Abstract:
:Endothelial cell-specific molecule 1 (ESM-1; endocan) is expressed by endothelial cells, and it can be overexpressed in diabetic patients. However, little is known concerning diabetic patients with acute ST-segment elevation myocardial infarction (STEMI). Therefore, we assessed serum ESM-1 level in patients having type 2 diabetes mellitus (T2DM) STEMI; 72 patients with DM (38 with and 34 without vascular disease) and 33 individuals as a control group were included. There was a significant difference in serum ESM-1 level between the T2DM group and the control group (P = .03). There was also a significant difference in serum ESM-1 level between the T2DM with STEMI group and newly diagnosed T2DM group without vascular disease (P = .01). In patients with T2DM, serum ESM-1 levels correlated positively with high-sensitivity C-reactive protein levels and the neutrophil to lymphocyte ratio (r = .321, P = .006 and r = .320, P = .006). Our findings suggest that serum ESM-1 level may be a novel endothelial dysfunction biomarker and it may be related to vascular disease in T2DM.
journal_name
Angiologyjournal_title
Angiologyauthors
Qiu CR,Fu Q,Sui J,Zhang Q,Wei P,Wu Y,Zhu K,Lu Y,Wan Pdoi
10.1177/0003319716634581subject
Has Abstractpub_date
2017-01-01 00:00:00pages
74-78issue
1eissn
0003-3197issn
1940-1574pii
0003319716634581journal_volume
68pub_type
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