Assessment of keratocyte density in patients with keratoconus not using contact lenses.

Abstract:

PURPOSE:To assess the keratocyte density (KD) in the cornea of patients with keratoconus not using contact lenses. METHOD:In this pilot study, the eyes (n = 68) of 35 patients with the diagnosis of keratoconus, who did not use contact lenses and the eyes(n = 70) of 35 healthy controls were prospectively examined using the Heidelberg Retinal Tomography Rostock cornea module (HRT3/RCM). The cases with keratoconus and controls were compared with regard to KD in the anteroposterior stromal layers. RESULTS:Of the cases with keratoconus, 15 (42.9%) were men and 20 (57.1%) were women. The mean age was 21.1 ± 11.1 (range =14-41) years. Of the controls, 26 (73.9%) were men and 9 (26.1%)were women. The mean age was 23.9 ± 12.9 (range = 14-35) years.Of the 68 eyes with keratoconus, 22 (28.2%) had mild keratoconus, 23 (35.9%) had moderate keratoconus, and 23 (35.9%) had severe keratoconus. The mean anterior stromal KD was 651.4 ± 89 cells per square millimeter in cases with keratoconus and 879.4 ± 75 cells per square millimeter in controls (P < 0.05). The mean anterior stromal KD decreased by 25.9% in corneas with keratoconus. The mean posterior stromal KD was found to be 363.6 ± 74 cells per square millimeter in cases with keratoconus and 469.7 ± 56 cells per square millimeter in controls (P< 0.01). The mean posterior stromal KD decreased by 22.6% in corneas with keratoconus. The anterior stromal KD was higher than the posterior stromal KD (P < 0.001). No significant relationships were found between the stromal KD data and central corneal thickness or steepest keratometric. CONCLUSIONS:The KD in the anterior and posterior corneal stroma was decreased in patients with keratoconus, but without the use of contact lens, compared with healthy controls. This density difference was independent from the central corneal thickness and the stage of keratoconus.

journal_name

Cornea

journal_title

Cornea

authors

Timucin OB,Karadag MF,Cinal A

doi

10.1097/ICO.0b013e3182000fd4

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

576-9

issue

5

eissn

0277-3740

issn

1536-4798

pii

00003226-201105000-00016

journal_volume

30

pub_type

杂志文章

相关文献

CORNEA文献大全
  • Cyclosporine A Downregulates MMP-3 and MMP-13 Expression in Cultured Pterygium Fibroblasts.

    abstract:PURPOSE:To investigate the regulation of matrix metalloproteinase (MMP)-3 and MMP-13 expression over time and in the presence of cyclosporine A (CsA) in primary cultured human pterygium fibroblasts. We also examined the effects of CsA on cultured human pterygium fibroblasts. METHODS:Primary cultured human pterygium fi...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000477

    authors: Kim YH,Jung JC,Jung SY,Kim YI,Lee KW,Park YJ

    更新日期:2015-09-01 00:00:00

  • Double-Line Reflection Pattern as a Simple Method to Determine Graft Orientation of Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To describe a simple finding, consisting of a double-line reflection from the graft inside the anterior chamber, that can be used to determine the correct donor tissue orientation in Descemet membrane endothelial keratoplasty: which we would like to call Berrospi's sign. METHODS:Evaluation of the presence of l...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001889

    authors: Berrospi RD,Galvis V,Bhogal M,Tello A

    更新日期:2019-06-01 00:00:00

  • A stepwise approach to donor preparation and insertion increases safety and outcome of Descemet membrane endothelial keratoplasty.

    abstract:PURPOSE:Lamellar techniques for selective replacement of diseased corneal structures have recently been improved. Descemet membrane endothelial keratoplasty (DMEK) allows the sole replacement of the endothelium--Descemet membrane layer (EDM). However, wide-spread use of DMEK is currently limited because of problems wit...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ico.0b013e3182000e2e

    authors: Kruse FE,Laaser K,Cursiefen C,Heindl LM,Schlötzer-Schrehardt U,Riss S,Bachmann BO

