Coumarin-induced skin necrosis following heparin-induced thrombocytopenia and thrombosis. A case report.

Abstract:

:A severe thrombotic thrombocytopenic status, induced by heparin in a sixty-nine-year-old woman undergoing total hip joint arthroplasty, was treated by switching the anticoagulant therapy to coumarin, which induced skin necrosis. There appeared to be a possible causal relation between the severe immune reaction to heparin and the condition that predisposed to skin necrosis in the presence of coumarin. In patients who express a strong immune response to heparin, a different anticoagulant approach other than use of coumarin congeners appears to be justified.

journal_name

Angiology

journal_title

Angiology

authors

Shahak A,Pósán E,Szücs G,Rigó J,Boda Z

doi

10.1177/000331979604700715

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

725-7

issue

7

eissn

0003-3197

issn

1940-1574

journal_volume

47

pub_type

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