Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs.

Abstract:

:The effect of a 3 month daily administration of 800 mg pentoxifylline (Trental 400 bds) or placebo was assessed under double blind crossover design in 18 patients (12 males and 6 females) with peripheral occlusive arterial disease in respect of painfree walking distance and various hemorheological and hemostasiological variables, platelet aggregation, serum cholesterol and triglycerides. In first treatment period walking distance significantly increased with pentoxifylline by 46% from baseline 121 +/- 15 m and by 4% with placebo from baseline 134 +/- 18 m. Pentoxifylline administration furthermore yielded significant decrease in whole blood and plasma viscosity and significant increase in erythrocyte deformability. This was paralleled by distinct reduction of fibrinogen, platelet aggregation and euglobulin lysis time, also plethysmographic variables showed positive changes pointing to improvement of limb perfusion. The results of the study suggest that treatment of peripheral occlusive vascular disease by a drug improving blood fluidity through correction of hemorheological and hemostasiological factors turns especially promising and beneficial since the action centers finally on the languishing microcirculation in the ischemic tissue.

journal_name

Angiology

journal_title

Angiology

authors

Strano A,Davi G,Avellone G,Novo S,Pinto A

doi

10.1177/000331978403500709

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

459-66

issue

7

eissn

0003-3197

issn

1940-1574

journal_volume

35

pub_type

临床试验,杂志文章
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    authors: Ilkay E,Tirikli L,Ozercan I,Yavuzkir M,Karaca I,Rahman A,Arslan N

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  • Impedance cardiography for repeated determination of stroke volume in elderly hypertensives: correlation with pulsed Doppler echocardiography.

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  • Front-loaded infusion therapy of rT-PA during active menstruation. A case report.

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    journal_title:Angiology

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    doi:10.1177/000331979404500408

    authors: Lee DW,Garza JL

    更新日期:1994-04-01 00:00:00

  • Transcranial Doppler velocities in patients with thromboangiitis obliterans.

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    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979704800609

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    更新日期:1997-06-01 00:00:00

  • The echocardiographic features of an aneurysm of the inter-atrial septum.

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    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978403500310

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    更新日期:1984-03-01 00:00:00

  • Clinical efficacy of micronized purified flavonoid fraction (MPFF) in edema.

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    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970005100106

    authors: Olszewski W

    更新日期:2000-01-01 00:00:00

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    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319709355802

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    更新日期:2010-04-01 00:00:00

  • The natural history of unexpected Doppler mitral regurgitation.

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    pub_type: 杂志文章

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    更新日期:1989-05-01 00:00:00

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    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978803900701

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    更新日期:1988-07-01 00:00:00

  • Lipid profile and peripheral vascular disease in arseniasis-hyperendemic villages in Taiwan.

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    journal_title:Angiology

    pub_type: 杂志文章

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    更新日期:1997-04-01 00:00:00

  • Impact of diabetes and smoking epidemic in the Middle East on the presentation with acute coronary syndrome in very young patients.

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    journal_title:Angiology

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    更新日期:2012-01-01 00:00:00

  • A 25-year-old patient with low cardiac risk factors having a combination of variant angina and severe coronary arterial lesions--a case report.

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    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970005100911

    authors: Hara Y,Komatsu J,Hiasa G,Ohtsuka T,Suzuki M,Shigematsu Y,Ohkura T,Hamada M,Hiwada K

    更新日期:2000-09-01 00:00:00

  • Gastrointestinal complications after open heart surgery: incidence and determinants of risk factors.

    abstract::Acute mesenteric ischemia is a rare but serious complication of open heart surgery. Between January 2009 and January 2012, 1360 adult patients underwent open heart surgery with cardiopulmonary bypass at our institution; 29 patients presented gastrointestinal complications. Eight patients developed acute mesenteric isc...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319713482357

    authors: Sever K,Ozbek C,Goktas B,Bas S,Ugurlucan M,Mansuroglu D

    更新日期:2014-05-01 00:00:00

  • Early exercise test in acute myocardial infarction treated with intravenous streptokinase.

