Aqueous tear production in patients with neurotrophic keratitis.


:The purpose of this study was to determine whether corneal epithelial defects and epitheliopathy in patients with unilateral dysfunction of the ophthalmic division of the trigeminal nerve (neurotrophic keratitis) is associated with reduced aqueous tear production. Sensation of the skin, cornea, and nasal mucosa, aqueous tear production by Schirmer 1 testing, nasal-lacrimal reflex, and exposure zone rose bengal staining were evaluated in the affected and fellow eyes of subjects with neurotrophic keratitis (n = 5), eyes of subjects who had recent herpes zoster ophthalmicus (HZO) and who did not develop neurotrophic keratitis (n = 4), and normal controls (n = 10). Sensation in the brow and upper lid skin and nasal mucosa was absent on the affected side of patients with neurotrophic keratitis, but was intact in all other groups. Corneal sensation and Schirmer 1 test values were significantly reduced (p < or = 0.05) in eyes with neurotrophic keratitis compared with the other groups. The nasal-lacrimal reflex was absent on the involved side of subjects with neurotrophic keratitis but was intact in subjects with HZO without keratopathy, and in normal controls (p < 0.008). Rose bengal keratitis staining scores were significantly increased in eyes with neurotrophic keratitis compared with the other groups (p < 0.05). We conclude that neurotrophic keratitis is associated with reduced cutaneous, nasal mucosal, and corneal sensation on the affected side, as well as marked reduction in aqueous tear production with loss of the nasal-lacrimal reflex. It is possible that the corneal epithelial pathology in neurotrophic keratitis is due in part to aqueous tear deficiency.






Heigle TJ,Pflugfelder SC




Has Abstract


1996-03-01 00:00:00














  • Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.

    abstract:PURPOSE:To compare the effects of levobunolol hydrochloride and timolol maleate on tear volume, precorneal tear film stability, and corneal epithelial barrier function in normal human eyes. SUBJECTS AND METHODS:The study population consisted of 14 healthy volunteers. To obtain pretreatment baseline values, we determin...


    pub_type: 杂志文章


    authors: Ishibashi T,Yokoi N,Kinoshita S

    更新日期:2003-11-01 00:00:00

  • In vitro susceptibilities of bacterial ocular isolates to fluoroquinolones.

    abstract:PURPOSE:To evaluate and compare the in vitro antimicrobial activity of levofloxacin versus ciprofloxacin and ofloxacin against ocular isolates from patients with bacterial conjunctivitis. METHODS:The in vitro antimicrobial susceptibilities of ocular isolates to levofloxacin, ofloxacin, and ciprofloxacin were determine...


    pub_type: 杂志文章


    authors: Graves A,Henry M,O'Brien TP,Hwang DG,Van Buskirk A,Trousdale MD

    更新日期:2001-04-01 00:00:00

  • Gentamicin-resistant pseudomonal infection. Rationale for a redefinition of ophthalmic antimicrobial sensitivities.

    abstract::Eight pseudomonal species were involved in 106 invasive infections of the eye; all were community acquired. Eighteen percent of the total and 9% of the Pseudomonas aeruginosa strains were gentamicin resistant, as defined using conventional criteria. All 10 cases of "resistant" pseudomonal (nine P. aeruginosa) keratiti...


    pub_type: 杂志文章


    authors: Ormerod LD,Heseltine PN,Alfonso E,Becker MI,Kenyon KR,Baerveldt G,Smith RE

    更新日期:1989-09-01 00:00:00

  • Moderately Long-Term Safety and Efficacy of Repeat Penetrating Keratoplasty.

    abstract:PURPOSE:To investigate the moderately long-term safety and efficacy of repeat penetrating keratoplasty (PK) for treatment of a failed PK graft. METHODS:Retrospective consecutive clinical case series. Of 992 consecutive cases that underwent PK at Baptist Eye Institute, Kyoto, Japan, between April 1998 and September 201...


    pub_type: 杂志文章


    authors: Kitazawa K,Wakimasu K,Kayukawa K,Yokota I,Inatomi T,Hieda O,Sotozono C,Kinoshita S

    更新日期:2018-10-01 00:00:00

  • Ocular Capnocytophaga infection in an edentulous, immunocompetent host.

    abstract::Severe microbial keratitis developed in a 74-year-old women receiving long-term corticosteroids. Corneal smears revealed slender, fusiform gram-negative bacilli, but the lesion continued to worsen despite intensive antibiotic treatment. After several days, Capnocytophaga sputigena was identified on culture. Specific a...


    pub_type: 杂志文章


    authors: Ormerod LD,Foster CS,Paton BG,Haaf J,Baker AS

    更新日期:1988-01-01 00:00:00

  • Corneal pathology in microphthalmia with linear skin defects syndrome.

