Abstract:
PURPOSE:To assess the effect of cataract surgery on semiautomated human corneal endothelial cell density (ECD) estimation using noncontact specular microscopy. METHODS:In this prospective clinical study, 62 consecutive patients undergoing cataract surgery were studied. To evaluate possible variations of accuracy and agreement under clinical circumstances, the corneal ECD was determined before and after cataract surgery. The parameter ECD (cells/mm) in the central and paracentral cornea was consecutively determined with 2 algorithms available in a noncontact specular microscope [fixed-frame method (FFM) and automatic center method (ACM)]. The postoperative evaluation was performed at 1 day, after 4 weeks, and after 6 months. The accuracy, the relative error, and the 95% limits of agreement (LoA) were determined for both counting methods. RESULTS:The overall group-averaged accuracy was -19.4 cells/mm (0.86%) centrally and -17.3 cells/mm (0.76%) paracentrally. The LoA (95% CI) were within 234 cells/mm (10.4%) and 250 cells/mm (10.9%), respectively. After cataract surgery, a slight decrease in accuracy was noted in the central (2.09%) and paracentral areas (1.76%). The relative error increased from 3.66% to 6.02% centrally and from 4.96% to 6.55% paracentrally. The LoA (95% CI) increased from +/-194 cells/mm to +/-304 cells/mm centrally and from +/-275 cells/mm to +/-322 cells/mm paracentrally. In the later postoperative period, endothelial stabilization improved the accuracy and agreement in ECD estimation. CONCLUSIONS:The estimation of ECD after cataract surgery employing current algorithms was achieved with a clinically acceptable level of accuracy and agreement. However, the analysis of images in the early postoperative period as well as paracentral corneal areas revealed larger variabilities. This revealed that the FFM and ACM counting methods cannot be used interchangeably under all circumstances. The ACM seemed preferable when only low-quality images were available and permitted determination of additional qualitative endothelial cell parameters.
journal_name
Corneajournal_title
Corneaauthors
Wirbelauer C,Wollensak G,Pham DTdoi
10.1097/01.ico.0000141234.48967.e3subject
Has Abstractpub_date
2005-03-01 00:00:00pages
135-40issue
2eissn
0277-3740issn
1536-4798pii
00003226-200503000-00003journal_volume
24pub_type
杂志文章相关文献
CORNEA文献大全abstract:PURPOSE:To determine the prevalence of herpes simplex virus type 1 (HSV-1) DNA in failed Descemet membrane stripping automated endothelial keratoplasty (DSAEK) grafts. METHODS:A retrospective interventional case series of patients with DSAEK graft failure treated at the New York Eye and Ear Infirmary between January 2...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31829b6d0c
更新日期:2013-09-01 00:00:00
abstract::The iridocorneal-endothelial (ICE) syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The pu...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To evaluate if donor corneas obtained from deaths occurring because of septicemia can be used for corneal transplantation. STUDY DESIGN:Prospective study. METHODS:Eleven septicemic donor corneas were used in the study and 10 donor corneas from deaths because of causes other than septicemia were used as contro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000858
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:Alkaline corneal epithelial wound closure rates in rabbit eyes were compared after topical applications of amniotic membrane suspension, autologous serum, or preservative-free artificial tears. METHODS:Thirty rabbits were divided into 3 randomization groups of 10 rabbits each. Central corneal alkali wound was ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318173138a
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:To document the relationship of iris cavernous hemangiomas with multiorgan hemangiomas in a child. METHODS:A 7-year-old girl with kidney hemangiomas, brain hemangiomas, and skin hemangiomas developed blurred vision and darkening of the right iris. She had undergone 6 previous brain surgeries and multiple revis...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3180303b46
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To investigate the in vivo, corneal, biomechanical changes after corneal collagen cross-linking (CXL) using the Ocular Response Analyzer (ORA) in patients with keratoconus and post-laser in situ keratomileusis (LASIK) ectasia. METHODS:Single-center, prospective, randomized, controlled, clinical trial. After CX...