    更新日期:2011-05-01 00:00:00

  • Onset of ocular graft-versus-host disease symptoms after allogeneic hematopoietic stem cell transplantation.

    abstract:OBJECTIVE:To study the factors affecting the time to onset of ocular graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS:A retrospective chart review of 200 patients with ocular GVHD was performed to evaluate the association between various do...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000340

    authors: Shikari H,Amparo F,Saboo U,Dana R

    更新日期:2015-03-01 00:00:00

  • Recurrence Rate and Graft Stability With Fibrin Glue Compared With Suture and Autologous Blood Coagulum for Conjunctival Autograft Adherence in Pterygium Surgery: A Meta-Analysis.

    abstract:PURPOSE:To minimize recurrence and improve graft stability after pterygium surgery, conjunctival autograft adherence is done using fibrin glue (FG) or autologous blood coagulum (ABC). But there are studies that have reported conflicting or inconclusive results. This meta-analysis was conducted to evaluate the postopera...

    journal_title:Cornea

    pub_type: 杂志文章,meta分析

    doi:10.1097/ICO.0000000000001270

    authors: Maiti R,Mukherjee S,Hota D

    更新日期:2017-10-01 00:00:00

  • Corneal endothelial cell damage after lens extraction using the fluid-based system compared to ultrasound phacoemulsification in human cadaver eyes.

    abstract:PURPOSE:To compare the endothelial cell damage after lens removal using a fluid-based system to conventional ultrasound. METHODS:Twenty human cadaver eyes were randomized to undergo phacoemulsification using either a fluid-based system or conventional ultrasound. After surgery, each corneoscleral button was removed, s...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/01.ico.0000130184.56514.51

    authors: Sandoval HP,Al Sarraf O,Vroman DT,Solomon KD

    更新日期:2004-10-01 00:00:00

  • Conjunctival proliferation after a mild pepper spray injury in a young child.

    abstract:PURPOSE:To report a case of conjunctival proliferation in a 2.5-year-old boy after initial evidence of a mild chemical injury after ocular exposure to pepper spray (oleoresin capsicum). METHODS:Case report with ophthalmologic and histologic findings. RESULTS:A child presented with mild conjunctival injection and chem...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318206cad9

    authors: Gerber S,Frueh BE,Tappeiner C

    更新日期:2011-09-01 00:00:00

  • Effect of Descemet Membrane Endothelial Keratoplasty on Color Vision in Patients With Fuchs Dystrophy.

    abstract:PURPOSE:To assess changes in color discernment after Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS:In this prospective, single-center study, the study group was composed of 26 patients with FECD, aged 46 to 85 years, who underwent DMEK as a singl...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000871

    authors: Price DA,Price MO,Lopez A,Price FW Jr

    更新日期:2016-08-01 00:00:00

  • Risk factors for graft failure after penetrating keratoplasty: 5-year follow-up from the corneal transplant epidemiological study.

    abstract:PURPOSE:To evaluate corneal graft survival over a 5-year period and to investigate whether factors related to the donor, eye bank practices, the recipient, surgery, and postoperative course influenced the outcome. METHODS:Nine hundred ninety-eight patients were randomly selected and monitored in the subsequent 3 years...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318206895a

    authors: Fasolo A,Capuzzo C,Fornea M,Franch A,Birattari F,Carito G,Cucco F,Prosdocimo G,Sala M,Delle Noci N,Primavera V,Frigo AC,Grigoletto F,Ponzin D,CORTES Study Group.

