Abnormalities of the extracellular matrix in keratoconus corneas.

abstract：PURPOSE:Dry eye syndrome (DES) is a common eye disease caused by tear deficiency or excessive tear evaporation. Because the tear film layers play a major role in the pathogenesis of the evaporative dry eye, some previous articles have suggested the possible mechanism of dyslipidemia and DES. However, the previous resul...

journal_title：Cornea

authors： Choi HR,Lee JH,Lee HK,Song JS,Kim HC

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:To demonstrate the role of intrinsic hyaluronic acid (HA) in the entrapment of inflammatory cells by amniotic membrane (AM) in vitro. METHODS:HA concentration in AM was analyzed by the sandwich protein binding assay, and the approximate molecular weight was measured by gel filtration chromatography. To localiz...

journal_title：Cornea

authors： Higa K,Shimmura S,Shimazaki J,Tsubota K

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:In humans, loss-of-function mutations in the gene encoding Chordin-like 1 (CHRDL1) cause X-linked megalocornea (MGC1), characterized by bilateral corneal enlargement, decreased corneal thickness, and increased anterior chamber depth (ACD). We sought to determine whether Chrdl1 knockout (KO) mice would recapitul...

journal_title：Cornea

authors： Chen D,Liu Y,Shu G,Chen C,Sullivan DA,Kam WR,Hann S,Fowler M,Warman ML

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To review the development of artificial corneas (prostheses and tissue equivalents) for transplantation, and to provide recent updates on our tissue-engineered replacement corneas. METHODS:Modified natural polymers and synthetic polymers were screened for their potential to replace damaged portions of the huma...

journal_title：Cornea

authors： Griffith M,Hakim M,Shimmura S,Watsky MA,Li F,Carlsson D,Doillon CJ,Nakamura M,Suuronen E,Shinozaki N,Nakata K,Sheardown H

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:To report spontaneous corneal perforation as a presenting sign of unilateral Terrien marginal degeneration in a young adult. METHODS:A 19-year-old woman presented with sudden loss of vision in her left eye of 1-day duration. Examination revealed superior corneal thinning with superficial vascularization and se...

journal_title：Cornea

authors： Srinivasan S,Murphy CC,Fisher AC,Freeman LB,Kaye SB

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:To evaluate clinical and ultrasonographic findings associated with advanced microbial keratitis with concurrent endophthalmitis. METHODS:We performed a retrospective analytical study of patients with severe microbial keratitis who underwent ocular ultrasonography for possible endophthalmitis at our institution...

journal_title：Cornea

authors： Christopher KL,Hood CT,Mian SI,Ayres B

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To evaluate the prevalence of undiagnosed and asymptomatic human immunodeficiency virus (HIV) infection in patients with ocular surface squamous neoplasia (OSSN) in a referral hospital in Karnataka, South India. METHODS:A consecutive series of patients presenting with OSSN were evaluated in an academic center ...

journal_title：Cornea

authors： Pradeep TG,Gangasagara SB,Subbaramaiah GB,Suresh MB,Gangashettappa N,Durgappa R

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:To investigate the efficacy and safety of subconjunctival bevacizumab injection for the treatment of impending recurrent pterygium. METHODS:A prospective, randomized, single-masked, controlled trial was conducted in 80 patients with impending recurrent pterygium. Patients were randomized into 4 groups using ra...

journal_title：Cornea

authors： Lekhanont K,Patarakittam T,Thongphiew P,Suwan-apichon O,Hanutsaha P

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:To study the predisposing conditions, treatments, and visual outcomes of nontraumatic corneal perforations. METHODS:A retrospective chart review was conducted of all nontraumatic corneal perforations seen between January 1992 and December 1998, with > or = 3 months of follow-up, at the Cornea Service Wills Eye...

journal_title：Cornea

authors： Lekskul M,Fracht HU,Cohen EJ,Rapuano CJ,Laibson PR

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To investigate the feasibility of using Brillouin microscopy for assessment of corneal edema in patients with Fuchs endothelial corneal dystrophy (FECD). Brillouin microscopy analyzes the frequency shift of light inelastically scattered by naturally occurring acoustic waves in a small volume of tissue. The resu...

