Synthetic epikeratoplasty in rhesus monkeys with human type IV collagen.

Abstract:

:Human type IV collagen discs were found to support proliferation and adhesion of rabbit corneal epithelial cells in tissue culture. To assess the biocompatibility of this synthetic collagen for epikeratoplasty, seven eyes of seven rhesus monkeys underwent epikeratoplasty with lenticules made of human type IV collagen. Eye rubbing by the animals expulsed two of the lenticules and caused failure of two to epithelialize completely. The remaining three lenticules epithelialized, remained clear, and caused no adverse effects on the eye. Two of these lenticules developed focal areas of subepithelial thinning 3 months postoperatively and the third lenticule has remained stable for 30 months. The presence of epithelial attachment components at the epithelial-lenticule interface was demonstrated by immunolocalization. Histopathologic and ultrastructural examination revealed focal areas of epithelial invasion and degradation of the lenticule. Neutral proteases were detected in the thinning region of one specimen. Human type IV collagen supports epithelialization in vivo and may have potential as a biomaterial for epikeratoplasty, but the stability of the material must be improved.

journal_name

Cornea

journal_title

Cornea

authors

Thompson KP,Hanna KD,Gipson IK,Gravagna P,Waring GO 3rd,Johnson-Wint B

doi

10.1097/00003226-199301000-00007

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

35-45

issue

1

eissn

0277-3740

issn

1536-4798

journal_volume

12

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Changes in corneal autofluorescence and corneal epithelial barrier function with aging.

    abstract::Corneal epithelial permeability studies using fluorophotometers were performed on 90 eyes of 51 normal subjects. After recording the autofluorescence of the cornea (AFC) and of the lens (AFL), we applied 20 microliters of 2% sodium fluorescein to the conjunctival sac. The corneal fluorescence 45 min later (F45), which...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199311000-00006

    authors: Chang SW,Hu FR

    更新日期:1993-11-01 00:00:00

  • Vision-related impact on quality of life in an elderly patient population after corneal transplantation.

    abstract:PURPOSE:The aim of this study was to assess the vision-related quality of life (QOL) and satisfaction of elderly patients who underwent corneal transplantations. METHODS:Survey data using a modified version of the Visual Function Index were collected in February-March 2013 from 175 patients (age ≥65 years) of 414 elig...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000021

    authors: Puri S,Robinson SB,Wang J,Sikder S

    更新日期:2014-02-01 00:00:00

  • Keratoconus.

    abstract::Keratoconus is a bilateral disorder of corneal shape which may be sporadic or genetically determined. Early corneal thinning suggests that a functional loss of structural elements is a primary event in the disease. Tensile strength of the cornea is reduced and is expressed by signs of rupture and scarring in Bowman's ...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:

    authors: Bron AJ

    更新日期:1988-01-01 00:00:00

  • Coexistent congenital hereditary endothelial dystrophy and congenital glaucoma.

    abstract:PURPOSE:To retrospectively evaluate the coexistence of congenital glaucoma with congenital hereditary endothelial dystrophy. METHODS:Ten infants presented to our hospital with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). These patients were diagnosed with congenital glaucoma. All patients...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31804e4579

    authors: Ramamurthy B,Sachdeva V,Mandal AK,Vemuganti GK,Garg P,Sangwan VS

    更新日期:2007-07-01 00:00:00

  • Recurrence of keratoconic pathology in penetrating keratoplasty buttons originally transplanted for keratoconus.

    abstract:PURPOSE:Study aimed to examine buttons removed from patients originally grafted for KC (group 1) for signs of recurrence at a cellular level and compare them with buttons removed from patients originally grafted for other conditions (group 2). The study further aimed to compare buttons from group 1 exhibiting high asti...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181967024

    authors: Brookes NH,Niederer RL,Hickey D,McGhee CN,Sherwin T

    更新日期:2009-07-01 00:00:00

  • Incidence and Outcomes of Positive Donor Rim Cultures and Infections in the Cornea Preservation Time Study.

    abstract:PURPOSE:To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS). METHODS:Donor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Incidence...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0000000000001654

    authors: Mian SI,Aldave AJ,Tu EY,Ayres BD,Jeng BH,Macsai MS,Nordlund ML,Penta JG,Pramanik S,Szczotka-Flynn LB,Ayala AR,Liang W,Maguire MG,Lass JH

    更新日期:2018-09-01 00:00:00

  • The prevalence of positive hepatitis B, hepatitis C, and HIV serology in cornea donors prescreened by medical and social history in Ontario, Canada.

