Clinical Characteristics and Outcomes of Ocular Cicatricial Pemphigoid: A Cohort Study and Literature Review.


PURPOSE:Ocular cicatricial pemphigoid (OCP) is a rare systemic autoimmune disease and a potentially blinding subepithelial blistering disorder. The purpose of this study was to describe the clinical spectrum of the disease and to assess the efficacy and safety of immunosuppressive agents in a cohort of patients with OCP. METHODS:We conducted a monocentric retrospective cross-sectional cohort study of all unselected consecutive patients diagnosed with progressive OCP. Ocular and extra ophthalmological involvement as well as histological findings were gathered. Other outcomes were exposures to immunosuppressive agents defined by the use of a particular treatment. For each exposure, success in controlling ocular inflammation was graded as a complete response, response, or failure. Relapses and adverse events (AE) were also recorded. RESULTS:Seventeen patients (34 affected eyes), 35% of whom were women, were included, with an age at diagnosis of 75 ± 11 years. Corneal involvement was diagnosed in 30 of 34 eyes, and 22 of 34 eyes had progressive fibrosing conjunctival involvement. Sixty-two exposures to immunosuppressive agents or biologics were recorded: dapsone, n = 26; mycophenolate mofetil, n = 6; azathioprine, n = 4; cyclophosphamide, n = 10; rituximab, n = 14; and intravenous immunoglobulin, n = 2. Rates of response and of complete response achievement during the first 3 months were 84% and 45%, respectively. Response rates were 100%, 100%, 86%, 85%, and 80% for intravenous immunoglobulin, mycophenolate mofetil, rituximab, dapsone, and cyclophosphamide, respectively. Thirteen percent of those drugs were discontinued because of an adverse event in 4 patients. CONCLUSIONS:This study describes the efficacy of immunosuppressants or biologics with an acceptable safety profile for OCP.






Fremont F,Pelissier-Suarez C,Fournié P,Porterie M,Thevenin A,Astudillo L,Paricaud K,Gualino V,Soler V,Pugnet G




Has Abstract


2019-11-01 00:00:00














  • Keratitis resulting from Thielavia subthermophila Mouchacca.

    abstract:PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined m...


    pub_type: 杂志文章


    authors: Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE

    更新日期:2009-10-01 00:00:00

  • Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the Veterans Health Administration.

    abstract:PURPOSE:To determine the proportion of patients who were dispensed amantadine and diagnosed with corneal edema or Fuchs dystrophy within specified time frames. METHODS:Postmarketing surveillance study. The national Veterans Health Administration pharmacy and clinical databases were used to identify a cohort of veteran...


    pub_type: 杂志文章


    authors: French DD,Margo CE

    更新日期:2007-10-01 00:00:00

  • Advances in the management of keratomycosis and Acanthamoeba keratitis.

    abstract:PURPOSE:In the late 1960s, the management of fungal keratitis was a serious unresolved problem. Little was known of the epidemiology of the disease, and there were no antifungal agents formulated for use in the eye. METHODS:A thorough review of the literature was done back to 1969 on clinical reports and experimental ...


    pub_type: 杂志文章,评审


    authors: O'Day DM,Head WS

    更新日期:2000-09-01 00:00:00

  • Colchicine in tear fluid of treated patients with familial Mediterranean fever.

    abstract:PURPOSE:The study aimed to determine whether detectable concentrations of colchicine are present in the tear fluid of treated patients with familial Mediterranean fever (FMF) and thus demonstrate a possible route by which colchicine reaches the corneal surface. METHODS:Tear fluid samples (50-100 microL) were collected...


    pub_type: 杂志文章


    authors: Leibovitch I,Alster Y,Scherrmann JM,Azmon B,Barequet IS,Livneh A,O'Brien TP,Lazar M,Loewenstein A

    更新日期:2003-04-01 00:00:00

  • Characterization of Corneal Donor Tissue Lesions by Anterior Segment Optical Coherence Tomography Compared With Eye Bank Technician Slit-Lamp Examination.

    abstract:PURPOSE:To compare anterior segment spectral-domain optical coherence tomography (OCT) with eye bank technician slit-lamp examination (SLE) in characterizing lesions in donor corneas. METHODS:Twenty-nine donor corneas identified by eye bank technicians to have opacities or lesions potentially representing pathologic f...


    pub_type: 杂志文章


    authors: Hsu ST,Perry I,Botsay S,Ko N,Stinnett SS,Kuo AN,Shieh C

    更新日期:2018-10-01 00:00:00

  • Corneal endothelial damage after trabeculectomy with mitomycin C in two patients with glaucoma with cornea guttata.

