Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye.

Abstract:

PURPOSE:The aim of this study was to evaluate the effectiveness of punctal occlusion using hypromellose 2% in patients with dry eye. METHODS:In this prospective, randomized single-blinded clinical trial, we evaluated 76 eyes of 38 patients (36 women and 2 men) with dry eye secondary to rheumatic diseases. In each patient, the lower lacrimal punctum of 1 eye was occluded using hypromellose 2%, whereas the contralateral eye underwent a simulation of the procedure (control group). Patients' eyes were assessed for burning, itching, redness, foreign body sensation, and tearing based on a visual scale questionnaire (score, 0-10). We also performed objective tests for evaluation of dry eye using a Schirmer test with anesthesia (basal tear secretion test), the tear film break-up time test, and fluorescein and rose bengal staining tests at 0, 28, and 56 days after treatment. RESULTS:Fluorescein and rose bengal staining tests showed that there was a significant reduction in signs after occlusion using hypromellose. The symptoms measured by the visual scale were significantly reduced. The values of the Schirmer test with anesthesia and the break-up time test increased significantly. The effects persisted for up to 8 weeks. There were no dropouts or reported side effects during the 24-month follow-up. CONCLUSIONS:Our results suggest that punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye.

journal_name

Cornea

journal_title

Cornea

authors

Capita L,Chalita MR,dos Santos-Neto LL

doi

10.1097/ICO.0000000000000325

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

188-92

issue

2

eissn

0277-3740

issn

1536-4798

journal_volume

34

pub_type

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