Recent Surgical Trends in Pediatric Corneal Transplantation: A 13-Year Review.


PURPOSE:Corneal transplantation is the standard of care for pediatric corneal opacities, but little consensus exists on optimal surgical management. Our goal was to evaluate cross-sectional data of donor and recipient characteristics collected from eye banks providing tissue for pediatric corneal transplant cases to assess surgical trends in pediatric keratoplasty over the past 13 years. METHODS:We performed a retrospective review of recipient data, collected from 4 major eye banks, for pediatric patients (<18 years) who underwent corneal transplantation between January 2005 and December 2017. We analyzed trends in surgical indications, types of keratoplasty, and donor/recipient characteristics. RESULTS:Our database included 2620 total pediatric cases. Penetrating keratoplasty (PKP) remains the most common surgery performed (79.8%), but more partial-thickness transplant cases [eg, endothelial keratoplasty (EK)] have been performed since 2008. The most commonly reported transplant indication was ectasias/thinnings (34.1%) overall and congenital opacities (17.0%) in children less than 5 years. Average donor age was significantly lower for the youngest recipient age group of less than 5 years (P < 0.001); endothelial cell count was also higher, and death-to-surgery time was lower for PKP and EK cases versus other keratoplasties. CONCLUSIONS:Indications for transplant vary across age groups but are consistent with previous reports. Popularity of partial-thickness transplants has increased since 2008. Surgeons prefer younger donor tissue for younger patients and have higher thresholds for endothelial cell count for PKP and EK cases. Centralized tracking of pediatric keratoplasty cases is necessary for further investigation of long-term outcomes.






Zhu AY,Prescott CR




Has Abstract


2019-05-01 00:00:00
















  • Posterior lamellar keratoplasty using descemetorhexis and organ-cultured donor corneal tissue (Melles technique).

    abstract:PURPOSE:To report the clinical results of posterior lamellar keratoplasty (PLK) using predissected organ-cultured donor corneal tissue implanted after stripping of the Descemet membrane. METHODS:Twenty-two eyes of 22 patients in whom a PLK procedure was performed for pseudophakic bullous keratopathy and/or Fuchs endot...


    pub_type: 杂志文章


    authors: Nieuwendaal CP,Lapid-Gortzak R,van der Meulen IJ,Melles GJ

    更新日期:2006-09-01 00:00:00

  • Human allograft limbal transplantation for corneal surface reconstruction.

    abstract::Limbal allograft transplantation was performed consecutively in 16 eyes with thermal or chemical burns (n = 5), Terrien's degeneration (n = 2), congenital sclerocornea (n = 1), Stevens-Johnson syndrome (n = 1), and chronic keratoconjunctivitis (n = 7), by transplanting randomly selected cadaver limbocorneal grafts to ...


    pub_type: 杂志文章


    authors: Tsai RJ,Tseng SC

    更新日期:1994-09-01 00:00:00

  • In vivo biomechanical changes after corneal collagen cross-linking for keratoconus and corneal ectasia: 1-year analysis of a randomized, controlled, clinical trial.

    abstract:PURPOSE:To investigate the in vivo, corneal, biomechanical changes after corneal collagen cross-linking (CXL) using the Ocular Response Analyzer (ORA) in patients with keratoconus and post-laser in situ keratomileusis (LASIK) ectasia. METHODS:Single-center, prospective, randomized, controlled, clinical trial. After CX...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Greenstein SA,Fry KL,Hersh PS

    更新日期:2012-01-01 00:00:00

  • The brilliant beauty of the eye: light reflex from the cornea and tear film.

    abstract:PURPOSE:Light reflex from the cornea and tear film as contributors to beautiful eyes ("eye sparkling") are reviewed. METHODS:A systematic literature review was conducted using "Purkinje-Sanson image," "corneal light reflex," "corneal topography," "corneal wavefront aberration," and "tear interference image" as search ...


    pub_type: 杂志文章,评审


    authors: Goto E

    更新日期:2006-12-01 00:00:00

  • Endothelial keratoplasty: the influence of insertion techniques and incision size on donor endothelial survival.

    abstract:PURPOSE:To determine the acute endothelial cell damage from trephination and tissue insertion in endothelial keratoplasty (EK) surgery. The influence of insertion technique (forceps insertion vs "pull-through" insertion) of donor tissue and incision size (3 vs 5 mm length) was assessed. METHODS:Forty precut 8.-mm-diam...


    pub_type: 杂志文章


    authors: Terry MA,Saad HA,Shamie N,Chen ES,Phillips PM,Friend DJ,Holiman JD,Stoeger C

    更新日期:2009-01-01 00:00:00

  • A New Approach for the Calculation of Total Corneal Astigmatism Considering the Magnitude and Orientation of Posterior Corneal Astigmatism and Thickness.