    abstract:PURPOSE:To report two patients with glaucoma who exhibited severe damage to the corneal endothelium after a trabeculectomy with mitomycin C (MMC). METHODS:This study includes clinical histories and specular microscopic pictures of the cases. RESULTS:Both patients were middle-aged women, underwent trabeculectomy with ...


    pub_type: 杂志文章


    authors: Fukuchi T,Hayakawa Y,Hara H,Abe H

    更新日期:2002-04-01 00:00:00

  • Bristle Worm-Induced Keratouveitis: A Case Report.

    abstract:PURPOSE:To report keratouveitis arising from corneal penetration by a bristle worm seta (bristle). METHODS:We report on a 64-year-old woman presenting with uniocular pain, redness, reduced vision, discharge, and pustular rash of the hands after cleaning out her marine aquarium containing bristle worms and rubbing her ...


    pub_type: 杂志文章


    authors: Kirk J,Gunn D,Wong N,Minchin E,Darcy K

    更新日期:2020-05-01 00:00:00

  • Mycobacterium fortuitum keratitis. Clinicopathologic correlates and corticosteroid effects in an animal model.

    abstract::Mycobacterium fortuitum keratitis is an indolent infection of traumatized corneas in humans. To study this disorder in an animal model, 10(4) M fortuitum organisms (10 microliters) were inoculated into the stroma of both corneas of 16 New Zealand albino rabbits. Eight of the rabbits were also given bilateral subconjun...


    pub_type: 杂志文章


    authors: Paschal JF,Holland GN,Sison RF,Berlin OG,Bruckner DA,Dugel PU,Foos RY

    更新日期:1992-11-01 00:00:00

  • The fellow eye of patients with aphakic bullous keratopathy.

    abstract::The fellow normal-appearing eyes of 23 patients with unilateral aphakic bullous keratopathy were examined by wide-field specular microscopy and pachymetry. All patients had: pseudophakic or aphakic bullous keratopathy in one eye; unoperated fellow eye on no medication; no other ocular disease; and no endothelial gutta...


    pub_type: 杂志文章


    authors: Roberts CW,Boruchoff SA,Kenyon KR

    更新日期:1984-01-01 00:00:00

  • Moderately Long-Term Safety and Efficacy of Repeat Penetrating Keratoplasty.

    abstract:PURPOSE:To investigate the moderately long-term safety and efficacy of repeat penetrating keratoplasty (PK) for treatment of a failed PK graft. METHODS:Retrospective consecutive clinical case series. Of 992 consecutive cases that underwent PK at Baptist Eye Institute, Kyoto, Japan, between April 1998 and September 201...


    pub_type: 杂志文章


    authors: Kitazawa K,Wakimasu K,Kayukawa K,Yokota I,Inatomi T,Hieda O,Sotozono C,Kinoshita S

    更新日期:2018-10-01 00:00:00

  • Conjunctival proliferation after a mild pepper spray injury in a young child.

    abstract:PURPOSE:To report a case of conjunctival proliferation in a 2.5-year-old boy after initial evidence of a mild chemical injury after ocular exposure to pepper spray (oleoresin capsicum). METHODS:Case report with ophthalmologic and histologic findings. RESULTS:A child presented with mild conjunctival injection and chem...


    pub_type: 杂志文章


    authors: Gerber S,Frueh BE,Tappeiner C

    更新日期:2011-09-01 00:00:00

  • Partitioning an Artificial Anterior Chamber With a Latex Diaphragm to Simulate Anterior and Posterior Segment Pressure Dynamics: The "DMEK Practice Stage," Where Surgeons Can Rehearse the "DMEK Dance".

    abstract:PURPOSE:To present a novel apparatus for simulating the anterior and posterior segment pressure dynamics involved in executing Descemet membrane endothelial keratoplasty (DMEK) surgery when using a chamber-shallowing technique. METHODS:An artificial anterior chamber (AAC), 18-mm trephine, latex glove, two 3-mL syringe...


    pub_type: 杂志文章


    authors: Sáles CS,Straiko MD,Fernandez AA,Odell K,Dye PK,Tran KD

    更新日期:2018-02-01 00:00:00

  • Amniotic membrane transplantation with anterior stromal micropuncture for treatment of painful bullous keratopathy in eyes with poor visual potential.

    abstract:PURPOSE:To report the use of anterior stromal micropuncture and amniotic membrane transplantation in the management of painful bullous keratopathy in patients with poor visual potential. METHODS:Interventional case series. A retrospective review was performed to identify all patients who were treated by one of us (A.J...


    pub_type: 杂志文章


    authors: Sonmez B,Kim BT,Aldave AJ

    更新日期:2007-02-01 00:00:00

  • Very low risk of light-induced retinal damage during Boston keratoprosthesis surgery: a rabbit study.

