Influence of the ultrasound contrast agent Levovist on human nailfold capillary microcirculation.

Abstract:

:Little is known about the behavior of ultrasound contrast microbubbles in human capillaries. The evaluation of circulatory effects of echo contrast media may bring valuable information for the interpretation of echo contrast phenomena in the human myocardium. In 12 healthy volunteers (aged 31 +/- 6.7 years; five women), nailfold capillaries were examined by means of TV microscopy. The authors investigated acral microcirculation at rest and after local cold application with and without saccharide-based microbubbles (10 mL Levovist 300 mg/mL IV). The mean blood flow velocity at rest was 1.18 +/- 0.18 mm/s (mean value +/-1 SD) and 1.11 +/- 0.11 mm/s (mean value +/- 1 SD) after the injection of Levovist (ns). One minute after local cold exposure a decrease of the blood flow velocity by 61% before and by 75% after intravenous Levovist was found. In both groups the cold-induced decrease of blood flow velocity was statistically significant (p<0.01), whereas there was no significant difference in flow reaction between the two groups. No wall adhesion of blood cells or extravasation of contrast into the surrounding tissue was detected. After intravenous injection of a regular dose of saccharide-based microbubbles Levovist, no change of blood cell flow velocity and no wall adhesion or extravasation could be found at rest and after cold application in human nailfold capillaries. Since microcirculatory flow characteristics in the finger nailfold capillaries are not influenced by Levovist, it might be assumed also that myocardial blood flow behavior remains unchanged, so that this contrast agent may be used as a flow tracer for cardiac investigation.

journal_name

Angiology

journal_title

Angiology

authors

Immer FF,Seiler AM,Aeschbacher BC,Mahler F,Saner H

doi

10.1177/000331970005100205

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

123-9

issue

2

eissn

0003-3197

issn

1940-1574

journal_volume

51

pub_type

杂志文章
  • Serum magnesium and potassium in acute myocardial infarction: relationship to existing beta-blockade and infarct size.

    abstract::Patients (n = 314) with acute myocardial infarction (AMI) were divided into three groups according to the time elapsed from onset of chest pain to when the first sample for determination of magnesium (s-Mg1) and potassium (s-K1) was drawn (A: hours 0-6; B: hours 6-10, and C: hours 10-24). Potassium and Mg were also me...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979304400502

    authors: Landmark K,Urdal P

    更新日期:1993-05-01 00:00:00

  • Peripheral arterial disease is prevalent but underdiagnosed and undertreated in the primary care setting in central Greece.

    abstract::We investigated the prevalence of peripheral arterial disease (PAD). Primary Care Health Centers (n = 14) in Thessaly (central Greece) recruited 436 participants, mean age 71 (50-79) years. Peripheral arterial disease was considered present if the ankle-brachial index (ABI) was <0.9 or >1.4 in at least 1 leg. Asymptom...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319712439092

    authors: Argyriou C,Saleptsis V,Koutsias S,Giannoukas AD

    更新日期:2013-02-01 00:00:00

  • Serum γ-glutamyltransferase activity in patients with nonvalvular atrial fibrillation.

    abstract::Procoagulant and prothrombotic states in patients with chronic atrial fibrillation (AF) are higher than those in patients with normal sinus rhythm. We assessed and compared serum γ-glutamyltranferase (GGT) activity in elderly patients with nonvalvular AF and control participants with normal sinus rhythm. Consecutive p...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319712438956

    authors: Tekin G,Tekin YK,Senarslan DA,Gocmen AY,Senarslan O,Erbay AR

    更新日期:2013-02-01 00:00:00

  • Percutaneous transluminal coronary angioplasty of anomalous coronary arteries. Case reports.

    abstract::To date, technical experience reported in the literature is very limited on angioplasty in patients with anomalous coronary arteries. Balloon angioplasty may be a more favorable approach for revascularization in these vessels. A major factor is selection of the guiding catheter. The authors report 4 patients with seve...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979604700112

    authors: Oral D,Dağalp Z,Pamir G,Alpman A,Omürlü K,Erol C,Kervancioğlu C,Telli HH

    更新日期:1996-01-01 00:00:00

  • A study on left atrial transport function. Effect of age or left ventricular ejection fraction on left atrial storage fraction.

