Abstract:
PURPOSE:This report describes a case of multiple myeloma that presented as bilateral eyelid ecchymoses and corneal crystals in the absence of widespread signs of systemic disease. METHODS:A 55-year-old man was found to have the sudden appearance of bilateral eyelid ecchymoses after he flexed 90 degrees at the waist. On examination, amyloid deposition was found in the area of the lid ecchymoses, and corneal crystals were dispersed centrally and peripherally throughout all levels of the cornea on slit lamp examination. Urinalysis revealed Bence-Jones proteins and free kappa light chains. Bone marrow plasmacytosis suggested multiple myeloma. RESULT:Ophthalmic and systemic findings led to a workup, which resulted in a diagnosis of multiple myeloma. CONCLUSION:Our case demonstrates that multiple myeloma may present clinically with ophthalmic findings such as bilateral eyelid ecchymoses and corneal crystals in the absence of widespread signs of disease. The ocular findings may be the first manifestations of disease. Therefore, a systemic workup should be performed on patients with this presentation, including urine and bone marrow analyses.
journal_name
Corneajournal_title
Corneaauthors
Goldstein DA,Schteingart MT,Birnbaum AD,Tessler HHdoi
10.1097/01.ico.0000154381.13237.a3subject
Has Abstractpub_date
2005-08-01 00:00:00pages
757-8issue
6eissn
0277-3740issn
1536-4798pii
00003226-200508000-00021journal_volume
24pub_type
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