Abstract:
PURPOSE:To evaluate the efficacy of intraoperative mitomycin-C in excision of ocular surface neoplasia for prevention of recurrence. METHODS:Seven patients (eight eyes), three men and four women, aged 56 to 87 years (mean, 73.8 years), with lesions suspicious for corneal or conjunctival neoplasia, were operated on between October 1998 and March 2000. During excision of the lesion, mitomycin-C 0.02% was applied intraoperatively for 5 minutes. In two cases, excision was combined with conjunctival limbal autograft transplantation. All excised lesions were sent for histopathologic evaluation. RESULTS:During the follow-up period ranging from 6 to 28 months (mean, 16 months) one patient (one eye) died of an unrelated cause. Histopathologic study showed four cases of squamous cell carcinoma, one case of carcinoma in situ, two cases of dysplasia, and one case of actinic keratosis. Of the eight eyes, no clinical recurrence of the lesion occurred in seven eyes, whereas one eye with squamous cell carcinoma showed mild recurrence 5 months after surgery and was successfully treated with topical mitomycin-C. Up to the last follow-up of this case 10 months later, the lesion did not recur. CONCLUSION:The excision of conjunctival and corneal epithelial neoplasia combined with the intraoperative use of mitomycin-C seems to reduce the recurrence rate. The combined use of mitomycin-C and conjunctival limbal autograft transplantation in two cases did not alter the surgical outcome. More cases and a longer follow-up are needed to establish the efficacy of such an approach.
journal_name
Corneajournal_title
Corneaauthors
Siganos CS,Kozobolis VP,Christodoulakis EVdoi
10.1097/00003226-200201000-00004subject
Has Abstractpub_date
2002-01-01 00:00:00pages
12-6issue
1eissn
0277-3740issn
1536-4798journal_volume
21pub_type
杂志文章相关文献
CORNEA文献大全abstract::The treatment of herpes simplex keratitis has ranged from simple debridement to the use of prototypic antiviral agents specific to the herpes family, such as acyclovir. The various treatment modalities for dendritic keratitis, for the most part, have been effective. However, in recent years numerous reports of antivir...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199505000-00017
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31823f7685
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:Evaluation of a new method to visualize distribution and morphology of human corneal nerves (Adelta- and C-fibers) by means of fluorescence staining, confocal laser scanning microscopy, and 3-dimensional (3D) reconstruction. METHODS:Trephinates of corneas with a diagnosis of Fuchs corneal dystrophy were sliced...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000154384.05614.8f
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:In our report, we present a suspected case of donor-derived Acanthamoeba keratitis after deep anterior lamellar keratoplasty. To the authors' knowledge, there have been no confirmed cases of Acanthamoeba keratitis transmission through corneal transplantation. METHODS:Deep anterior lamellar keratoplasty was per...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002517
更新日期:2020-09-16 00:00:00
abstract::The present study describes biochemical and morphological differences of pseudophakic bullous keratopathy (PBK) corneas as compared with normal corneas. At the ultrastructural level, all PBK corneas studied had abnormal fibrillar material posterior to the Descemet's membrane. In addition, two of the six PBK buttons ha...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to describe the clinical features of infectious scleritis with distinct inciting events and to analyze the factors associated with poor visual outcome. METHODS:We retrospectively reviewed the predisposing factors, clinical findings, isolated organisms, complications, and outcomes of p...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000174
更新日期:2014-08-01 00:00:00
abstract::Corneal epithelial permeability studies using fluorophotometers were performed on 90 eyes of 51 normal subjects. After recording the autofluorescence of the cornea (AFC) and of the lens (AFL), we applied 20 microliters of 2% sodium fluorescein to the conjunctival sac. The corneal fluorescence 45 min later (F45), which...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199311000-00006
更新日期:1993-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to report the successful medical management of 2 cases of late-onset endothelial keratoplasty-related stromal interface infections. METHODS:All cases of endothelial keratoplasty-related infections treated with intrastromal antifungal injections were compiled. The following information...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000192
更新日期:2014-09-01 00:00:00
abstract::Absorbable intracanalicular collagen implants were placed in both canaliculi of one eye of nine human volunteers. The other eye served as a control. Twenty-four hours later 2% sodium fluorescein was placed into both conjunctival sacs. Serial corneal fluorescein concentrations were measured with a scanning ocular fluor...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199111000-00009
更新日期:1991-11-01 00:00:00
abstract::Recently, it was suggested that the use of the Advanced Medical Optics Complete MoisturePlus multipurpose cleaning solution might be a risk factor for contracting Acanthamoeba keratitis, and the manufacturer voluntarily recalled it in May 2007. Polymerase chain reaction amplification and sequencing of a variable part ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318183a34b
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:To describe 3-dimensional optical coherence tomography (OCT) findings in a case of granular corneal dystrophy. METHODS:A 1310-nm high-speed swept-source OCT prototype was used to image the 3-dimensional structures of the cornea of a patient with granular corneal dystrophy. RESULTS:Three-dimensional OCT clearl...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31802e1e50
更新日期:2007-04-01 00:00:00
abstract:PURPOSE:To report the indications, long-term structural and functional outcomes, and prognostic factors for the success of penetrating and lamellar corneal patch grafts. METHODS:This is a retrospective analysis of 49 patients who underwent the corneal patch graft procedure over 8 years. The baseline, preoperative, and...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002529
更新日期:2020-09-29 00:00:00
abstract:PURPOSE:To report the potential risk of severe positive vitreous pressure during combined penetrating keratoplasty, cataract extraction, and intraocular lens implantation (triple procedure), using positive end-expiratory pressure (PEEP) during general endotracheal anesthesia. METHODS:This is a case report of a 32-year...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000945
