Treatment of neurotrophic keratopathy with nicergoline.

Abstract:

PURPOSE:The aim of this study was to determine the effect of nicergoline in patients with neurotrophic keratopathy. METHODS:This is a prospective, noncomparative interventional study. The study included 27 eyes of 24 patients with neurotrophic keratopathy who were unresponsive to conventional therapy. Patients were treated with 10 mg of oral nicergoline twice daily for at least 2 weeks. Slit-lamp examination, photography, corneal fluorescein dye testing, Cochet-Bonnet corneal sensitivity, and best-corrected visual acuity tests were performed before and after treatment. Tear nerve growth factor levels were measured before and after treatment. RESULTS:In 23 eyes (85%), epithelial defects healed completely between 7 and 30 days of treatment with nicergoline (mean, 15.6 ± 8.0 days). Epithelial defects persisted in 4 eyes (15%). The mean corneal sensitivity before and after treatment with nicergoline was 20.5 ± 8.5 and 30.2 ± 10.8 mm, respectively (P < 0.001). The best-corrected visual acuity (measured in units according to the logarithm of the minimum angle of resolution) was significantly improved from 1.1 ± 0.6 to 0.8 ± 0.6 (P < 0.001). The tear nerve growth factor levels were significantly higher ranging from 3.2 ± 0.3 to 6.2 ± 0.3 pg/mL (P < 0.001). CONCLUSIONS:Treatment with nicergoline helps patients with neurotrophic keratopathy in whom conventional treatment has failed.

journal_name

Cornea

journal_title

Cornea

authors

Lee YC,Kim SY

doi

10.1097/ICO.0000000000000348

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

303-7

issue

3

eissn

0277-3740

issn

1536-4798

journal_volume

34

pub_type

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