Abstract：
PURPOSE:The aim of this study was to evaluate glaucoma onset and progression after implantation of Boston Keratoprostheses (B-KPro) and the role of glaucoma surgery. METHODS:Records of patients with B-KPro implantation during 2004 to 2009 were reviewed. Parameters relevant to B-KPro surgery and glaucoma status were recorded. The data were analyzed in 5 groups based on the preoperative diagnosis. RESULTS:One hundred six eyes of 87 patients were included, and the average age was 54 ± 6.7 years. Forty-six percent were female. Eighteen eyes had a B-KPro with a titanium back plate, and the others had a poly(methyl methacrylate) back plate. Thirty-three eyes were pseudophakic, and the rest were left aphakic. The follow-up time was 3.3 ± 1.0 years. Indications for implantation included past infection, congenital glaucoma, trauma, autoimmune diseases, aniridia, burns, and others. Sixty-six percent of the eyes had glaucoma preoperatively, and 26% developed de novo glaucoma afterward. The mean intraocular pressure (by finger palpation) was 16.5 ± 5.7 mm Hg. Reliable visual field tests were only available in 59% of the eyes; hence, the cup-to-disc ratio of the optic nerve head was used as the main outcome measure. In B-KPro-implanted eyes with glaucoma, 65% had undergone glaucoma surgery at some point, and 30% did not show progression. Thirty-one percent of the total cohort had disc pallor with a cup-to-disc ratio of <0.8. CONCLUSIONS:Glaucoma in B-KPro remains a challenge, despite aggressive attempts to slow down its progression. Patients with glaucoma before B-KPro implantation should be considered for glaucoma surgery before or simultaneously with B-KPro implantation. The high number of eyes with disc pallor suggests that additional mechanisms other than elevated intraocular pressure may play a role in optic neuropathy.
journal_name
Corneajournal_title
Corneaauthors
Crnej A,Paschalis EI,Salvador-Culla B,Tauber A,Drnovsek-Olup B,Shen LQ,Dohlman CHdoi
10.1097/ICO.0000000000000067subject
Has Abstractpub_date
2014-04-01 00:00:00pages
349-54issue
4eissn
0277-3740issn
1536-4798journal_volume
33pub_type
杂志文章相关文献
CORNEA文献大全abstract：PURPOSE:To report the first use of Descemet stripping automated endothelial keratoplasty (DSAEK) for spontaneous Descemet membrane detachment in a patient with osteogenesis imperfecta (OI), keratoconus, and acute bullous keratopathy. METHODS:A case report of a 25-year-old man with OI and symptomatic unilateral bullous...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e318225418b
更新日期：2012-07-01 00:00:00
abstract：PURPOSE:To describe the Oxford Scheme for grading ocular surface staining in dry eye and to discuss optimization of stain detection using various dyes and filters. Also, to propose a sequence of testing for dry eye diagnosis. METHODS:The grading of corneal and conjunctival staining is described, using the Oxford Schem...
journal_title：Cornea
pub_type： 杂志文章,评审
doi：10.1097/00003226-200310000-00008
更新日期：2003-10-01 00:00:00
abstract：:Secondary corneal amyloidosis is a rare finding and only 17 cases have been reported in the literature. A case of unilateral secondary localized corneal amyloidosis is presented in a patient with bilateral interstitial keratitis and other stigmata of tertiary syphilis. ...
