The intraoperative use of mitomycin-C in excision of ocular surface neoplasia with or without limbal autograft transplantation.


PURPOSE:To evaluate the efficacy of intraoperative mitomycin-C in excision of ocular surface neoplasia for prevention of recurrence. METHODS:Seven patients (eight eyes), three men and four women, aged 56 to 87 years (mean, 73.8 years), with lesions suspicious for corneal or conjunctival neoplasia, were operated on between October 1998 and March 2000. During excision of the lesion, mitomycin-C 0.02% was applied intraoperatively for 5 minutes. In two cases, excision was combined with conjunctival limbal autograft transplantation. All excised lesions were sent for histopathologic evaluation. RESULTS:During the follow-up period ranging from 6 to 28 months (mean, 16 months) one patient (one eye) died of an unrelated cause. Histopathologic study showed four cases of squamous cell carcinoma, one case of carcinoma in situ, two cases of dysplasia, and one case of actinic keratosis. Of the eight eyes, no clinical recurrence of the lesion occurred in seven eyes, whereas one eye with squamous cell carcinoma showed mild recurrence 5 months after surgery and was successfully treated with topical mitomycin-C. Up to the last follow-up of this case 10 months later, the lesion did not recur. CONCLUSION:The excision of conjunctival and corneal epithelial neoplasia combined with the intraoperative use of mitomycin-C seems to reduce the recurrence rate. The combined use of mitomycin-C and conjunctival limbal autograft transplantation in two cases did not alter the surgical outcome. More cases and a longer follow-up are needed to establish the efficacy of such an approach.






Siganos CS,Kozobolis VP,Christodoulakis EV




Has Abstract


2002-01-01 00:00:00














  • Corneal Subbasal Nerve Density and Sensitivity After Pars Plana Vitrectomy Using Contact or Noncontact Wide-Angle Viewing Systems.

    abstract:PURPOSE:To assess corneal subbasal nerve density (SBND) and corneal sensitivity (CS) after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) without intraoperative 360-degree laser treatment using contact or noncontact panoramic viewing systems. METHODS:This is a prospective study of 34 eyes affe...


    pub_type: 杂志文章


    authors: Tosi GM,Bacci T,Tarantello A,Martone G,Traversi C,Marigliani D,Cevenini G,Virgili G

    更新日期:2018-09-01 00:00:00

  • Recovery of Corneal Clarity After DMEK Followed by Rebubbling Versus Uneventful DMEK.

    abstract:PURPOSE:To evaluate the effect of a single rebubbling procedure after Descemet membrane endothelial keratoplasty (DMEK) on corneal backscatter and endothelial cell loss (ECL). METHODS:Medical records of 130 consecutive DMEK cases (118 patients) were reviewed and 3 groups were formed: group 1 (n = 32), consisting of DM...


    pub_type: 杂志文章


    authors: Lazaridis A,Fydanaki O,Giallouros E,Georgalas I,Kymionis G,Sekundo W,Droutsas K

    更新日期:2018-07-01 00:00:00

  • Pentacam-based big bubble deep anterior lamellar keratoplasty in patients with keratoconus.

    abstract:PURPOSE:To describe the clinical results of Pentacam-based big bubble deep anterior lamellar keratoplasty (DALK) to achieve an intended 90% depth of initial lamellar trephination. METHODS:Fifty consecutive eyes of 50 patients with keratoconus, keratoglobus, and anterior stromal scars were included. DALK was performed ...


    pub_type: 杂志文章


    authors: Riss S,Heindl LM,Bachmann BO,Kruse FE,Cursiefen C

    更新日期:2012-06-01 00:00:00

  • Clinical outcomes of corneal graft infections caused by multi-drug resistant Pseudomonas aeruginosa.

    abstract:PURPOSE:The aim was to assess the clinical outcomes of corneal graft infections caused by multi-drug resistant Pseudomonas aeruginosa (MDR-PA). METHODS:This is a retrospective case series of 38 patients with corneal graft infections caused by MDR-PA managed from June to December 2011. Clinical and demographic details,...