    更新日期:2011-12-01 00:00:00

  • The effect of the fourth-generation fluoroquinolones on corneal reepithelialization after penetrating keratoplasty.

    abstract:PURPOSE:To compare the effects of topical moxifloxacin and gatifloxacin on corneal reepithelialization after penetrating keratoplasty. METHODS:In this single-center, open-label, prospective study, 46 consecutive patients requiring penetrating keratoplasty were alternately assigned to receive either postoperative moxif...

    journal_title:Cornea

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.ico.0000157420.11448.d4

    authors: Moshirfar M,Marx DP,Kumar R

    更新日期:2005-10-01 00:00:00

  • Delayed, bilateral descemet's membrane detachments with spontaneous resolution: Implications for nonsurgical treatment.

    abstract:PURPOSE:To report a case of delayed bilateral Descemet's detachment with spontaneous resolution in one eye following successful treatment of the fellow eye. METHOD:Case report. RESULTS:A 78-year-old male who underwent uncomplicated bilateral cataract extraction with phacoemulsification developed delayed bilateral Des...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318197eef1

    authors: Couch SM,Baratz KH

    更新日期:2009-12-01 00:00:00

  • Corneal Endothelium and Phacoemulsification.

    abstract::Phacoemulsification has become the most commonly used procedure in cataract surgery owing to the development of new devices and surgical techniques; however, corneal endothelial damage still represents a serious complication. Although several factors are known to cause corneal endothelial damage, effects of irrigating...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000000990

    authors: Takahashi H

    更新日期:2016-11-01 00:00:00

  • Diagnosis of Aspergillus keratitis in vivo with confocal microscopy.

    abstract::Confocal microscopy provides a new, noninvasive way of imaging the human cornea in vivo. One of its most important clinical uses is the diagnosis and management of infectious keratitis. The authors used tandem scanning confocal microscopy to image the corneas in two culture-proven cases of Aspergillus keratitis. Funga...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Winchester K,Mathers WD,Sutphin JE

    更新日期:1997-01-01 00:00:00

  • Candida albicans interface infection after deep anterior lamellar keratoplasty.

    abstract:PURPOSE:To report a case of interface infection by Candida albicans after deep anterior lamellar keratoplasty (DALK). METHODS:A 30-year-old man with keratoconus underwent DALK. Four weeks after surgery, the patient developed multiple infiltrates in the graft-host interface with absence of intraocular infection. Donor ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318074e475

    authors: Fontana L,Parente G,Di Pede B,Tassinari G

    更新日期:2007-08-01 00:00:00

  • Descemet-stripping automated endothelial keratoplasty by using suture for donor insertion.

    abstract:PURPOSE:To describe a new technique for donor insertion in cases of Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:This is a retrospective case series study of a novel method to introduce the donor tissue in DSAEK. This is a report of 16 cases that underwent the DSAEK procedure. The surgical te...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e31816f62bd

    authors: Sarnicola V,Toro P

    更新日期:2008-08-01 00:00:00

  • Moderately Long-Term Safety and Efficacy of Repeat Penetrating Keratoplasty.

    abstract:PURPOSE:To investigate the moderately long-term safety and efficacy of repeat penetrating keratoplasty (PK) for treatment of a failed PK graft. METHODS:Retrospective consecutive clinical case series. Of 992 consecutive cases that underwent PK at Baptist Eye Institute, Kyoto, Japan, between April 1998 and September 201...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001694

    authors: Kitazawa K,Wakimasu K,Kayukawa K,Yokota I,Inatomi T,Hieda O,Sotozono C,Kinoshita S

    更新日期:2018-10-01 00:00:00

  • Cell Therapy of Corneal Diseases.

    abstract::Mesenchymal stem cells isolated from connective tissues are pluripotent and differentiate into phenotypes of connective tissue cell lineages (osteoblasts, chondrocytes, and adipocytes) in vitro and in vivo. They have been used to treat mouse models of connective tissue disease such as lumican-null (Lum) and mucopolysa...

    journal_title:Cornea

    pub_type: 杂志文章,评审

    doi:10.1097/ICO.0000000000001010

    authors: Kao WW,Coulson-Thomas VJ

    更新日期:2016-11-01 00:00:00

  • Elevated tear IgG and conjunctival plasma cell infiltrate in a graft versus host disease patient.

    abstract::Two patients developed graft versus host disease (GvHD) following allogeneic bone marrow transplantation for leukemia. One patient developed acute GvHD 12 days after transplantation, and the second developed chronic GvHD 100 days after transplantation. Tear analysis and conjunctival impression cytology were performed....