journal_title：Cornea
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：PURPOSE:To quantify all minor/major adverse events in a large cohort of consecutive corneal transplants, particularly in respect to penetrating keratoplasty (PKP). METHODS:All corneal transplants in the Auckland region over a 10-year period (2000-2009) were identified through the New Zealand National Eye Bank. Relevan...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000001481
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the psychometric properties of the Keratoconus Outcomes Research Questionnaire (KORQ) in patients enrolled in the Save Sight Keratoconus Registry. METHODS:A cross-sectional study was conducted utilizing prospectively collected web-based registry data. The psychometric prop...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000002169
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:Xeroderma pigmentosum (XP) is an extreme hypersensitivity to sunlight causing skin freckling and pigmentary changes because of defective DNA repair mechanisms. The purpose of this article is to evaluate the spectrum of ocular and systemic features in XP at a tertiary eye care center in India over 32 years. MET...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000002499
更新日期：2020-11-30 00:00:00
abstract：PURPOSE:Evaluation of a new method to visualize distribution and morphology of human corneal nerves (Adelta- and C-fibers) by means of fluorescence staining, confocal laser scanning microscopy, and 3-dimensional (3D) reconstruction. METHODS:Trephinates of corneas with a diagnosis of Fuchs corneal dystrophy were sliced...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/01.ico.0000154384.05614.8f
更新日期：2005-07-01 00:00:00
abstract：PURPOSE:To evaluate corneal graft survival over a 5-year period and to investigate whether factors related to the donor, eye bank practices, the recipient, surgery, and postoperative course influenced the outcome. METHODS:Nine hundred ninety-eight patients were randomly selected and monitored in the subsequent 3 years...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e318206895a
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To evaluate and compare corneal higher-order aberrations (HOAs) after Descemet stripping automated endothelial keratoplasty (DSAEK), femtosecond laser-assisted penetrating keratoplasty (FLAK), and conventional penetrating keratoplasty (PKP). METHODS:A retrospective comparison of consecutive surgical series of ...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3182151df2
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:To compare higher-order aberrations (HOAs) after small incision lenticule extraction (SMILE) in patients with and without intraoperative angle kappa adjustments. METHODS:This is a retrospective case series. One hundred six eyes of 106 patients who underwent SMILE at Tianjin Eye Hospital (Tianjin Medical Univer...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000002274
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:To report on a patient in whom hyperopic Implantable Collamer Lenses (ICL, STAAR Surgical, Nidau, Switzerland) and limbal relaxing incisions have been beneficial for the correction of hyperopic astigmatism after laser in situ keratomileusis (LASIK). METHODS:The 48-year-old man had undergone LASIK to correct hi...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31818a7de3
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To compare Tono-Pen AVIA (TPA) intraocular pressure (IOP) measurements performed at the limbus with central corneal Tono-Pen AVIA (TPA) intraocular pressure. METHODS:Fifty-one patients attending our outpatient department with a best corrected visual acuity of ≥ 20/40, no corneal disease, and no astigmatism gre...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31827c9d25
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:The purpose of this study was to determine the correct concentration and duration of application of trypan blue dye to Descemet membrane endothelial keratoplasty (DMEK) donor corneal tissue before transplant to enhance visibility while minimizing damage to the tissue. METHODS:Corneas were precut for DMEK using...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000001074
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of superficial keratectomy and conjunctival advancement hood flap (SKCAHF) for the treatment of bullous keratopathy in canine patients. METHODS:Nine dogs (12 eyes) diagnosed with progressive corneal edema underwent superficial keratectomy followed by placement of conjunctival advanceme...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000000966
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Measurement of central corneal thickness (CCT) plays an essential role in the diagnosis and treatment of many ocular diseases. In this study, we aimed to compare the CCT measurements obtained using the Scheimpflug system (Pentacam; Oculus, Inc) with a retinal optical coherence tomography device (Stratus OCT; Ca...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31820128a4
更新日期：2011-06-01 00:00:00
abstract：:The pharmacokinetics and toxicity of subconjunctival (S/C) amphotericin B (AmB) were evaluated in Dutch-belted rabbits. Following the S/C injection of 1,500 micrograms of AmB, corneal and aqueous levels were determined by bioassay. The highest levels were present in the periphery of debrided corneas at 1 h (90.12 +/- ...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/00003226-199109000-00010
更新日期：1991-09-01 00:00:00
abstract：:Mesenchymal stem cells isolated from connective tissues are pluripotent and differentiate into phenotypes of connective tissue cell lineages (osteoblasts, chondrocytes, and adipocytes) in vitro and in vivo. They have been used to treat mouse models of connective tissue disease such as lumican-null (Lum) and mucopolysa...