    abstract:PURPOSE:To determine the prevalence of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) in the serum of cornea donors who had been previously screened by social and medical history by the Eye Bank of Canada, Ontario Division. METHOD:A retrospective examination of the donor records of the Ey...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Armstrong SA,Gangam N,Chipman ML,Rootman DS

    更新日期:1997-09-01 00:00:00

  • Histologic evaluation of human posterior lamellar discs for femtosecond laser Descemet's stripping endothelial keratoplasty.

    abstract:PURPOSE:To evaluate the histologic changes in corneal structure after femtosecond laser preparation of posterior lamellar discs, more specifically, the smoothness of the stromal bed and the accuracy of the predicted depth of the horizontal lamellar cut. MATERIALS AND METHODS:Nineteen human donor eyes unsuitable for tr...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318183a379

    authors: Cheng YY,Kang SJ,Grossniklaus HE,Pels E,Duimel HJ,Frederik PM,Hendrikse F,Nuijts RM

    更新日期:2009-01-01 00:00:00

  • In Situ Corneal Cross-Linking for Recurrent Corneal Melting After Boston Type 1 Keratoprosthesis.

    abstract:PURPOSE:To present a new treatment modality for recurrent corneal melting in a patient with a Boston type I keratoprosthesis (B-KPro) including in situ corneal cross-linking (CXL) and lamellar keratoplasty (LKP) as combined treatment. METHODS:Case report. RESULTS:Our report concerns a 27-year-old man whose case histo...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000830

    authors: Tóth G,Bucher F,Siebelmann S,Bachmann B,Hermann M,Szentmáry N,Nagy ZZ,Cursiefen C

    更新日期:2016-06-01 00:00:00

  • One-year results of PRK in low and moderate myopia: fewer than 0.5% of eyes lose two or more lines of vision.

    abstract:PURPOSE:To retrospectively evaluate the results of myopic photorefractive keratectomy (PRK) for different levels of intended correction, including analysis of loss of best spectacle-corrected visual acuity. METHODS:Four hundred seventy-five consecutive eyes with 1 year of follow-up that had PRK for the correction of 1...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200003000-00011

    authors: Kapadia MS,Wilson SE

    更新日期:2000-03-01 00:00:00

  • The effect of subconjunctival suramin on corneal neovascularization in rabbits.

    abstract:PURPOSE:To evaluate the effect of subconjunctival injection of suramin on corneal neovascularization in rabbits. METHODS:Corneal neovascularization was induced by silk suturing of the corneal stroma in 40 eyes of 40 male New Zealand white rabbits. Five days after suture placement, all rabbits were randomly divided int...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ae91e3

    authors: Lee HS,Chung SK

    更新日期:2010-01-01 00:00:00

  • Diagnosis of Aspergillus keratitis in vivo with confocal microscopy.

    abstract::Confocal microscopy provides a new, noninvasive way of imaging the human cornea in vivo. One of its most important clinical uses is the diagnosis and management of infectious keratitis. The authors used tandem scanning confocal microscopy to image the corneas in two culture-proven cases of Aspergillus keratitis. Funga...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Winchester K,Mathers WD,Sutphin JE

    更新日期:1997-01-01 00:00:00

  • Keratitis and corneal melt with ketorolac tromethamine after conductive keratoplasty.

    abstract:PURPOSE:To report a case of keratitis and corneal melt after conductive keratoplasty (CK) enhancement. METHOD:Case report. RESULTS:A 52-year-old woman with emmetropic presbyopia had undergone previous CK for monovision and underwent CK enhancement 4 years later. Postoperatively, she was managed with ketorolac trometh...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ef6ec7

    authors: Khalifa YM,Mifflin MD

    更新日期:2011-04-01 00:00:00

  • Treatment of Acute Corneal Hydrops With Combined Intracameral Gas and Approximation Sutures in Patients With Corneal Ectasia.

    abstract:PURPOSE:To assess the efficacy and safety of combined intracameral sulfur hexafluoride and full-thickness corneal sutures in the treatment of acute corneal hydrops (CH). METHODS:This is an uncontrolled series of cases with keratoconus (KC), keratoglobus (KG), and pellucid marginal degeneration that presented with CH o...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002155

    authors: Mohebbi M,Pilafkan H,Nabavi A,Mirghorbani M,Naderan M

    更新日期:2020-02-01 00:00:00

  • Salzmann's nodular degeneration of the cornea: a review and case series.