    abstract:PURPOSE:To evaluate a new method of calculation of total corneal astigmatism based on Gaussian optics and the power design of a spherocylindrical lens (C) in the healthy eye and to compare it with keratometric (K) and power vector (PV) methods. METHODS:A total of 92 healthy eyes of 92 patients (age, 17-65 years) were ...


    pub_type: 杂志文章


    authors: Piñero DP,Caballero MT,Nicolás-Albujer JM,de Fez D,Camps VJ

    更新日期:2018-06-01 00:00:00

  • Efficacy of standardized and quality-controlled cord blood serum eye drop therapy in the healing of severe corneal epithelial damage in dry eye.

    abstract:PURPOSE:We standardized quality-controlled cord blood serum (CBS)-based eye drops and evaluated the efficacy of 1-month CBS treatment in the healing of diseased corneal epithelium in severe dry eye (DE) patients. METHODS:Seventeen graft-versus-host disease (GVHD) and 13 Sjogren syndrome patients with severe persistent...


    pub_type: 临床试验,杂志文章


    authors: Versura P,Profazio V,Buzzi M,Stancari A,Arpinati M,Malavolta N,Campos EC

    更新日期:2013-04-01 00:00:00

  • Anterior-Segment Optical Coherence Tomography and Scanning Electron Microscopy to Evaluate Corneal Epithelial Changes in Patients Undergoing Glaucoma Therapy.

    abstract:PURPOSE:To measure corneal epithelial thickness (CET) in patients with glaucoma using anterior-segment optical coherence tomography and to evaluate CET changes in relation to corneal epithelial microvilli analyzed by scanning electron microscopy (SEM). METHODS:Twenty-two eyes (16 patients) being treated with preservat...


    pub_type: 杂志文章


    authors: Cennamo G,Montorio D,Del Prete S,Del Prete A,Cennamo G

    更新日期:2018-12-01 00:00:00

  • Optical Coherence Tomography Assessment of the Cornea During Corneal Swelling: Should the Term "Descemet Membrane Folds" Be Reconsidered?

    abstract:PURPOSE:Previous work has suggested that Descemet membrane (DM) folds arise in response to corneal swelling. However, their origin has not been closely explored. In this study, we used optical coherence tomography to evaluate whether DM folds arise secondary to folds in the middle stroma. METHODS:Serial optical cohere...


    pub_type: 杂志文章


    authors: Annadanam A,Stoeger CG,Galloway JD,Hikes MT,Jun AS

    更新日期:2019-06-01 00:00:00

  • Tandem-scanning (confocal) microscopy of the full-thickness cornea.

    abstract::We have utilized a radically new type of optical scanning microscope to study the full-thickness morphology of the intact cornea in an excised human eye bank eye and in freshly sacrificed rabbit eyes in situ. This technology enables one to study corneal morphology layer by layer in extremely thin sections, only distur...


    pub_type: 杂志文章


    authors: Lemp MA,Dilly PN,Boyde A

    更新日期:1985-01-01 00:00:00

  • Binocular vision recovery in bilateral keratoplasty.

    abstract:PURPOSE:To determine the benefit of bilateral penetrating keratoplasty with regard to binocular vision. METHODS:We compared patients who underwent corneal transplantation bilaterally with patients who had successful corneal transplantation in one eye and corneal disease in the other eye. Specifically, changes in fusio...


    pub_type: 杂志文章


    authors: Sampaio R,Held E,Cohen EJ,Grewal S,Rapuano CJ,Smith AF,Laibson PR

    更新日期:2001-07-01 00:00:00

  • Elevated tear IgG and conjunctival plasma cell infiltrate in a graft versus host disease patient.

    abstract::Two patients developed graft versus host disease (GvHD) following allogeneic bone marrow transplantation for leukemia. One patient developed acute GvHD 12 days after transplantation, and the second developed chronic GvHD 100 days after transplantation. Tear analysis and conjunctival impression cytology were performed....


    pub_type: 杂志文章


    authors: Heitman KF,Lam KW,Maskin SL,Yee RW,Lawton AW

    更新日期:1988-01-01 00:00:00

  • Corneoscleral epithelial cysts: evidence of developmental etiology.

    abstract:PURPOSE:To describe the clinical features, histopathology, surgical management and possible etiopathogenesis of corneoscleral epithelial cysts. METHODS:Three patients with corneoscleral epithelial cysts underwent surgical ablation of the cysts. Material obtained during surgery was subjected to histopathologic analysis...


    pub_type: 杂志文章


    authors: Rao SK,Fogla R,Biswas J,Padmanabhan P

    更新日期:1998-07-01 00:00:00

  • Riboflavin/ultraviolet a crosslinking of the paracentral cornea.

    abstract:PURPOSE:The depth of corneal crosslinking (CXL) does not seem homogeneous within the treatment area but shows a reduction toward the periphery of the cornea. This study was undertaken to investigate this reduction effect and to look for possible solutions. METHODS:Ten corneas were investigated by means of an optical c...


