Changes in corneal autofluorescence and corneal epithelial barrier function with aging.

Abstract:

:Corneal epithelial permeability studies using fluorophotometers were performed on 90 eyes of 51 normal subjects. After recording the autofluorescence of the cornea (AFC) and of the lens (AFL), we applied 20 microliters of 2% sodium fluorescein to the conjunctival sac. The corneal fluorescence 45 min later (F45), which paralleled the corneal epithelial permeability to fluorescein, was measured by fluorophotometer and analyzed. All parameters of the two eyes of each subject correlated well with each other. There was positive correlation between AFL and patient age and between AFC and patient age (r = 0.78, p < 0.001, and r = 0.74, p < 0.001, respectively). The F45 increased exponentially with advancing age (r = 0.67, p < 0.001). The strong correlation between AFC and AFL in each eye (r = 0.79, p < 0.001) indicated corresponding aging processes in both the cornea and the lens. The increase in epithelial permeability with age possibly represents a subclinical breakdown of barrier function, rendering the corneas more vulnerable to insults.

journal_name

Cornea

journal_title

Cornea

authors

Chang SW,Hu FR

doi

10.1097/00003226-199311000-00006

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

493-9

issue

6

eissn

0277-3740

issn

1536-4798

journal_volume

12

pub_type

杂志文章

相关文献

CORNEA文献大全
  • The effect of aqualase and phacoemulsification on the corneal endothelium.

    abstract:PURPOSE:To compare corneal endothelial cell loss after cataract surgery by phacoemulsification and by Aqualase. METHODS:This was a prospective, randomized study of 75 eyes of 75 patients undergoing cataract surgery. Patients were randomly assigned to receive either phacoemulsification or Aqualase for cataract removal....

    journal_title:Cornea

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ICO.0b013e3181af7c43

    authors: Hu V,Hughes EH,Patel N,Whitefield LA

    更新日期:2010-03-01 00:00:00

  • Laser-assisted in situ keratomileusis complications in diabetes mellitus.

    abstract:PURPOSE:To report the incidence of complications and the refractive results in patients with diabetes mellitus treated with laser-assisted in situ keratomileusis (LASIK). METHODS:A retrospective review of the charts, focusing on 6-month postoperative data, was performed on 30 eyes from patients with diabetes and 150 a...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200204000-00002

    authors: Fraunfelder FW,Rich LF

    更新日期:2002-04-01 00:00:00

  • Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions.

    abstract::Specular microscopy can provide a noninvasive morphologic analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiologic reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corn...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0b013e31815892da

    authors: McCarey BE,Edelhauser HF,Lynn MJ

    更新日期:2008-01-01 00:00:00

  • Contralateral Autologous Corneal Transplantation Experience in Mexico City.

    abstract:PURPOSE:The aim of this study is to expand the limited knowledge regarding autologous contralateral penetrating keratoplasty. METHODS:We report the retrospective outcomes of patients who received autokeratoplasty and contralateral opaque corneas in the donor eye at a tertiary care ophthalmology hospital in Mexico City...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001020

    authors: Perez-Balbuena AL,Ancona-Lezama D,Delgado-Pelayo S,Martinez JD

    更新日期:2017-01-01 00:00:00

  • Primary graft failure: a case control investigation of a purported cluster.

    abstract::Primary graft failure is a rare but major complication of penetrating keratoplasty. An apparent clustering of four cases during a 1-month period led to a review of all 778 keratoplasties performed by nine surgeons at Massachusetts Eye and Ear Infirmary from July 1, 1986 to June 30, 1988. The objectives of this study w...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199407000-00005

    authors: Mead MD,Hyman L,Grimson R,Schein OD

    更新日期:1994-07-01 00:00:00

  • Vortex keratopathy of the corneal graft.

    abstract::We examined the surface epithelium of 30 eyes with color specular microscopy at 3-month intervals 1-18 months following penetrating keratoplasty. At least three examinations were performed on most eyes. We found a vortex keratopathy to be present in 70% of these eyes. In nine eyes, this vortex pattern was present at e...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199103000-00001

    authors: Mathers WD,Lemp MA

    更新日期:1991-03-01 00:00:00

  • Transient band-like keratopathy after treatment for seborrheic dermatitis.

