Abstract:
:Regulatory T cells (Tregs) are essential for the maintenance of immune homeostasis. Studies of Treg are not only necessary for understanding the mechanism of immune homeostasis but also extremely useful for the development of treatments of various immune diseases. Forkhead box P3 (Foxp3) was identified as the master gene responsible for the immune-suppressing activity of Tregs. The promoter region and several intronic enhancers, designated conserved noncoding sequence (CNS) 0, 1, 2, and 3, at the Foxp3 gene locus have important roles in Foxp3 expression and Treg development. We demonstrated that transcription factors Nr4a and Smad2/3 are required for development of thymic Tregs and induced Tregs, respectively. In addition to transcription factors, Treg-specific DNA demethylation has been shown to be important for Treg stability. In particular, DNA demethylation of CNS2 was implicated in Treg stability, and members of the ten-eleven translocation family of demethylation factors were recently demonstrated to have important roles in 5'-C-phosphate-G-3' demethylation at CNS2. This article summarizes recent findings regarding the roles of transcription factors and epigenetic modifications in the differentiation, maintenance, and function of Tregs. This review will facilitate clinical application of Tregs to diseases in the field of ophthalmology, including uveitis and age-related macular degeneration.
journal_name
Corneajournal_title
Corneaauthors
Ito M,Iizuka-Koga M,Ando M,Yoshimura Adoi
10.1097/ICO.0000000000001720subject
Has Abstractpub_date
2018-11-01 00:00:00pages
S42-S49eissn
0277-3740issn
1536-4798journal_volume
37 Suppl 1pub_type
杂志文章,评审相关文献
CORNEA文献大全abstract:PURPOSE:To investigate the correlations between the biomechanical indices determined in Scheimpflug-based corneal biomechanical assessments and the severity of keratoconus (KC) based on corneal tomographic assessments in patients with different stages of KC. METHODS:Fifty-three patients who presented with clinical KC ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002129
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To determine whether preserved amniotic membrane can be used to reconstruct the ocular surface after excision of the invading granulation material typical of LOGIC syndrome (laryngeal and ocular granulation tissue in children from the Indian subcontinent). METHODS:Granulation tissue was dissected and excised f...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200110000-00016
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To describe severe acute corneal hydrops in a patient with previously undiagnosed keratoconus, in which anterior segment optical coherence tomography (AS-OCT) revealed a protruding ridge of tissue on either side of Descemet membrane (DM) break, treated successfully with ultrathin Descemet-stripping automated en...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002464
更新日期:2020-09-09 00:00:00
abstract:PURPOSE:To report a case of interface infection by Candida albicans after deep anterior lamellar keratoplasty (DALK). METHODS:A 30-year-old man with keratoconus underwent DALK. Four weeks after surgery, the patient developed multiple infiltrates in the graft-host interface with absence of intraocular infection. Donor ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318074e475
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:To evaluate changes in the anterior chamber of eyes that have undergone Descemet membrane endothelial keratoplasty (DMEK) and to identify factors that affect these changes. METHODS:This retrospective study included 25 pseudophakic eyes of 25 patients who underwent DMEK. We determined the preoperative and posto...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002535
更新日期:2020-09-29 00:00:00
abstract:PURPOSE:To demonstrate the use of anterior segment optical coherence tomography (ASOCT) in planning phototherapeutic keratectomy (PTK) removal of central corneal stromal scarring. METHODS:A 62-year-old male presented with central corneal scars associated with significant ocular surface disease. Videokeratographies obt...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181930b9f
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To review the clinical course, treatment, and visual outcomes of keratitis with endophthalmitis caused by the filamentary fungus Fusarium. METHOD:One hundred fifty-nine cases of Fusarium keratitis at Bascom Palmer Eye Institute between January 1, 1987 and August 21, 2000 were reviewed. Ten patients with cultur...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200305000-00004
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To describe the histopathologic characteristics of a 51-year-old Castroviejo square graft that remained functional for more than 50 years and to describe the wound-healing characteristics over this period of time. METHODS:An 80-year-old woman with a history of keratoconus underwent penetrating keratoplasty wit...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181861cb2
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To evaluate the stromal interface quality after femtosecond laser full lamellar cuts in gamma-irradiated corneas (VisionGraft sterile cornea) and to determine the limits of the cut depth using the VisionGraft as donor corneas for laser-assisted lamellar anterior keratoplasty. METHODS:Fourteen VisionGraft corne...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000614
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:To investigate the tear levels of matrix metalloproteinases (MMPs), myeloperoxidase (MPO), and tissue inhibitor of metalloproteinase-1 in eyes after Boston keratoprosthesis type I (B-KPro) implantation and to correlate these markers with the established B-KPro prognostic categories. METHODS:Tear washes were co...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000893
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:We describe the first case of minimally invasive corneal neurotization with the great auricular nerve (GAN) to treat unilateral neurotrophic keratopathy. We assessed corneal sensation and reinnervation by esthesiometry and confocal microscopy over 12 months of follow-up, and we provide a detailed description of...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001549
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:Recent new reports of possible iatrogenic transmission of Creutzfeldt-Jakob disease (CJD) in Europe have prompted renewed scrutiny of current Eye Bank Association of America criteria for evaluation of potential corneal donors in this country. A prior study evaluated the risk of CJD occurring in U.S. corneal don...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To examine the tissue samples of 2 corneal recipients from a rabies-infected donor for the presence of rabies to explain their survival. METHODS:Interventional case series with a review of the literature. The explanted corneal donor buttons were examined via nested reverse transcriptase polymerase chain reacti...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e3181e4572a