    pub_type: 杂志文章


    authors: Koller T,Schumacher S,Fankhauser F 2nd,Seiler T

    更新日期:2013-02-01 00:00:00

  • Toxicity and pharmacokinetics of subconjunctival amphotericin B. An experimental study.

    abstract::The pharmacokinetics and toxicity of subconjunctival (S/C) amphotericin B (AmB) were evaluated in Dutch-belted rabbits. Following the S/C injection of 1,500 micrograms of AmB, corneal and aqueous levels were determined by bioassay. The highest levels were present in the periphery of debrided corneas at 1 h (90.12 +/- ...


    pub_type: 杂志文章


    authors: O'Day DM,Smith R,Stevens JB,Williams TE,Robinson RD,Head WS

    更新日期:1991-09-01 00:00:00

  • The castroviejo square graft: wound healing after 51 years.

    abstract:PURPOSE:To describe the histopathologic characteristics of a 51-year-old Castroviejo square graft that remained functional for more than 50 years and to describe the wound-healing characteristics over this period of time. METHODS:An 80-year-old woman with a history of keratoconus underwent penetrating keratoplasty wit...


    pub_type: 杂志文章


    authors: Graue-Hernández EO,Harocopos G,Bradley JC,Smith ME,Mannis MJ

    更新日期:2009-04-01 00:00:00

  • Keratoconus, myopia, and personality.

    abstract:PURPOSE:To determine whether there is an association between keratoconus and personality attributes including obsessionality traits. METHODS:We reviewed all charts in the regional contact lens clinic, identifying patients who had attended from January 1997 to January 2000 and had a diagnosis of either keratoconus or m...


    pub_type: 杂志文章


    authors: Cooke CA,Cooper C,Dowds E,Frazer DG,Jackson AJ

    更新日期:2003-04-01 00:00:00

  • Risk Factors for Ocular Involvement in Pediatric Graft-Versus-Host Disease.

    abstract:PURPOSE:To identify risk factors for ocular graft-versus-host disease (oGVHD) in children with graft-versus-host disease (GVHD). METHODS:This retrospective cohort study identified 38 children diagnosed with GVHD who underwent an ophthalmological examination. Survival to onset of oGVHD after transplant was analyzed usi...


    pub_type: 杂志文章


    authors: Hébert M,Archambault C,Doyon C,Ospina LH,Robert MC

    更新日期:2021-01-18 00:00:00

  • Hemangiogenesis and lymphangiogenesis in corneal pathology.

    abstract:PURPOSE:We characterized the presence of hemangiogenesis (HA) and lymphangiogenesis (LA) in human corneal specimens exhibiting 13 underlying pathologies. METHODS:Human corneal specimens were obtained from consenting subjects (n = 2 or n = 3 for each pathology; total sample size, n = 35). The pathological specimens wer...


    pub_type: 杂志文章


    authors: Tshionyi M,Shay E,Lunde E,Lin A,Han KY,Jain S,Chang JH,Azar DT

    更新日期:2012-01-01 00:00:00

  • Scanning electron microscopic study: the effect of balanced salt solution on rabbit corneal endothelium.

    abstract::A serial study was carried out with the scanning electron microscope every 5 h to examine the endothelial alterations that occur when the rabbit cornea remains in the eye after enucleation. The findings are compared with those encountered when the cornea with a scleral rim was removed from the globe immediately after ...


    pub_type: 杂志文章


    authors: Bonafonte S,Aguirre Vila-Coro A,Aguirre Vila-Coro A

    更新日期:1985-01-01 00:00:00

  • Fellow Eye Comparison of Descemet Membrane Endothelial Keratoplasty and Penetrating Keratoplasty.

    abstract:PURPOSE:To compare the visual outcomes and postoperative complications in patients undergoing penetrating keratoplasty (PKP) in 1 eye followed by Descemet membrane endothelial keratoplasty (DMEK) in their fellow eye. METHODS:A retrospective analysis of 11 patients, who underwent a PKP procedure first in 1 eye and then...


    pub_type: 杂志文章


    authors: Maier AK,Gundlach E,Gonnermann J,Klamann MK,Eulufi C,Bertelmann E,Joussen AM,Torun N

    更新日期:2013-10-01 00:00:00

  • Sweet syndrome presenting as resistant conjunctivitis.

    abstract:PURPOSE:We report a patient with chronic Sweet syndrome (SS) treated by anti-Tumor Necrosis Factor (TNF) therapy, who presented with a severe bilateral chemosis. METHODS:Case report. RESULTS:Conjunctival biopsy revealed an ocular localization of SS. CONCLUSIONS:SS is a rare disorder that usually affects middle-age w...