journal_title:Cornea
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ICO.0b013e31821eea66
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:In a Strampelli osteo-odonto-keratoprosthesis, a patch of oral mucosa is frequently used to cover the ocular surface after implantation of an osteodental lamina into the eye. In many cases, gross modifications in the eye covering become apparent a few years later. The aim of this study was to investigate the hi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000170695.98078.42
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:To report a case of keratitis and corneal melt after conductive keratoplasty (CK) enhancement. METHOD:Case report. RESULTS:A 52-year-old woman with emmetropic presbyopia had undergone previous CK for monovision and underwent CK enhancement 4 years later. Postoperatively, she was managed with ketorolac trometh...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181ef6ec7
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To report a case of epithelial ingrowth (downgrowth) occurring in a phakic corneal transplant patient after traumatic wound dehiscence with iris prolapse that was successfully eradicated with early surgical intervention. METHODS:Interventional case report of a 70-year-old monocular, phakic patient who develope...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200303000-00023
更新日期:2003-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to describe the clinical features of infectious scleritis with distinct inciting events and to analyze the factors associated with poor visual outcome. METHODS:We retrospectively reviewed the predisposing factors, clinical findings, isolated organisms, complications, and outcomes of p...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000174
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:To assess the keratocyte density (KD) in the cornea of patients with keratoconus not using contact lenses. METHOD:In this pilot study, the eyes (n = 68) of 35 patients with the diagnosis of keratoconus, who did not use contact lenses and the eyes(n = 70) of 35 healthy controls were prospectively examined using...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182000fd4
更新日期:2011-05-01 00:00:00
abstract::During wound healing, corneal tissue has to restore its transparency for proper vision. Various cytokines and growth factors are believed to orchestrate cellular behavior in a healing cornea. This review summarizes the roles of 1 such factor, the proinflammatory cytokine tumor necrosis factor (TNF)-alpha, in the proce...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e31812f6d14
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:To evaluate the effect of various ceramides on the apoptosis of corneal fibroblasts and to determine the pathway on which they act. METHOD:Corneal fibroblasts isolated and cultured from New Zealand white rabbits were exposed to various concentrations of ceramide types II and VI and phytoceramide types II and V...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000134000.52886.c3
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To present a case of acute idiopathic endotheliitis occurred early after corneal collagen cross-linking (CXL) for progressive keratoconus, and to discuss possible risk factors, causes, and other similar complications in the literature. METHODS:A 24-year-old woman with bilateral keratoconus underwent a corneal ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000110
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:To evaluate a new method of calculation of total corneal astigmatism based on Gaussian optics and the power design of a spherocylindrical lens (C) in the healthy eye and to compare it with keratometric (K) and power vector (PV) methods. METHODS:A total of 92 healthy eyes of 92 patients (age, 17-65 years) were ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001577
更新日期:2018-06-01 00:00:00
abstract::This paper reviews the data of Frank et al. in the light of increasing concern over the safety of contact lenses used for extended wear. Relative risks were calculated for four types of contact lenses (CLs): extended wear soft, daily wear soft, rigid gas-permeable (RGP), and polymethylmethacrylate (PMMA) lenses--worn ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199010001-00024
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To evaluate endothelial cell damage after eye bank preparation and passage through 1 of 2 different injectors for Descemet membrane endothelial keratoplasty grafts. METHODS:Eighteen Descemet membrane endothelial keratoplasty grafts were prepared by Lions VisionGift with the standard partial prepeel technique a...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000690
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:The goal of this study was to prospectively assess the deep lamellar endothelial keratoplasty (DLEK) wound anatomy and its evolution during the 12 months after surgery, using optical coherence tomography (OCT). METHODS:The eyes of 8 patients (1 eye per patient) who consecutively underwent DLEK for Fuchs dystro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181c58f32
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To review the development of artificial corneas (prostheses and tissue equivalents) for transplantation, and to provide recent updates on our tissue-engineered replacement corneas. METHODS:Modified natural polymers and synthetic polymers were screened for their potential to replace damaged portions of the huma...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/01.ico.0000263120.68768.f8
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:To determine the incidence of postkeratoplasty fungal endophthalmitis and keratitis at the New York Eye and Ear Infirmary. To determine whether there is a relationship between culture-positive corneoscleral donor material and postoperative infection. METHODS:The microbiologic records of corneoscleral donor rim...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico..0000138832.3486.70
更新日期:2005-04-01 00:00:00
abstract::Detachment of Descemet's membrane is an unusual cause of postoperative corneal edema. The typical detachment is small and usually limited to the area near the limbal wound. These peripheral detachments usually heal without sequelae as endothelium spreads over the area and secretes a new Descemet's membrane. We report ...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::We report a case of corneal allograft rejection that occurred in a gravid woman 1 year following transplantation. This is the first report, to our knowledge, of corneal allograft rejection occurring in a pregnant woman. ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-198706040-00009
更新日期:1987-01-01 00:00:00
abstract::Posterior amorphous corneal dystrophy (PACD) is a rare autosomal-dominant disease, generally classified with the pre-Descemet's dystrophies. It is characterized by deep stromal corneal opacification, flat corneas with low keratometry values, and central thinning. To our knowledge, only one previous ultrastructural stu...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::The introduction of the excimer laser for keratorefractive surgery in the 1990 s permanently reshaped the treatment landscape for correcting refractive errors, such as myopia, hyperopia, and astigmatism. Until that point, these treatments had relied on less predictable techniques, such as radial keratotomy and automat...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e31826ab0a7
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:Previous work has suggested that Descemet membrane (DM) folds arise in response to corneal swelling. However, their origin has not been closely explored. In this study, we used optical coherence tomography to evaluate whether DM folds arise secondary to folds in the middle stroma. METHODS:Serial optical cohere...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001908
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:The objective of this study was to produce a porcine corneal acellular matrix (ACM) and assess its possibility for biomedical applications. METHODS:Porcine corneas were treated with various concentrations of sodium dodecylsulfate for different lengths of time. Optimal conditions for processing the ACM were not...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181dc8184
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Successful limbal allotransplantation allows regression of limbal stem cell deficiency features. Transplant survival is presumed if clinical improvement occurs. However, positive proof of surviving transplanted stem cells remains difficult. This follow-up study attempted to prove donor cell survival 5 years aft...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200105000-00014
更新日期:2001-05-01 00:00:00
abstract:PURPOSE:To report a case of recurrent conjunctival myofibrosarcoma treated with wide surgical excision, cryotherapy, and triple sequential applications of episcleral brachytherapy. METHODS:A single case of recurrent conjunctival myofibrosarcoma. RESULTS:A 54-year-old man with a history of a renal transplant presented...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001158
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To report a patient with refractory keratitis after a Boston type I keratoprosthesis treated with corneal collagen cross-linking (CXL). METHODS:Case report. RESULTS:A 29-year-old man with a history of chemical burn in the left eye underwent keratoprosthesis implantation. He developed infectious keratitis 4 mo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000509
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To assess the long-term clinical course of dry eye in patients with chronic graft-versus-host disease (cGVHD). METHODS:A prospective case series of 49 patients with cGVHD was conducted. Complete history and ophthalmic examination were performed at baseline and at 36 months (range, 26-53). All patients received...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181e9b3bf
更新日期:2011-02-01 00:00:00