    abstract::Left atrial (LA) storage fraction is defined as the ratio of storage volume of the left atrium (LA) during ventricular systole to left ventricular (LV) stroke volume. To test their hypothesis that left atrial (LA) storage fraction is increased to compensate for impaired LV filling in the heart of aged subjects or with...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979404501108

    authors: Nishigaki K,Arakawa M,Miwa H,Kagawa K,Noda T,Ito Y

    更新日期:1994-11-01 00:00:00

  • Nitrendipine monotherapy in severe hypertension.

    abstract::Nitrendipine is a new dihydropyridine derivative developed specifically for the treatment of hypertension. Oral nitrendipine was administered to twelve patients with severe hypertension (diastolic blood pressure greater than 114 mm/Hg). All antihypertensive drugs were discontinued at least 72 hours prior to nitrendipi...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:

    authors: Mroczek WJ,Burris JF

    更新日期:1988-01-01 00:00:00

  • Effects of intravenous streptokinase and CLS 2210 (calcium dobesilate) on the biochemical markers of early acute myocardial infarction: a historic comparison with both studies.

    abstract::In a previous double-blind, randomized study, CLS 2210 (a new formulation of calcium dobesilate) or placebo was administered by intravenous infusion to 41 patients having their first acute myocardial infarction. In the present study 19 comparable patients were treated intravenously with streptokinase under identical c...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979204300904

    authors: Szlavy L,Repa I,Lengye I,Lamboy L

    更新日期:1992-09-01 00:00:00

  • Fate of incidental, asymptomatic lesions discovered during percutaneous coronary intervention.

    abstract::The authors aimed to determine the incidence and angiographic features associated with plaque progression requiring nontarget lesion percutaneous coronary intervention after culprit lesion percutaneous coronary intervention. Of 945 consecutive percutaneous coronary interventions reviewed, 100 patients who required non...

    journal_title:Angiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0003319707303889

    authors: Caymaz HO,Yüksel G

    更新日期:2008-04-01 00:00:00

  • Fascial pathways of extravasation of blood in lower abdomen following angiography-anatomic and clinical correlation.

    abstract::The extravasation of urine following traumatic rupture of the urethra or periurethral abscess is well known to clinicians. The extravasation of blood following angiography, in the same anatomical space, is rare. Extravasation of fluids in the lower abdomen, groin and external genitalia follows distinct anatomical path...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978403501009

    authors: Khan SA,Desai PG,Jayachandran S,Smith N

    更新日期:1984-10-01 00:00:00

  • Mortality and morbidity in patients with intermittent claudication in relation to the location of the occlusive atherosclerosis in the leg.

    abstract::Mortality and morbidity from cerebrovascular and coronary arterial disease over a period of six years were studied in 224 non-diabetic patients with intermittent claudication. Patients with multiple arterial stenoses in the leg had a lower six-year survival than patients with single stenoses (55% versus 77%), with a h...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978503600508

    authors: Jonason T,Ringqvist I

    更新日期:1985-05-01 00:00:00

  • Effect of oral pentoxifylline therapy on venous lower extremity ulcers due to deep venous incompetence.

    abstract::The effect of oral pentoxifylline, administered 1,200 mg/day (400 mg slow-release tablets tid) through six weeks, was studied in 10 patients with established deep venous incompetence and persisting venous ulcers. The following parameters were used for verification of the therapeutic result: venous patency (VP) and val...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978904000811

    authors: Angelides NS,Weil von der Ahe CA

    更新日期:1989-08-01 00:00:00

  • Adipose-Derived Mesenchymal Stem Cells in the Treatment of Diabetic Foot Ulcers: A Review of Preclinical and Clinical Studies.

    abstract::This review provides an outline of the use of adipose-derived mesenchymal stem cells (AMSCs) in the treatment of diabetic foot ulcers (DFUs). A systematic search of PubMed and the Cochrane database was performed on October 2, 2019. Eighteen studies were identified (14 preclinical and 4 clinical). Studies in animal mod...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/0003319720939467

    authors: Álvaro-Afonso FJ,Sanz-Corbalán I,Lázaro-Martínez JL,Kakagia D,Papanas N

    更新日期:2020-10-01 00:00:00

  • Headache, thrombolytic therapy, and chronic subdural hemorrhage--a case report.

    abstract::Subdural hematomas are well known but infrequent complications of thrombolytic therapy. Although these are usually associated with head trauma, the authors describe a case of a patient who received a particularly aggressive thrombolytic regimen and presented six months later with complaints of nothing more than a head...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979404500112

    authors: Nathan PE,Sonenblick D,Chakote V,Wolf R,Sacchi TJ

    更新日期:1994-01-01 00:00:00

  • Placebo-controlled, double-blind trial of hemodilution in peripheral occlusive arterial disease.

