Effects of lacrimal occlusion with collagen and silicone plugs on patients with conjunctivitis associated with dry eye.


PURPOSE:To determine whether canalicular occlusion with collagen and silicone plugs reduces the severity of symptoms in patients with conjunctivitis secondary to dry eye. METHODS:This was a prospective, randomized, double-masked study conducted at a single center in Mexico, in which 61 patients with dry eye/conjunctivitis were assigned to progressive lacrimal occlusion with collagen and silicone plugs or a sham procedural group. Outcome variables included total and individual dry eye and conjunctivitis symptom scores, moisturizing agent usage, best-corrected visual acuity, ocular comfort level, visual performance, corneal/conjunctival fluorescein staining, and incidence of adverse events. RESULTS:Total dry eye and conjunctival symptom scores were reduced by 43.7 and 33.7%, respectively 2 weeks after occlusion of all four lacrimal canaliculi with collagen plugs, increasing to 77.4 and 72.1% 2 weeks later following superior canalicular occlusion of both eyes with silicone plugs and inferior placement of collagen plugs. At the 8-week visit (4 weeks after silicone plug implantation of the inferior canaliculi of both eyes), the reduction in total dry eye and conjunctival symptom scores further increased to 94.2 and 93.0%, respectively, accompanied by a marked decline in each of the seven individual symptom scores (dryness, watery eyes, itching, burning, foreign body, fluctuating vision, and light sensitivity). In concert with these changes, moisturizing agent usage and corneal/conjunctival fluorescein staining decreased in a progressive fashion over the 8-week study period, and best-corrected visual acuity, ocular comfort, and visual performance improved in the absence of any treatment-related adverse events except for one case of epiphora. The response of patients to lacrimal occlusion can be sharply contrasted with the sham procedure group, which remained relatively unchanged from baseline at each of the study visits. CONCLUSIONS:Progressive lacrimal occlusion with collagen and silicone plugs was of clinical benefit to patients with dry eye and conjunctivitis.






Nava-Castaneda A,Tovilla-Canales JL,Rodriguez L,Tovilla Y Pomar JL,Jones CE




Has Abstract


2003-01-01 00:00:00














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    pub_type: 杂志文章


    authors: Tunc M,Yildirim U,Yuksel H,Cheng X,Humayun M,Ratner B

    更新日期:2009-08-01 00:00:00

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    abstract:PURPOSE:Young children are prone to develop amblyopia after penetrating injury. We sought to evaluate the management of penetrating corneal injury without intraocular foreign body (IOFB) in children


    pub_type: 杂志文章


    authors: Segev F,Assia EI,Harizman N,Barequet I,Almer Z,Raz J,Moisseiev J

    更新日期:2007-04-01 00:00:00

  • Treatment of advanced acanthamoeba keratitis with deep lamellar keratectomy and conjunctival flap.

    abstract:PURPOSE:To describe whether deep lamellar keratectomy with a conjunctival flap is effective for the treatment of Acanthamoeba keratitis. METHODS:Two patients (three eyes) had at least a 4-week history of painful keratitis misdiagnosed as herpetic keratitis and bacterial keratitis. Both patients were started on multipl...


    pub_type: 杂志文章


    authors: Cremona G,Carrasco MA,Tytiun A,Cosentino MJ

    更新日期:2002-10-01 00:00:00

  • Optical coherence tomography anatomy of the corneal endothelial transplantation wound.

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    pub_type: 杂志文章


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    更新日期:2010-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Gumus K

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    authors: Maeno A,Naor J,Lee HM,Hunter WS,Rootman DS

    更新日期:2000-01-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2009-09-01 00:00:00

  • Altered conjunctival response after contact lens-related corneal inflammation.

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    authors: Stapleton F,Ramachandran L,Sweeney DF,Rao G,Holden BA

    更新日期:2003-07-01 00:00:00

  • Heterozygous Avellino corneal dystrophy 9 years after photorefractive keratectomy: natural or laser-induced accelerated course?

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    authors: Park SH,Mok J,Joo CK,Kim MS

    更新日期:2009-05-01 00:00:00

  • Scanning electron microscopic study: the effect of balanced salt solution on rabbit corneal endothelium.

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    pub_type: 杂志文章


    authors: Bonafonte S,Aguirre Vila-Coro A,Aguirre Vila-Coro A

    更新日期:1985-01-01 00:00:00

  • Corneal nerve structure and function after long-term wear of fluid-filled scleral lens.

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    authors: Wang Y,Kornberg DL,St Clair RM,Lee M,Muhic I,Ciralsky JB,Alzaga Fernandez A,Sood P,Sippel KC,Rosenblatt MI

    更新日期:2015-04-01 00:00:00

  • Advances in the management of keratomycosis and Acanthamoeba keratitis.

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    pub_type: 杂志文章,评审


    authors: O'Day DM,Head WS

    更新日期:2000-09-01 00:00:00

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    authors: Schmitt-Bernard CF,Schneider C,Argilés A

    更新日期:2002-07-01 00:00:00

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    authors: Chang SW,Hu FR

    更新日期:1993-11-01 00:00:00

  • Psychometric Properties of the Keratoconus Outcomes Research Questionnaire: A Save Sight Keratoconus Registry Study.

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  • Progressive replacement of oral mucosa by conjunctiva in osteo-odonto-keratoprosthesis: preliminary observations.

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    authors: Pecorella I,Maurizio T,Antonio C,Giancarlo F

    更新日期:2006-02-01 00:00:00

  • Conjunctival malignant melanoma-associated pseudomelanoma of the apposing tarsal conjunctiva.

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    pub_type: 杂志文章


    authors: Reddy S,Finger PT,Kurli M,Bui A,Iacob CE

    更新日期:2006-10-01 00:00:00

  • Corneal perforation with secondary congenital aphakia in Peters anomaly.

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    authors: Banning CS,Blackmon DM,Song CD,Grossniklaus HE

    更新日期:2005-01-01 00:00:00

  • Treatment of Acute Corneal Hydrops With Combined Intracameral Gas and Approximation Sutures in Patients With Corneal Ectasia.

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  • Clinicopathologic correlation of textural interface opacities in descemet stripping automated endothelial keratoplasty: a case study.

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    authors: Newman LR,Rosenwasser GO,Dubovy SR,Matthews JL

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  • Ocular surface reconstruction with cultivated limbal epithelium in a patient with unilateral stem cell deficiency caused by Epidermolysis bullosa dystrophica hallopeau-Siemens.

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    pub_type: 杂志文章


    authors: Dohlman CH,Doane MG

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:1998-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Alió JL,Agdeppa MC,Uceda-Montanes A

    更新日期:2011-03-01 00:00:00