:Keratoconus is a bilateral disorder of corneal shape which may be sporadic or genetically determined. Early corneal thinning suggests that a functional loss of structural elements is a primary event in the disease. Tensile strength of the cornea is reduced and is expressed by signs of rupture and scarring in Bowman's layer, scarring in the substantia propria, and rupture of Descemet's membrane. The overall stretching of the cornea results in an increase in curvature while an increased area of the corneal surfaces probably determines the onset and form of Fleischer's ring and the occurrence of endothelial polymegathism. Biochemical studies have shown an increase in collagenolysis and of reduceable collagen cross-links, but there is inconsistent evidence of altered solubility or of hydroxyproline or proteoglycan content. Of recent interest is the characterization of proteoglycan bridges along and between corneal collagen fibrils in keratoconus and the apparent loss of keratan sulphate demonstrated by electron-histochemical and x-ray diffraction techniques. The manner in which this could interfere with corneal strength is discussed.






Bron AJ


Has Abstract


1988-01-01 00:00:00














  • The economic burden of dry eye disease in the United States: a decision tree analysis.

    abstract:PURPOSE:The aim of this study was to estimate both the direct and indirect annual cost of managing dry eye disease (DED) in the United States from a societal and a payer's perspective. METHODS:A decision analytic model was developed to estimate the annual cost for managing a cohort of patients with dry eye with differ...


    pub_type: 杂志文章


    authors: Yu J,Asche CV,Fairchild CJ

    更新日期:2011-04-01 00:00:00

  • Clinical, histopathologic, and ultrastructural characteristics of BIGH3(TGFBI) amyloid corneal dystrophies are supportive of the existence of a new type of LCD: the LCDi.

    abstract:PURPOSE:To assess the morphologic differences of three types of lattice corneal dystrophies (LCDs) from histologic, immunohistochemical, and ultrastructural studies. METHODS:Corneas from three patients, one LCD1, one His626Arg-LCD, and one LCD3A were processed for Congo red, betaig-h3(541-564) antibodies immunostainin...


    pub_type: 杂志文章


    authors: Schmitt-Bernard CF,Schneider C,Argilés A

    更新日期:2002-07-01 00:00:00

  • Subtenon Bupivacaine for Postoperative Pain in Patients Undergoing Pterygium Excision: A Double-Blinded Randomized Control Trial.

    abstract:PURPOSE:Patients undergoing primary pterygium excision with autologous conjunctival autograft and human tissue adhesive in New Zealand, currently receive subconjunctival anesthesia with oral postoperative analgesia for pain. Our aim was to investigate the potential added benefit of intraoperative subtenon bupivacaine t...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Bhikoo R,Hughes K,Vather R,Murphy C

    更新日期:2019-08-01 00:00:00

  • Risk factors for graft failure after penetrating keratoplasty: 5-year follow-up from the corneal transplant epidemiological study.

    abstract:PURPOSE:To evaluate corneal graft survival over a 5-year period and to investigate whether factors related to the donor, eye bank practices, the recipient, surgery, and postoperative course influenced the outcome. METHODS:Nine hundred ninety-eight patients were randomly selected and monitored in the subsequent 3 years...


    pub_type: 杂志文章


    authors: Fasolo A,Capuzzo C,Fornea M,Franch A,Birattari F,Carito G,Cucco F,Prosdocimo G,Sala M,Delle Noci N,Primavera V,Frigo AC,Grigoletto F,Ponzin D,CORTES Study Group.

    更新日期:2011-12-01 00:00:00

  • Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia.

    abstract:PURPOSE:To investigate the distribution and relative level of expression of the receptor tyrosine kinases, epidermal growth factor receptor (EGFR), ErbB2 and ErbB3, in human ocular surface epithelia. METHODS:Immunofluorescent staining was performed to identify expression of the EGFR, ErbB2 and ErbB3 in the corneal, li...


    pub_type: 杂志文章


    authors: Liu Z,Carvajal M,Carraway CA,Carraway K,Pflugfelder SC

    更新日期:2001-01-01 00:00:00

  • Association Between Season, Temperature and Causative Organism in Microbial Keratitis in the UK.

    abstract:PURPOSE:Microbial keratitis (MK) is a major cause of corneal blindness worldwide. Variations in season and temperature can affect MK incidence due to specific causative organisms; however, few studies have examined these factors in the UK. METHODS:Retrospective review of all corneal scrapes from patients with MK prese...