    abstract::A number of uncontrolled trials has suggested that hemodilution is effective in peripheral occlusive arterial disease. This study was aimed at proving or disproving the efficacy of hemodilution by using a randomized, placebo-controlled, double-blind crossover design. Twenty-four stable claudicants with long, collatera...

    journal_title:Angiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/000331978904000509

    authors: Ernst E,Matrai A,Kollar L

    更新日期:1989-05-01 00:00:00

  • Nutraceuticals in lipid-lowering treatment: a narrative review on the role of chitosan.

    abstract::Lipid-lowering drugs may cause adverse effects and, although lipid targets may be achieved, a substantial residual cardiovascular (CV) risk remains. Treatment with agents mimicking proteins present in the body, such as incretin-based therapies, provided promising results. However, in order to improve lipids and CV ris...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/0003319714542999

    authors: Patti AM,Katsiki N,Nikolic D,Al-Rasadi K,Rizzo M

    更新日期:2015-05-01 00:00:00

  • A serial observation of coronary thrombi in vivo by a new percutaneous transluminal coronary angioscope.

    abstract::This study was undertaken to observe coronary thrombus formation serially from an antegrade perspective by means of a new thin flexible angioscope that has an inflatable balloon at the distal tip and an angulation mechanism. To test its capabilities, thrombi were induced in the left anterior descending coronary artery...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979204300202

    authors: Mizuno K,Miyamoto A,Isojima K,Kurita A,Senoo A,Arai T,Kikuchi M,Nakamura H

    更新日期:1992-02-01 00:00:00

  • Nonselective left internal mammary artery angiography during right transradial coronary angiography: a simple, rapid, and safe technique.

    abstract::Internal mammary artery angiography is increasingly required, but the technique for left internal mammary artery (LIMA) angiography during right transradial coronary angiography is not well established. The authors investigated the feasibility and safety of a new, simple, and rapid nonselective technique. Following ri...

    journal_title:Angiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/000331970105201107

    authors: Cha KS,Kim MH,Hung JS,Woo JS,Kim YD,Kim JS

    更新日期:2001-11-01 00:00:00

  • Brachial artery catheterization via cutdown and a direct needle puncture.

    abstract::Brachial artery catheterization via cutdown and a direct needle puncture was evaluated in 369 patients undergoing arteriography at the authors' medical center from January, 1970, to March, 1988. The indications for retrograde brachial arteriography were absence of palpable femoral pulses, failure of a femoral approach...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978904000306

    authors: Vaghei R,Terrell EB,Kunyosying U

    更新日期:1989-03-01 00:00:00

  • Hemodynamics and gas exchange during angioscopy in the dog.

    abstract::We have previously developed a technique for the in vivo visualization of the pulmonary arteries in the experimental animal with a fiberoptic instrument (angioscope). To assess the potential hemodynamic and gas exchange effects of angioscopy, we studied five dogs before and after pulmonary embolization. Sequential obs...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978403500205

    authors: Shure D,Moser KM,Konopka RG

    更新日期:1984-02-01 00:00:00

  • Intravenous leiomyomatosis extending into the right ventricular cavity: one-stage radical operation using cardiopulmonary bypass--a case report.

    abstract::The authors describe a 47-year-old woman with intravenous leiomyomatosis (IVL) extending into the right ventricular cavity. This rare entity is a neoplasm originating from smooth muscle of the uterus, with vermiform extensions into the inferior vena cava. The patient underwent a one-stage operation under simultaneous ...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970005100608

    authors: Wakiyama H,Sugimoto T,Ataka K,Yamashita C,Tsuji Y,Nakagiri K,Inoue K,Okada M

    更新日期:2000-06-01 00:00:00

  • The antihypertensive effects of a pure and selective serotonin-receptor blocking agent (R 41 468) in elderly patients.

    abstract::In a first experiment, an acute intravenous administration of 10 mg R 41 468, a pure serotonin-receptor blocking agent with high selectivity for blood vessels and thrombocytes and devoid of central effects, dramatically reduced systolic and diastolic blood pressure in 23 elderly hypertensive patients. Heart rate and c...

    journal_title:Angiology

    pub_type: 临床试验,杂志文章

    doi:10.1177/000331978103200206

    authors: De Cree J,Leempoels J,De Cock W,Geukens H,Verhaegen H

    更新日期:1981-02-01 00:00:00

  • Relationship between mean platelet volume and atherosclerosis in young patients with ST elevation myocardial infarction.