    pub_type: 杂志文章


    authors: Jain R,Murthy SI,Motukupally SR

    更新日期:2014-01-01 00:00:00

  • Bilateral eyelid ecchymoses and corneal crystals: an unusual presentation of multiple myeloma.

    abstract:PURPOSE:This report describes a case of multiple myeloma that presented as bilateral eyelid ecchymoses and corneal crystals in the absence of widespread signs of systemic disease. METHODS:A 55-year-old man was found to have the sudden appearance of bilateral eyelid ecchymoses after he flexed 90 degrees at the waist. O...


    pub_type: 杂志文章


    authors: Goldstein DA,Schteingart MT,Birnbaum AD,Tessler HH

    更新日期:2005-08-01 00:00:00

  • Human allograft limbal transplantation for corneal surface reconstruction.

    abstract::Limbal allograft transplantation was performed consecutively in 16 eyes with thermal or chemical burns (n = 5), Terrien's degeneration (n = 2), congenital sclerocornea (n = 1), Stevens-Johnson syndrome (n = 1), and chronic keratoconjunctivitis (n = 7), by transplanting randomly selected cadaver limbocorneal grafts to ...


    pub_type: 杂志文章


    authors: Tsai RJ,Tseng SC

    更新日期:1994-09-01 00:00:00

  • Risk Factors for Sporadic Diffuse Lamellar Keratitis After Microkeratome Laser-Assisted In Situ Keratomileusis: A Retrospective Large Database Analysis.

    abstract:PURPOSE:To determine the factors associated with sporadic diffuse lamellar keratitis (DLK) after microkeratome laser-assisted in situ keratomileusis (LASIK). METHODS:This large database retrospective study included consecutive cases of LASIK performed between 2007 and 2016 at Care-Vision Laser Centers, Tel-Aviv, Israe...


    pub_type: 杂志文章


    authors: Segev F,Mimouni M,Sela T,Munzer G,Kaiserman I

    更新日期:2018-09-01 00:00:00

  • Ocular surface reconstruction with cultivated limbal epithelium in a patient with unilateral stem cell deficiency caused by Epidermolysis bullosa dystrophica hallopeau-Siemens.

    abstract:PURPOSE:To report a case of partial limbal stem cell deficiency (LSCD) caused by epidermolysis bullosa dystrophica mutilans Hallopeau-Siemens treated by transplantation of autologous ex vivo expanded limbal epithelium. METHODS:Review of the clinical findings of an 11.5-year-old boy with unilateral LSCD and epidermolys...


    pub_type: 杂志文章


    authors: Thanos M,Pauklin M,Steuhl KP,Meller D

    更新日期:2010-04-01 00:00:00

  • Epithelial innervation of human cornea: a three-dimensional study using confocal laser scanning fluorescence microscopy.

    abstract:PURPOSE:Evaluation of a new method to visualize distribution and morphology of human corneal nerves (Adelta- and C-fibers) by means of fluorescence staining, confocal laser scanning microscopy, and 3-dimensional (3D) reconstruction. METHODS:Trephinates of corneas with a diagnosis of Fuchs corneal dystrophy were sliced...


    pub_type: 杂志文章


    authors: Guthoff RF,Wienss H,Hahnel C,Wree A

    更新日期:2005-07-01 00:00:00

  • Cluster of Post-Operative Endophthalmitis Caused by Acanthamoeba T10 Genotype - A First Report.

    abstract:PURPOSE:To report a cluster of postoperative Acanthamoeba endophthalmitis after routine cataract surgeries. METHODS:A brief summary of sentinel events leading to the referral of 4 patients of postoperative endophthalmitis to our hospital is followed by clinical descriptions and the various diagnostic approaches and in...


    pub_type: 杂志文章


    authors: Rammohan R,Hajib Naraharirao M,Veerappan S,Vijayaraghavan P,Rajaraman R,Manayath GJ,Dsouza P,Radhakrishnan S,Venkatapathy N,Lakshmipathi D,Madhuravasal Krishnan J,Raghavan A

