Abstract:
PURPOSE:To determine if concurrent use of 5% natamycin and 2% econazole offers greater benefits than monotherapy with 5% natamycin for the management of fungal keratitis. METHODS:Subjects presenting to the cornea service were treated with 5% natamycin and 2% econazole used concurrently. We compared the results with a historical control of patients treated with 5% natamycin in the same calendar year. The same clinical and examination protocol including inclusion and exclusion criteria was used for both groups. RESULTS:We compared results of 47 subjects on concurrent use of 5% natamycin and 2% econazole with all 53 subjects who had received 5% natamycin in a previous study (historical controls). Baseline characteristics were similar between the 2 groups. There were no significant differences (P=0.9) between the 2 arms for success (defined as a healed or healing ulcer). CONCLUSIONS:Concurrent use of 5% natamycin and 2% econazole does not appear to offer additional benefits over monotherapy with 5% natamycin for the management of fungal keratitis.
journal_name
Corneajournal_title
Corneaauthors
Prajna NV,Nirmalan PK,Mahalakshmi R,Lalitha P,Srinivasan Mdoi
10.1097/01.ico.0000134193.64357.82subject
Has Abstractpub_date
2004-11-01 00:00:00pages
793-6issue
8eissn
0277-3740issn
1536-4798pii
00003226-200411000-00007journal_volume
23pub_type
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