    pub_type: 杂志文章


    authors: Michel G,Lhermitte B,Cribier B,Speeg-Schatz C,Bourcier T

    更新日期:2008-12-01 00:00:00

  • Potentiation by cyclic AMP of the stimulatory effect of epidermal growth factor on corneal epithelial migration.

    abstract:PURPOSE:To provide insight into the mechanism by which epidermal growth factor (EGF) stimulates corneal epithelial migration, we investigated the possible interaction between EGF and cyclic AMP (cAMP) signaling pathways during epithelial migration with an organ culture system for the rabbit cornea. METHODS:Rabbit corn...


    pub_type: 杂志文章


    authors: Nakamura M,Nishida T

    更新日期:2003-05-01 00:00:00

  • Therapeutic effect of topical 5-fluorouracil in conjunctival squamous carcinoma is associated with changes in matrix metalloproteinases and tissue inhibitor of metalloproteinases expression.

    abstract:PURPOSE:To evaluate matrix metalloproteinases (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 expression in a case of conjunctival intraepithelial squamous cell carcinoma (SCC) treated with topical 5-fluorouracil (5-FU) chemotherapy. METHODS:Clinicopathologic case report. RESULTS:A 71-year-old male...


    pub_type: 杂志文章


    authors: Iovieno A,Lambiase A,Moretti C,Perrella E,Bonini S

    更新日期:2009-08-01 00:00:00

  • Femtosecond Laser-Assisted Keratolimbal Allograft Transplantation for the Treatment of Total Limbal Stem Cell Deficiency.

    abstract:PURPOSE:To investigate the surgical procedure and therapeutic efficacy of femtosecond (FS) laser-assisted keratolimbal allograft (KLAL) transplantation in the treatment of eyes with total limbal stem cell deficiency. METHODS:Ten eyes from 10 patients who underwent FS laser-assisted KLAL transplantation were enrolled. ...


    pub_type: 杂志文章


    authors: Qi X,Duan F,Li X,Zhang X,Li N,Liu M,Gao H

    更新日期:2019-10-01 00:00:00

  • Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty in Pseudophakic Eyes Compared With Triple-DMEK at 1-Year Follow-up.

    abstract:PURPOSE:To compare the survival rate 1 year after Descemet membrane endothelial keratoplasty (DMEK) in pseudophakic eyes versus combined phacoemulsification and DMEK (triple-DMEK). METHODS:Retrospective, interventional, consecutive case series. From all DMEKs performed from January 1, 2017, to June 30, 2018, we select...


    pub_type: 杂志文章


    authors: Fajardo-Sanchez J,de Benito-Llopis L

    更新日期:2020-12-22 00:00:00

  • Frequency of positive donor rim cultures after penetrating keratoplasty using hypothermic and organ-cultured donor corneas.

    abstract:PURPOSE:To compare the frequency of positive rim cultures after penetrating keratoplasty using corneas preserved by hypothermic and organ culture storage. To evaluate the influence of standard procurement techniques on the frequency of microbial donor rim contamination. METHODS:Six hundred four donor corneas stored at...


    pub_type: 杂志文章


    authors: Fontana L,Errani PG,Zerbinati A,Musacchi Y,Di Pede B,Tassinari G

    更新日期:2007-06-01 00:00:00

  • Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection.

    abstract:PURPOSE:To describe an invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. METHODS:A 51-year-old man developed a conjunctival mass that was excised and proved to be a spindle cell carcinoma. A tumor recurrence 20 months later was evaluated by ultrasound biomicroscopy (UBM) ...


    pub_type: 杂志文章


    authors: Shields JA,Eagle RC,Marr BP,Shields CL,Grossniklaus HE,Stulting RD

    更新日期:2007-09-01 00:00:00

  • Indications for penetrating keratoplasty and associated procedures, 1989-1995.

    abstract:PURPOSE:To identify changing trends in indications for penetrating keratoplasty and associated surgical procedures. METHODS:Review of charts from all patients who underwent penetrating keratoplasty at Wills Eye Hospital from January 1, 1989 through December 31, 1995. RESULTS:A total of 2,442 corneal transplants were ...


    pub_type: 杂志文章


    authors: Lois N,Kowal VO,Cohen EJ,Rapuano CJ,Gault JA,Raber IM,Laibson PR

    更新日期:1997-11-01 00:00:00

  • Slit-lamp, confocal, and light microscopic findings of corneal siderosis.

    abstract:PURPOSE:To report the clinical, histopathologic, and confocal findings of corneal siderosis. METHODS:A 35-year-old man presented after a car battery explosion with diffuse left corneal anterior stromal pigment deposition and an intraocular metallic foreign body of the left iris. The corneal pigment was analyzed by con...


    pub_type: 杂志文章


    authors: Witherspoon SR,Hogan RN,Petroll WM,Mootha VV

    更新日期:2007-12-01 00:00:00