    更新日期:2021-02-01 00:00:00

  • Incidence and clinical characteristics of enterococcus keratitis.

    abstract:PURPOSE:To study the incidence, clinically relevant factors, and antibiotic sensitivity profile of cases of enterococcal keratitis presenting at the New York Eye and Ear Infirmary between January 1, 1996, and December 31, 2005. METHODS:The records of all corneal cultures submitted to the Microbiology Laboratory of the...


    pub_type: 杂志文章


    authors: Rau G,Seedor JA,Shah MK,Ritterband DC,Koplin RS

    更新日期:2008-09-01 00:00:00

  • "Pleats fold" technique of amniotic membrane transplantation for management of corneal perforations.

    abstract:PURPOSE:The aim of this study was to examine the efficacy and surgical success rates of amniotic membrane (AM) transplantation performed for corneal perforation closure using a novel technique. METHODS:This study included 6 eyes from 6 patients with corneal perforation who had received AM transplantation between May 2...


    pub_type: 杂志文章


    authors: Namba H,Narumi M,Nishi K,Goto S,Hayashi S,Yamashita H

    更新日期:2014-06-01 00:00:00

  • Elevated tear IgG and conjunctival plasma cell infiltrate in a graft versus host disease patient.

    abstract::Two patients developed graft versus host disease (GvHD) following allogeneic bone marrow transplantation for leukemia. One patient developed acute GvHD 12 days after transplantation, and the second developed chronic GvHD 100 days after transplantation. Tear analysis and conjunctival impression cytology were performed....


    pub_type: 杂志文章


    authors: Heitman KF,Lam KW,Maskin SL,Yee RW,Lawton AW

    更新日期:1988-01-01 00:00:00

  • Limbal stem cell-sparing lamellar keratoplasty for the management of advanced keratoglobus.

    abstract:PURPOSE:To describe the technique and outcomes of limbal stem cell-sparing lamellar keratoplasty (LSCS-LKP) for the management of advanced keratoglobus (KGB). METHODS:In a sequential interventional case series from March 2010 to December 2012, 8 eyes of 6 patients with advanced KGB underwent an LSCS-LKP. Three patient...


    pub_type: 杂志文章


    authors: Karimian F,Baradaran-Rafii A,Faramarzi A,Akbari M

    更新日期:2014-01-01 00:00:00

  • Efficacy of Intraductal Meibomian Gland Probing on Tear Function in Patients With Obstructive Meibomian Gland Dysfunction.

    abstract:PURPOSE:To assess the efficacy and safety of intraductal meibomian gland probing in patients with obstructive meibomian gland dysfunction who experienced little improvement with eyelid warming, massage, or artificial tears. METHODS:Forty-nine patients with obstructive meibomian gland dysfunction were randomly divided ...


    pub_type: 杂志文章


    authors: Ma X,Lu Y

    更新日期:2016-06-01 00:00:00

  • Trends in contact lens-related corneal ulcers at a tertiary referral center.

    abstract:PURPOSE:To evaluate the changes and trends in the number and characteristics of contact lens-related ulcers (CLRUs) and to compare the results with those of previously published series at our institution. METHODS:Medical records of all patients diagnosed with presumed bacterial corneal ulcers seen at the Cornea Servic...


    pub_type: 杂志文章


    authors: Yildiz EH,Airiani S,Hammersmith KM,Rapuano CJ,Laibson PR,Virdi AS,Hongyok T,Cohen EJ

    更新日期:2012-10-01 00:00:00

  • Assessment of the Tear Meniscus Using Optical Coherence Tomography in Patients With Type 2 Diabetes Mellitus.

    abstract:PURPOSE:To analyze tear meniscus dimensions with Fourier domain-optical coherence tomography (FD-OCT) in patients with type 2 diabetes mellitus. METHODS:Patients with type 2 diabetes without diabetic retinopathy (DR) (n = 54), with nonproliferative DR (n = 45), with proliferative DR (PDR) (n = 25), and controls (n = 4...