    pub_type: 杂志文章,多中心研究


    authors: Walkden A,Fullwood C,Tan SZ,Au L,Armstrong M,Brahma AK,Chidambaram JD,Carley F

    更新日期:2018-12-01 00:00:00

  • Measurement of Quality of Life in Keratoconus.

    abstract:PURPOSE:To identify and assess the quality of questionnaires used to measure quality of life in keratoconus and guide selection of the most appropriate questionnaire for evaluating the impact of keratoconus. METHODS:A literature search was carried out in Scopus, Web of Science, PubMed, MEDLINE, Cochrane, and PsycINFO ...


    pub_type: 杂志文章,评审


    authors: Kandel H,Pesudovs K,Watson SL

    更新日期:2020-03-01 00:00:00

  • Bacterial infection of a neurotrophic cornea in an immunocompromised subject.

    abstract::The following is a case report of a 61-year-old woman with a 10-year history of pemphigus vulgaris, successfully treated with steroids and cytotoxic agents. The patient developed severe herpes zoster ophthalmicus, complicated by a staph-indolent corneal ulcer. This case illustrates several of the many unfortunate opht...


    pub_type: 杂志文章


    authors: Webb RM,Duke MA

    更新日期:1985-01-01 00:00:00

  • Topical autologous platelet-rich plasma eyedrops for acute corneal chemical injury.

    abstract:PURPOSE:Evaluation of efficacy of autologous platelet-rich plasma eyedrops as an adjunct to standard medical treatment as compared with standard medical treatment with artificial tears in acute ocular chemical injury. METHODS:Twenty eyes with grade III to grade V chemical injury were randomly assigned to 2 groups. Gro...


    pub_type: 杂志文章,随机对照试验


    authors: Panda A,Jain M,Vanathi M,Velpandian T,Khokhar S,Dada T

    更新日期:2012-09-01 00:00:00

  • Diagnosis of subclinical keratoconus using posterior elevation measured with 2 different methods.

    abstract:PURPOSE:To compare the efficacy of posterior corneal elevation, measured by 2 methods, in discriminating subclinical keratoconus from normal corneas. METHODS:In 30 consecutive patients with subclinical keratoconus, and 37 candidates for refractive surgery, posterior corneal elevation was measured using Pentacam's rota...


    pub_type: 杂志文章


    authors: de Sanctis U,Aragno V,Dalmasso P,Brusasco L,Grignolo F

    更新日期:2013-07-01 00:00:00

  • On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome.

    abstract::The iridocorneal endothelial (ICE) syndrome is potentially a blinding condition as a result of glaucoma and/or corneal decompensation. The basic pathology seems to be in the corneal endothelium, which many studies confirm takes on a characteristic slit lamp appearance of hammered silver and image reversal with the spe...


    pub_type: 杂志文章


    authors: Sherrard ES,Frangoulis MA,Muir MG

    更新日期:1991-05-01 00:00:00

  • Ocular Manifestations of Chordin-like 1 Knockout Mice.

    abstract:PURPOSE:In humans, loss-of-function mutations in the gene encoding Chordin-like 1 (CHRDL1) cause X-linked megalocornea (MGC1), characterized by bilateral corneal enlargement, decreased corneal thickness, and increased anterior chamber depth (ACD). We sought to determine whether Chrdl1 knockout (KO) mice would recapitul...


    pub_type: 杂志文章


    authors: Chen D,Liu Y,Shu G,Chen C,Sullivan DA,Kam WR,Hann S,Fowler M,Warman ML

    更新日期:2020-09-01 00:00:00

  • Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery.

    abstract:PURPOSE:To study dry eye and analyze pathogenic factors in patients after cataract surgery. METHODS:A total of 37 patients (50 eyes) were studied by using a 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ25) and Ocular Surface Disease Index (OSDI) 3 days before and 1 week, 1 month, and 3 months a...


    pub_type: 杂志文章


    authors: Li XM,Hu L,Hu J,Wang W

    更新日期:2007-10-01 00:00:00

  • Cataract extraction after implantation of a type I Boston keratoprosthesis.

    abstract:PURPOSE:To describe cataract extraction and intraocular lens placement in a patient with an existing Type I Boston keratoprosthesis. METHODS:Case report to describe the surgical technique used to remove a cataract that developed after Boston keratoprosthesis placement. RESULTS:Extracapsular cataract extraction by usi...