journal_title：Cornea

authors： Eltony AM,Clouser F,Shao P,Pineda R 2nd,Yun SH

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:To describe severe acute corneal hydrops in a patient with previously undiagnosed keratoconus, in which anterior segment optical coherence tomography (AS-OCT) revealed a protruding ridge of tissue on either side of Descemet membrane (DM) break, treated successfully with ultrathin Descemet-stripping automated en...

journal_title：Cornea

authors： Blitzer AL,Liles CA,Harocopos GJ,Reidy JJ,Farooq AV

更新日期：2020-09-09 00:00:00

abstract：:Effective chemotherapy for Acanthamoeba keratitis has been hampered because of the marked resistance of the parasites to a variety of antimicrobial agents. In view of the fact that topical Brolene (propamidine isethionate) and neosporin are currently considered to be the medical treatment of choice in Europe, we sough...

journal_title：Cornea

authors： Alizadeh H,Silvany RE,Meyer DR,Dougherty JM,McCulley JP

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to report the successful medical management of 2 cases of late-onset endothelial keratoplasty-related stromal interface infections. METHODS:All cases of endothelial keratoplasty-related infections treated with intrastromal antifungal injections were compiled. The following information...

journal_title：Cornea

authors： Tu EY,Hou J

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:To ascertain whether offsetting the Descemet membrane endothelial keratoplasty (DMEK) punch can expand the donor pool in conjunction with prepunched and preloaded services by recapturing the corneas otherwise excluded by the conventional central clear zone criteria. METHODS:In this retrospective review of corn...

journal_title：Cornea

authors： Kornberg DL,Prabhu S,Sales CS,Williams RS,Clover J,Tran KD

更新日期：2020-10-01 00:00:00

abstract：:The fellow normal-appearing eyes of 23 patients with unilateral aphakic bullous keratopathy were examined by wide-field specular microscopy and pachymetry. All patients had: pseudophakic or aphakic bullous keratopathy in one eye; unoperated fellow eye on no medication; no other ocular disease; and no endothelial gutta...

journal_title：Cornea

authors： Roberts CW,Boruchoff SA,Kenyon KR

更新日期：1984-01-01 00:00:00

abstract：:This study attempts to measure the quantitative contribution of major chemical fractions of the whole bovine cornea to ultraviolet (UV) absorption between 240 and 300 nm, with special attention to the biologically significant range of 290-300 nm. The cornea was divided into water-insoluble, nonprotein small water-solu...

journal_title：Cornea

authors： Mitchell J,Cenedella RJ

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:To present a case series of patients with Boston keratoprosthesis type I (KPro) who have had successful ptosis repair with Müller muscle-conjunctiva resection (MMCR). METHODS:Patients with KPros managed with MMCR for ptosis were identified. Records were examined to obtain preoperative and postoperative visual ...

journal_title：Cornea

authors： Lim JM,Bang GM,Cortina MS,de la Cruz J,Setabutr P

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:To develop and measure the uptake of a local guideline for herpes simplex keratitis (HSK) and to standardize initial antiviral therapy in Australia. METHODS:The Registered Nurses' Association of Ontario Toolkit: "Implementation of Best Practice Guidelines" was used to develop, implement, and evaluate the guide...

journal_title：Cornea

authors： Cabrera-Aguas M,Kerdraon Y,Symes RJ,McCluskey P,Samarawickrama C,Rawlinson W,Watson SL

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined m...

journal_title：Cornea

authors： Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:To report the indications, long-term structural and functional outcomes, and prognostic factors for the success of penetrating and lamellar corneal patch grafts. METHODS:This is a retrospective analysis of 49 patients who underwent the corneal patch graft procedure over 8 years. The baseline, preoperative, and...

journal_title：Cornea

authors： Sharma S,Rathi A,Murthy SI,Trivedi M,Patel C,Mohamed A,Chaurasia S

更新日期：2020-09-29 00:00:00

abstract：:Detachment of Descemet's membrane is an unusual cause of postoperative corneal edema. The typical detachment is small and usually limited to the area near the limbal wound. These peripheral detachments usually heal without sequelae as endothelium spreads over the area and secretes a new Descemet's membrane. We report ...

