Abstract:
PURPOSE:To evaluate the morphological features of the corneal limbus as measured by in vivo confocal microscopy (IVCM) following standard and accelerated corneal collagen cross-linking (CXL) for keratoconus. METHODS:Patients with progressive keratoconus scheduled to undergo standard CXL (group 1; 31 patients, 3 mW/cm, 370 nm, 30 minutes), or accelerated CXL (group 2; 20 patients, 9 mW/cm, 370 nm, 10 minutes) in the worse eye were included in this prospective study. Thirty eyes of 30 age-matched patients served as controls (group 3). All patient eyes underwent IVCM scanning of the central cornea and the inferior limbal area at baseline and 1, 3, and 6 months after CXL. RESULTS:After CXL, epithelial regrowth was complete by day 4 in both groups 1 and 2. There were no statistically significant differences between the baseline mean central corneal wing or basal cell density, limbus-palisade middle or basal cell densities of groups 1, 2, or 3. At postoperative months 1, 3, and 6, there were no statistically significant differences in either central or limbus-palisade epithelial cell densities or diameters in keratoconic eyes that underwent standard or accelerated CXL (P > 0.05). The morphology of the limbal cells was preserved as well. CONCLUSIONS:The morphology of limbus structures seems to be preserved following standard and accelerated CXL in short-term follow-up, as measured using IVCM.
journal_name
Corneajournal_title
Corneaauthors
Uçakhan ÖÖ,Bayraktutar Bdoi
10.1097/ICO.0000000000001029subject
Has Abstractpub_date
2017-01-01 00:00:00pages
78-84issue
1eissn
0277-3740issn
1536-4798journal_volume
36pub_type
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