    abstract:PURPOSE:To describe a case of transient band-like keratopathy after ocular exposure to fluocinonide cream and ketoconazole shampoo. DESIGN:Observational case report. RESULTS:A 40-year-old patient presented with acute pain, photophobia, lacrimation, and redness in 1 eye. The symptoms began while using fluocinonide cre...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000138854.33956.3d

    authors: Savage HI,Edgington B,Appel J

    更新日期:2005-04-01 00:00:00

  • Comparison of the effect of amniotic membrane suspension and autologous serum on alkaline corneal epithelial wound healing in the rabbit model.

    abstract:PURPOSE:Alkaline corneal epithelial wound closure rates in rabbit eyes were compared after topical applications of amniotic membrane suspension, autologous serum, or preservative-free artificial tears. METHODS:Thirty rabbits were divided into 3 randomization groups of 10 rabbits each. Central corneal alkali wound was ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318173138a

    authors: Shahriari HA,Tokhmehchi F,Reza M,Hashemi NF

    更新日期:2008-12-01 00:00:00

  • The association of keratoconus with immune disorders.

    abstract:PURPOSE:To evaluate the association between keratoconus (KC) and immune disorders (IDs). METHODS:A retrospective observational case-control study of all the members in the Central District of Clalit Health Services in Israel who were diagnosed to have KC (years 2000-2007; n = 426) and 1704 age- and gender-matched cont...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181cb410b

    authors: Nemet AY,Vinker S,Bahar I,Kaiserman I

    更新日期:2010-11-01 00:00:00

  • Colocalization of hyaluronan and water in rabbit corneas after photorefractive keratectomy by specific staining for hyaluronan and by quantitative microradiography.

    abstract:PURPOSE:Endogenous hyaluronan (HA) has previously been shown to be a part of corneal wound healing after photorefractive keratectomy (PRK). HA is known to bind considerable amounts of water. This study aimed to show whether HA colocalized with water in the wound area after PRK. METHODS:Five New Zealand White rabbits w...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Weber BA,Fagerholm P,Johansson B

    更新日期:1997-09-01 00:00:00

  • Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia.

    abstract:PURPOSE:To investigate the distribution and relative level of expression of the receptor tyrosine kinases, epidermal growth factor receptor (EGFR), ErbB2 and ErbB3, in human ocular surface epithelia. METHODS:Immunofluorescent staining was performed to identify expression of the EGFR, ErbB2 and ErbB3 in the corneal, li...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200101000-00016

    authors: Liu Z,Carvajal M,Carraway CA,Carraway K,Pflugfelder SC

    更新日期:2001-01-01 00:00:00

  • The castroviejo square graft: wound healing after 51 years.

    abstract:PURPOSE:To describe the histopathologic characteristics of a 51-year-old Castroviejo square graft that remained functional for more than 50 years and to describe the wound-healing characteristics over this period of time. METHODS:An 80-year-old woman with a history of keratoconus underwent penetrating keratoplasty wit...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181861cb2

    authors: Graue-Hernández EO,Harocopos G,Bradley JC,Smith ME,Mannis MJ

    更新日期:2009-04-01 00:00:00

  • Determining Factors for Fast Corneal Sensitivity Recovery After Pterygium Excision.

    abstract:PURPOSE:To establish determining factors for fast corneal sensitivity (CS) recovery after pterygium excision. METHODS:Thirty-two eyes of 14 males and 18 females with primary nasal pterygium were recruited. Differences in CS (in the 4 quadrants and the center using a Cochet-Bonnet esthesiometer), pterygium corneal area...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000932

    authors: Julio G,Campos P,Pujol P,Munguia A,Mas-Aixala E

    更新日期:2016-12-01 00:00:00

  • Diabetes and corneal cell densities in humans by in vivo confocal microscopy.

    abstract:PURPOSE:Diabetes is accompanied by an increased autofluorescence of the cornea, probably because of accumulation of advanced glycation end products (AGEs). The pathogenic mechanism is still unknown. This study aimed to quantify differences in corneal cell densities between diabetic patients and healthy controls. METHO...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000224635.49439.d1

    authors: Quadrado MJ,Popper M,Morgado AM,Murta JN,Van Best JA

    更新日期:2006-08-01 00:00:00

  • Corneal endothelial cell damage after lens extraction using the fluid-based system compared to ultrasound phacoemulsification in human cadaver eyes.