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To identify whether histopathologic presence of neovascularization is predictive for allograft failure following penetrating keratoplasty for herpes simplex virus (HSV) keratitis. METHODS:Retrospective, interventional case series of 62 consecutive patients with HSV keratitis who underwent penetrating keratopla...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31819c4e55
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:To study two cases of corneal scarring due to trauma (one case) and infection (one case) unrelated to a previous photorefractive keratectomy (PRK) for the correction of myopia. METHODS:The patients are part of an Institutional Review Board-approved study of the safety and efficacy of PRK. Both patients underwe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199811000-00007
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:To determine the factors associated with clinically significant dry eye after keratorefractive surgery. METHODS:This is a large database retrospective study that included consecutive cases of myopic laser in situ keratomileusis (LASIK) or photorefractive keratectomy performed between 2008 and 2016 at Care-Visi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002152
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:To compare the endothelial cell damage after lens removal using a fluid-based system to conventional ultrasound. METHODS:Twenty human cadaver eyes were randomized to undergo phacoemulsification using either a fluid-based system or conventional ultrasound. After surgery, each corneoscleral button was removed, s...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000130184.56514.51
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31823f7685
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To assess the effects of corneal collagen cross-linking (CXL) on contrast sensitivity (CS), visual acuity, and corneal topography investigating possible predictors of efficacy. METHODS:Sixty-eight eyes of 34 patients with progressive keratoconus were enrolled in this prospective study. CXL was performed in one...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31826672e2
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of amniotic membrane in corneal ulcers refractive to conventional treatment and amniotic membrane with fibrin glue in corneal perforations. METHODS:Amniotic membrane transplantation (AMT) was performed in 33 eyes from 32 patients for corneal ulcers refractive to conventional treatment....
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000151547.08113.d1
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To investigate infant tear film secretion and protein profile, and to compare major tear proteins, such as immunoglobulin A, lactoferrin, and lysozyme, with those of adult controls. METHODS:Tears were collected, with a cellulose rod, from 40 healthy infants (19 female infants and 21 male infants, gestational d...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181f22cd9
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To assess the long-term clinical course of dry eye in patients with chronic graft-versus-host disease (cGVHD). METHODS:A prospective case series of 49 patients with cGVHD was conducted. Complete history and ophthalmic examination were performed at baseline and at 36 months (range, 26-53). All patients received...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181e9b3bf
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:Decorin is a small chondroitin sulfate proteoglycan that inhibits vascular endothelial cell migration and tube formation. Membrane type 1-matrix metalloproteinase (MT1-MMP) has been shown to be an important angiogenic enzyme in the cornea. We evaluated the specific role of MT1-MMP in decorin cleavage in the cor...
journal_title:Cornea
pub_type: 杂志文章,收录出版
doi:10.1097/ICO.0b013e31822816e0
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To describe the association of water exposure with contact lens (CL)-related disease and explore the guidelines regarding water exposure to CL wearers, provided by CL manufacturing industry, global public health, and CL-related professional associations. METHODS:A review of the literature was conducted by sear...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0000000000001898
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To investigate the efficacy of a topical anti-tumor necrosis factor-α agent, infliximab, in a mouse model of experimental dry eye (EDE). METHODS:EDE was induced in C57BL/6 mice, with or without topical treatment consisting of balanced salt solution or 0.001%, 0.01%, or 0.1% infliximab solutions. Tear volume an...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31826a80ea
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To analyze the role of initial intraoperative intraocular pressure (IOP) in graft adhesion in Descemet membrane endothelial keratoplasty (DMEK) during early follow-up. METHODS:This retrospective, observational, single-center case series included 118 eyes from 118 consecutive patients treated between May and Ju...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001055
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate corneal graft survival over a 5-year period and to investigate whether factors related to the donor, eye bank practices, the recipient, surgery, and postoperative course influenced the outcome. METHODS:Nine hundred ninety-eight patients were randomly selected and monitored in the subsequent 3 years...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318206895a
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To report a case of corneal infection with Chrysosporium parvum, a filamentous fungus usually associated with pulmonary infections. METHODS:A 43-year-old Saudi man had a corneal stromal infiltrate and perforation of his left eye. He was treated with a therapeutic penetrating keratoplasty and topical and system...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:PURPOSE:To study changes in structure and barrier function of the corneal epithelium after penetrating keratoplasty. METHODS:Sixty-nine eyes of 56 patients undergoing penetrating keratoplasty were studied. Fifty-six age-matched normal eyes served as controls. Corneal epithelial structure was studied by using specular ...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine whether long-term wear of a fluid-filled scleral lens alters basal tear production, corneal sensation, corneal nerve density, and corneal nerve morphology in 2 disease categories. METHODS:Patients recruited from the Prosthetic Replacement of the Ocular Surface Ecosystem (...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000381
更新日期:2015-04-01 00:00:00