    abstract:PURPOSE:The aim of this study was to assess the possibility of light damage to the retina by a surgical microscope during implantation of a Boston Keratoprosthesis (B-KPro) in rabbits. METHODS:The retinal irradiance from a Zeiss OPMI Lumera S7 operating microscope was measured at the working distance (16.5 cm). Light ...


    pub_type: 杂志文章


    authors: Salvador-Culla B,Behlau I,Sayegh RR,Stacy RC,Dohlman CH,Delori F

    更新日期:2014-02-01 00:00:00

  • Comparison of Oculus Pentacam and Stratus optical coherence tomography for measurement of central corneal thickness.

    abstract:PURPOSE:Measurement of central corneal thickness (CCT) plays an essential role in the diagnosis and treatment of many ocular diseases. In this study, we aimed to compare the CCT measurements obtained using the Scheimpflug system (Pentacam; Oculus, Inc) with a retinal optical coherence tomography device (Stratus OCT; Ca...


    pub_type: 杂志文章


    authors: Ceylan OM,Turk A,Erdurman C,Mumcuoglu T,Erdem U,Gokce G,Dagli S

    更新日期:2011-06-01 00:00:00

  • Glaucoma progression and role of glaucoma surgery in patients with Boston keratoprosthesis.

    abstract:PURPOSE:The aim of this study was to evaluate glaucoma onset and progression after implantation of Boston Keratoprostheses (B-KPro) and the role of glaucoma surgery. METHODS:Records of patients with B-KPro implantation during 2004 to 2009 were reviewed. Parameters relevant to B-KPro surgery and glaucoma status were re...


    pub_type: 杂志文章


    authors: Crnej A,Paschalis EI,Salvador-Culla B,Tauber A,Drnovsek-Olup B,Shen LQ,Dohlman CH

    更新日期:2014-04-01 00:00:00

  • Chrysosporium parvum keratomycosis.

    abstract:PURPOSE:To report a case of corneal infection with Chrysosporium parvum, a filamentous fungus usually associated with pulmonary infections. METHODS:A 43-year-old Saudi man had a corneal stromal infiltrate and perforation of his left eye. He was treated with a therapeutic penetrating keratoplasty and topical and system...


    pub_type: 杂志文章


    authors: Wagoner MD,Badr IA,Hidayat AA

    更新日期:1999-09-01 00:00:00

  • Automated analysis of wide-field specular photomicrographs.

    abstract::This report describes computerized image enhancement and analysis from the digitized image of a wide-field specular micrograph to produce an output of frequency distribution of cell areas. The steps involved including image smoothing and averaging, followed by automated scanning to detect individual cell boundaries, a...


    pub_type: 杂志文章


    authors: Hirst LW,Sterner RE,Grant DG

    更新日期:1984-01-01 00:00:00

  • Herpes simplex keratitis after intravitreal triamcinolone acetonide.

    abstract:PURPOSE:To report a case of recurrent herpes simplex virus (HSV) epithelial keratitis after intravitreal triamcinolone acetonide injection for the treatment of diabetic macular edema. METHODS:Case report. RESULTS:We describe a case of a 59-year-old woman with a history of ocular HSV disease and severe proliferative d...


    pub_type: 杂志文章


    authors: Shtein RM,Stahl RM,Saxe SJ,Mian SI

    更新日期:2007-06-01 00:00:00

  • Clinicohistopathological findings of gelatinous droplike corneal dystrophy among Asians.

    abstract::We describe the findings in nine Asian-Indian patients with gelatinous droplike corneal dystrophy (GDCD). Most patients showed initial signs of bilateral decreased vision and photophobia at an early age. The siblings were affected in four cases, and parental consanguinity was recorded in seven cases. We classified the...


    pub_type: 杂志文章


    authors: Li S,Edward DP,Ratnakar KS,Reddy M,Tso MO

    更新日期:1996-07-01 00:00:00

  • Intracameral amphotericin B injection in the management of deep keratomycosis.

    abstract:PURPOSE:To report the use of intracameral amphotericin B in the management of deep keratomycosis. METHODS:Four patients with deep keratomycosis unresponsive to conventional medical treatment underwent repeated intracameral injections of 5 microg amphotericin B in 0.1 mL 5% dextrose through a paracentesis. Three to 13 ...


    pub_type: 杂志文章


    authors: Kuriakose T,Kothari M,Paul P,Jacob P,Thomas R

    更新日期:2002-10-01 00:00:00

  • Subconjunctival bevacizumab for corneal neovascularization.

    abstract:PURPOSE:To describe whether subconjunctival bevacizumab decreases corneal neovascularization in patients with ocular surface inflammatory diseases. METHODS:The study is a retrospective case series that includes 8 eyes of 7 patients with corneal neovascularization. Patients received 1-3 injections of 2.5 mg subconjunct...