    abstract:PURPOSE:To compare the endothelial cell damage after lens removal using a fluid-based system to conventional ultrasound. METHODS:Twenty human cadaver eyes were randomized to undergo phacoemulsification using either a fluid-based system or conventional ultrasound. After surgery, each corneoscleral button was removed, s...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000130184.56514.51

    authors: Sandoval HP,Al Sarraf O,Vroman DT,Solomon KD

    更新日期:2004-10-01 00:00:00

  • Expression of Peroxiredoxin 2 and Vascular Endothelial Growth Factor Receptor 2 in Pterygium.

    abstract:PURPOSE:The expression of peroxiredoxin 2 and vascular endothelial growth factor receptor 2 (VEGFR2) was detected in pterygium to investigate whether they are involved in the pathogenesis or recurrence of pterygium and to evaluate the association between peroxiredoxin 2 and VEGFR2 in pterygium. METHODS:Ten normal bulb...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001213

    authors: Wang Y,Lin J,Chen L,Wang L,Hao P,Han R,Ying M,Li X

    更新日期:2017-07-01 00:00:00

  • Axenfeld's anomaly associated with Down's syndrome.

    abstract::We report a case of a patient with Down's syndrome and keratoconus with acute hydrops who was incidentally noted to have Axenfeld's anomaly. We also review the systemic abnormalities associated with Axenfeld's anomaly and the implications of the diagnosis. To our knowledge, Axenfeld's anomaly has not previously been r...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199203000-00012

    authors: Stokes DW,Parrish CM

    更新日期:1992-03-01 00:00:00

  • Infectious scleritis in Taiwan-a 10-year review in a tertiary-care hospital.

    abstract:PURPOSE:The aim of this study was to describe the clinical features of infectious scleritis with distinct inciting events and to analyze the factors associated with poor visual outcome. METHODS:We retrospectively reviewed the predisposing factors, clinical findings, isolated organisms, complications, and outcomes of p...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000174

    authors: Ho YF,Yeh LK,Tan HY,Chen HC,Chen YF,Lin HC,Chen SY,Hui-Kang D,Hsiao CH

    更新日期:2014-08-01 00:00:00

  • Evaluation of corneal topography with Orbscan II in first-degree relatives of patients with keratoconus.

    abstract:PURPOSE:To evaluate the corneal topographic characteristics of first-degree relatives of patients with keratoconus with corneal topography to determine the incidence of clinical keratoconus and topographic abnormalities. METHODS:Between February and August 2006, Orbscan II analysis was done in 144 eyes of 72 cases who...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318165d110

    authors: Kaya V,Utine CA,Altunsoy M,Oral D,Yilmaz OF

    更新日期:2008-06-01 00:00:00

  • Effect of intravitreal ranibizumab on corneal endothelium in age-related macular degeneration.

    abstract:PURPOSE:To determine the effect of intravitreal injection of ranibizumab on the corneal endothelium in patients with choroidal neovascularization in age-related macular degeneration. METHODS:Observational prospective case series study. Fifty-two eyes of 52 consecutive patients (29 men, 23 women; age range, 61-80 years...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181ca33d2

    authors: Pérez-Rico C,Benítez-Herreros J,Castro-Rebollo M,Gómez-Sangil Y,Germain F,Montes-Mollón MA,Teus MA

    更新日期:2010-08-01 00:00:00

  • Synergistic effects of hyaluronan and fibronectin on epithelial migration in rabbit cornea in vitro.

    abstract:PURPOSE:We investigated the interactions of hyaluronan with extracellular matrix proteins (fibronectin, laminin, and type IV collagen) on corneal epithelial migration by using an organ-culture system of rabbit corneas. METHODS:Rabbit corneal blocks were cultured in the absence or presence of various reagents for a tot...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-199911000-00011

    authors: Nakamura M,Nishida T

    更新日期:1999-11-01 00:00:00

  • Development of the Modified Lenticule Edge Dissection Technique for Small Incision Lenticule Extraction.

    abstract:PURPOSE:To identify and develop an efficient technique to separate the lenticule edge in small incision lenticule extraction (SMILE). METHODS:Four hundred eyes of 400 consecutive patients with myopia assigned to receive SMILE were included in the study. Eyes with poor-quality laser treatment were excluded, and the sec...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001691

    authors: Liu M,Wang H,Lin H,Liu Q

    更新日期:2018-10-01 00:00:00

  • Prevalence of positive microbiology results from donor cornea tissue in different methods of corneal transplantation.