    pub_type: 杂志文章


    authors: Harissi-Dagher M,Colby KA

    更新日期:2008-02-01 00:00:00

  • Safety of Intracameral Injection of Minimal Bactericidal Concentration of Povidone Iodine on the Corneal Endothelium in a Rabbit Model.

    abstract:PURPOSE:To investigate the safety of intracameral injection of minimum bactericidal concentration (MBC) of povidone iodine (PI) on the corneal endothelium in a rabbit model as a proposed method of prophylaxis against postoperative endophthalmitis. METHODS:We included 32 New Zealand white rabbits in the study. Twenty-f...


    pub_type: 杂志文章


    authors: ElKitkat RS,Ebeid WM,Habib EK,Shoukry Y

    更新日期:2016-01-01 00:00:00

  • Changes in corneal autofluorescence and corneal epithelial barrier function with aging.

    abstract::Corneal epithelial permeability studies using fluorophotometers were performed on 90 eyes of 51 normal subjects. After recording the autofluorescence of the cornea (AFC) and of the lens (AFL), we applied 20 microliters of 2% sodium fluorescein to the conjunctival sac. The corneal fluorescence 45 min later (F45), which...


    pub_type: 杂志文章


    authors: Chang SW,Hu FR

    更新日期:1993-11-01 00:00:00

  • The effect of the fourth-generation fluoroquinolones on corneal reepithelialization after penetrating keratoplasty.

    abstract:PURPOSE:To compare the effects of topical moxifloxacin and gatifloxacin on corneal reepithelialization after penetrating keratoplasty. METHODS:In this single-center, open-label, prospective study, 46 consecutive patients requiring penetrating keratoplasty were alternately assigned to receive either postoperative moxif...


    pub_type: 临床试验,杂志文章


    authors: Moshirfar M,Marx DP,Kumar R

    更新日期:2005-10-01 00:00:00

  • Implantable Collamer Lens implantation and limbal relaxing incisions for the correction of hyperopic astigmatism after laser in situ keratomileusis.

    abstract:PURPOSE:To report on a patient in whom hyperopic Implantable Collamer Lenses (ICL, STAAR Surgical, Nidau, Switzerland) and limbal relaxing incisions have been beneficial for the correction of hyperopic astigmatism after laser in situ keratomileusis (LASIK). METHODS:The 48-year-old man had undergone LASIK to correct hi...


    pub_type: 杂志文章


    authors: Kamiya K,Shimizu K,Komatsu M

    更新日期:2010-01-01 00:00:00

  • Efficacy of plasma rich in growth factors for the treatment of dry eye.

    abstract:PURPOSE:To evaluate the efficacy of plasma rich in growth factors (PRGF) for the treatment of moderate/severe dry eye. METHODS:PRGF treatment was administered to 16 patients who had moderate/severe dry eye diagnosed and who had not responded previously to other standard treatments. We quantified several growth factors...


    pub_type: 杂志文章


    authors: López-Plandolit S,Morales MC,Freire V,Grau AE,Durán JA

    更新日期:2011-12-01 00:00:00

  • Corneal decompensation in mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. A clinicopathologic case report.

    abstract::The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observed and possibly implicate this organelle in the pathogenesis of corne...


    pub_type: 杂志文章


    authors: Chang TS,Johns DR,Stark WJ,Drachman DB,Green WR

    更新日期:1994-05-01 00:00:00

  • Is your office safe? Yes.

    abstract::Contact lens (CL) fitting carries the risk of transmitting infectious agents, including adenovirus and Pseudomonas. Therefore, a number of precautions must be observed to ensure safety in the office. Paramount among these is hand washing, both immediately after contact with a patient's eyes and again between patients....


    pub_type: 杂志文章,评审


    authors: Cohen EJ

    更新日期:1990-01-01 00:00:00

  • Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy).

    abstract:PURPOSE:Subepithelial amyloidosis of the cornea, or gelatinous drop-like corneal dystrophy (GDD), is a severe form of corneal stromal amyloidosis predominantly found in the Japanese population. GDD causes severe visual disturbances with irritating symptoms, and keratoplasty is inevitably complicated by early recurrence...


    pub_type: 杂志文章


    authors: Shimazaki J,Shimmura S,Tsubota K

    更新日期:2002-03-01 00:00:00

  • Bilateral iridocorneal endothelial syndrome: case report and review of the literature.