    pub_type: 杂志文章


    authors: Baek J,Doh SH,Chung SK

    更新日期:2015-12-01 00:00:00

  • Cytotoxicity of intracameral injection drugs to corneal endothelium as evaluated by corneal endothelial cell culture.

    abstract::The cell culture method was used to quantitatively evaluate the cytotoxicity to porcine corneal endothelial cells by drugs in the usual concentrations of intracameral injections (ICI). Time-dependent cytotoxicity of drugs was evaluated quantitatively; dye exclusion assay by trypan blue was used as a viability assay; a...


    pub_type: 杂志文章


    authors: Chang CH,Lin CP,Wang HZ

    更新日期:1995-01-01 00:00:00

  • Conjunctival flap surgery for calcified scleromalacia after cosmetic conjunctivectomy.

    abstract:PURPOSE:To investigate the long-term clinical course of scleromalacia with calcified plaque as a complication of cosmetic conjunctivectomy with topical mitomycin C (MMC) application and to introduce a surgical method for this complication using calcified plaque removal and/or conjunctival flap surgery. METHODS:Eleven ...


    pub_type: 杂志文章


    authors: Kwon HJ,Nam SM,Lee SY,Ahn JM,Seo KY

    更新日期:2013-06-01 00:00:00

  • Outcomes of Flap Lift Laser In Situ Keratomileusis Enhancements in a Large Patient Population: Does Application of a Bandage Contact Lens Affect Incidence of Epithelial Ingrowth?

    abstract:PURPOSE:To compare the incidence of corneal epithelial ingrowth (EIG) and the visual outcomes of enhancement with laser in situ keratomileusis (LASIK) by flap lift when a bandage soft contact lens (CL) was fitted after the procedure and when it was not. METHODS:This is a multicenter, retrospective, interventional case...


    pub_type: 杂志文章,多中心研究


    authors: Ortega-Usobiaga J,Baviera-Sabater J,Llovet-Osuna F,González-López F,Bilbao-Calabuig R,Llovet-Rausell A,Beltrán-Sanz J

    更新日期:2019-12-01 00:00:00

  • Functional Morphology of the Lipid Layer of the Tear Film.

    abstract::Meibomian glands secrete the oily layer of the tear film, which prevents excessive evaporation of tear fluid. Dysfunction of meibomian glands is not only one of the causes of evaporative dry eye but also one of the main causes of entire dry eye. To understand the pathophysiology of meibomian gland dysfunction, it is i...


    pub_type: 杂志文章,评审


    authors: Arita R,Fukuoka S,Morishige N

    更新日期:2017-11-01 00:00:00

  • Mucous membrane pemphigoid with fatal bronchial involvement in a seventeen-year-old girl.

    abstract:PURPOSE:This study was designed to report a case of biopsy-proven mucous membrane pemphigoid with severe bronchial involvement in a young woman. METHODS:Case report of a 17-year-old girl who presented with worsening dyspnea, skin rash, and bilateral ocular injection, symblepharon, and fornix foreshortening. Conjunctiv...


    pub_type: 杂志文章


    authors: Gamm DM,Harris A,Mehran RJ,Wood M,Foster CS,Mootha VV

    更新日期:2006-05-01 00:00:00

  • Keratinizing corneal intraepithelial neoplasia.

    abstract::Corneal intraepithelial neoplasia (CIN) is the term applied by some authors to the spectrum of disease ranging from mild dysplasia to carcinoma in situ. Such lesions usually are associated with dysplastic or neoplastic processes at the limbus or adjacent conjunctiva; isolated corneal dysplasia is rare. Clinically, CIN...


    pub_type: 杂志文章


    authors: Brown HH,Glasgow BJ,Holland GN,Foos RY

    更新日期:1989-09-01 00:00:00

  • Ocular morbidity associated with airbag deployment: a report of seven cases and a review of the literature.