    abstract::The aim of this study was to assess the value of the early exercise test (ET) in patients with acute myocardial infarction (AMI) treated with IV streptokinase (SK). The authors studied 70 patients with first AMI; 31 were treated with SK and 39 were not. Before discharge everyone was given early exercise up to 5-6 METs...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979104200903

    authors: Hamouratidis N,Katsaliakis N,Manoudis F,Lazaridis K,Tselegaridis T,Stravelas V,Simeonidou E,Roussis S

    更新日期:1991-09-01 00:00:00

  • Increased fasting plasma insulin concentrations are associated with the severity of angiographic coronary artery disease.

    abstract::Fasting plasma insulin concentrations were obtained in 82 patients (51 men and 31 women), mean age 60 +/- 11 years, with a body mass index >25 kg/m(2) who had coronary angiography because of suspected symptomatic coronary artery disease (CAD). Obstructive CAD was diagnosed if there was >50% obstruction of > or =1 vess...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970505600302

    authors: Sukhija R,Aronow WS,Nayak D,Ahn C,Weiss MB

    更新日期:2005-05-01 00:00:00

  • HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study.

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    journal_title:Angiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/000331970505600101

    authors: Cesarone MR,Belcaro G,Pellegrini L,Ledda A,Di Renzo A,Vinciguerra G,Ricci A,Gizzi G,Ippolito E,Fano F,Dugall M,Acerbi G,Cacchio M

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  • Intravascular laser therapy of acute myocardial infarction.

    abstract::The efficacy of a new method of treatment, endovascular blood irradiation with He-Ne laser, developed by the authors, was studied in 295 patients with primary acute transmural myocardial infarction (MI). Twenty-four-hour Holter monitoring findings before and after laser irradiation suggested the possibility of prevent...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:

    authors: Kipshidze NN,Chapidze GE,Bokhua MR,Marsagishvili LA,Dolidze NK,Eristavi DG

    更新日期:1990-09-01 00:00:00

  • Methods of evaluation and quantification of microangiopathy in high perfusion microangiopathy (chronic venous insufficiency and diabetic microangiopathy).

    abstract::Noninvasive tests have been developed to provide qualitative and quantitative information that can offer answers to most questions posed in venous diseases. While duplex scanning is used to assess the macrocirculation, microcirculatory methods assess and quantify venous microangiopathy. Laser Doppler flowmetry is used...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:

    authors: Cesarone MR,De Sanctis MT,Incandela L,Belcaro G,Griffin M,Cacchio M

    更新日期:2001-10-01 00:00:00

  • Behavior of circulating endothelin-1 in a group of patients with acute myocardial infarction.

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    journal_title:Angiology

    pub_type: 临床试验,杂志文章

    doi:10.1177/000331979905000803

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    更新日期:1999-08-01 00:00:00

  • The relationship between lower extremity functional strength and severity of peripheral arterial disease.

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    journal_title:Angiology

    pub_type: 杂志文章

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    更新日期:2004-07-01 00:00:00

  • Aortic coarctation with two intercostal aneurysms, appearing radiographically as a subclavian aneurysm. A case report.

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    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979604700117

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    更新日期:1996-01-01 00:00:00

  • Effect of intravenous naftidrofuryl on transcutaneous oxygen pressure in severe peripheral vascular disease.

    abstract::Intravenous naftidrofuryl has been shown to improve transcutaneous oxygen pressure values in patients with severe ischemia of the lower limbs who were considered unsuitable for reconstructive surgery. Although it did not alter the outcome in patients with rest pain, the clinical impression is that it afforded symptoma...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978904001007

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    更新日期:1989-10-01 00:00:00

  • Combination of calcium channel blockers and beta blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. The Netherlands Working Group on Cardiovascular Resear

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    journal_title:Angiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1177/000331979905000602

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  • Platelet half-life, plasma thromboxane B2 and circulating endothelial-cells in peripheral vascular disease.

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    更新日期:1986-02-01 00:00:00

  • Common carotid artery wall properties in Takayasu's arteritis.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 临床试验,杂志文章

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    更新日期:1985-03-01 00:00:00