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Heitman KF,Lam KW,Maskin SL,Yee RW,Lawton AW

    更新日期:1988-01-01 00:00:00

  • New Freeware for Image Analysis of Lissamine Green Conjunctival Staining.

    abstract:PURPOSE:Lissamine green (LG) is often used in addition to fluorescein to assess the severity of conjunctival damage in dry eye syndrome, which is graded manually. Our purpose was to describe an algorithm designed for image analysis of LG conjunctival staining. METHODS:Twenty pictures of patients suffering from dry eye...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002617

    authors: Courrier E,Renault D,Dib E,Urrea C,Kaspi M,Fournier C,Lépine T,Chiambaretta F,Hor G,He Z,Garcin T,Thuret G,Gain P

    更新日期:2020-12-18 00:00:00

  • Intraoperative mitomycin C and corneal endothelium after pterygium surgery.

    abstract:PURPOSE:To determine the effect of mitomycin C (MMC) on the corneal endothelium after primary pterygium surgery. METHODS:This prospective, interventional, nonrandomized, observer-masked study included 46 consecutive patients (51 eyes) with primary pterygium. The bare sclera technique with 1-minute application of 0.02%...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3181a3c548

    authors: Pérez-Rico C,Benítez-Herreros J,Montes-Mollón MA,Germain F,Castro-Rebollo M,Gómez-SanGil Y,Paz-Moreno J,Teus MA

    更新日期:2009-12-01 00:00:00

  • Evaluation of Anterior and Posterior Corneal Irregularity After Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To investigate the changes in anterior and posterior corneal irregularity after Descemet membrane endothelial keratoplasty (DMEK). METHODS:This retrospective study included 27 eyes of 23 patients who underwent DMEK and 27 eyes of age-matched healthy controls. Corneal irregularity indexes, surface regularity of...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001722

    authors: Oyakawa I,Hayashi T,Kobashigawa Y,Matsuzawa A,Takahashi H,Kato N

    更新日期:2018-11-01 00:00:00

  • In vivo biomechanical changes after corneal collagen cross-linking for keratoconus and corneal ectasia: 1-year analysis of a randomized, controlled, clinical trial.

    abstract:PURPOSE:To investigate the in vivo, corneal, biomechanical changes after corneal collagen cross-linking (CXL) using the Ocular Response Analyzer (ORA) in patients with keratoconus and post-laser in situ keratomileusis (LASIK) ectasia. METHODS:Single-center, prospective, randomized, controlled, clinical trial. After CX...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/ICO.0b013e31821eea66

    authors: Greenstein SA,Fry KL,Hersh PS

    更新日期:2012-01-01 00:00:00

  • Tandem-scanning (confocal) microscopy of the full-thickness cornea.

    abstract::We have utilized a radically new type of optical scanning microscope to study the full-thickness morphology of the intact cornea in an excised human eye bank eye and in freshly sacrificed rabbit eyes in situ. This technology enables one to study corneal morphology layer by layer in extremely thin sections, only distur...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Lemp MA,Dilly PN,Boyde A

    更新日期:1985-01-01 00:00:00

  • White-to-white corneal diameter in the Tehran Eye Study.

    abstract:PURPOSE:To determine the mean corneal diameter and its determinants in the population of Tehran. METHODS:From the Tehran Eye Study participants who were sampled through a stratified cluster approach, those in the first 4 municipality districts of Tehran were selected, and after applying the inclusion and exclusion cri...

