Comparison of the effect of amniotic membrane suspension and autologous serum on alkaline corneal epithelial wound healing in the rabbit model.

Abstract:

PURPOSE:Alkaline corneal epithelial wound closure rates in rabbit eyes were compared after topical applications of amniotic membrane suspension, autologous serum, or preservative-free artificial tears. METHODS:Thirty rabbits were divided into 3 randomization groups of 10 rabbits each. Central corneal alkali wound was produced in both eyes of the rabbits by applying a 5-mm round filter paper, soaked in 1 N NaOH, for 60 seconds. Group 1 animals received preservative-free artificial tears in 1 eye and amniotic membrane suspension in the other eye; group 2 animals received preservative-free artificial tears in 1 eye and autologous serum in the other eye; and group 3 animals received autologous serum in 1 eye and amniotic membrane suspension in the other eye. The treatment was dosed 4 times a day with the eyedrops, and epithelial wound closure was recorded using slit lamp. The data were analyzed to determine the rate of wound closure. RESULTS:The mean wound radius closure rate was 67.8 +/- 5.2 microm/h for autologous serum-treated eyes, 74.5 +/- 5.4 microm/h for amniotic membrane suspension-treated eyes, and 66.8 +/- 5.0 microm/h for preservative-free artificial tear-treated eyes. CONCLUSIONS:This study shows that alkali-injured corneal epithelial wounds heal faster when treated with amniotic membrane suspension than with autologous serum or preservative-free artificial tears.

journal_name

Cornea

journal_title

Cornea

authors

Shahriari HA,Tokhmehchi F,Reza M,Hashemi NF

doi

10.1097/ICO.0b013e318173138a

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1148-50

issue

10

eissn

0277-3740

issn

1536-4798

pii

00003226-200812000-00010

journal_volume

27

pub_type

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