:A review of the literature was conducted by sear...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0000000000001898
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To report a patient with refractory keratitis after a Boston type I keratoprosthesis treated with corneal collagen cross-linking (CXL). METHODS:Case report. RESULTS:A 29-year-old man with a history of chemical burn in the left eye underwent keratoprosthesis implantation. He developed infectious keratitis 4 mo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000509
更新日期:2015-09-01 00:00:00
abstract::The histological and ultrastructural pathology of two corneas that were removed from an infant with congenital glaucoma prior to keratoplasty is described. Clinically, the glaucoma was suspected to be due to an inapparent congenital viral infection, although there was no serological proof. Macroscopic and light micros...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to describe the clinicopathologic correlation of textural interface opacities (TIOs) in a Descemet stripping automated endothelial keratoplasty (DSAEK) donor button after its removal. METHODS:A 75-year-old woman underwent combined phacoemulsification with intraocular lens placement an...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000057
更新日期:2014-03-01 00:00:00
abstract::We report the case of a 34-year-old man who had uncomplicated cataract surgery in his left eye. Medical history was significant for atopic dermatitis, requiring oral immunosuppressive medications. Two days after the surgery, the patient presented with pain, photophobia, decreased vision, and a small corneal abrasion. ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318182262c
更新日期:2009-01-01 00:00:00
abstract::Specular microscopy can provide a noninvasive morphologic analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiologic reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corn...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e31815892da
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the corneal thickness asymmetry indices in a large pool of patients with keratoconus derived using anterior segment optical coherence tomography (AS-OCT) in comparison with established Scheimpflug imaging-derived keratoconus classification indices. METHODS:Six specific ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000275
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To investigate the effects of diquafosol sodium (DQS) eye drops, a purinergic P2Y2 receptor agonist, on tear film stability in patients with unstable tear film (UTF). METHODS:Two prospective studies were conducted. One was an exploratory nonrandomized trial on 39 eyes with dry eye symptoms and short tear film ...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/ICO.0b013e3182930b1d
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To study the predisposing conditions, treatments, and visual outcomes of nontraumatic corneal perforations. METHODS:A retrospective chart review was conducted of all nontraumatic corneal perforations seen between January 1992 and December 1998, with > or = 3 months of follow-up, at the Cornea Service Wills Eye...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200005000-00011
更新日期:2000-05-01 00:00:00
abstract:PURPOSE:The aim of this study was to describe the clinical features of infectious scleritis with distinct inciting events and to analyze the factors associated with poor visual outcome. METHODS:We retrospectively reviewed the predisposing factors, clinical findings, isolated organisms, complications, and outcomes of p...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000174
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:To determine how ocular surface epithelium adjusts to an increase in cell replication after treatment with the opioid antagonist naltrexone (NTX). METHODS:Adult male rats were given twice daily injections of 30 mg/kg NTX or vehicle for 7 days. Outcomes of NTX administration included DNA synthesis (monitored wi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000224646.66472.aa
更新日期:2006-08-01 00:00:00