Abstract:
:Drugs such as dipyridamole (200 micrograms/kg/min), an adenosine uptake inhibitor, and theophylline (300 micrograms/kg/min), an adenosine receptor antagonist, respectively increased and decreased postischemic hyperemia in normal subjects, as well as in POAD patients. Moreover, dipyridamole pretreatment was able to antagonize the reduction of peak flow induced by nifedipine, and the potentiating effect of flunarizine on postischemic hyperemia was affected significantly by theophylline, thus suggesting a possible interference of calcium entry blocker drugs with the endogenous adenosine system. In a cellular model (polymorphonuclear leukocytes--PMN) the inhibitory effect of calcium entry blockers on stimulated functions (degranulation and free radical production) was highly antagonized by theophylline. Finally, a 1H-NMR spectroscopy study showed a binding interaction between adenosine and flunarizine on the cell membrane. An adenosine-receptor coupling to the calcium entry blocker channels is suggested.
journal_name
Angiologyjournal_title
Angiologyauthors
Di Perri T,Pasini FL,Pecchi S,De Franco V,Damiani P,Pasqui AL,Capecchi PL,Orrico A,Materazzi M,Domini Ldoi
10.1177/000331978904000307subject
Has Abstract,Author List Incompletepub_date
1989-03-01 00:00:00pages
190-8issue
3eissn
0003-3197issn
1940-1574journal_volume
40pub_type
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