    abstract::We present the case of a 47-year-old woman with bilateral iridocorneal endothelial syndrome. The iridocorneal endothelial syndrome has heretofore been considered a unilateral disorder. However, a review of the literature and examination of the patient presented in this report indicate that bilateral occurrence of the ...


    pub_type: 杂志文章,评审


    authors: Hemady RK,Patel A,Blum S,Nirankari VS

    更新日期:1994-07-01 00:00:00

  • Sclerocorneal Intrastromal Lamellar Keratoplasty for Pellucid Marginal Degeneration.

    abstract:PURPOSE:Surgical management of advanced pellucid marginal degeneration is challenging. To correct both corneal thinning and induced corneal astigmatism, we propose a modified intrastromal lamellar sclero-keratoplasty. METHODS:Corneal thinning was mapped using perioperative optical coherence tomography (OCT). Then thro...


    pub_type: 杂志文章


    authors: Guindolet D,Petrovic A,Doan S,Cochereau I,Gabison EE

    更新日期:2016-06-01 00:00:00

  • Treatment of advanced acanthamoeba keratitis with deep lamellar keratectomy and conjunctival flap.

    abstract:PURPOSE:To describe whether deep lamellar keratectomy with a conjunctival flap is effective for the treatment of Acanthamoeba keratitis. METHODS:Two patients (three eyes) had at least a 4-week history of painful keratitis misdiagnosed as herpetic keratitis and bacterial keratitis. Both patients were started on multipl...


    pub_type: 杂志文章


    authors: Cremona G,Carrasco MA,Tytiun A,Cosentino MJ

    更新日期:2002-10-01 00:00:00

  • Comparison of Tono-Pen AVIA intraocular pressure measurements performed at limbus with central corneal Tono-Pen AVIA intraocular pressure.

    abstract:PURPOSE:To compare Tono-Pen AVIA (TPA) intraocular pressure (IOP) measurements performed at the limbus with central corneal Tono-Pen AVIA (TPA) intraocular pressure. METHODS:Fifty-one patients attending our outpatient department with a best corrected visual acuity of ≥ 20/40, no corneal disease, and no astigmatism gre...


    pub_type: 杂志文章


    authors: Sharma R,Majumdar S,Sobti A,Arora T,Agarwal T,Dada T

    更新日期:2013-07-01 00:00:00

  • Corneal pathology in microphthalmia with linear skin defects syndrome.

    abstract:PURPOSE:To describe the histopathology of the cornea in microphthalmia with linear streaks (MLS) syndrome. METHODS:Two patients with MLS syndrome underwent penetrating keratoplasty. This study describes the histopathology and investigates immunophenotype of the corneal extracellular matrix by using keratan sulfate and...


    pub_type: 杂志文章


    authors: Kapur R,Tu EY,Toyran S,Shah P,Vangveeravong S,Lloyd WC 3rd,Edward DP

    更新日期:2008-07-01 00:00:00

  • What causes keratoconus?

    abstract:PURPOSE:The etiology of keratoconus has been the subject of numerous studies. Here, we review the body of literature that attempts to determine what causes keratoconus. METHODS:A review of the published literature was performed to evaluate the possible causes of keratoconus and how the different etiologies may play a ...


    pub_type: 杂志文章,评审


    authors: Sugar J,Macsai MS

    更新日期:2012-06-01 00:00:00

  • Biomicroscopic and histopathologic observations after corneal laser photocoagulation in a rabbit model of corneal neovascularization.

    abstract::Corneal neovascularization complicates many anterior segment diseases. Corneal laser photocoagulation using yellow light (577 nm) has been shown to reduce corneal neovascularization. No histopathologic studies of the effects of this treatment on the eye have been reported, however. Target (cornea) and nontarget (iris,...


    pub_type: 杂志文章


    authors: Hemady RK,Baer JC,Foster CS

    更新日期:1993-05-01 00:00:00

  • In vitro amoebicidal activity of propamidine and pentamidine isethionate against Acanthamoeba species and toxicity to corneal tissues.

    abstract::Effective chemotherapy for Acanthamoeba keratitis has been hampered because of the marked resistance of the parasites to a variety of antimicrobial agents. In view of the fact that topical Brolene (propamidine isethionate) and neosporin are currently considered to be the medical treatment of choice in Europe, we sough...


    pub_type: 杂志文章


    authors: Alizadeh H,Silvany RE,Meyer DR,Dougherty JM,McCulley JP

    更新日期:1997-01-01 00:00:00