Abstract:
:Corneal epithelial permeability studies using fluorophotometers were performed on 90 eyes of 51 normal subjects. After recording the autofluorescence of the cornea (AFC) and of the lens (AFL), we applied 20 microliters of 2% sodium fluorescein to the conjunctival sac. The corneal fluorescence 45 min later (F45), which paralleled the corneal epithelial permeability to fluorescein, was measured by fluorophotometer and analyzed. All parameters of the two eyes of each subject correlated well with each other. There was positive correlation between AFL and patient age and between AFC and patient age (r = 0.78, p < 0.001, and r = 0.74, p < 0.001, respectively). The F45 increased exponentially with advancing age (r = 0.67, p < 0.001). The strong correlation between AFC and AFL in each eye (r = 0.79, p < 0.001) indicated corresponding aging processes in both the cornea and the lens. The increase in epithelial permeability with age possibly represents a subclinical breakdown of barrier function, rendering the corneas more vulnerable to insults.
journal_name
Corneajournal_title
Corneaauthors
Chang SW,Hu FRdoi
10.1097/00003226-199311000-00006subject
Has Abstractpub_date
1993-11-01 00:00:00pages
493-9issue
6eissn
0277-3740issn
1536-4798journal_volume
12pub_type
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