    abstract::Increased mean platelet volume (MPV) is associated with poor clinical outcome in patients with acute coronary syndrome. We evaluated the predictive role of MPV in young patients with acute myocardial infarction (AMI). This study includes 373 patients who presented to our hospital with AMI (group 1: 134 young patients,...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319712448834

    authors: Ozkan B,Uysal OK,Duran M,Sahin DY,Elbasan Z,Tekin K,Cagliyan CE,Cayli M

    更新日期:2013-07-01 00:00:00

  • Clinical, bacteriologic and echocardiographic evaluation of infective endocarditis in Ankara, Turkey.

    abstract::This study consists of a retrospective evaluation of microbiologic, echocardiographic, and clinical characteristics of patients with infective endocarditis seen at Türkiye Yüksek Ihtisas and SSK Ihtisas Hospitals during the previous 5 years to provide a basis for comparison with other series. The study was performed r...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970205300210

    authors: Heper G,Yorukoglu Y

    更新日期:2002-03-01 00:00:00

  • Renal artery dissection following marathon running.

    abstract::A 38-year-old, previously healthy man presented with flank pain after competing in a marathon. Initial laboratory tests and urinalysis were essentially normal. Both contrast enhanced-computed tomography and magnetic resonance angiography showed an infarcted region of the left lower kidney without renal artery dissecti...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/0003319707310278

    authors: Iqbal FM,Goparaju M,Yemme S,Lewis BE

    更新日期:2009-02-01 00:00:00

  • Future/novel uses of beta blockers in clinical therapeutics.

    abstract::Beta-blocker usage in the United Kingdom centers around propranolol and oxprenolol as noncardioselective drugs, atenolol and metoprolol as cardioselective agents, and pindolol or oxprenolol when partial agonist activity is desired. Any meaningful comparison of a novel beta blocker against the established drugs must be...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978603700312

    authors: Maclean D

    更新日期:1986-03-01 00:00:00

  • Association between serum fetuin-A levels, carotid artery stiffness, and intima-media thickness in patients with normotensive obstructive sleep apnea syndrome.

    abstract::Increased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association b...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319713497421

    authors: Akyuz A,Oran M,Alpsoy S,Mutlu LC,Akkoyun DC,Guzel S,Alp R

    更新日期:2014-08-01 00:00:00

  • Primary stenting of the superior mesenteric artery for treatment of chronic mesenteric ischemia--a case report.

    abstract::Percutaneous transluminal angioplasty (PTA) has been well described in the treatment of mesenteric artery stenoses but has met with limited success in ostial lesions. The authors describe a case of a 79-year-old woman diagnosed with chronic mesenteric ischemia associated with a 22-pound weight loss and postprandial pa...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979905000108

    authors: Forauer AR,McLean GK

    更新日期:1999-01-01 00:00:00

  • Cardiac effects of alcohol.

    abstract::There is little information on the echocardiographic evaluation of left ventricular performance after the ingestion of alcohol. Therefore, we obtained echocardiograms and systolic time intervals in 9 normal subjects before and after a cocktail party. These subjects drank 5-6 ounces of 87 proof whiskey during the party...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978003101103

    authors: Gould L,Reddy CV,Singh BK,Zen B

    更新日期:1980-11-01 00:00:00

  • Cardiorenal anemia syndrome: do erythropoietin and iron therapy have a place in the treatment of heart failure?

    abstract::The cardiorenal anemia syndrome in congestive heart failure (CHF) is an independent risk factor for vascular morbidity and mortality. Several factors play a role in the pathogenesis of anemia in CHF, including inflammation, impaired renal function, use of certain antihypertensive or cardioprotective agents, and gastro...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/0003319708316169

    authors: Pagourelias ED,Koumaras C,Kakafika AI,Tziomalos K,Zorou PG,Athyros VG,Karagiannis A

    更新日期:2009-02-01 00:00:00

  • The association between ankle brachial pressure index and pulse wave velocity: clinical implication of pulse wave velocity.

    abstract:OBJECTIVE:The aim of this study was to assess the relationship between ankle brachial pressure index and pulse wave velocity in patients with peripheral arterial disease. METHODS:Brachial-knee and brachial-ankle pulse wave velocity were measured by pneumoplethysmography using cuffs in a standard technique. Correlation...

    journal_title:Angiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/0003319708329335

    authors: Khandanpour N,Armon MP,Jennings B,Clark A,Meyer FJ

    更新日期:2009-12-01 00:00:00