    pub_type: 杂志文章


    authors: Doctor PP,Bhat PV,Foster CS

    更新日期:2008-10-01 00:00:00

  • A new nonhuman primate model of severe dry eye.

    abstract:PURPOSE:The aim of this study was to establish a new rhesus monkey model of severe dry eye. METHODS:A total of 8 rhesus monkeys were used for the study. Four monkeys had their main lacrimal gland and nictitating membrane surgically removed (group 1). Another 4 monkeys had a similar surgery with further application of ...


    pub_type: 杂志文章


    authors: Qin Y,Tan X,Zhang Y,Jie Y,Labbe A,Pan Z

    更新日期:2014-05-01 00:00:00

  • MT1-MMP cleavage of the antiangiogenic proteoglycan decorin: role in corneal angiogenesis.

    abstract:PURPOSE:Decorin is a small chondroitin sulfate proteoglycan that inhibits vascular endothelial cell migration and tube formation. Membrane type 1-matrix metalloproteinase (MT1-MMP) has been shown to be an important angiogenic enzyme in the cornea. We evaluated the specific role of MT1-MMP in decorin cleavage in the cor...


    pub_type: 杂志文章,收录出版


    authors: Mimura T,Chang JH,Kim TI,Onguchi T,Kojima T,Sakimoto T,Azar DT

    更新日期:2011-10-01 00:00:00

  • Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology.

    abstract:PURPOSE:The normal cornea is devoid of blood and lymphatic vessels but can become vascularized secondary to a variety of corneal diseases and surgical manipulations. Whereas corneal (hem)angiogenesis, i.e., the outgrowth of new blood vessels from preexisting limbal vessels, is obvious both clinically and histologically...


    pub_type: 杂志文章,评审


    authors: Cursiefen C,Chen L,Dana MR,Streilein JW

    更新日期:2003-04-01 00:00:00

  • Enhancing DMEK Success by Identifying Optimal Levels of Trypan Blue Dye Application to Donor Corneal Tissue.

    abstract:PURPOSE:The purpose of this study was to determine the correct concentration and duration of application of trypan blue dye to Descemet membrane endothelial keratoplasty (DMEK) donor corneal tissue before transplant to enhance visibility while minimizing damage to the tissue. METHODS:Corneas were precut for DMEK using...


    pub_type: 杂志文章


    authors: Majmudar PA,Johnson L

    更新日期:2017-02-01 00:00:00

  • The fate of scleral grafts in the cornea.

    abstract::There have been reports of the clearing of sclera that has been grafted into the cornea. This clearing was studied in the rabbit by transplanting full-thickness scleral buttons or by implanting slivers of sclera, both autografts and allografts, into the cornea. Some clearing around the edges of the implanted scleral t...


    pub_type: 杂志文章


    authors: Maurice DM,Singh T

    更新日期:1996-03-01 00:00:00

  • Comparative study of descemet stripping automated endothelial keratoplasty donor preparation by Moria CBm microkeratome, horizon microkeratome, and Intralase FS60.

    abstract:PURPOSE:To evaluate the quality of stromal bed and the safety on endothelium in preparation of donor tissue for Descemet stripping automated endothelial keratoplasty in a masked fashion using 2 mechanical microkeratomes and a femtosecond laser. METHODS:Deep anterior lamellar dissection was performed on 15 donor cornea...


    pub_type: 杂志文章


    authors: Mootha VV,Heck E,Verity SM,Petroll WM,Lakshman N,Muftuoglu O,Bowman RW,McCulley JP,Cavanagh HD

    更新日期:2011-03-01 00:00:00

  • Multimodal Assessment of Corneal Thinning Using Optical Coherence Tomography, Scheimpflug Imaging, Pachymetry, and Slit-Lamp Examination.

    abstract:PURPOSE:To assess the relationship between corneal thinning measured by clinician-graded slit-lamp examination compared with ultrasound pachymetry (USP), anterior segment optical coherence tomography (AS-OCT), and the Pentacam. METHODS:Patients with corneal thinning underwent USP, AS-OCT, Pentacam measurements and sta...


    pub_type: 杂志文章


    authors: Oatts JT,Keenan JD,Mannis T,Lietman TM,Rose-Nussbaumer J

    更新日期:2017-04-01 00:00:00

  • Nanoscale topography of the corneal epithelial basement membrane and Descemet's membrane of the human.

    abstract:PURPOSE:Quantitatively define and compare the nanoscale topography of the corneal epithelial basement membrane (anterior basement membrane) and Descemet's membrane (posterior basement membrane) of the human. METHODS:Human corneas not suitable for transplantation were obtained from the Wisconsin Eye Bank. The corneas w...


    pub_type: 杂志文章


    authors: Abrams GA,Schaus SS,Goodman SL,Nealey PF,Murphy CJ

    更新日期:2000-01-01 00:00:00