    abstract:PURPOSE:To describe the histopathology of the cornea in microphthalmia with linear streaks (MLS) syndrome. METHODS:Two patients with MLS syndrome underwent penetrating keratoplasty. This study describes the histopathology and investigates immunophenotype of the corneal extracellular matrix by using keratan sulfate and...


    pub_type: 杂志文章


    authors: Kapur R,Tu EY,Toyran S,Shah P,Vangveeravong S,Lloyd WC 3rd,Edward DP

    更新日期:2008-07-01 00:00:00

  • Descemet's stripping automated endothelial keratoplasty (DSAEK) using corneal donor tissue not acceptable for use in penetrating keratoplasty as a result of anterior stromal scars, pterygia, and previous corneal refractive surgical procedures.

    abstract:PURPOSE:The purpose of this study was to evaluate outcomes of Descemet's stripping automated endothelial keratoplasty (DSAEK) using anterior stromal flawed (ASF) donor corneas that were unsuitable for use in full-thickness penetrating keratoplasty as a result of stromal scars, pterygia, or previous corneal refractive s...


    pub_type: 杂志文章


    authors: Phillips PM,Terry MA,Shamie N,Chen ES,Hoar KL,Stoeger C,Friend DJ,Saad HA

    更新日期:2009-09-01 00:00:00

  • Corneal complications of herpes zoster ophthalmicus. Prevention and treatment.

    abstract::Corneal complications of herpes zoster ophthalmicus include pseudodendritic keratitis, late mucous adherent keratopathy, varied forms of stromal keratitis, and exposure/neurotrophic keratopathy. Prophylactic therapy of acute herpes zoster ophthalmicus with oral acyclovir is of proven benefit in reducing the incidence ...


    pub_type: 杂志文章


    authors: Cobo LM

    更新日期:1988-01-01 00:00:00

  • Robotically Assisted Pterygium Surgery: First Human Case.

    abstract:PURPOSE:Little research has been done on robotic ocular microsurgery. This study aims to demonstrate the feasibility of pterygium surgery using a robotic surgical system. METHODS:Robot-assisted pterygium surgery was performed on a 73-year-old patient with nasal and temporal pterygia using the DaVinci Si HD robotic Sur...


    pub_type: 杂志文章


    authors: Bourcier T,Chammas J,Becmeur PH,Danan J,Sauer A,Gaucher D,Liverneaux P,Mutter D

    更新日期:2015-10-01 00:00:00

  • Intraocular lens power calculation after automated lamellar keratoplasty for high myopia.

    abstract:PURPOSE:To report intraocular lens (IOL) power calculation in 2 eyes that were highly undercorrected by previous myopic automated lamellar keratoplasty (ALK). METHODS:A 35-year-old man underwent bilateral myopic ALK, which caused high residual myopia (-9.0 -4.0 x 171 and -9.5 -4.5 x 74). The patient then underwent cat...


    pub_type: 杂志文章


    authors: Lee SH,Tsai CY,Liou SW,Tsai RJ,Ho JD

    更新日期:2008-10-01 00:00:00

  • Surgical monovision and monovision reversal in LASIK.

    abstract:PURPOSE:This study was designed to assess the success of surgical monovision in presbyopic patients. METHODS:A university refractive surgery center retrospective chart review of 82 patients who elected to undergo surgical monovision with laser in situ keratomileusis (LASIK) between January 2000 and January 2003 was co...


    pub_type: 杂志文章


    authors: Reilly CD,Lee WB,Alvarenga L,Caspar J,Garcia-Ferrer F,Mannis MJ

    更新日期:2006-02-01 00:00:00

  • The stability of corneal topography in the post-blink interval.

    abstract:PURPOSE:Videokeratoscopes provide a wealth of information about the topography of the ocular surface. Although there have been numerous studies of the accuracy and precision of videokeratoscopes with inanimate test objects, little information exists on their precision (repeatability) for real eyes. METHODS:To investig...


    pub_type: 杂志文章


    authors: Buehren T,Collins MJ,Iskander DR,Davis B,Lingelbach B

    更新日期:2001-11-01 00:00:00

  • The prevalence of positive hepatitis B, hepatitis C, and HIV serology in cornea donors prescreened by medical and social history in Ontario, Canada.

    abstract:PURPOSE:To determine the prevalence of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) in the serum of cornea donors who had been previously screened by social and medical history by the Eye Bank of Canada, Ontario Division. METHOD:A retrospective examination of the donor records of the Ey...


    pub_type: 杂志文章


    authors: Armstrong SA,Gangam N,Chipman ML,Rootman DS

    更新日期:1997-09-01 00:00:00

  • Tear film volume and protein analysis in full-term newborn infants.