    abstract:PURPOSE:To review ocular injuries secondary to airbag deployment that were seen in our institution and were reported in the literature. METHODS:Patients examined at our institution between 1997 and 2000 were evaluated for ocular injuries caused by airbags. A review of the medical literature using Medline was performed...


    pub_type: 杂志文章,评审


    authors: Ball DC,Bouchard CS

    更新日期:2001-03-01 00:00:00

  • Adhesion of Acanthamoeba on Silicone Hydrogel Contact Lenses.

    abstract:PURPOSE:To evaluate adhesion of Acanthamoeba trophozoites to different silicone hydrogel contact lens (SHCL) generations with and without multipurpose contact lens care solution (MPS) treatment. METHODS:Acanthamoeba lugdunensis L3a trophozoites were inoculated onto discs trimmed from SHCLs: first generation, Air Optix...


    pub_type: 杂志文章


    authors: Lee GH,Lee JE,Park MK,Yu HS

    更新日期:2016-05-01 00:00:00

  • Survival after transplantation of corneas from a rabies-infected donor.

    abstract:PURPOSE:To examine the tissue samples of 2 corneal recipients from a rabies-infected donor for the presence of rabies to explain their survival. METHODS:Interventional case series with a review of the literature. The explanted corneal donor buttons were examined via nested reverse transcriptase polymerase chain reacti...


    pub_type: 杂志文章,评审


    authors: Vetter JM,Frisch L,Drosten C,Ross RS,Roggendorf M,Wolters B,Müller T,Dick HB,Pfeiffer N

    更新日期:2011-02-01 00:00:00

  • Role of impression cytology in diagnosis of ocular surface neoplasia.

    abstract:PURPOSE:To compare the accuracy of impression cytology in the diagnosis of ocular surface neoplasia with tissue histology. METHODS:We reviewed the histories of patients diagnosed with ocular surface neoplasia at the Chiang Mai University Hospital. All patients underwent both impression cytology and tissue biopsy. We c...


    pub_type: 杂志文章


    authors: Tananuvat N,Lertprasertsuk N,Mahanupap P,Noppanakeepong P

    更新日期:2008-04-01 00:00:00

  • New graft inserter for descemet stripping automated endothelial keratoplasty.

    abstract:PURPOSE:The aim of this study was to introduce a newly developed graft inserter for Descemet stripping automated endothelial keratoplasty, which can be readily used with 1 hand, and to examine endothelial cell loss (ECL) after graft insertion using this new inserter in an ex vivo rabbit model. METHODS:Rabbit corneal g...


    pub_type: 杂志文章


    authors: Toyama T,Honda N,Usui T,Amano S

    更新日期:2014-04-01 00:00:00

  • Primary Localized Conjunctival Amyloidosis Presenting Corneal Whorl-like Opacity Patterns.

    abstract:PURPOSE:To report an unusual case of corneal whorl-like opacity patterns in a patient of primary localized conjunctival amyloidosis. METHODS:Case report and review of literature. RESULTS:A 35-year old man with a case of primary localized conjunctival amyloidosis presented with corneal whorl-like opacity patterns and ...


    pub_type: 杂志文章


    authors: Sharma VK,Agarwal M,Tyagi A,Sati A

    更新日期:2020-07-01 00:00:00

  • Corneal subepithelial nodular scarring treated with phototherapeutic keratectomy in a child with Rothmund-Thomson syndrome.

    abstract:PURPOSE:To report the use of excimer laser phototherapeutic keratectomy (PTK) in the treatment of corneal subepithelial nodular scarring in a child with Rothmund-Thomson syndrome (RTS), a form of ectodermal dysplasia. METHODS:A case report and review of the literature. RESULTS:Excimer laser PTK successfully treated t...


    pub_type: 杂志文章


    authors: Stahl J,Fulcher S,Berkeley R

    更新日期:2000-01-01 00:00:00