Abstract:
PURPOSE:The study aimed to determine whether detectable concentrations of colchicine are present in the tear fluid of treated patients with familial Mediterranean fever (FMF) and thus demonstrate a possible route by which colchicine reaches the corneal surface. METHODS:Tear fluid samples (50-100 microL) were collected from eight FMF patients on long-term colchicine treatment. Colchicine tear fluid concentrations were determined in all patients by radioimmunoassay using goat anticolchicine antibodies and [3H]colchicine (Dupont, Wilmington, DE). RESULTS:Detectable concentrations of colchicine, with no apparent effect on the ocular surface, were found in all tear fluid samples (median, 0.46 ng/mL; range, 0.24-1.05 ng/mL). CONCLUSIONS:This study provides evidence of the route by which colchicine, given systemically, reaches the corneal surface and thus gives credence to the possible inhibitory effect of this drug on corneal wound healing in the cases described in the literature.
journal_name
Corneajournal_title
Corneaauthors
Leibovitch I,Alster Y,Scherrmann JM,Azmon B,Barequet IS,Livneh A,O'Brien TP,Lazar M,Loewenstein Adoi
10.1097/00003226-200304000-00001subject
Has Abstractpub_date
2003-04-01 00:00:00pages
191-3issue
3eissn
0277-3740issn
1536-4798journal_volume
22pub_type
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