    abstract:PURPOSE:To investigate infant tear film secretion and protein profile, and to compare major tear proteins, such as immunoglobulin A, lactoferrin, and lysozyme, with those of adult controls. METHODS:Tears were collected, with a cellulose rod, from 40 healthy infants (19 female infants and 21 male infants, gestational d...


    pub_type: 杂志文章


    authors: Esmaeelpour M,Watts PO,Boulton ME,Cai J,Murphy PJ

    更新日期:2011-04-01 00:00:00

  • A combined approach of amniotic membrane and oral mucosa transplantation for fornix reconstruction in severe symblepharon.

    abstract:PURPOSE:To evaluate the results of a combined approach of cicatrix lysis, intraoperative mitomycin C (MMC) application, oral mucosal transplantation (OMT), and amniotic membrane transplantation (AMT) for surgery of severe symblepharon. METHODS:This prospective study included 32 eyes with severe symblepharon in which a...


    pub_type: 杂志文章


    authors: Kheirkhah A,Ghaffari R,Kaghazkanani R,Hashemi H,Behrouz MJ,Raju VK

    更新日期:2013-02-01 00:00:00

  • Can we measure corneal biomechanical changes after collagen cross-linking in eyes with keratoconus?--a pilot study.

    abstract:PURPOSE:To assess changes in biomechanical properties of human cornea after treatment of keratoconus with UV-A-riboflavin corneal collagen cross-linking (CXL). DESIGN:Single-center, prospective, interventional study. METHODS:Ten eyes of 10 patients aged 26.5 +/- 5.7 (mean +/- SD) years with progressive keratoconus we...


    pub_type: 杂志文章


    authors: Goldich Y,Barkana Y,Morad Y,Hartstein M,Avni I,Zadok D

    更新日期:2009-06-01 00:00:00

  • Effects of diquafosol sodium eye drops on tear film stability in short BUT type of dry eye.

    abstract:PURPOSE:To investigate the effects of diquafosol sodium (DQS) eye drops, a purinergic P2Y2 receptor agonist, on tear film stability in patients with unstable tear film (UTF). METHODS:Two prospective studies were conducted. One was an exploratory nonrandomized trial on 39 eyes with dry eye symptoms and short tear film ...


    pub_type: 杂志文章,随机对照试验


    authors: Shimazaki-Den S,Iseda H,Dogru M,Shimazaki J

    更新日期:2013-08-01 00:00:00

  • Conjunctival proliferation after a mild pepper spray injury in a young child.

    abstract:PURPOSE:To report a case of conjunctival proliferation in a 2.5-year-old boy after initial evidence of a mild chemical injury after ocular exposure to pepper spray (oleoresin capsicum). METHODS:Case report with ophthalmologic and histologic findings. RESULTS:A child presented with mild conjunctival injection and chem...


    pub_type: 杂志文章


    authors: Gerber S,Frueh BE,Tappeiner C

    更新日期:2011-09-01 00:00:00

  • Eyelid Tattooing Induces Meibomian Gland Loss and Tear Film Instability.

    abstract:PURPOSE:To investigate the changes of meibomian gland (MG) and tear film stability in subjects with eyelid tattoos. METHODS:Forty female subjects were recruited. Ten subjects had eyelid tattoos and 30 subjects did not (control group). Tear film break-up time (TBUT) measurement and fluorescein staining were performed t...


    pub_type: 杂志文章


    authors: Lee YB,Kim JJ,Hyon JY,Wee WR,Shin YJ

    更新日期:2015-07-01 00:00:00

  • Descemet Membrane Endothelial Keratoplasty for Failed Penetrating Keratoplasty: Visual Outcomes and Graft Survival.

    abstract:PURPOSE:To evaluate outcomes and graft survival of Descemet membrane endothelial keratoplasty (DMEK) for failed penetrating keratoplasty (PK). METHODS:Ninety-three DMEK procedures performed in 84 eyes of 77 patients with failed PK were retrospectively reviewed. The main outcomes were corrected distance visual acuity a...


    pub_type: 杂志文章


    authors: Pasari A,Price MO,Feng MT,Price FW Jr

    更新日期:2019-02-01 00:00:00

  • Effects of basic FGF and TGF beta 1 on F-actin and ZO-1 organization during cat endothelial wound healing.

    abstract::Previous studies suggest the existence of two separate and distinct mechanisms of endothelial wound healing (i.e., cell migration and cell spreading), which may be controlled by unique, injury-dependent, wound-related factors. The purpose of our study was to evaluate potential biologic mediators regulating healing of ...


    pub_type: 杂志文章


    authors: Petroll WM,Jester JV,Barry-Lane PA,Cavanagh HD

    更新日期:1996-09-01 00:00:00

  • Association Between Sleep Quality, Mood Status, and Ocular Surface Characteristics in Patients With Dry Eye Disease.

