Treatment of vascular inner ear disease with pentoxifylline: a 4-week, controlled, randomized trial.

Abstract:

:The efficacy of pentoxifylline (PXF) in vascular inner ear disease (VIED) was studied comparing PXF and placebo in a 4-week study; 60 patients with unilateral loss of hearing, vertigo, dizziness, tinnitus (analyzed with an analogue scale line), and cochlear flow reduction were included. The aim of the study was to study the effect of PXF (1800 mg/day) in VIED considering clinical outcome and cochlear flow. All patients completed the study. Improvement in cochlear flow (p<0.05) and a decrease in score in both groups were observed. The cochlear flow increase was 287.5% in the PXF group vs 168% in the placebo group (119.5% difference; p<0.02). There was a difference in score decrease (44.1% larger) in the PXF group (p<0.05). PXF was more effective considering flow and symptoms.

journal_name

Angiology

journal_title

Angiology

authors

Incandela L,Cesarone MR,Belcaro G,De Sanctis MT,Nicolaides AN,Griffin M,Geroulakos G,Ramaswami G

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

S19-22

eissn

0003-3197

issn

1940-1574

journal_volume

53 Suppl 1

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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