    abstract::Salzmann's nodular degeneration is a rare, noninflammatory, slowly progressive, degenerative condition. Bluish-white nodules raised above the surface of the cornea characterize it. It has usually developed in corneas with a history of phlyctenulosis, trachoma, vernal keratoconjunctivitis, measles, scarlet fever, and v...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/01.ico.0000153100.74033.ef

    authors: Das S,Link B,Seitz B

    更新日期:2005-10-01 00:00:00

  • Experimental transplantation of corneal epithelium-like cells induced by Pax6 gene transfection of mouse embryonic stem cells.

    abstract:PURPOSE:Corneal epithelial stem cells are deficient in cases of limbal disorders, leading to conjunctival epithelial ingrowth, vascularization, and eventually visual disturbance. We introduced the eye development-associated transcription factor pax6 to embryonic stem (ES) cells and tested whether pax6-transfected cells...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31814fa814

    authors: Ueno H,Kurokawa MS,Kayama M,Homma R,Kumagai Y,Masuda C,Takada E,Tsubota K,Ueno S,Suzuki N

    更新日期:2007-12-01 00:00:00

  • Correlation of corneal elevation with severity of keratoconus by means of anterior and posterior topographic analysis.

    abstract:PURPOSE:To investigate the severity of keratoconus in terms of corneal elevation differences with 2 different reference surfaces using topographic analysis. METHODS:Eighty-six eyes of 50 patients with keratoconus of various clinical stages (61 male and 25 female eyes) with mean age of 37.3 ± 11.6 years were evaluated....

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0B013E31823D1EE0

    authors: Ishii R,Kamiya K,Igarashi A,Shimizu K,Utsumi Y,Kumanomido T

    更新日期:2012-03-01 00:00:00

  • Adenovirus epithelial keratitis.

    abstract::The authors sought to determine whether adenovirus could infect human corneal epithelium in vivo. They reviewed the medical records of six patients with adenovirus-positive viral corneal cultures who were examined at the Bascom Palmer Eye Institute between March 21, 1986, and December 31, 1992. The six patients with a...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Chodosh J,Miller D,Stroop WG,Pflugfelder SC

    更新日期:1995-03-01 00:00:00

  • Evaluation of corneal topography with Orbscan II in first-degree relatives of patients with keratoconus.

    abstract:PURPOSE:To evaluate the corneal topographic characteristics of first-degree relatives of patients with keratoconus with corneal topography to determine the incidence of clinical keratoconus and topographic abnormalities. METHODS:Between February and August 2006, Orbscan II analysis was done in 144 eyes of 72 cases who...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318165d110

    authors: Kaya V,Utine CA,Altunsoy M,Oral D,Yilmaz OF

    更新日期:2008-06-01 00:00:00

  • Cataract extraction after implantation of a type I Boston keratoprosthesis.

    abstract:PURPOSE:To describe cataract extraction and intraocular lens placement in a patient with an existing Type I Boston keratoprosthesis. METHODS:Case report to describe the surgical technique used to remove a cataract that developed after Boston keratoprosthesis placement. RESULTS:Extracapsular cataract extraction by usi...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31815b7d69

    authors: Harissi-Dagher M,Colby KA

    更新日期:2008-02-01 00:00:00

  • Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease.

    abstract:PURPOSE:To evaluate the efficacy of superficial keratectomy and conjunctival advancement hood flap (SKCAHF) for the treatment of bullous keratopathy in canine patients. METHODS:Nine dogs (12 eyes) diagnosed with progressive corneal edema underwent superficial keratectomy followed by placement of conjunctival advanceme...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000966

    authors: Horikawa T,Thomasy SM,Stanley AA,Calderon AS,Li J,Linton LL,Murphy CJ

    更新日期:2016-10-01 00:00:00

  • Reflective meniscometry: a new field of dry eye assessment.

    abstract:PURPOSE:To report a newly developed noninvasive method to measure the radius of tear meniscus curvature (reflective meniscometry) and its application to normal eyes, dry eyes, and other ocular surface conditions. METHODS:Two types of meniscometer--photographic and video--were devised. Both use tear meniscus as a conca...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200005001-00008

    authors: Yokoi N,Bron AJ,Tiffany JM,Kinoshita S

    更新日期:2000-05-01 00:00:00

  • Endothelial keratoplasty without Descemet stripping after failed penetrating keratoplasty.