    journal_title:Cornea

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ICO.0b013e3181a9d0a9

    authors: Hashemi H,KhabazKhoob M,Yazdani K,Mehravaran S,Mohammad K,Fotouhi A

    更新日期:2010-01-01 00:00:00

  • Femtosecond Laser-Assisted Keratolimbal Allograft Transplantation for the Treatment of Total Limbal Stem Cell Deficiency.

    abstract:PURPOSE:To investigate the surgical procedure and therapeutic efficacy of femtosecond (FS) laser-assisted keratolimbal allograft (KLAL) transplantation in the treatment of eyes with total limbal stem cell deficiency. METHODS:Ten eyes from 10 patients who underwent FS laser-assisted KLAL transplantation were enrolled. ...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002041

    authors: Qi X,Duan F,Li X,Zhang X,Li N,Liu M,Gao H

    更新日期:2019-10-01 00:00:00

  • Sequential therapeutic penetrating keratoplasty with cryopreserved and fresh corneal tissue for severe infectious keratitis: a case-control study.

    abstract:PURPOSE:Sequential therapeutic penetrating keratoplasty (TPK) using a cryopreserved cornea followed soon after by a fresh optical grade cornea for severe infectious keratitis may improve the survival of the optical graft. The aim of this study was to compare the therapeutic efficacy, visual outcomes, and graft survival...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e318203217c

    authors: Lim LS,Arundhati A,Tan DT

    更新日期:2011-07-01 00:00:00

  • Characterization of Corneal Donor Tissue Lesions by Anterior Segment Optical Coherence Tomography Compared With Eye Bank Technician Slit-Lamp Examination.

    abstract:PURPOSE:To compare anterior segment spectral-domain optical coherence tomography (OCT) with eye bank technician slit-lamp examination (SLE) in characterizing lesions in donor corneas. METHODS:Twenty-nine donor corneas identified by eye bank technicians to have opacities or lesions potentially representing pathologic f...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000001700

    authors: Hsu ST,Perry I,Botsay S,Ko N,Stinnett SS,Kuo AN,Shieh C

    更新日期:2018-10-01 00:00:00

  • The Effect of Intraoperative Angle Kappa Adjustment on Higher-Order Aberrations Before and After Small Incision Lenticule Extraction.

    abstract:PURPOSE:To compare higher-order aberrations (HOAs) after small incision lenticule extraction (SMILE) in patients with and without intraoperative angle kappa adjustments. METHODS:This is a retrospective case series. One hundred six eyes of 106 patients who underwent SMILE at Tianjin Eye Hospital (Tianjin Medical Univer...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0000000000002274

    authors: Shao T,Wang Y,Ng ALK,Chan TCY,Hao W,Zhang J,Cheng GPM,Jhanji V

    更新日期:2020-05-01 00:00:00

  • Limbal stem cell-sparing lamellar keratoplasty for the management of advanced keratoglobus.

    abstract:PURPOSE:To describe the technique and outcomes of limbal stem cell-sparing lamellar keratoplasty (LSCS-LKP) for the management of advanced keratoglobus (KGB). METHODS:In a sequential interventional case series from March 2010 to December 2012, 8 eyes of 6 patients with advanced KGB underwent an LSCS-LKP. Three patient...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:10.1097/ICO.0b013e3182a9b1ac

    authors: Karimian F,Baradaran-Rafii A,Faramarzi A,Akbari M

    更新日期:2014-01-01 00:00:00

  • Two treatments of eye bank donor corneas.

    abstract::The many published studies on sterile procedures used by eye banks have included none until now on ways to optimize sterile handling of corneas procured in the morgues of forensic pathologists. The present study sought to discover if fewer positive cultures would be reported at the time of surgery from corneas which h...

    journal_title:Cornea

    pub_type: 杂志文章

    doi:

    authors: Farge EJ,Fort RA

    更新日期:1985-01-01 00:00:00