journal_title：Cornea
pub_type： 杂志文章,评审
doi：10.1097/ICO.0000000000001010
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:To study the corneal biocompatibility of bevacizumab on various cultured human corneal cells. METHODS:Cell cultures of corneal keratinocytes (CKs), corneal fibroblasts (CFs), and corneal endothelial cells (CECs) were harvested from human donor eyes and exposed to various concentrations of bevacizumab (0.25-5.0...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3180de1d0a
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:To document the relationship of iris cavernous hemangiomas with multiorgan hemangiomas in a child. METHODS:A 7-year-old girl with kidney hemangiomas, brain hemangiomas, and skin hemangiomas developed blurred vision and darkening of the right iris. She had undergone 6 previous brain surgeries and multiple revis...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3180303b46
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine whether long-term wear of a fluid-filled scleral lens alters basal tear production, corneal sensation, corneal nerve density, and corneal nerve morphology in 2 disease categories. METHODS:Patients recruited from the Prosthetic Replacement of the Ocular Surface Ecosystem (...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000000381
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:To report a case of chronic recurrent multifocal osteomyelitis (CRMO) with conjunctival involvement. METHODS:Retrospective chart review. RESULTS:A 10-year-old girl who complained of fatigue and debilitating pain in both hips and legs for >1 year had recurrent episodes of redness and discharge in both eyes wit...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3181589309
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:To investigate the pachymetric changes of collagen cross-linking in corneas with edema because of endothelial dysfunction. METHODS:Interventional case series included 25 eyes of 25 consecutive patients with corneal edema for at least 4 months related to Fuchs endothelial dystrophy, corneal graft failure, and p...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3181c296c2
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To investigate mutations of the human transforming growth factor beta-induced gene (TGFBI), transforming growth factor-beta-induced gene product (betaig-h3, keratoepithelin), in Japanese patients with Avellino corneal dystrophy (ACD), lattice corneal dystrophy (LCD), granular corneal dystrophy (GCD), and Reis-B...
journal_title：Cornea
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1097/00003226-200011000-00015
更新日期：2000-11-01 00:00:00
abstract：PURPOSE:To report 2 cases of ocular chemical burns associated with the use of a swim goggle antifog agent and to review the literature for this and similar antifog products. METHODS:Case reports and systematic review of the medical literature, material safety data, product safety reports, and consumer reviews. RESULT...
journal_title：Cornea
pub_type： 杂志文章,评审
doi：10.1097/ICO.0000000000000706
更新日期：2016-02-01 00:00:00
abstract：:We performed a retrospective analysis of 291 consecutive scleral rim cultures, taken at the time of corneal transplantation, from 1981 to 1986. There were 82 positive cultures (39%), and the most common pathogen was Staphylococcus epidermidis, with 24 positive cultures (30%). Ten of these (42%) were resistant to genta...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/00003226-198706030-00016
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:To report a case of nevirapine-induced Stevens-Johnson syndrome (SJS) misdiagnosed as viral keratitis. METHODS:A 35-year-old AIDS patient, on antiretroviral therapy (ART) with stavudine, nevirapine, and lamivudine, developed bilateral ocular congestion and irritation. He was being treated elsewhere for bilater...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31815b941b
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:To describe a new technique for donor insertion in cases of Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:This is a retrospective case series study of a novel method to introduce the donor tissue in DSAEK. This is a report of 16 cases that underwent the DSAEK procedure. The surgical te...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31816f62bd
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:The depth of corneal crosslinking (CXL) does not seem homogeneous within the treatment area but shows a reduction toward the periphery of the cornea. This study was undertaken to investigate this reduction effect and to look for possible solutions. METHODS:Ten corneas were investigated by means of an optical c...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e318269059b
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:In humans, loss-of-function mutations in the gene encoding Chordin-like 1 (CHRDL1) cause X-linked megalocornea (MGC1), characterized by bilateral corneal enlargement, decreased corneal thickness, and increased anterior chamber depth (ACD). We sought to determine whether Chrdl1 knockout (KO) mice would recapitul...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000002371
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To report intraocular lens (IOL) power calculation in 2 eyes that were highly undercorrected by previous myopic automated lamellar keratoplasty (ALK). METHODS:A 35-year-old man underwent bilateral myopic ALK, which caused high residual myopia (-9.0 -4.0 x 171 and -9.5 -4.5 x 74). The patient then underwent cat...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31817c41fc
更新日期：2008-10-01 00:00:00