    abstract:PURPOSE:To evaluate sleep and mood status in patients with dry eye disease (DED) and analyze the association between sleep quality, mood status, and ocular surface characteristics. METHODS:Consecutive patients with DED (N = 106) and age- and sex-matched healthy controls (N = 50) were enrolled. Tear fluid break up time...


    pub_type: 杂志文章


    authors: Wu M,Liu X,Han J,Shao T,Wang Y

    更新日期:2019-03-01 00:00:00

  • In Situ Corneal Cross-Linking for Recurrent Corneal Melting After Boston Type 1 Keratoprosthesis.

    abstract:PURPOSE:To present a new treatment modality for recurrent corneal melting in a patient with a Boston type I keratoprosthesis (B-KPro) including in situ corneal cross-linking (CXL) and lamellar keratoplasty (LKP) as combined treatment. METHODS:Case report. RESULTS:Our report concerns a 27-year-old man whose case histo...


    pub_type: 杂志文章


    authors: Tóth G,Bucher F,Siebelmann S,Bachmann B,Hermann M,Szentmáry N,Nagy ZZ,Cursiefen C

    更新日期:2016-06-01 00:00:00

  • The effect of the fourth-generation fluoroquinolones on corneal reepithelialization after penetrating keratoplasty.

    abstract:PURPOSE:To compare the effects of topical moxifloxacin and gatifloxacin on corneal reepithelialization after penetrating keratoplasty. METHODS:In this single-center, open-label, prospective study, 46 consecutive patients requiring penetrating keratoplasty were alternately assigned to receive either postoperative moxif...


    pub_type: 临床试验,杂志文章


    authors: Moshirfar M,Marx DP,Kumar R

    更新日期:2005-10-01 00:00:00

  • Ocular mucin visualization by confocal laser scanning microscopy.

    abstract:PURPOSE:To describe a new method of visualizing human conjunctiva goblet cell mucin secretion by using a combination of impression cytology and laser scanning microscopy. METHODS:By assembling a Z-stack of confocal microscopy images taken from human impression cytology samples, we obtained 3-dimensional information ab...


    pub_type: 杂志文章


    authors: Peral A,Pintor J

    更新日期:2008-05-01 00:00:00

  • On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome.

    abstract::The iridocorneal endothelial (ICE) syndrome is potentially a blinding condition as a result of glaucoma and/or corneal decompensation. The basic pathology seems to be in the corneal endothelium, which many studies confirm takes on a characteristic slit lamp appearance of hammered silver and image reversal with the spe...


    pub_type: 杂志文章


    authors: Sherrard ES,Frangoulis MA,Muir MG

    更新日期:1991-05-01 00:00:00

  • Ocular streptococcal infections.

    abstract::Streptococcal infections are an important cause of corneal ulcers, endophthalmitis, conjunctivitis, and dacryocystitis. We retrospectively reviewed 53 ocular streptococcal infections diagnosed and followed at Wills Eye Hospital between January 1, 1984, and July 1, 1986. Corneal ulcers (23 of 53; 43%) and endophthalmit...


    pub_type: 杂志文章


    authors: Jones S,Cohen EJ,Arentsen JJ,Laibson PR

    更新日期:1988-01-01 00:00:00

  • Corneal chromoblastomycosis.

    abstract:PURPOSE:We sought to illustrate the difficulty in managing uncommon, pigmented mold-related corneal ulceration and to highlight the role of itraconazole in treating these patients. METHOD:We describe the management and clinical course of a patient with a recurring corneal infection caused by Fonsecaea pedrosoi and dis...


    pub_type: 杂志文章,评审


    authors: Barton K,Miller D,Pflugfelder SC

    更新日期:1997-03-01 00:00:00

  • Expression of phosphorylated heat shock protein 27 during corneal epithelial wound healing.

    abstract:PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...


    pub_type: 杂志文章


    authors: Jain S,De la Cruz J,Kang E,Kojima T,Chang JH,Kim JY

    更新日期:2012-07-01 00:00:00

  • Corneal Transplantation in Auckland, New Zealand, 1999-2009: Indications, Patient Characteristics, Ethnicity, Social Deprivation, and Access to Services.

    abstract:PURPOSE:To analyze characteristics and indications for corneal transplantation in patients undergoing penetrating, lamellar, and endothelial keratoplasty in Auckland, New Zealand (NZ). METHODS:Corneal transplantation data from the NZ National Eye Bank and hospital records of corneal transplant recipients in the Auckla...


    pub_type: 杂志文章


    authors: Crawford AZ,McKelvie J,Craig JP,McGhee CN,Patel DV

    更新日期:2017-05-01 00:00:00