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:The efficacy of gene therapy using nonviral vector based on polyplex micelle has been studied against corneal neovascularization in mice. METHODS:A block copolymer, poly(ethylene glycol) (PEG)-block-polycation carrying ethylenediamine units in the side chain (PEG-b-P[Asp(DET)]), was prepared. PEG-b-P[Asp(DET)]...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318206c893
更新日期:2011-12-01 00:00:00
abstract::Mycobacterium fortuitum keratitis is an indolent infection of traumatized corneas in humans. To study this disorder in an animal model, 10(4) M fortuitum organisms (10 microliters) were inoculated into the stroma of both corneas of 16 New Zealand albino rabbits. Eight of the rabbits were also given bilateral subconjun...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:PURPOSE:We report a patient with chronic Sweet syndrome (SS) treated by anti-Tumor Necrosis Factor (TNF) therapy, who presented with a severe bilateral chemosis. METHODS:Case report. RESULTS:Conjunctival biopsy revealed an ocular localization of SS. CONCLUSIONS:SS is a rare disorder that usually affects middle-age w...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31817f8147
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:To present the clinical outcome of 2 cases of severe dry eye associated with Nivolumab, with 1 case progressing to corneal perforation. DESIGN:Case report. CASE 1:: A 58-year-old man with metastatic melanoma was referred for the management of severe bilateral dry eyes after undergoing his sixth cycle of Nivol...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000724
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Clinical research addressing the issue of donor globe decontamination is yet to establish convincing data for the optimal choice of an antimicrobial agent. METHODS:In a donor-globe decontamination study, the antimicrobial effectiveness of a fluoroquinolone antibiotic (ciprofloxacin, 0.3%) was evaluated for the...
journal_title:Cornea
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00003226-199801000-00008
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine the correct concentration and duration of application of trypan blue dye to Descemet membrane endothelial keratoplasty (DMEK) donor corneal tissue before transplant to enhance visibility while minimizing damage to the tissue. METHODS:Corneas were precut for DMEK using...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001074
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Sequential therapeutic penetrating keratoplasty (TPK) using a cryopreserved cornea followed soon after by a fresh optical grade cornea for severe infectious keratitis may improve the survival of the optical graft. The aim of this study was to compare the therapeutic efficacy, visual outcomes, and graft survival...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318203217c
更新日期:2011-07-01 00:00:00
abstract::To evaluate an innovative technique for intrastromal air injection to achieve deep anterior lamellar keratoplasty (DALK) with bare Descemet membrane (DM). Thirty-four eyes with anterior corneal pathology, including 27 with keratoconus, underwent DALK. After 400 μm trephination with a suction trephine, ultrasound pachy...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31823f8f2d
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Endogenous hyaluronan (HA) has previously been shown to be a part of corneal wound healing after photorefractive keratectomy (PRK). HA is known to bind considerable amounts of water. This study aimed to show whether HA colocalized with water in the wound area after PRK. METHODS:Five New Zealand White rabbits w...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:PURPOSE:To report on a patient in whom hyperopic Implantable Collamer Lenses (ICL, STAAR Surgical, Nidau, Switzerland) and limbal relaxing incisions have been beneficial for the correction of hyperopic astigmatism after laser in situ keratomileusis (LASIK). METHODS:The 48-year-old man had undergone LASIK to correct hi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31818a7de3
更新日期:2010-01-01 00:00:00
abstract::In order to evaluate the effect of a commonly used sodium hyaluronate preparation (Healon, Pharmacia AB, Uppsala, Sweden) on the incidence of endothelial rejection, endothelial cell loss, intraocular pressure, and corneal thickness after penetrating keratoplasty, we conducted a randomized clinical trial. Patients were...
journal_title:Cornea
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-10-01 00:00:00
abstract:PURPOSE:The aim of this study is to determine the effect of variation of the exposure time of near-infrared irradiation on corneal stiffening after a bacteriochlorophyll derivative (WST11) with dextran (WST-D) application. METHODS:One hundred four paired eyes of 3-month-old New Zealand White rabbits were included in t...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001272
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To report impression cytologic (IC) results after corneal cross-linking (CXL) using riboflavin and ultraviolet-A light in the treatment of keratoconus and compare the data with those from a group of subjects with the same disease. METHODS:Forty eyes were distributed into 2 groups: patients in group 1 underwent...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/ICO.0b013e3181d4f91a
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To report a case of traumatic flap partial dislocation and subsequent diffuse lamellar inflammation 14 months after laser in situ keratomileusis (LASIK) retreatment. METHODS:Case report of a late flap dislocation that occurred during routine recreational activity (struck with a finger in the right eye while pl...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/00003226-200208000-00015
更新日期:2002-08-01 00:00:00
abstract::We have utilized a radically new type of optical scanning microscope to study the full-thickness morphology of the intact cornea in an excised human eye bank eye and in freshly sacrificed rabbit eyes in situ. This technology enables one to study corneal morphology layer by layer in extremely thin sections, only distur...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:To determine whether autologous Descemet stripping endothelial keratoplasty is technically feasible and whether it eliminates the risk of endothelial rejection in "only eyes" at high risk of immunological rejection. METHODS:This is a prospective observational interventional study from 2016 to 2018 with a 24-mo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002184
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To investigate the clinical features and outcomes for conjunctival melanoma based on patient age. METHODS:A retrospective review of patients with conjunctival melanoma managed at a single tertiary referral center from April 18, 1974, to September 9, 2019. Clinical features and outcomes were compared by patient...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002449
更新日期:2020-07-30 00:00:00