Modification of cardiometabolic risk through cannabinoid type-1 receptor antagonism.

Abstract:

:Large-scale epidemiological studies show that hypertension, diabetes, and dyslipidaemia are highly prevalent among obese individuals. Regrettably, preventive efforts have failed to abolish the increasing prevalence of obesity worldwide. The endocannabinoid system is implicated in the regulation of appetite, food intake, lipids, and glucose metabolism. Rimonabant is the first type-1 endocannabinoid receptor blocker that has been shown to improve the serum lipid profile, insulin and glucose levels, and blood pressure. In particular, the RIO (rimonabant in obesity) studies documented the beneficial metabolic effects of rimonabant. These favorable metabolic effects exceed by about 50% those anticipated by weight reduction, possibly due to modulation of the endocannabinoid system in peripheral tissues. The beneficial effects, however, seem to come at the cost of an increased risk of psychiatric disorders. However, given the efficacy of this treatment and the magnitude of the obesity problem, rimonabant may prove to be a valuable adjunct in targeting obesity-related cardiovascular risk factors.

journal_name

Angiology

journal_title

Angiology

authors

Andrikopoulos GK,Tzeis S

doi

10.1177/0003319708320938

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

44S-8S

issue

2 Suppl

eissn

0003-3197

issn

1940-1574

pii

0003319708320938

journal_volume

59

pub_type

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