Abstract:
PURPOSE:Subepithelial amyloidosis of the cornea, or gelatinous drop-like corneal dystrophy (GDD), is a severe form of corneal stromal amyloidosis predominantly found in the Japanese population. GDD causes severe visual disturbances with irritating symptoms, and keratoplasty is inevitably complicated by early recurrence. This study was conducted to evaluate the efficacy of limbal stem cell transplantation (LSCT) for the treatment of GDD. METHODS:Nine consecutive eyes of seven patients with GDD were treated with LSCT. Limbal grafts were obtained from cadaver eyes. All eyes underwent lamellar or penetrating keratoplasty simultaneously with LSCT. Intensive epithelial management and immunosuppression therapy was performed. RESULTS:With a mean observation period of 4 years, eight (88.9%) of nine eyes did not show any signs of recurrence. Five grafts remained clear, and seven eyes had an improvement in vision. Glaucoma and rejection were observed in five and three eyes, respectively, and two eyes with glaucoma required surgical intervention. CONCLUSIONS:Limbal stem cell transplantation is effective for the prevention of recurrence in GDD. Control of intraocular pressure and rejection are the keys to long-term maintenance of clear grafts.
journal_name
Corneajournal_title
Corneaauthors
Shimazaki J,Shimmura S,Tsubota Kdoi
10.1097/00003226-200203000-00010subject
Has Abstractpub_date
2002-03-01 00:00:00pages
177-80issue
2eissn
0277-3740issn
1536-4798journal_volume
21pub_type
杂志文章相关文献
CORNEA文献大全abstract:PURPOSE:This report describes a case of multiple myeloma that presented as bilateral eyelid ecchymoses and corneal crystals in the absence of widespread signs of systemic disease. METHODS:A 55-year-old man was found to have the sudden appearance of bilateral eyelid ecchymoses after he flexed 90 degrees at the waist. O...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000154381.13237.a3
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of systemic or topical administration of cyclosporin A (CsA) after limbal transplantation of stem cell allografts in rabbits. METHODS:Thirty-six rabbits underwent corneal epithelial debridement and limbal ablation to induce ocular surface disease and were then treated by limbal allo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199907000-00012
更新日期:1999-07-01 00:00:00
abstract::Two patients developed graft versus host disease (GvHD) following allogeneic bone marrow transplantation for leukemia. One patient developed acute GvHD 12 days after transplantation, and the second developed chronic GvHD 100 days after transplantation. Tear analysis and conjunctival impression cytology were performed....
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To determine the effect of mitomycin C (MMC) on the corneal endothelium after primary pterygium surgery. METHODS:This prospective, interventional, nonrandomized, observer-masked study included 46 consecutive patients (51 eyes) with primary pterygium. The bare sclera technique with 1-minute application of 0.02%...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181a3c548
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:To examine the effect of successful repositioning/rebubbling of the graft on endothelial cell counts (ECCs) in eyes after Descemet stripping automated endothelial keratoplasty. METHODS:This retrospective study reviewed the outcomes of 58 eyes that underwent Descemet stripping automated endothelial keratoplasty...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181cb40f6
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:We aimed to minimize the effect of ocular microfluctuations during videokeratoscopy to improve the qualitative and quantitative analysis of corneal topography. METHODS:A technique was developed to measure the tilt, displacement, and cyclotorsion in multiple videokeratographs from the same cornea. This informat...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200205000-00003
更新日期:2002-05-01 00:00:00
abstract::The present study describes biochemical and morphological differences of pseudophakic bullous keratopathy (PBK) corneas as compared with normal corneas. At the ultrastructural level, all PBK corneas studied had abnormal fibrillar material posterior to the Descemet's membrane. In addition, two of the six PBK buttons ha...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:PURPOSE:To describe the clinical signs of Descemet membrane (DM) detachment due to forceps-related birth injury and its subsequent management using optical coherence tomography. METHODS:Case report. RESULTS:A 3-day-old term infant presented with left eye corneal clouding and a definitive history of traumatic forceps-...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001147
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:To characterize the clinical presentation of limbal stem cell deficiency (LSCD) associated with glaucoma surgeries. METHODS:This is a retrospective cross-sectional study of patients with LSCD and glaucoma who presented to the Stein Eye Institute at the University of California, Los Angeles, between 2009 and 20...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002249
更新日期:2020-05-01 00:00:00
abstract::Previous studies suggest the existence of two separate and distinct mechanisms of endothelial wound healing (i.e., cell migration and cell spreading), which may be controlled by unique, injury-dependent, wound-related factors. The purpose of our study was to evaluate potential biologic mediators regulating healing of ...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:PURPOSE:To introduce an improved technique of pterygium surgery and to compare postoperative results between this technique and previous techniques. METHODS:In a retrospective survey, the records of 216 consecutive eyes with primary pterygium that underwent surgery by three different techniques were reviewed. The new ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200110000-00006
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To report clinical, in vivo confocal microscopy and ex vivo histopathologic findings of Salzmann nodular degeneration (SND). METHODS:A 48-year-old woman with symptoms of ocular irritation and decreased visual acuity caused by SND in both eyes was treated by corneal scraping and phototherapeutic keratectomy (PT...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000214215.75496.a5
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To identify changing trends in indications for penetrating keratoplasty and associated surgical procedures. METHODS:Review of charts from all patients who underwent penetrating keratoplasty at Wills Eye Hospital from January 1, 1989 through December 31, 1995. RESULTS:A total of 2,442 corneal transplants were ...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of transepithelial cross-linking (CXL) in keratoconic eyes after Intacs implantation. PATIENTS AND METHODS:Twenty-five eyes of 17 patients with bilateral keratoconus underwent Intacs implantation with subsequent cross-linking (CXL) treatment. Inclusion criteria were absence of corneal ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318191b83d