    abstract:PURPOSE:To evaluate outcomes of endothelial keratoplasty (EK) without Descemet membrane stripping for treatment of failed penetrating keratoplasty (PKP). METHODS:Retrospective cohort study of all eyes that underwent EK without Descemet membrane stripping for failed PKP at one institution between May 2008 and June 2010...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31823f8c59

    authors: Heitor de Paula F,Kamyar R,Shtein RM,Sugar A,Mian SI

    更新日期:2012-06-01 00:00:00

  • Corneal Cross-Linking With Verteporfin and Nonthermal Laser Therapy.

    abstract:PURPOSE:To test whether verteporfin with a nonthermal laser increases corneal mechanical stiffness and resistance to enzymatic degradation ex vivo. METHODS:Thirty human corneas (n = 5 per group) were treated with verteporfin alone (V), irradiated with nonthermal laser therapy (689 nm) alone (NTL), or received combined...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001473

    authors: Alageel SA,Arafat SN,Salvador-Culla B,Kolovou PE,Jahanseir K,Kozak A,Braithwaite GJC,Ciolino JB

    更新日期:2018-03-01 00:00:00

  • Bilateral iridocorneal endothelial syndrome: case report and review of the literature.

    abstract::We present the case of a 47-year-old woman with bilateral iridocorneal endothelial syndrome. The iridocorneal endothelial syndrome has heretofore been considered a unilateral disorder. However, a review of the literature and examination of the patient presented in this report indicate that bilateral occurrence of the ...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/00003226-199407000-00015

    authors: Hemady RK,Patel A,Blum S,Nirankari VS

    更新日期:1994-07-01 00:00:00

  • Impression cytology study of conjunctival epithelial phenotypes on the healing ocular surface after pterygium excision.

    abstract:PURPOSE:To compare the process of conjunctival epithelial regeneration after three types of pterygium excision procedures. METHODS:Thirty-eight patients (45 eyes) with primary pterygium were randomly assigned to a bare-sclera procedure (group 1, 15 eyes of 12 patients), bare-sclera with intraoperative mitomycin C (MMC...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003226-200104000-00002

    authors: Tseng SH,Chen YT,Cheng HC,Huang FC,Lee SC,Chen FK

    更新日期:2001-04-01 00:00:00

  • Comparison of Topical Application of TSG-6, Cyclosporine, and Prednisolone for Treating Dry Eye.

    abstract:PURPOSE:To compare the therapeutic effects of topical tumor necrosis factor (TNF)-α-stimulated gene/protein-6 (TSG-6) with those of cyclosporine and prednisolone eye drops in NOD.B10.H2 mice, a model for inflammation-mediated dry eye. METHODS:The 12-week-old NOD.B10.H2 mice were topically administered recombinant TSG-...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000756

    authors: Kim YJ,Ryu JS,Park SY,Lee HJ,Ko JH,Kim MK,Wee WR,Oh JY

    更新日期:2016-04-01 00:00:00

  • Long-term corneal clarity after spontaneous repair of an iatrogenic descemetorhexis in a patient with Fuchs dystrophy.

    abstract:PURPOSE:To report a case of long-term corneal clarity after spontaneous resolution of corneal edema associated with iatrogenic endothelial trauma in a patient with Fuchs dystrophy. METHODS:Retrospective case report. RESULTS:An 84-year-old woman with Fuchs dystrophy experienced an iatrogenic descemetorhexis during com...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182886aaa

    authors: Koenig SB

    更新日期:2013-06-01 00:00:00

  • Anterior-Segment Optical Coherence Tomography and Scanning Electron Microscopy to Evaluate Corneal Epithelial Changes in Patients Undergoing Glaucoma Therapy.

    abstract:PURPOSE:To measure corneal epithelial thickness (CET) in patients with glaucoma using anterior-segment optical coherence tomography and to evaluate CET changes in relation to corneal epithelial microvilli analyzed by scanning electron microscopy (SEM). METHODS:Twenty-two eyes (16 patients) being treated with preservat...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001752

    authors: Cennamo G,Montorio D,Del Prete S,Del Prete A,Cennamo G

    更新日期:2018-12-01 00:00:00

  • Visual Function and Higher-Order Aberrations in Eyes After Corneal Transplantation: How to Improve Postoperative Quality of Vision.

    abstract::An understanding of corneal optics is important to optimize the visual outcome after eye surgery. Recent advances in the surgical techniques of lamellar keratoplasty have changed the strategies used for corneal transplantation. Lamellar keratoplasty has the advantage of having a lower rate of graft rejection, superior...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000000589

    authors: Yamaguchi T,Satake Y,Dogru M,Ohnuma K,Negishi K,Shimazaki J

    更新日期:2015-11-01 00:00:00