journal_title：Cornea

authors： Morrison LK,Talley TW,Waltman SR

更新日期：1989-12-01 00:00:00

abstract：PURPOSE:To report on surgical reduction of oculodermal melanosis in 6 patients presenting with severe episcleral pigmentation. METHODS:After informed consent was obtained, surgical reduction of ocular pigmentation with ocular dermal melanosis was performed on 3 children, 2 girls and 1 boy male, who were cosmetically h...

journal_title：Cornea

authors： Kim TI,Yoon J,Choi J,Tchah H

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To report a 64-year-old woman's case of infectious crystalline keratopathy (ICK) that occurred 9 years after the penetrating keratoplasty (PKP). METHODS:This study includes clinical history and histopathologic findings of the case. RESULTS:As historic background, the patient underwent PKP for lattice dystroph...

journal_title：Cornea

authors： Matsumoto A,Sano Y,Nishida K,Yokoi N,Hara J,Kinoshita S

更新日期：1998-01-01 00:00:00

abstract：:The authors sought to determine whether adenovirus could infect human corneal epithelium in vivo. They reviewed the medical records of six patients with adenovirus-positive viral corneal cultures who were examined at the Bascom Palmer Eye Institute between March 21, 1986, and December 31, 1992. The six patients with a...

journal_title：Cornea

authors： Chodosh J,Miller D,Stroop WG,Pflugfelder SC

更新日期：1995-03-01 00:00:00

abstract：:Previous studies suggest the existence of two separate and distinct mechanisms of endothelial wound healing (i.e., cell migration and cell spreading), which may be controlled by unique, injury-dependent, wound-related factors. The purpose of our study was to evaluate potential biologic mediators regulating healing of ...

journal_title：Cornea

authors： Petroll WM,Jester JV,Barry-Lane PA,Cavanagh HD

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:The objective of this study was to produce a porcine corneal acellular matrix (ACM) and assess its possibility for biomedical applications. METHODS:Porcine corneas were treated with various concentrations of sodium dodecylsulfate for different lengths of time. Optimal conditions for processing the ACM were not...

journal_title：Cornea

authors： Zhou Y,Wu Z,Ge J,Wan P,Li N,Xiang P,Gao Q,Wang Z

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To report eyes with keratoconus that progressed during pregnancy. METHODS:Seven eyes of 4 patients with progression of keratoconus during pregnancy were included in this study. The mean age of patients and the mean follow-up duration were 29.3 years and 39 months, respectively. Progressive keratoconus was docu...

journal_title：Cornea

authors： Bilgihan K,Hondur A,Sul S,Ozturk S

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To present four cases of localized corneal amyloidosis secondary to trichiasis and to discuss its pathogenesis. METHODS:Medical and pathologic records of four patients with corneal amyloidosis secondary to trichiasis were reviewed retrospectively. Two patients underwent trichiasis surgery and then lamellar ker...

journal_title：Cornea

authors： Lin PY,Kao SC,Hsueh KF,Chen WY,Lee SM,Lee FL,Shiuh WM

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To determine the benefit of bilateral penetrating keratoplasty with regard to binocular vision. METHODS:We compared patients who underwent corneal transplantation bilaterally with patients who had successful corneal transplantation in one eye and corneal disease in the other eye. Specifically, changes in fusio...

journal_title：Cornea

authors： Sampaio R,Held E,Cohen EJ,Grewal S,Rapuano CJ,Smith AF,Laibson PR

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To describe a new technique for handling Descemet stripping automated endothelial keratoplasty (DSAEK) specimens intraoperatively and during processing. METHODS:The processing method begins by adding a drop of eosin to the specimen intraoperatively, followed by submersion in 10% formalin solution. The specimen...

journal_title：Cornea

authors： Steven Houston SK,Morgan O,Olsakovsky LA,Phillips PM,Ghazi NG

更新日期：2010-12-01 00:00:00