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To report a case of keratitis and corneal melt after conductive keratoplasty (CK) enhancement. METHOD:Case report. RESULTS:A 52-year-old woman with emmetropic presbyopia had undergone previous CK for monovision and underwent CK enhancement 4 years later. Postoperatively, she was managed with ketorolac trometh...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181ef6ec7
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:This study was designed to determine how patients with pellucid marginal corneal degeneration (PMCD) are managed in a tertiary corneal practice. METHODS:A retrospective chart review of 45 patients with PMCD from a corneal referral practice was performed. Information collected from the medical records included ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000153555.82278.5b
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:To evaluate the results of a combined approach of cicatrix lysis, intraoperative mitomycin C (MMC) application, oral mucosal transplantation (OMT), and amniotic membrane transplantation (AMT) for surgery of severe symblepharon. METHODS:This prospective study included 32 eyes with severe symblepharon in which a...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318247983d
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To report a case of delayed bilateral Descemet's detachment with spontaneous resolution in one eye following successful treatment of the fellow eye. METHOD:Case report. RESULTS:A 78-year-old male who underwent uncomplicated bilateral cataract extraction with phacoemulsification developed delayed bilateral Des...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318197eef1
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:To study dry eye and analyze pathogenic factors in patients after cataract surgery. METHODS:A total of 37 patients (50 eyes) were studied by using a 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ25) and Ocular Surface Disease Index (OSDI) 3 days before and 1 week, 1 month, and 3 months a...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31812f67ca
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure (IOP) with three different instruments, Goldmann applanation tonometer (GAT), noncontact tonometer, and Tono-Pen after photorefractive keratectomy (PRK) for myopia. METHODS:A prospective case series study to evaluate preoperative and postoperative IOP measurements of 149 ey...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200101000-00006
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To present four cases of localized corneal amyloidosis secondary to trichiasis and to discuss its pathogenesis. METHODS:Medical and pathologic records of four patients with corneal amyloidosis secondary to trichiasis were reviewed retrospectively. Two patients underwent trichiasis surgery and then lamellar ker...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/00003226-200307000-00020
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:To document the relationship of iris cavernous hemangiomas with multiorgan hemangiomas in a child. METHODS:A 7-year-old girl with kidney hemangiomas, brain hemangiomas, and skin hemangiomas developed blurred vision and darkening of the right iris. She had undergone 6 previous brain surgeries and multiple revis...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3180303b46
更新日期:2007-05-01 00:00:00
abstract::Two containers ("Iowa" and "Virginia") commonly used for transporting donor corneas, and various packing methods were evaluated for constancy of temperature maintenance. The larger Iowa container was found to be superior for extended storage. Packing methods that allowed the vials (containing McCarey-Kaufman medium) t...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::This study attempts to measure the quantitative contribution of major chemical fractions of the whole bovine cornea to ultraviolet (UV) absorption between 240 and 300 nm, with special attention to the biologically significant range of 290-300 nm. The cornea was divided into water-insoluble, nonprotein small water-solu...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199505000-00007
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:To compare the rate of epithelial healing of corneal erosion in an animal model with 2 commercial formulations of fourth-generation fluoroquinolones: 0.3% gatifloxacin and 0.5% moxifloxacin. METHODS:Corneal erosions, 6 mm in diameter, were created in 28 rabbit eyes. The rabbits were randomized to receive topic...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318041f08e
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the antiangiogenic activity of AU6, a novel 6-amino acid peptide derived from Kringle V of human apolipoprotein (a). METHODS:RF/6A rhesus macaque choroid endothelial cells were used for in vitro studies. MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sul...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000032
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:To evaluate the treatment with topical 1% cyclosporine A (CsA) in patients with subepithelial corneal infiltrates (SEIs). METHODS:We retrospectively reviewed the records of 9 patients (12 eyes) before and after the treatment with CsA 1% eyedrops twice daily. All patients had been treated with topical corticost...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181c33034
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:In our report, we present a suspected case of donor-derived Acanthamoeba keratitis after deep anterior lamellar keratoplasty. To the authors' knowledge, there have been no confirmed cases of Acanthamoeba keratitis transmission through corneal transplantation. METHODS:Deep anterior lamellar keratoplasty was per...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002517
更新日期:2020-09-16 00:00:00
abstract:PURPOSE:To examine the validity of the observations made by specialist corneal surgeons that there seems to be an absence or loss of older patients with keratoconus (KC). METHODS:Using a PubMed search and key words such as KC, epidemiology, mortality, mitral valve prolapse, atopy, and asthma, the literature related to...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e31825aba0e
更新日期:2013-04-01 00:00:00
abstract::Posterior polymorphous corneal dystrophy (PPD) is a rare bilateral, autosomal-dominant disease. The presence of the epitheliumlike endothelium and the thickening of Descemet's membrane by the posterior collagenous layer (PCL) has been reported in the majority of published cases. Reepithelialization of the posterior co...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00