    abstract:PURPOSE:To evaluate the prevalence of positive microbiology results (culture and/or Gram stain) in donor cornea tissue with newer transplant methods and to assess if the results subsequently correlate with higher incidence of clinical infection. METHODS:A retrospective review of the microbiology records of 569 consecu...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182542368

    authors: Garg S,Said B,Farid M,Steinert RF

    更新日期:2013-02-01 00:00:00

  • Topical drug formulations for prolonged corneal anesthesia.

    abstract:PURPOSE:Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ability to delay corneal healing makes them unsuitable for long-term use. In this study, we examined the effect of the site 1 sodium channel blocker tetrodotoxin (TTX) on the duration of cornea...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31828cbfe6

    authors: Wang L,Shankarappa SA,Tong R,Ciolino JB,Tsui JH,Chiang HH,Kohane DS

    更新日期:2013-07-01 00:00:00

  • Alkali Burn of the Ocular Surface Associated With a Commonly Used Antifog Agent for Eyewear: Two Cases and a Review of Previous Reports.

    abstract:PURPOSE:To report 2 cases of ocular chemical burns associated with the use of a swim goggle antifog agent and to review the literature for this and similar antifog products. METHODS:Case reports and systematic review of the medical literature, material safety data, product safety reports, and consumer reviews. RESULT...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000000706

    authors: Welling JD,Pike EC,Mauger TF

    更新日期:2016-02-01 00:00:00

  • Surgical monovision and monovision reversal in LASIK.

    abstract:PURPOSE:This study was designed to assess the success of surgical monovision in presbyopic patients. METHODS:A university refractive surgery center retrospective chart review of 82 patients who elected to undergo surgical monovision with laser in situ keratomileusis (LASIK) between January 2000 and January 2003 was co...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000178722.19317.7b

    authors: Reilly CD,Lee WB,Alvarenga L,Caspar J,Garcia-Ferrer F,Mannis MJ

    更新日期:2006-02-01 00:00:00

  • Effect of cross-linking on corneal thickness in patients with corneal edema.

    abstract:PURPOSE:To investigate the pachymetric changes of collagen cross-linking in corneas with edema because of endothelial dysfunction. METHODS:Interventional case series included 25 eyes of 25 consecutive patients with corneal edema for at least 4 months related to Fuchs endothelial dystrophy, corneal graft failure, and p...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181c296c2

    authors: Cordeiro Barbosa MM,Barbosa JB Jr,Hirai FE,Hofling-Lima AL

    更新日期:2010-06-01 00:00:00

  • Combined Excimer Laser Photoablation and Amniotic Membrane Overlay for Relief of Symptomatic Discomfort in Gelatinous Drop-like Corneal Dystrophy.

    abstract:PURPOSE:To describe the efficacy of combined excimer laser photoablation and amniotic overlay membrane in the relief of symptomatic discomfort in a 17-year-old patient who had gelatinous drop-like corneal dystrophy. METHODS:The best-corrected visual acuity (BCVA) was measured with Snellen letters. Slit-lamp examinatio...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000526

    authors: Alex AF,Eter N,Uhlig CE

    更新日期:2015-10-01 00:00:00

  • Keratoconus, myopia, and personality.

    abstract:PURPOSE:To determine whether there is an association between keratoconus and personality attributes including obsessionality traits. METHODS:We reviewed all charts in the regional contact lens clinic, identifying patients who had attended from January 1997 to January 2000 and had a diagnosis of either keratoconus or m...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/00003226-200304000-00011

    authors: Cooke CA,Cooper C,Dowds E,Frazer DG,Jackson AJ

    更新日期:2003-04-01 00:00:00

  • White-to-white corneal diameter in the Tehran Eye Study.

    abstract:PURPOSE:To determine the mean corneal diameter and its determinants in the population of Tehran. METHODS:From the Tehran Eye Study participants who were sampled through a stratified cluster approach, those in the first 4 municipality districts of Tehran were selected, and after applying the inclusion and exclusion cri...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0b013e3181a9d0a9

    authors: Hashemi H,KhabazKhoob M,Yazdani K,Mehravaran S,Mohammad K,Fotouhi A

    更新日期:2010-01-01 00:00:00