Bilateral eyelid ecchymoses and corneal crystals: an unusual presentation of multiple myeloma.

Abstract:

PURPOSE:This report describes a case of multiple myeloma that presented as bilateral eyelid ecchymoses and corneal crystals in the absence of widespread signs of systemic disease. METHODS:A 55-year-old man was found to have the sudden appearance of bilateral eyelid ecchymoses after he flexed 90 degrees at the waist. On examination, amyloid deposition was found in the area of the lid ecchymoses, and corneal crystals were dispersed centrally and peripherally throughout all levels of the cornea on slit lamp examination. Urinalysis revealed Bence-Jones proteins and free kappa light chains. Bone marrow plasmacytosis suggested multiple myeloma. RESULT:Ophthalmic and systemic findings led to a workup, which resulted in a diagnosis of multiple myeloma. CONCLUSION:Our case demonstrates that multiple myeloma may present clinically with ophthalmic findings such as bilateral eyelid ecchymoses and corneal crystals in the absence of widespread signs of disease. The ocular findings may be the first manifestations of disease. Therefore, a systemic workup should be performed on patients with this presentation, including urine and bone marrow analyses.

journal_name

Cornea

journal_title

Cornea

authors

Goldstein DA,Schteingart MT,Birnbaum AD,Tessler HH

doi

10.1097/01.ico.0000154381.13237.a3

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

757-8

issue

6

eissn

0277-3740

issn

1536-4798

pii

00003226-200508000-00021

journal_volume

24

pub_type

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